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All Journal Abdi Cendekia: Jurnal Pengabdian Masyarakat Health & Medical Sciences Jurnal Sains Farmasi dan Kesehatan Galen: Jurnal Ilmu Farmasi dan Kesehatan
Razoki
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Uji Efek Antihiperglikemia Kombinasi Fraksi Aktif Ekstrak Etanol Daun Alpukat (Persea Americana Mill) dan Ekstrak Ikan Gabus (Channa Striata) pada Tikus Wistar (Rattus Norvegius) Joanna Elvia Harefa; Razoki; Gusbakti Rusip
Abdi Cendekia : Jurnal Pengabdian Masyarakat Vol 3 No 2 (2024): Juli
Publisher : Yayasan Zia Salsabila

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.61253/abdicendekia.v3i2.249

Abstract

Diabetes melitus merupakan suatu kumpulan gejala klinis (sindromaklinis) yang timbul karena adanya peningkatan kadar glukosa darah kronis akibat kekurangan insulin, baik relatif maupun absolut. Perkembangan pemanfaatan berbagai bahan alam di bidang kesehatan yaitu sebagai obat tradisional telah dijadikan sebagai alternatif pengobatan bagi masyarakat dengan didukung oleh penelitian yang terkait dan data yang ilmiah. Ikan gabus adalah sejenis ikan predator yang hidup di air tawar. Diketahui bahwa ikan ini sangat kaya akan albumin salah satu jenis protein yang tinggi dimanfaatkan sebagai sumber antioksidan dan antihiperglikemia maupun antidiabetes. Tujuan penelitian ini adalah untuk mengetahui efek antihiperglikemia dari fraksi ekstrak etanol daun alpukat dan ekstrak ikan gabus sebagai antihiperglikemia pada tikus wistar. Metode pengumpulan data yang digunakan adalah eksperimental laboratorium, penelitian ini menggunakan rancangan randomized post-test control group design. Hasil penelitian menunjukkan kombinasi kedua ekstrak dapat memberikan efek sinergis dalam menurunkan kadar gula darah, serta menentukan dosis yang tepat dan menilai potensi toksisitasnya.
Rationality of Drug Administration in Patients with Diabetes Mellitus at Royal Prima Hospital Medan Lubis, Graida Tsuraiya; Simanjuntak, Nerly Juli Pranita; Razoki
Health & Medical Sciences Vol. 2 No. 4 (2025): August
Publisher : Indonesian Journal Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.47134/phms.v2i4.436

Abstract

Acute and chronic diseases caused by poor lifestyle choices or genetics are becoming more common over time and do not seem to be decreasing each year.  This study aims to determine whether the treatment of type 2 diabetes mellitus patients with or without hypertension at Royal Prima Medan Hospital is appropriate.  Descriptive research methodology, namely cross-sectional data, was used in this study.  Retrospective data collection was conducted using information from medical records at one of the Royal Prima Medan University Hospitals from November 2023 to April 2024. Based on 93 medical records, the findings showed that the right drug, right indication, and right dose were all 100% rational.  Moderate drug interactions accounted for 67% of all drug interactions, major interactions 18%, and minor interactions 15%.  In conclusion, Royal Prima University Hospital in Medan had 100% rational medical data for the period November 2023-April 2024.
Analisis Faktor-Faktor yang Mempengaruhi Pengobatan Pasien TB di Puskesmas PB Selayang II Kota Medan Monica Silviyana Simbolon; Erida Novriani; Razoki
Jurnal Sains Farmasi Dan Kesehatan Vol. 3 No. 1 (2025): Mei - Agustus
Publisher : CV. ITTC INDONESIA

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.62379/jfkes.v3i1.2642

Abstract

Tuberculosis (TB) is an infectious disease that is one of the leading causes of death in the world. Indonesia ranks second highest in global TB cases, with Medan City being one of the areas with significant cases. This study aims to analyze the factors that influence the treatment of TB patients at the PB Selayang II Health Center in Medan City. The study used a qualitative descriptive method with an in-depth interview approach to ten TB patients until information saturation was reached. The results of the analysis showed that the factors that most influenced the treatment of TB patients were compliance, knowledge, and demographic factors such as age, educations. Family support, personal motivation, and the role of health workers also play an important role in the success of treatment. This study concludes that interventions to improve patient compliance and knowledge, as well as paying attention to socio-economic conditions, are very important in TB control programs at the primary health care level.
Evaluasi Drug Related Problems (DRPs) pada Pasien Diabetes Melitus dengan Komplikasi Hipertensi Rawat Inap di RSU Royal Prima Marelan Herna Nurlaila Maulidia; Razoki; Novitaria Br Sembiring
Galen: Jurnal Riset Ilmu Farmasi dan Kesehatan Vol. 1 No. 2 (2025): Galen: Jurnal Riset Ilmu Farmasi dan Kesehatan
Publisher : PT Pustaka Cendekia Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.71417/galen.v1i2.25

Abstract

Penelitian ini dilakukan untuk menilai kejadian Drug Related Problems (DRPs) pada pasien yang menderita diabetes melitus tipe 2 disertai komplikasi hipertensi yang dirawat inap di RSU Royal Prima Marelan. Metode: Penelitian yang digunakan bersifat deskriptif retrospektif, dengan analisis data rekam medis pasien selama periode Januari hingga Maret 2024. Jumlah subjek penelitian sebanyak 54 resep pada rekam medis, mayoritas berusia 50 tahun ke atas sebanyak 41 pasien (76%) dan berjenis kelamin Perempuan sebanyak 35 pasien (65%). Hasil: Dari hasil evaluasi ditemukan 58 kejadian DRPs, yang paling dominan berupa interaksi obat sebanyak 33 kejadian (57%), diikuti oleh penggunaan obat tanpa indikasi medis yang jelas sebanyak 12 kejadian (21%), efek samping obat sebanyak 7 kejadian (12%), serta ketidaktepatan dalam pemilihan obat sebanyak sebanyak 6 kejadian (10%). Kesimpulan: Hasil ini menunjukkan perlunya pemantauan terapi yang lebih ketat dan kolaborasi antar tenaga medis untuk mengurangi risiko DRPs.
Efektifitas Daun Kersen (Muntingia Calabura L.) Terhadap Profil Histologi Tikus Putih Jantan (Rattus Norvrgicus) Diabetes Mellitus Telaumbanua, David Charles; Erida Novriani; Razoki
Jurnal Sains Farmasi Dan Kesehatan Vol. 3 No. 1 (2025): Mei - Agustus
Publisher : CV. ITTC INDONESIA

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.62379/jfkes.v3i1.3242

Abstract

Diabetic mellitus (DM) is a degenerative condition marked by high blood suger levels brought on by a malfunction in the metabolisme of insulin. Serious side effect, such as harm to organs including the pancreas can result from uncontrolled diabetes mellitus the use of medicanal plants, such the kersen leaf (Muntingia calabura L.), which includes active substances like flavonoids, alkaloids, saponins and tannins whith possible antidiabetetic effects, is one altenate therapy option that is presently being investigated. Using male white rats (Rattus norvegicus) with diabetes, this study intends to assess the impact of an ethanolic extract of (Muntingia calabura L.) leaves on the pancreas and identify the optimal dosage for mitigating pancreatic cell damage. Five groups are used in this pure experimental study: three treatment groups that get extract doses of 150,300 and 600 mg/kgBW; a positive control that receives glibencalmide; and a negative control that receives Na CMC. Assessments were made of pancreatic histology and blood glucose levels. The results should offer scientific validation for the long-standing practice of using cherry leaves to treat diabetes.
Antibacterial Activity of Abelmoschus manihot L. Leaf Extract Ointment Against Pseudomonas aeruginosa Fani Lolyta Br Sihotang; Nerly Juli Pranita Simanjuntak; Razoki
Galen: Jurnal Riset Ilmu Farmasi dan Kesehatan Vol. 1 No. 2 (2025): Galen: Jurnal Riset Ilmu Farmasi dan Kesehatan
Publisher : PT Pustaka Cendekia Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.71417/galen.v1i2.42

Abstract

Diabetes mellitus is a chronic metabolic disorder characterized by hyperglycemia resulting from insulin resistance or deficiency. One of its severe complications is diabetic foot ulcers, which are prone to infection, especially by Pseudomonas aeruginosa—a Gram-negative opportunistic bacterium capable of forming biofilms and highly resistant to common antibiotics. This resistance complicates wound healing and increases the risk of amputation, emphasizing the need for alternative treatments. Abelmoschus manihot L. (Gedi leaves) contains bioactive compounds such as flavonoids, tannins, and phenolics, which are believed to possess antibacterial properties. This study aims to evaluate the potential of ethanolic Gedi leaf extract as an active ingredient in antibacterial ointment formulations. Ethanolic extracts were prepared and formulated into ointments at concentrations of 2%, 4%, 6%, and 8%. The formulations were tested for physical properties (pH, spreadability, organoleptic characteristics) and antibacterial activity against P. aeruginosa using the disk diffusion method. Results showed that the ointments had a uniform semi-solid texture, a characteristic herbal aroma, green color, and pH values ranging from 6.3 to 6.7—suitable for topical application. Spreadability ranged between 4.1 cm and 5.3 cm. The inhibition zones for the 2%, 4%, 6%, and 8% formulations were 6.67 mm, 8.00 mm, and 10.67 mm, respectively. No inhibition was observed with the negative control (DMSO), while the positive control (Bioplacenton) showed a 15.00 mm zone. In conclusion, Gedi leaf extract ointment demonstrated effective antibacterial activity against P. aeruginosa, with consistent physical properties across all concentrations. These findings suggest its potential as a natural topical therapy for treating bacterial infections in diabetic foot ulcers.
Uji Anti Hiperglikemik Ekstrak Etanol Daun Salam (Syzygium Polyanthum (Wight.) Walp) Dan Daun Cepcepan (Castanopsis Costata (Blume) A. Dc.) Terhadap Tikus Putih Devortivo Hartono Putra; Erida Novriani; Razoki
Jurnal Sains Farmasi Dan Kesehatan Vol. 3 No. 2 (2025): September - Desember
Publisher : CV. ITTC INDONESIA

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.62379/jfkes.v3i2.3399

Abstract

Hyperglycemia, characterized by elevated blood glucose levels, is a key clinical feature of diabetes mellitus. In recent years, medicinal plants have gained attention as alternative therapies due to their relatively minimal side effects. This study aimed to explore the potential of acombined ethanol extract of bay leaf (Syzgium polyanthum) and cepcepan leaf (castanopsis costata) in lowering blood flucose leveles in white rats (Rattus norvegicus) induced with alloxan. The extraction process was carried out using the maceration methos with 96% ethanol. Phytochemical screening revealed the presence of active compounds such as flavonoids, alkoloids, tannins, saponins, and steroid. The rats were divided into six groups: a normal group. A negative control group (alloxan only), a positive control group (glibenclamide 0.45 mg/kgBB), and three treatment groups receiving the combined extract at doses of 120 mg/kgBW, 250mg/kgBW, and 500mg/kgBW. Blood glucose levels were monitored from day 0 to day 15. ANOVA analysis showed a reduction in glucose levels among the treatment groups, althought the results were not statistically significant (p > 0.05). nevertheless, a consistent downward trend was observed, particularyl in the group receiving 250mg/kgBW. These findings suggest that the ethanol extract combination of bay and cepcepan leaves holds promise as an antihyperlycemic agent. However, frurther research is necessary to confirm its efficacy and fully understand its mechanism of action.
Co-Authors Devortivo Hartono Putra Erida Novriani Fani Lolyta Br Sihotang Gusbakti Rusip Herna Nurlaila Maulidia Joanna Elvia Harefa Lubis, Graida Tsuraiya Monica Silviyana Simbolon Nerly Juli Pranita Simanjuntak Novitaria Br Sembiring Simanjuntak, Nerly Juli Pranita Telaumbanua, David Charles