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All Journal Jurnal Kesehatan Amanah Jurnal An-Najat: Jurnal Ilmu Farmasi dan Kesehatan Jurnal Sains Farmasi dan Kesehatan Jurnal Indah Sains dan Klinis
Astriani Natalia
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Dentistry Health Professions Medicine & Pharmacology Neuroscience Nursing Physics Public Health Veterinary

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Uji Kadar Gula pada Susu Meal Replacement di Kota Medan dengan Spektofotometri UV-Vis Marini Marini; Rena Meutia; Astriani Natalia; Nerly Juli Pranita Simanjuntak
An-Najat Vol. 3 No. 2 (2025): Mei : An-Najat : Jurnal Ilmu Farmasi dan Kesehatan
Publisher : STIKes Ibnu Sina Ajibarang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.59841/an-najat.v3i2.2545

Abstract

Diabetes and obesity are closely related, with obesity as a nutritional problem that continues to increase. Obesity occurs due to an imbalance in energy intake and expenditure, while diabetes is often not realized until serious complications appear. A diet high in fiber and low in sugar can reduce the risk of diabetes. Meal replacements such as powdered milk and snack bars can be used, but consumption needs to be limited because their nutritional content is less than ideal and has the potential to cause health problems if consumed excessively. The research was carried out using quantitative and qualitative methods on 3 types of meal replacement milk powder drinks, namely brand A, brand B and brand C. This was done by collecting samples deliberately according to the inclusion and exclusion criteria, which is the sampling strategy used in this research. then research evaluation carried out 3 types of tests; Molisch's test, Benedict's test and Fehling's test. The results of the research show that the three samples of meal replacement milk circulating in the city of Medan contain sugar, but are quite safe for consumption in general and the sugar content in meal replacement milk does not exceed the daily sugar level.
Efektivitas Ekstrak Etanol Biji Alpukat (Persea americana Mill.) dalam Penurunan Hiperurisemia pada Mencit (Mus musculus L.) Sylvia Winata; Rena Meutia; Astriani Natalia; Asyrun Alkhairi Lubis
Jurnal Kesehatan Amanah Vol. 9 No. 1 (2025): Jurnal Kesehatan Amanah
Publisher : Universitas Muhammadiyah Manado

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.57214/jka.v9i1.764

Abstract

Hyperuricemia is a degenerative condition due to increased blood uric acid levels from purine metabolism, often occurring in the elderly. Avocado seeds (Persea americana Mill.) contain flavonoids with antioxidant and anti-inflammatory properties that can inhibit xanthine oxidation. This study evaluated the effectiveness of its extract in reducing uric acid levels in potassium bromate-induced male mice. Mice were divided into six groups: negative control (Na CMC 0.5%), positive control (allopurinol 10 mg/kg BW), three treatment groups (avocado seed extract 120, 150, and 180 mg/kg BW), and normal group. Uric acid levels were measured for seven days using one-way ANOVA test and BNT test LSD method. The results showed that doses of 120-180 mg/kg BW effectively reduced uric acid levels, with the optimal dose of 150 mg/kg BW reducing hyperuricemia by 37.3% (p = 0.118).
Avocado Seed Ethanol Extract's Ability to Reduce Hyperuricemia in Mice Sylvia Winata; Rena Meutia; Astriani Natalia; Asyrun Alkhairi Lubis
Jurnal Indah Sains dan Klinis Vol 6 No 1 (2025): Jurnal Indah Sains dan Klinis
Publisher : Yayasan Penelitian dan Inovasi Sumatera

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52622/jisk.v6i1.01

Abstract

Background: Hyperuricemia causes uric acid buildup in the blood, often in older people due to how the body processes purines. Studies show avocado seeds (Persea americana Mill.) may reduce blood uric acid through their flavonoid content, which fights off oxygen molecules and reduces inflammation, stopping a process called xanthine oxidation. Objective: This study aims to assess the effectiveness of avocado seed extract in lowering uric acid levels in male mice. Method: Mice were induced with potassium bromate, and the mice were divided into six groups of five individuals each. The groups included a negative control (Na CMC 0.5%), a positive control (allopurinol 10 mg/kg BW), treatment 1 (avocado seed extract 120 mg/kg BW), treatment 2 (avocado seed extract 150 mg/kg BW), treatment 3 (avocado seed extract 180 mg/kg BW), and a normal group (not treated). Checked uric acid levels for seven days. Then, used a statistical test and a BNT test with the LSD method to examine the results. Results: The findings showed that avocado seed extract given at a dose of 120-180 mg/kg body weight can reduce uric acid levels in mice. Conclusion: The best dose, 150 mg/kg BW, reduced hyperuricemia levels by 37.3%, with a significance value of 0.118
Identifikasi Kandungan Deksametason Dalam Jamu Asam Urat Dan Rematik Yang Beredar Di Kota Medan Caroline Theodora; Astriani Natalia; Rena Meutia; Nerly Juli Pranita Simanjuntak
Jurnal Sains Farmasi Dan Kesehatan Vol. 2 No. 3 (2025): Januari - April
Publisher : CV. ITTC INDONESIA

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.62379/jfkes.v2i3.2461

Abstract

Jamu masih kerap digunakan oleh masyarakat dalam pengobatan. Sampai saat ini BPOM masih saja menemukan beberapa produk jamu yang mengandung Bahan Kimia Obat yang membahayakan konsumennya. Penelitian ini bertujuan untuk mengidentifikasi apakah terdapat kandungan BKO dalam produk jamu asam urat dan rematik yang beredar di Kota Medan. Analisis kualitatif dilakukan dengan metode Kromatografi Lapis Tipis (KLT), sedangkan penetapan kadar Deksametason dilakukan dengan Spektrofotometri Uv-Vis. 6 sampel yang diperoleh diberi kode A, B, C, D, E dan F. Dari 6 sampel yang diperoleh didapat 2 sampel yang tidak memiliki Nomor Ijin Edar (NIE). Setelah dilakukan analisis hasil menunjukkan bahwa 2 sampel yang tidak memiliki NIE positif mengandung Deksametason dengan nilai Rf 0,5 dimana Rf ini sama dengan Rf dari baku Deksametason. Uji spektrofotometri Uv-Vis menunjukkan bahwa dalam 1 kemasan sampel B memiliki kandungan deksametason sebesar 81,7 mg sedangkan, sampel F memiliki kandungan deksametason sebesar 77,3 mg.
Uji Daya Hambat Gel Semprot Ekstrak Daun Kersen (Mutingia Calabura L.) Terhadap Bakteri Staphylococcus Aureus Pada Pasien Penderita Luka Diabetes Melitus Dhea Lovita Nasution; Astriani Natalia; Rena Meutia; Nerly Juli Pranita Simanjuntak
Jurnal Sains Farmasi Dan Kesehatan Vol. 3 No. 1 (2025): Mei - Agustus
Publisher : CV. ITTC INDONESIA

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.62379/jfkes.v3i1.3265

Abstract

Diabetes mellitus (DM) is caused by a metabolic disorder that affects the pancreas and is characterized by elevated blood sugar levels, also known as a metabolic disorder, which is caused by a decrease in the amount of insulin produced by the pancreas. Elevated blood sugar levels are also known as hyperglycemia. DM can potentially cause several complications, both macro- and microvascular. DM can cause cardiovascular disorders, which are serious and can be effectively managed if treated promptly, potentially leading to hypertension and heart attacks. Based on the above background, the researcher aims to study the effects of ethanol extract from Kersen leaves (Muntingia Calabura L.) on Staphylococcus aureus bacteria in diabetic patients with wounds, using varying concentrations of 1%, 1.25%, 1.5%, 1.75%, and 2%. Methods: The Kersen leaf extract was obtained through 96% ethanol maceration, then formulated into a spray gel using Carbopol 940 as a base. Stability evaluation included organoleptic testing, pH measurement, drying time, and spray pattern assessment. Antibacterial activity was tested using the disk diffusion method.Results: The spray gel demonstrated good physical stability over 21 days of storage. The antibacterial test yielded inhibition zones with diameters of 9.97 mm (1%), 16.01 mm (1.5%), 15.24 mm (1.75%), and 14.37 mm (2%), classified as moderate efficacy. The 1.5% concentration provided the highest inhibitory effect, although it was still below the positive control (clindamycin 1%). Conclusion: It has been demonstrated that the kersen leaf extract gel spray (Mutigia calabura L.) exhibits antibacterial activity in inhibiting the growth of S. Aureus bacteria, as evidenced by the formation of clear zones (inhibition zones) around the disk medium during testing. There is a direct correlation between the concentration of kersen leaf extract in the gel spray formulation and its antibacterial efficacy, with the highest efficacy at a concentration of 1.5%. This study provides a potential alternative for the treatment of diabetic wound infections using natural ingredients.
Co-Authors Asyrun Alkhairi Lubis Caroline Theodora Dhea Lovita Nasution Marini Marini Nerly Juli Pranita Simanjuntak Rena Meutia Sylvia Winata