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Uji Toksisitas Subkronik Ekstrak Etanol Biji Ketumbar (Coriandrum Sativum L.) Terhadap Fungsi Jantung Dan Paru-Paru Pada Tikus Jantan (Rattus Norvegicu.) Jennie Try Varian Laoli; Nerly Juli Pranita Simanjuntak; Finna Piska
An-Najat Vol. 2 No. 3 (2024): AGUSTUS - An-Najat: Jurnal Ilmu Farmasi dan Kesehatan
Publisher : STIKes Ibnu Sina Ajibarang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.59841/an-najat.v2i3.1530

Coriander seed plant (Coriandrum sativum.) Apiaceae family As an alternative medicine to reduce various risk factors for heart disease including LDL cholesterol levels and high blood pressure, characterization and preparation of ethanol extract of coriander seeds (EEBK) using the maceration method was the first step in this research, followed by with subchronic toxicity testing. Subchronic toxicity testing used male rats (Rattus Norvegicu.) each of which was divided into 5 groups, namely control CMC Na 0.5%, EEBK doses of 100, 200, 400 and 500 mg/kg bw. In the subchronic toxicity test, the parameters observed included toxic symptoms, changes in body weight, death, as well as microscopic and macroscopic examination of organs, including hematological examination. This observation lasted for 28 days. Subchronic test data were analyzed using the Statistical Product and Service Solution with two-way ANOVA, followed by the Tukey and Kruskal-Wallis post-hoc test. Findings from the subchronic toxicity study indicated that EEBK did not have a toxic effect, because there was no significant difference in changes relative organ weight, body weight, number of mouse deaths, toxic symptoms, organ macroscopic, and hematological values were compared with the control group (P > 0.05).

Uji Kadar Gula pada Susu Meal Replacement di Kota Medan dengan Spektofotometri UV-Vis Marini Marini; Rena Meutia; Astriani Natalia; Nerly Juli Pranita Simanjuntak
An-Najat Vol. 3 No. 2 (2025): Mei : An-Najat : Jurnal Ilmu Farmasi dan Kesehatan
Publisher : STIKes Ibnu Sina Ajibarang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.59841/an-najat.v3i2.2545

Diabetes and obesity are closely related, with obesity as a nutritional problem that continues to increase. Obesity occurs due to an imbalance in energy intake and expenditure, while diabetes is often not realized until serious complications appear. A diet high in fiber and low in sugar can reduce the risk of diabetes. Meal replacements such as powdered milk and snack bars can be used, but consumption needs to be limited because their nutritional content is less than ideal and has the potential to cause health problems if consumed excessively. The research was carried out using quantitative and qualitative methods on 3 types of meal replacement milk powder drinks, namely brand A, brand B and brand C. This was done by collecting samples deliberately according to the inclusion and exclusion criteria, which is the sampling strategy used in this research. then research evaluation carried out 3 types of tests; Molisch's test, Benedict's test and Fehling's test. The results of the research show that the three samples of meal replacement milk circulating in the city of Medan contain sugar, but are quite safe for consumption in general and the sugar content in meal replacement milk does not exceed the daily sugar level.

Aktivitas Nano Spray Gel Ekstrak Kulit Nanas (Ananas comosus L.) terhadap Pertumbuhan Bakteri Staphylococcus epidermidis pada Ulkus Diabetes Melitus Secara In Vitro Jesiska Muaratan; Astriani Natalia Br Ginting; Rena Meutia; Nerly Juli Pranita Simanjuntak
Jurnal Riset Ilmu Kesehatan Umum dan Farmasi (JRIKUF) Vol. 3 No. 3 (2025): Jurnal Riset Ilmu Kesehatan Umum dan Farmasi (JRIKUF)
Publisher : LPPM STIKES KESETIAKAWANAN SOSIAL INDONESIA

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.57213/jrikuf.v3i3.659

Diabetic ulcers are complications of diabetes mellitus often associated with bacterial infections like Staphylococcus epidermidis. Pineapple peel is rich in secondary metabolites including flavonoids with potential antibacterial effects. This study aimed to assesss the antibacterial activity of nano spray gel made with pineapple peel extract against Staphylococcus epidermidis through in vitro testing. This research employed a laboratory experimental design using nano spray gel formulations at varying concentrations of 25%, 50%, and 75% of pineapple peel extract. Flavonoids, alkaloids, tannins, and saponins are confirmed by phytochemical analysis. Only the formulation with 75% demonstrated antibacterial activity effect, with an average inhibition zone of 8.61 mm (medium category). 25% and 50% formulations show no inhibition. Pure extract showed a 15.42 mm zone (strong), while the positive control (clindamycin) produced 29.69 mm (very strong) inhibition zone. PSA results indicated particle size averaged 1480 nm, exceeding the nanoemulsion standard (<500 nm). Nano spray gel with 75% pineapple peel extract demonstrated antibacterial activity against S. epidermidis, although the particle size did not meet nanoemulsion criteria.

Identifikasi Kandungan Deksametason Dalam Jamu Asam Urat Dan Rematik Yang Beredar Di Kota Medan Caroline Theodora; Astriani Natalia; Rena Meutia; Nerly Juli Pranita Simanjuntak
Jurnal Sains Farmasi Dan Kesehatan Vol. 2 No. 3 (2025): Januari - April
Publisher : CV. ITTC INDONESIA

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.62379/jfkes.v2i3.2461

Jamu masih kerap digunakan oleh masyarakat dalam pengobatan. Sampai saat ini BPOM masih saja menemukan beberapa produk jamu yang mengandung Bahan Kimia Obat yang membahayakan konsumennya. Penelitian ini bertujuan untuk mengidentifikasi apakah terdapat kandungan BKO dalam produk jamu asam urat dan rematik yang beredar di Kota Medan. Analisis kualitatif dilakukan dengan metode Kromatografi Lapis Tipis (KLT), sedangkan penetapan kadar Deksametason dilakukan dengan Spektrofotometri Uv-Vis. 6 sampel yang diperoleh diberi kode A, B, C, D, E dan F. Dari 6 sampel yang diperoleh didapat 2 sampel yang tidak memiliki Nomor Ijin Edar (NIE). Setelah dilakukan analisis hasil menunjukkan bahwa 2 sampel yang tidak memiliki NIE positif mengandung Deksametason dengan nilai Rf 0,5 dimana Rf ini sama dengan Rf dari baku Deksametason. Uji spektrofotometri Uv-Vis menunjukkan bahwa dalam 1 kemasan sampel B memiliki kandungan deksametason sebesar 81,7 mg sedangkan, sampel F memiliki kandungan deksametason sebesar 77,3 mg.

Activity Test Of Salam Extract (Syzygium polyanthum) On Diabetes Disease Using White Rats (Ratus Novergicus) Hikmad Elsi Enoni Harefa; Astriani Natalia Br Ginting; Rena Meutia; Nerly Juli Pranita Simanjuntak
Jurnal Sains Farmasi Dan Kesehatan Vol. 3 No. 1 (2025): Mei - Agustus
Publisher : CV. ITTC INDONESIA

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.62379/jfkes.v3i1.2609

Diabetes Mellitus is a chronic metabolic disease characterized by elevated blood sugar levels due to impaired secretion or action of insulin. The use of herbal plants such as as salam leaves (syzygium polyanthum) is one of the alternative treatment methods. This study aims to evaluate the effectiveness and optimal dosage of salam leaf extract in lowering blood glucose levels in male rats (Rattus Novergicus) induced by alloxan. A total of 30 rats we divided into six groups: normal control, negative control, positive control (metformin), and three treatment groups with extract doses of 200, 300, and 400 Mg/KgBB. Blood glucose levels were measured on days 15,20,25, and 30. Data were analyzed using ANOVA with a significance level of 95%. The results show that salam leaf extract significantly lowers blood glucose levels, with the most effective dose being 400 Mg/KgBB. This study supports the potential of salam leaves as an effective, safe, and affordable natural antidiabetic agent.

Hubungan Sikap dan Motivasi Terhadap Kepatuhan Minum Obat Pasien Hipertensi di Puskesmas Medan Johor Nuraisyah Amanda; Nerly Juli Pranita Simanjuntak; Razoki , Razoki
Jurnal Sains Farmasi Dan Kesehatan Vol. 3 No. 1 (2025): Mei - Agustus
Publisher : CV. ITTC INDONESIA

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.62379/jfkes.v3i1.2913

Hipertensi merupakan kondisi medis serius yang memengaruhi lebih dari satu miliar orang di seluruh dunia, mengalami kerusakan pada arteri dan komplikasi, serta kematian dini, terutama di negara-negara berpenghasilan rendah dan menengah. Seseorang dapat menanggapi suatu keadaan atau kejadian secara positif dengan memiliki sikap yang positif. Motivasi seseorang adalah apa yang mendorong mereka untuk mengambil tindakan guna mencapai tujuan tertentu. Penelitian ini bertujuan untuk memastikan bagaimana pasien hipertensi di Pusat Kesehatan Medan Johor merasakan dan termotivasi untuk meminum obat sesuai resep. Kuesioner digunakan dalam desain deskriptif kuantitatif cross-sectional penelitian ini untuk mengukur kepatuhan, motivasi, dan sikap pasien. Pengambilan sampel secara purposif digunakan untuk memilih 70 responden dari antara pasien hipertensi yang datang selama bulan Januari dan Februari 2025. Uji chi square digunakan untuk analisis data univariat dan bivariat; nilai signifikansi p < 0,05 menunjukkan adanya hubungan, sedangkan nilai p> 0,05 menunjukkan tidak ada hubungan. Menurut temuan penelitian, 3 pasien (4,3%) memiliki sikap yang buruk, sedangkan 29 pasien (41,4%) memiliki sikap yang baik dan 38 pasien (54,3%) memiliki sikap yang sesuai. Tingkat motivasi baik sebanyak 59 pasien (84,3%), sedangkan yang memiliki motivasi cukup ada 11 pasien (15,7%). Tingkat kepatuhan yang baik dengan 67 pasien (95,7%), sementara terdapat 3 pasien (4,3%) yang tidak patuh. Kesimpulan terdapat hubungan antara sikap dan motivasi terhadap kepatuhan minum obat.

Formulation of Abelmoschus manihot Leaf Gel Using Carbopol and HPMC and Antibacterial Activity Against Pseudomonas aeruginosa Christina Amelia; Nerly Juli Pranita Simanjuntak; Erida Novriani
Galen: Jurnal Riset Ilmu Farmasi dan Kesehatan Vol. 1 No. 2 (2025): Galen: Jurnal Riset Ilmu Farmasi dan Kesehatan
Publisher : PT Pustaka Cendekia Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.71417/galen.v1i2.18

Diabetic foot ulcers are a chronic complication commonly experienced by patients with diabetes mellitus, often caused by Pseudomonas aeruginosa, a pathogenic bacterium with high antibiotic resistance. This study aimed to evaluate the effect of varying concentrations of Carbopol 940 and HPMC bases on the physical characteristics and antibacterial activity of gedi leaf (Abelmoschus manihot) extract gel preparations. The extract was obtained through maceration using 70% ethanol. The gel was formulated into six different formulas: three with HPMC (1%, 2%, and 3%) and three with Carbopol 940 (0.5%, 1%, and 2%), each containing 10% extract. Evaluations included physical characteristics (organoleptic properties, homogeneity, pH, viscosity, spreadability, and stability) and antibacterial activity against P. aeruginosa using the disk diffusion method. The results showed that all formulas met acceptable physical parameters. One-way ANOVA revealed a statistically significant difference in inhibition zone diameters among the formulas (p < 0.001). The formula containing 1% Carbopol exhibited the largest inhibition zone, indicating the most effective antibacterial activity against P. aeruginosa. These findings suggest that gedi leaf extract gel has promising potential as an alternative topical therapy for diabetic foot infections.

Evaluasi Penggunaan Antibiotik Pada Pasien Anak Rawat Inap Rsu Mitra Sejati Nerly Juli Pranita Simanjuntak; Simran Kaur; Razoki Razoki
Jurnal Sains Farmasi Dan Kesehatan Vol. 3 No. 1 (2025): Mei - Agustus
Publisher : CV. ITTC INDONESIA

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.62379/jfkes.v3i1.3103

Inappropriate use of antibiotics can lead to resistance and other negative impacts, especially in vulnerable groups such as children. Evaluation of antibiotic use is very important to ensure the effectiveness of therapy and avoid resistance. This study aims to evaluate the use of antibiotics in pediatric patients hospitalized at Mitra Sejati Hospital using the ATC/DDD method and 90% DU analysis. This study used a retrospective approach from the medical records of pediatric patients aged 1-18 years during October 2024 to February 2025. Based on the results of the study, it was found that the most widely used type of antibiotics was ceftriaxone (5,70 DDD/100 patient-days). While based on the results of 90% DU analysis, the most commonly prescribed antibiotics were ceftriaxone, cefixime syrup and tablet and azithromycin. These results indicate that most of antibiotic use at Mitra Sejati Hospital is included in the 90% DU segment, but routine monitoring is still needed to ensure the appropriateness of its use.

Evaluasi Penggunaan Antibiotik Pada Pasien Pneumonia Rawat Inap Di Rsu Mitra Sejati Nerly Juli Pranita Simanjuntak; Tasya Melisa Br Purba; Erida Novriani
Jurnal Sains Farmasi Dan Kesehatan Vol. 3 No. 1 (2025): Mei - Agustus
Publisher : CV. ITTC INDONESIA

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.62379/jfkes.v3i1.3104

Pneumonia is a lower respiratory tract infection that remains a leading cause of death globally. Irrational use of antibiotics in its treatment worsens antibiotic resistance. This study aims to evaluate antibiotic use in hospitalized pneumonia patients at RSU Mitra Sejati using ATC/DDD and DU90% methods. This descriptive observational study used secondary data from adult inpatient medical records between January and December 2023. Results showed 37 patients, majority male (51.35%), mostly aged 26–35 and 56–65 years. A total of 273 antibiotic uses were recorded, dominated by third-generation cephalosporins, especially Cefixime 200 mg (31.14%). ATC/DDD analysis showed highest DDD/100 days for Cefixime 200 mg (21.04), Levofloxacin 500 mg (18.32), and Ceftriaxone 1 g (12.87). DU90% analysis identified six antibiotics comprising 91.04% of total use, indicating rational use according to national guidelines.

Uji Daya Hambat Gel Semprot Ekstrak Daun Kersen (Mutingia Calabura L.) Terhadap Bakteri Staphylococcus Aureus Pada Pasien Penderita Luka Diabetes Melitus Dhea Lovita Nasution; Astriani Natalia; Rena Meutia; Nerly Juli Pranita Simanjuntak
Jurnal Sains Farmasi Dan Kesehatan Vol. 3 No. 1 (2025): Mei - Agustus
Publisher : CV. ITTC INDONESIA

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.62379/jfkes.v3i1.3265

Diabetes mellitus (DM) is caused by a metabolic disorder that affects the pancreas and is characterized by elevated blood sugar levels, also known as a metabolic disorder, which is caused by a decrease in the amount of insulin produced by the pancreas. Elevated blood sugar levels are also known as hyperglycemia. DM can potentially cause several complications, both macro- and microvascular. DM can cause cardiovascular disorders, which are serious and can be effectively managed if treated promptly, potentially leading to hypertension and heart attacks. Based on the above background, the researcher aims to study the effects of ethanol extract from Kersen leaves (Muntingia Calabura L.) on Staphylococcus aureus bacteria in diabetic patients with wounds, using varying concentrations of 1%, 1.25%, 1.5%, 1.75%, and 2%. Methods: The Kersen leaf extract was obtained through 96% ethanol maceration, then formulated into a spray gel using Carbopol 940 as a base. Stability evaluation included organoleptic testing, pH measurement, drying time, and spray pattern assessment. Antibacterial activity was tested using the disk diffusion method.Results: The spray gel demonstrated good physical stability over 21 days of storage. The antibacterial test yielded inhibition zones with diameters of 9.97 mm (1%), 16.01 mm (1.5%), 15.24 mm (1.75%), and 14.37 mm (2%), classified as moderate efficacy. The 1.5% concentration provided the highest inhibitory effect, although it was still below the positive control (clindamycin 1%). Conclusion: It has been demonstrated that the kersen leaf extract gel spray (Mutigia calabura L.) exhibits antibacterial activity in inhibiting the growth of S. Aureus bacteria, as evidenced by the formation of clear zones (inhibition zones) around the disk medium during testing. There is a direct correlation between the concentration of kersen leaf extract in the gel spray formulation and its antibacterial efficacy, with the highest efficacy at a concentration of 1.5%. This study provides a potential alternative for the treatment of diabetic wound infections using natural ingredients.

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