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All Journal Jurnal Sains dan Teknologi Jurnal Kesehatan Amanah Jurnal An-Najat: Jurnal Ilmu Farmasi dan Kesehatan Jurnal Ventilator: Jurnal Riset Ilmu Kesehatan dan Keperawatan Jurnal Riset Ilmu Kesehatan Umum dan Farmasi Jurnal Sains Farmasi dan Kesehatan Jurnal Indah Sains dan Klinis
Rena Meutia
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Computer Science & IT Dentistry Education Health Professions Medicine & Pharmacology Neuroscience Nursing Physics Public Health Veterinary

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Optimasi Formulasi Krim Minyak Jintan Hitam (Nigella Sativa Linn) Dengan Variasi Konsentrasi Asam Stearat Dan Trietanolamin Rico Sentosa Sihombing; Rena Meutia
Jurnal Ventilator Vol. 1 No. 3 (2023): September : Jurnal Ventilator
Publisher : Stikes Kesdam IV/Diponegoro Semarang, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.59680/ventilator.v1i3.434

Abstract

Black cumin oil (Nigella Sativa Linn) is rich in antioxidants. One of the substances contained in black cumin oil (Nigella Sativa Linn) which acts as an antioxidant is thermoquinone. Cream is a widely chosen preparation because it is one of the pharmaceutical preparations that is used topically for the treatment of various skin diseases. The purpose of this study was to determine whether Cumin (Nigella Sativa Linn) Oil (Nigella Sativa Linn) can be formulated as a cream dosage form. to find out the optimum concentration of black cumin oil cream formulation (Nigella Sativa Linn) with cream base variations (Stearic acid and TEA).This research is a longitudinal-experimental study. The tools used in this study were glassware, watch glass, evaporating cup, parchment paper, universal pH indicator, digital scale, mortar, stamper, waterbath, refrigerator, stirring rod, tweezers, spirit lamp, loop needle. The materials used in this study were Black Cumin (Nigella Sativa Linn) oil, TEA, White wax, Stearic Acid, White Vaseline, Methyl paraben, PEG, Aquadest. For organoleptic testing of cream, it can be seen from the observation of color, smell, and texture. The evaluation was carried out including organoleptic tests for homogeneity, absorption, and pH tests. Based on the research results, it can be concluded that black cumin oil can be formulated into cream preparations with varying concentrations of stearic acid and triethanolamine, although there are several tests that do not meet the requirements for cream preparation tests. The combination of stearic acid and triethanolamine with different concentrations can affect the physical quality which includes pH, spreadability and mechanical stability but has no effect on the organoleptic, cream type and homogeneity.
Uji Kadar Gula pada Susu Meal Replacement di Kota Medan dengan Spektofotometri UV-Vis Marini Marini; Rena Meutia; Astriani Natalia; Nerly Juli Pranita Simanjuntak
An-Najat Vol. 3 No. 2 (2025): Mei : An-Najat : Jurnal Ilmu Farmasi dan Kesehatan
Publisher : STIKes Ibnu Sina Ajibarang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.59841/an-najat.v3i2.2545

Abstract

Diabetes and obesity are closely related, with obesity as a nutritional problem that continues to increase. Obesity occurs due to an imbalance in energy intake and expenditure, while diabetes is often not realized until serious complications appear. A diet high in fiber and low in sugar can reduce the risk of diabetes. Meal replacements such as powdered milk and snack bars can be used, but consumption needs to be limited because their nutritional content is less than ideal and has the potential to cause health problems if consumed excessively. The research was carried out using quantitative and qualitative methods on 3 types of meal replacement milk powder drinks, namely brand A, brand B and brand C. This was done by collecting samples deliberately according to the inclusion and exclusion criteria, which is the sampling strategy used in this research. then research evaluation carried out 3 types of tests; Molisch's test, Benedict's test and Fehling's test. The results of the research show that the three samples of meal replacement milk circulating in the city of Medan contain sugar, but are quite safe for consumption in general and the sugar content in meal replacement milk does not exceed the daily sugar level.
Aktivitas Nano Spray Gel Ekstrak Kulit Nanas (Ananas comosus L.) terhadap Pertumbuhan Bakteri Staphylococcus epidermidis pada Ulkus Diabetes Melitus Secara In Vitro Jesiska Muaratan; Astriani Natalia Br Ginting; Rena Meutia; Nerly Juli Pranita Simanjuntak
Jurnal Riset Ilmu Kesehatan Umum dan Farmasi (JRIKUF) Vol. 3 No. 3 (2025): Juli : Jurnal Riset Ilmu Kesehatan Umum dan Farmasi (JRIKUF)
Publisher : LPPM STIKES KESETIAKAWANAN SOSIAL INDONESIA

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.57213/jrikuf.v3i3.659

Abstract

Diabetic ulcers are complications of diabetes mellitus often associated with bacterial infections like Staphylococcus epidermidis. Pineapple peel is rich in secondary metabolites including flavonoids with potential antibacterial effects. This study aimed to assesss the antibacterial activity of nano spray gel made with pineapple peel extract against Staphylococcus epidermidis through in vitro testing. This research employed a laboratory experimental design using nano spray gel formulations at varying concentrations of 25%, 50%, and 75% of pineapple peel extract. Flavonoids, alkaloids, tannins, and saponins are confirmed by phytochemical analysis. Only the formulation with 75% demonstrated antibacterial activity effect, with an average inhibition zone of 8.61 mm (medium category). 25% and 50% formulations show no inhibition. Pure extract showed a 15.42 mm zone (strong), while the positive control (clindamycin) produced 29.69 mm (very strong) inhibition zone. PSA results indicated particle size averaged 1480 nm, exceeding the nanoemulsion standard (<500 nm). Nano spray gel with 75% pineapple peel extract demonstrated antibacterial activity against S. epidermidis, although the particle size did not meet nanoemulsion criteria.
Efektivitas Ekstrak Etanol Biji Alpukat (Persea americana Mill.) dalam Penurunan Hiperurisemia pada Mencit (Mus musculus L.) Sylvia Winata; Rena Meutia; Astriani Natalia; Asyrun Alkhairi Lubis
Jurnal Kesehatan Amanah Vol. 9 No. 1 (2025): Jurnal Kesehatan Amanah
Publisher : Universitas Muhammadiyah Manado

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.57214/jka.v9i1.764

Abstract

Hyperuricemia is a degenerative condition due to increased blood uric acid levels from purine metabolism, often occurring in the elderly. Avocado seeds (Persea americana Mill.) contain flavonoids with antioxidant and anti-inflammatory properties that can inhibit xanthine oxidation. This study evaluated the effectiveness of its extract in reducing uric acid levels in potassium bromate-induced male mice. Mice were divided into six groups: negative control (Na CMC 0.5%), positive control (allopurinol 10 mg/kg BW), three treatment groups (avocado seed extract 120, 150, and 180 mg/kg BW), and normal group. Uric acid levels were measured for seven days using one-way ANOVA test and BNT test LSD method. The results showed that doses of 120-180 mg/kg BW effectively reduced uric acid levels, with the optimal dose of 150 mg/kg BW reducing hyperuricemia by 37.3% (p = 0.118).
Potensi Aktivitas Antibakteri Antara Ekstrak dan Fraksi Kulit Jeruk Terhadap Ulkus Diabetes Farren Farren; Rena Meutia; Astriani Natalia Br Ginting; Asyrun Alkhairi Lubis
Jurnal Kesehatan Amanah Vol. 9 No. 1 (2025): Jurnal Kesehatan Amanah
Publisher : Universitas Muhammadiyah Manado

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.57214/jka.v9i1.765

Abstract

Diabetic ulcers, a chronic complication of diabetes mellitus, result from long-term uncontrolled blood sugar levels and are characterised by infection-prone foot wounds. Staphylococcus aureus is often found as the bacteria that cause infection in these wounds. Antibiotic resistance has become a serious challenge in medicine, so alternatives such as orange peel (Citrus sinensis (L.) Osbeck) were investigated for their metabolite content with antibacterial potential. This study was designed experimentally with a Posttest Only Control Group Design approach. Orange peels were processed through sorting, drying, extraction using 96% ethanol, and fractionation with ethyl acetate. Antibacterial activity test was conducted by disc method against Staphylococcus aureus, using ethanol extract and ethyl acetate fraction. DMSO and mupirocin were used as negative and positive controls, with concentrations of 25%, 50%, and 75%. The results showed that the ethanol extract had antibacterial activity, with a concentration of 75% producing the largest inhibition zone (13.56 mm), including the medium category. However, the ethyl acetate fraction did not show antibacterial activity at all concentrations, presumably due to the low levels of extractable semipolar metabolites. Environmental factors such as UV light, humidity, and high temperature during drying are also thought to affect metabolite levels. It was concluded that ethanol extract of orange peel was more effective than ethyl acetate fraction in inhibiting the growth of Staphylococcus aureus.
Avocado Seed Ethanol Extract's Ability to Reduce Hyperuricemia in Mice Sylvia Winata; Rena Meutia; Astriani Natalia; Asyrun Alkhairi Lubis
Jurnal Indah Sains dan Klinis Vol 6 No 1 (2025): Jurnal Indah Sains dan Klinis
Publisher : Yayasan Penelitian dan Inovasi Sumatera

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52622/jisk.v6i1.01

Abstract

Background: Hyperuricemia causes uric acid buildup in the blood, often in older people due to how the body processes purines. Studies show avocado seeds (Persea americana Mill.) may reduce blood uric acid through their flavonoid content, which fights off oxygen molecules and reduces inflammation, stopping a process called xanthine oxidation. Objective: This study aims to assess the effectiveness of avocado seed extract in lowering uric acid levels in male mice. Method: Mice were induced with potassium bromate, and the mice were divided into six groups of five individuals each. The groups included a negative control (Na CMC 0.5%), a positive control (allopurinol 10 mg/kg BW), treatment 1 (avocado seed extract 120 mg/kg BW), treatment 2 (avocado seed extract 150 mg/kg BW), treatment 3 (avocado seed extract 180 mg/kg BW), and a normal group (not treated). Checked uric acid levels for seven days. Then, used a statistical test and a BNT test with the LSD method to examine the results. Results: The findings showed that avocado seed extract given at a dose of 120-180 mg/kg body weight can reduce uric acid levels in mice. Conclusion: The best dose, 150 mg/kg BW, reduced hyperuricemia levels by 37.3%, with a significance value of 0.118
Identifikasi Kandungan Deksametason Dalam Jamu Asam Urat Dan Rematik Yang Beredar Di Kota Medan Caroline Theodora; Astriani Natalia; Rena Meutia; Nerly Juli Pranita Simanjuntak
Jurnal Sains Farmasi Dan Kesehatan Vol. 2 No. 3 (2025): Januari - April
Publisher : CV. ITTC INDONESIA

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.62379/jfkes.v2i3.2461

Abstract

Jamu masih kerap digunakan oleh masyarakat dalam pengobatan. Sampai saat ini BPOM masih saja menemukan beberapa produk jamu yang mengandung Bahan Kimia Obat yang membahayakan konsumennya. Penelitian ini bertujuan untuk mengidentifikasi apakah terdapat kandungan BKO dalam produk jamu asam urat dan rematik yang beredar di Kota Medan. Analisis kualitatif dilakukan dengan metode Kromatografi Lapis Tipis (KLT), sedangkan penetapan kadar Deksametason dilakukan dengan Spektrofotometri Uv-Vis. 6 sampel yang diperoleh diberi kode A, B, C, D, E dan F. Dari 6 sampel yang diperoleh didapat 2 sampel yang tidak memiliki Nomor Ijin Edar (NIE). Setelah dilakukan analisis hasil menunjukkan bahwa 2 sampel yang tidak memiliki NIE positif mengandung Deksametason dengan nilai Rf 0,5 dimana Rf ini sama dengan Rf dari baku Deksametason. Uji spektrofotometri Uv-Vis menunjukkan bahwa dalam 1 kemasan sampel B memiliki kandungan deksametason sebesar 81,7 mg sedangkan, sampel F memiliki kandungan deksametason sebesar 77,3 mg.
Activity Test Of Salam Extract (Syzygium polyanthum) On Diabetes Disease Using White Rats (Ratus Novergicus) Hikmad Elsi Enoni Harefa; Astriani Natalia Br Ginting; Rena Meutia; Nerly Juli Pranita Simanjuntak
Jurnal Sains Farmasi Dan Kesehatan Vol. 3 No. 1 (2025): Mei - Agustus
Publisher : CV. ITTC INDONESIA

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.62379/jfkes.v3i1.2609

Abstract

Diabetes Mellitus is a chronic metabolic disease characterized by elevated blood sugar levels due to impaired secretion or action of insulin. The use of herbal plants such as as salam leaves (syzygium polyanthum) is one of the alternative treatment methods. This study aims to evaluate the effectiveness and optimal dosage of salam leaf extract in lowering blood glucose levels in male rats (Rattus Novergicus) induced by alloxan. A total of 30 rats we divided into six groups: normal control, negative control, positive control (metformin), and three treatment groups with extract doses of 200, 300, and 400 Mg/KgBB. Blood glucose levels were measured on days 15,20,25, and 30. Data were analyzed using ANOVA with a significance level of 95%. The results show that salam leaf extract significantly lowers blood glucose levels, with the most effective dose being 400 Mg/KgBB. This study supports the potential of salam leaves as an effective, safe, and affordable natural antidiabetic agent.
Uji Daya Hambat Gel Semprot Ekstrak Daun Kersen (Mutingia Calabura L.) Terhadap Bakteri Staphylococcus Aureus Pada Pasien Penderita Luka Diabetes Melitus Dhea Lovita Nasution; Astriani Natalia; Rena Meutia; Nerly Juli Pranita Simanjuntak
Jurnal Sains Farmasi Dan Kesehatan Vol. 3 No. 1 (2025): Mei - Agustus
Publisher : CV. ITTC INDONESIA

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.62379/jfkes.v3i1.3265

Abstract

Diabetes mellitus (DM) is caused by a metabolic disorder that affects the pancreas and is characterized by elevated blood sugar levels, also known as a metabolic disorder, which is caused by a decrease in the amount of insulin produced by the pancreas. Elevated blood sugar levels are also known as hyperglycemia. DM can potentially cause several complications, both macro- and microvascular. DM can cause cardiovascular disorders, which are serious and can be effectively managed if treated promptly, potentially leading to hypertension and heart attacks. Based on the above background, the researcher aims to study the effects of ethanol extract from Kersen leaves (Muntingia Calabura L.) on Staphylococcus aureus bacteria in diabetic patients with wounds, using varying concentrations of 1%, 1.25%, 1.5%, 1.75%, and 2%. Methods: The Kersen leaf extract was obtained through 96% ethanol maceration, then formulated into a spray gel using Carbopol 940 as a base. Stability evaluation included organoleptic testing, pH measurement, drying time, and spray pattern assessment. Antibacterial activity was tested using the disk diffusion method.Results: The spray gel demonstrated good physical stability over 21 days of storage. The antibacterial test yielded inhibition zones with diameters of 9.97 mm (1%), 16.01 mm (1.5%), 15.24 mm (1.75%), and 14.37 mm (2%), classified as moderate efficacy. The 1.5% concentration provided the highest inhibitory effect, although it was still below the positive control (clindamycin 1%). Conclusion: It has been demonstrated that the kersen leaf extract gel spray (Mutigia calabura L.) exhibits antibacterial activity in inhibiting the growth of S. Aureus bacteria, as evidenced by the formation of clear zones (inhibition zones) around the disk medium during testing. There is a direct correlation between the concentration of kersen leaf extract in the gel spray formulation and its antibacterial efficacy, with the highest efficacy at a concentration of 1.5%. This study provides a potential alternative for the treatment of diabetic wound infections using natural ingredients.
Antibacterial and Anti-Diarrheal Potential of Andaliman (Zanthoxylum acanthopodium DC) Methanol and Nanoemulsion Extract Chiuman , Linda; Singh, Wanti Natalia; Saragih, Delfia Rehuela; Rahyani, Oktavini Handayani Fikri; Rena Meutia
JST (Jurnal Sains dan Teknologi) Vol. 13 No. 2 (2024): July
Publisher : Universitas Pendidikan Ganesha

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.23887/jstundiksha.v13i2.80295

Abstract

Diarrhoea is one of the prevalent global health problems, causing cases of death and morbidity in various age groups for people around the world. Andaliman is a typical herbal plant of North Sumatra with multiple benefits that have been studied previously. This study aims to analyze the antibacterial and anti-diarrheal potential of methanol extract and nanoemulsion of Andaliman (Zanthoxylum acanthopodium). This study used laboratory experimental research with a post-test-only group design. Antibacterial testing was carried out using the disc diffusion method with three repetitions of four extract concentrations. The standard group used ciprofloxacin 5μg, and the control group used DMSO. Then, we continued with the microdilution method with an initial concentration of 500mg/Dl extract to determine the minimum inhibitory and kill levels. An anti-diarrhoea study was conducted using 30 Wistar rats treated with nanoemulsion extract. The standard group was given loperamide 3 mg/KgBB, and the control group was given CMC Na 0.25 ml. Rats were induced with castor oil, and the frequency of defecation and liquid faeces were observed for 1 hour. Andaliman (Zanthoxylum acanthopodium) methanol extract showed a moderate inhibitory effect against E.Coli, with KHM and KBM of 55.56 mg/mL. Potential as anti-diarrhoea, Andaliman nano emulsion extract showed a significant difference at 50mg/KgBB dose for diarrhoea frequency and loose stools. However, no significant differences were found in gastrointestinal and entero-pooling results. Based on the results, it can be concluded that methanol extract and nanoemulsion of andaliman (Zanthoxylum acanthopodium) showed antibacterial activity against E.Coli and showed anti-diarrhea potential. The expected implication is that andaliman can be an alternative treatment for diarrhoea, especially for diarrhoea caused by Escherichia coli.
Co-Authors Astriani Natalia Astriani Natalia Br Ginting Asyrun Alkhairi Lubis Caroline Theodora Chiuman , Linda Dhea Lovita Nasution Farren Farren Hikmad Elsi Enoni Harefa Jesiska Muaratan Marini Marini Nerly Juli Pranita Simanjuntak Rahyani, Oktavini Handayani Fikri Rico Sentosa Sihombing Saragih, Delfia Rehuela Singh, Wanti Natalia Sylvia Winata