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All Journal Indonesian Journal of Pharmaceutical Science and Technology AVERROUS: Jurnal Kedokteran dan Kesehatan Malikussaleh Journal of Social Research
Sary, Nirwana Lazuardi
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Humanities Computer Science & IT Dentistry Economics, Econometrics & Finance Education Health Professions Medicine & Pharmacology Nursing Public Health Social Sciences

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Hubungan Asupan Energi dan Makronutrien dengan IMT Pegawai di Kecamatan Johan Pahlawan Kabupaten Aceh Barat Rahmawati, Siti; Yusni, Yusni; Sary, Nirwana Lazuardi; Saminan, Saminan; Husnah, Husnah
AVERROUS: Jurnal Kedokteran dan Kesehatan Malikussaleh Averrous, Vol.9 No.1 Mei 2023
Publisher : Fakultas Kedokteran Universitas Malikussaleh

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29103/averrous.v9i1.9848

Abstract

Permasalah gizi ganda atau double burden malnutrition menjadi prioritas yang harus diperhatian dan segera ditangani. Pegawai merupakan pekerjaan yang memiliki prevalensi masalah gizi lebih dan obesitas yang tinggi. Asupan makanan (energi dan makronutrien) berpengaruh dan berperan penting terhadap gizi individu. Pemantauan gizi secara sederhana yang dapat dilakukan salah satunya adalah pengukuran Indeks Massa Tubuh (IMT) sehingga secara berkala dapat terkontrol status gizi seseorang. Penelitian ini bertujuan menganalisis hubungan asupan energi dan makronutrien yaitu karbohidrat, protein dan lemak dengan indeks massa tubuh pegawai. Penelitian ini menggunakan desain analitik observasional dengan rancangan cross-sectional. Subjek berjumlah 80 pegawai yang sesuai dengan kriteria inklusi dan ekslusi diambil dari tanggal 28 September-18 Oktober 2020. Asupan energi dan makronutrien diukur dengan kuesioner Semi Quatitative Food Frequency Questioner (SQ-FFQ) dan IMT dinilai dengan menimbang berat badan dan mengukur tinggi badan mengunakan timbanagn injak digital dan microtoice. Analisis komponen makanan menggunakan nutrisurvey dan uji statistik menggunakan uji korelasi spearman dan uji regresi linear berganda. Terdapat hubungan asupan energi p = 0,036 dengan IMT. Terdapat hubungan makronutrien karbohidrat p = 0,034dan lemak p = 0,040 dengan IMT. Tidak ada hubungan antara asupan makronutrien (protein) dengan IMT (p = 0,135). Hasil uji t parsial menunjukkan variabel dominan yang mempengaruhi IMT yaitu energi (0,032). Terdapat hubungan signifikan antara asupan energi dan makronutrien (karbohidrat dan lemak) dengan Indeks Massa Tubuh dan energi adalah faktor yang dominan mempengaruhi IMT pegawai.
The Impact of Photoaging on Skin: A Systematic Review Analysis Asyi, Muhammad Shanan; Syahrizal, Dedy; Sary, Nirwana Lazuardi; Husna, Fauzul
Journal of Social Research Vol. 3 No. 1 (2023): Journal of Social Research
Publisher : International Journal Labs

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55324/josr.v3i1.1708

Abstract

Aging of the skin is a complex biological process. The process of skin aging can be divided into two categories namely intrinsic and extrinsic aging. Intrinsic skin aging or natural aging is caused by changes in skin elasticity that occur with age. This type of aging cannot be prevented. While extrinsic skin aging is caused by environmental factors such as exposure to solar radiation (photoaging). In this study, the type of research approach used is a type of qualitative research through a literature review. The type of data used is the type of secondary data. Secondary data is a type of data obtained from certain parties or media indirectly, meaning that certain parties become intermediaries where they obtain and record these data beforehand. The aging process of the skin is influenced by intrinsic and extrinsic factors. The extrinsic factor that most influences the aging process of the skin is chronic sun exposure which is called photoaging. Sunlight contains 96% UVA and has the most significant biological effect compared to UVB and UVC. Several factors that affect photodamaging are skin type, pigmentation, and acclimatization. Skin changes that occur in photoaging include the presence of vesicles in the epidermis, reduced Langerhans cells, and enlarged and pale epidermal cells; in the dermis, there is an elastic mass; pigment changes in the form of dotted (irregular pigmentation) and hyperpigmentation.
Potential of avocado seed ethanol extract (Persea americana Mill. var Miki) as an anti-aging Alya, Syadza; Hasballah, Kartini; Fitria, Fitria; Harnelly, Essy; Sary, Nirwana Lazuardi
Indonesian Journal of Pharmaceutical Science and Technology Vol 13, No 1 (2026)
Publisher : Indonesian Journal of Pharmaceutical Science and Technology

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24198/ijpst.v13i1.69540

Abstract

Skin aging, characterized by decreased skin elasticity, is a global concern closely related to elastin degradation caused by oxidative stress and elastase activity. Natural ingredients rich in antioxidants are increasingly explored as potential anti-aging agents. Avocado (Persea americana) seeds contain various bioactive compounds that may protect elastin and slow the skin aging process. This study employed in silico and in vitro approaches to evaluate the antioxidant and anti-elastase activities of ethanol extract of avocado seeds from Bener Meriah, Aceh. Extraction was performed using maceration with 70% ethanol, followed by phytochemical screening. Antioxidant activity was assessed using the DPPH method. Anti-elastase activity was evaluated in silico through molecular docking against porcine pancreatic elastase (PPE) and in vitro using the SANA substrate and PPE enzyme. The avocado seed ethanol extract showed strong antioxidant activity with an IC₅₀ value of 47.31 ppm. It also demonstrated potent anti-elastase activity with an IC₅₀ value of 6.980 ppm. Molecular docking revealed that cholestan-3-ol, 2-methylene-, (3β,5α)- had a binding affinity of −8.0 kcal/mol, comparable to the control. Overall, the ethanol extract of avocado seeds exhibits very strong antioxidant and significant anti-elastase activities both in silico and in vitro, indicating its potential as a natural anti-aging agent.
Effect of Nutmeg on Collagen Remodeling and Epithelialization Using Picrosirius Red and Gold-Orange Staining Fitri, Maisyithoh Rahma; Husna, Fauzul; Suryadi, Taufik; Sary, Nirwana Lazuardi; Fitria, Fitria; Sari, Widya; Maisun, Maisun
Indonesian Journal of Pharmaceutical Science and Technology Vol 13, No 1 (2026)
Publisher : Indonesian Journal of Pharmaceutical Science and Technology

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24198/ijpst.v13i1.68928

Abstract

Burn injuries, especially second-degree burns, remain a global health concern. Their complex healing mechanisms and socioeconomic burden make them challenging to treat.  This study evaluates the effects of 3% nutmeg (Myristicafragrans) cream on collagen remodeling and epithelial regeneration in grade II burns, using advanced histological techniques.  A post-test-only experimental design was used. Five groups were included: normal control, untreated burn, burn treated with nutmeg cream, burn treated with silver sulfadiazine (SSD), and burn treated with both nutmeg cream and SSD. Collagen subtype distribution was examined using Picrosirius Red–Fast Green staining under polarized light. Epithelialization was assessed using Gold-Orange staining. Results showed that nutmeg cream significantly enhanced the transition from collagen type III to type I. It improved epithelial thickness and promoted keratohyalin granule formation compared to untreated burns. The combination therapy improved some histological features but did not consistently outperform single therapy by day 18. These findings indicate that nutmeg cream supports extracellular matrix remodeling and epithelial maturation. This validates its traditional use and suggests its potential as an accessible adjunctive therapy.  Overall, this study underscores the value of integrating plant-based bioactives with standard treatments to improve burn wound healing.
Co-Authors . Saminan Alya, Syadza Asyi, Muhammad Shanan Dedy Syahrizal Essy Harnelly Fitri, Maisyithoh Rahma Fitria Fitria Husna, Fauzul Husnah Husnah Kartini Hasballah Maisun, Maisun Siti Rahmawati Taufik Suryadi, Taufik Widya Sari Yusni Yusni