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All Journal Indonesian Journal of Pharmaceutical Science and Technology Journal SAGO Gizi dan Kesehatan Narra J Proceedings of International Conference on Multidiciplinary Research Pharmaceutical Sciences and Research (PSR) Jurnal Kedokteran Hewan Buletin Pengabdian
Husna, Fauzul
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Agriculture, Biological Sciences & Forestry Humanities Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Computer Science & IT Dentistry Economics, Econometrics & Finance Education Engineering Health Professions Immunology & microbiology Medicine & Pharmacology Nursing Public Health Social Sciences Veterinary

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The Effectiveness of Feeding Azolla Microphylla on Catfish (Clarias Batrachus) Growth Noviyanti, Anita; Husna, Fauzul; Ridhwan, Muhammad; Surya, Erdi; Armi, Armi; Masyudi, Masyudi; Walil, Kamalliansyah
International Conference on Multidisciplinary Research Vol 3, No 1 (2020): ICMR
Publisher : Universitas Serambi Mekkah

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (312.483 KB) | DOI: 10.32672/pic-mr.v3i1.2601

Abstract

The usage of Azolla Microphylla as fish feed provides several advantages for fish farmers such as; the low-cost, the easy-to-obtain, and the taste that is favoured by some freshwaterfish especially catfish (Clarias Batrachus). Azolla Microphylla is known as one ofPterideophyte aquatic plants that can be utilized as fish feed for catfish because of its highnutritional values, including N, P, Si, Ca, Fe, Mg, and some others. This study aims to analyzethe effectiveness of feeding Azolla Microphylla on catfish length and weight growth by anexperimental method. A completely randomized design was conducted with 5 treatments and 4repeatabilities using 20 fish farms containing a cluster of catfish with an average size of 5 cm,that regularly fed with Azolla Microphylla. The observation was conducted every 10 daysduring the treatment, with a total number of observations held 4 times in the 40-daystreatment. The result indicated that the treatment in P2, with a 60-gram dosage of AzollaMicrophylla feeding, gives the optimal growth on catfish length and weight compared to othertreatments. Best scores in P2 treatment is found in the fourth observation, where the catfishlength reaches around 28 cm, and the weight reached 100 gram. Based on the single factorANOVA test, the real difference values for each group and treatment which analysed at asignificance level of 0,05, namely FvaluesFtable, indicates a significant effect of AzollaMicrophylla on the catfish growth. The Tukey’s Honest Significant Difference test also showsa significant effect of the Azolla Microphylla feeding on the catfish length and weight growth.Therefore, feeding catfish with 60-gram of Azolla Microphylla creates an effective treatmentto gain catfish length and weight.Keywords: Azolla Microphylla, Feeding, Fish Feed, Catfish Growth 
Model Hewan Coba pada Penelitian Diabetes Husna, Fauzul; Suyatna, Franciscus D; Arozal, Wawaimuli; Purwaningsih, Erni H
Pharmaceutical Sciences and Research Vol. 6, No. 3
Publisher : UI Scholars Hub

Show Abstract | Download Original | Original Source | Check in Google Scholar

Abstract

The animal model has been widely used and contributed vastly to the scientific research over the years. While it can be used as an alternate subject in a study, the selection of the animal is crucial to assess and investigate the influence of the environment and genes on the pathogenesis of a disease. Many factors contribute to the choosing of the animal. They can be ranged from the similarities with the modelled object, easily looked after with less expensive cost, good reproductive performance, ability to produce blood and tissue samples, well-known genetic composition, and the status of the disease can be explained. Research has been taking place to investigate and find the best approach to prevent and deal with diabetes mellitus (DM) and insulin resistance and its complications. It starts with an initial in vitro method and finished with a clinical trial. Similarly, a series of in vivo studies using the animal model has been done aiming at figuring out its conditions or diseases that are identical to that of humans. This article discusses a variety of animal models frequently used in DM research.
Antioxidant and antiaging activity of Cinnamomum burmannii and Michelia champaca extract and combinations Qarani, Waisul; Husna, Fauzul; Yulia, Winda; Zulkarnain, Zulkarnain; Syahrizal, Dedy; Gani, Basri A.; Sary, Nirwana L.; Wardhani, Bantari WK.
Narra J Vol. 3 No. 2 (2023): August 2023
Publisher : Narra Sains Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52225/narra.v3i2.111

Abstract

Aging is a natural skin process that occurs due to intrinsic and extrinsic factors, such as excessive exposure to ultraviolet light (photoaging). The mechanism of damage involves the production of excess free radicals that trigger oxidative stress in the skin. Determining the natural products that have high antioxidant activities as antiaging is up most important. Cinnamomum burmannii and Michelia champaca are typical Aceh plants that are believed to have high antioxidant effects. The aim of this study was to determining the contents of C. burmannii and M. champaca as well as to determine the antioxidant and antiaging activities of either individually or combinations. The qualitative phytochemical and semi-quantitative analysis of the extracts were conducted using gas chromatography and mass spectroscopy (GC-MS). The antioxidant activity was examined by radical scavenging using the DPPH radical while the antiaging activity was tested the tyrosinase enzyme inhibition test. The phenolic and flavonoid contents of C. burmannii were higher than M. champaca (66.34 vs 24.71 mg gallic acid equivalent/gr) and (80.52 vs 60.20 mg quercetin equivalent/gr). The inhibitory concentration (IC₅₀) of M. champaca extract in inhibiting DPPH indicated that M. champaca had a better antioxidant activity than C. burmannii. The combination of C. burmannii and M. champaca extracts had a lower IC₅₀ compared to M. champaca alone. C. burmannii and M. champaca extract had a weak potential to inhibit tyrosinase activity (IC₅₀ value ≥1000 µg/mL). In conclusion, this study indicates that M. champaca and C. burmannii have strong antioxidant activities and these might associate with polyphenol contents.
Wound healing effect of nutmeg (Myristica fragrans) cream on second-degree burn in animal model Angilia, Ciecielia; Sary, Nirwana L.; Indah, Rosaria; Suryawati, Suryawati; Farsa, Bianda S.; Zeir, Haya A.; Fajri, Fauzan; Husna, Fauzul
Narra J Vol. 4 No. 1 (2024): April 2024
Publisher : Narra Sains Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52225/narra.v4i1.621

Abstract

Second-degree burn, the most common among burn degrees, underscores the importance of timely and proper treatment in influencing prognosis. Nutmeg (Myristica fragrans), renowned for its potent antibacterial and antifungal properties, also serves as an effective antiseptic for open wounds. The aim of this study was to identify the phytochemical constituents of nutmeg essential oil and analyze the wound healing effect of nutmeg cream on second-degree burns in an animal model. An experimental study with a completed randomized design was conducted on Rattus norvegicus strain Wistar rats with second-degree burn. This study had four groups and each group consisting of four rats: B (burn-treated base cream), B+N (burn-treated 3% nutmeg cream), B+SSD (burn-treated silver sulfadiazine (BSS)), and B+N+SSD (burn-treated 3% nutmeg cream and SSD in a 1:1 ratio). The phytochemical analysis of nutmeg essential oil was conducted by gas chromatography and mass spectroscopy (GC-MS). The burn diameter and burn wound healing percentage were measured from day 0 to 18. One-way ANOVA followed by post hoc analysis using the least significant difference (LSD) was employed to analysis the effect. The phytochemical analysis of nutmeg essential oil found that myristicin, terpinene-4-ol, terpinene, safrole and terpinolene were the most abundant putative compounds in nutmeg essential oil. On day 0, the average burn wound diameters were 1.4 cm in all groups and increases were observed in all groups in day 3. The wound diameter decreased until day 18 with the smallest burn wound diameter was found in the B+N group (0.86±0.37 cm), followed by B+SSD (0.93±0.29 cm). The B+SSD group exhibited the highest percentage of burn wound healing (56.80±14.05%), which was significantly different from the base cream (p<0.05). The percentage of burn wound healing in rats given 3% nutmeg cream was 41.88±13.81% suggesting that nutmeg cream could promote burn wound healing in rats induced by second-degree burns.
Nilai nutrisi ekstrak buah nipah dan pengaruhnya terhadap glucose transporter-2 (GLUT-2) pada tikus yang diinduksi STZ Fitri, Yulia; Wagustina, Silvia; Husna, Fauzul; Suryana, Suryana; Zakiah, Noni; Sastri, Sastri
Jurnal SAGO Gizi dan Kesehatan Vol 5, No 2 (2024): April
Publisher : Poltekkes Kemenkes Aceh

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30867/gikes.v5i2.1669

Abstract

Background: The nutritional content of nipah fruit such as zinc and fiber plays an important role in regulating blood sugar levels in diabetes patients (DM). One way to increase the concentration of nutritional value and bioactive substances in palm fruit is to extract it. Active compounds such as tannins, flavonoids, polysaccharides, saponins, and terpenoids in palm fruit extract can inhibit the activity of amylase and glucosidase enzymes, which are mediated by Glucose Transporter-2 (GLUT-2) so that they affect controlling blood sugar levels. GLUT-2 is a protein that plays a role in transporting glucose from outside to inside cells, so it plays an essential role in maintaining balanced blood sugar levels.Objective: This research aims to examine the nutrients in palm fruit extract and its effect on Glucose transporter-2 (GLUT-2) in STZ-induced  in rats.Method: This study is experimental research using experimental laboratory methods carried out in the FKH USK laboratory in June 2022. Making nipah fruit extract is carried out by maceration using 95% ethanol. Carbohydrate, protein, fat, zinc, and Fe levels were analyzed using the Luff Schoorl, Kjeldahl, Soxhletasi, and AAS test method. Testing for water content and crude fibre uses a gravimetric test. Twenty-five rat samples were divided into four groups and induced with STZ 40 mg/kg BW. Checking blood sugar levels is needed to see hyperglycemic conditions in rats. GLUT-2 measurement after administering nipah extract for one month using the ELISA technique. The data obtained were analyzed by an ANOVA test.Results: Based on the results, it was found that fruit extract contained 15,79% carbohydrates, 7,04% protein, 6,02% fat, 0,0327% zinc, water content 24,05% and crude fibre 0,36%. The average GLUT-2 level in the control group was 7,24 ± 1,35 ng/ml, the DM group was 6,75 ± 0,81 ng/ml, the DM+extract group was 6,84 ± 0,56 ng/ml, the DM+metformin group was 7,34 ± 0,86ng/ml, and the DM+extract+metformin group was 6,93± 1,01 ng/ml.Conclusion: Nipah fruit extract contains carbohydrates, protein, fat and zinc. Administration of palm fruit extract for one month did not significantly effect on GLUT-2 in various groups of rats (0,83).  
Antioxidant Potential, Anti-Diabetes, and Toxicity of Aceh Cinnamon Extract (Cinnamomum burmannii) Husna, Fauzul; Suhaila, Suhaila; Syahrizal, Dedy; Zulkarnain, Zulkarnain; Washilah, Hasya; Sahriana, Ananda Putri
Indonesian Journal of Pharmaceutical Science and Technology Vol 11, No 1 (2024)
Publisher : Indonesian Journal of Pharmaceutical Science and Technology

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24198/ijpst.v11i1.43182

Abstract

Indonesia as a mega biodiversity country must take a role in the development of herbal-based medicine. Cinnamon is often used empirically to overcome various health problems, especially diabetes.   This study aims to assess the effectiveness of Aceh cinnamon extract as an antioxidant and antidiabetic in vitro and to evaluate the toxicity of the extract. Cinnamons, obtained from coffee plantations in Simpang Teritit, Bener Meriah, Aceh, were macerated with 96% ethanol for extraction.  Furthermore, the extract phytochemical content was determined qualitatively, semiquantitatively (GC-MS), and quantitatively (levels of phenols, flavonoids, and total tannins).  The toxicity level was measured by an acute toxicity test based on the OECD and the BSLT assay.  The effectiveness as an antioxidant and anti-diabetes was determined in vitro by the DPPH inhibition method and α-glucosidase inhibition. The results of this study showed that cinnamon extract contains alkaloids, flavonoids, polyphenols, tannins, quinones, saponins, and triterpenoid compounds. The total amount of phenol, flavonoid, and tannin extract levels were 66.34 mg GAE/gr, 80.52 mg QE/gr, and 566.33 mg AT/gr. The IC50 extract value against DPPH was 16.07 ppm and against the enzyme, α-glucosidase was 123.52 ppm. In the acute toxicity test, the value of LD50 ≥15 grkg BWW was obtained and in the toxicity test with BSLT, LC50 extract was 350.57 ppm. Aceh cinnamon extract (Cinnamomum burmannii) has LD50 > 15 gr/kg BW and LC50 value >500 ppp which is categorized as a practically non-toxic ingredient and low toxicity agent with strong antioxidant activity and moderate antidiabetics.
COMPARATIVE STUDY OF BLOOD GLUCOSE LEVELS AND THE DEGREE OF LIVER AND KIDNEY DAMAGE IN DIABETIC ANIMAL MODELS INDUCED BY ALLOXAN, STREPTOZOTOCIN, AND STREPTOZOTOCIN-NICOTINAMIDE Miswari, Irna; Husna, Fauzul; Zulkarnain, Zulkarnain; Syahrizal, Dedy; Syahputra, Andika Ari; Hasan, Denny Irmawati
Jurnal Kedokteran Hewan Vol 19, No 2 (2025): June
Publisher : Universitas Syiah Kuala

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21157/j.ked.hewan.v19i2.40839

Abstract

The objective of this study was to assess differences in body weight, blood glucose levels, and liver and kidney tissue damage among rats induced with alloxan, streptozotocin, or streptozotocin-nicotinamide. This was an experimental study using a completely randomized design. The rats were allocated into four experimental groups. Group 1 (KN) was considered as the normal control group, while groups K1, K2, and K3 were induced with streptozotocin (60 mg/kg bw), alloxan (150 mg/kg bw), and nicotinamide (120 mg/kg bw) followed by streptozotocin (60 mg/kg bw), respectively. The compounds were administered intraperitoneally using suitable solvents. Body weight and blood glucose levels were monitored weekly. Upon completion of the study, liver and kidney tissues were harvested and processed for histopathological analysis using hematoxylin-eosin staining. The findings revealed that all diabetic induction models had significantly elevated blood glucose levels compared to the control group. Additionally, there were significantly differences (P0.05) in liver and kidney tissue damage among the groups treated with streptozotocin (STZ), alloxan, and STZnicotinamide. In conclusion, STZ induction produced more consistent hyperglycemia with less tissue damage compared to alloxan, while, nicotinamide co-administration effectively reduced cellular degeneration, suggesting its protective role against diabetes-induced tissue injury.
Pelatihan produksi roti gandum sebagai pangan fungsional di Gampong Kajhu Kabupaten Aceh Besar (Training on wheat bread production as a functional food in Kajhu Village, Aceh Besar District) Suryawati, S; Maysarah, Hilda; Nauval, Iflan; Safuni, Nani; Nova, Vera; Husna, Fauzul; Firdausa, Sarah; Suardi, Hijra Novia
Buletin Pengabdian Vol 1, No 1 (2021): Bull. Community. Serv.
Publisher : Universitas Syiah Kuala

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24815/bulpengmas.v1i1.20434

Abstract

The purpose of this activity was to train community members in Kajhu Village, Aceh Besar District to produce wheat bread with the addition of pumpkin. These community service activities were carried out in several stages which were socialization of the importance of a healthy lifestyle through focus group discussions by 3 experts in health field (clinical pharmacology, internal medicine, and clinical nutrition) and discussions about production, packaging, and product marketing. The result showed that 60 packs of bread with approximately 80 calories were produced every production time. Marketing and transaction (ordering) of products utilized online media. The sales value for 60 breads per day was Rp.420,000, with a profit of Rp. 180,000. This result was a good thing for Kajhu Village community group members because it could increase household income.In conclusion, the implementation of this product-based community service program has resulted in bread products with nutritious ingredients of wheat and pumpkin which have been clinically and experimentally (in other researches) proven to have anti-diabetic properties.
Effect of Nutmeg on Collagen Remodeling and Epithelialization Using Picrosirius Red and Gold-Orange Staining Fitri, Maisyithoh Rahma; Husna, Fauzul; Suryadi, Taufik; Sary, Nirwana Lazuardi; Fitria, Fitria; Sari, Widya; Maisun, Maisun
Indonesian Journal of Pharmaceutical Science and Technology Vol 13, No 1 (2026)
Publisher : Indonesian Journal of Pharmaceutical Science and Technology

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24198/ijpst.v13i1.68928

Abstract

Burn injuries, especially second-degree burns, remain a global health concern. Their complex healing mechanisms and socioeconomic burden make them challenging to treat.  This study evaluates the effects of 3% nutmeg (Myristicafragrans) cream on collagen remodeling and epithelial regeneration in grade II burns, using advanced histological techniques.  A post-test-only experimental design was used. Five groups were included: normal control, untreated burn, burn treated with nutmeg cream, burn treated with silver sulfadiazine (SSD), and burn treated with both nutmeg cream and SSD. Collagen subtype distribution was examined using Picrosirius Red–Fast Green staining under polarized light. Epithelialization was assessed using Gold-Orange staining. Results showed that nutmeg cream significantly enhanced the transition from collagen type III to type I. It improved epithelial thickness and promoted keratohyalin granule formation compared to untreated burns. The combination therapy improved some histological features but did not consistently outperform single therapy by day 18. These findings indicate that nutmeg cream supports extracellular matrix remodeling and epithelial maturation. This validates its traditional use and suggests its potential as an accessible adjunctive therapy.  Overall, this study underscores the value of integrating plant-based bioactives with standard treatments to improve burn wound healing.
Effects of Mesenchymal Stem Cell Secretome on Cardiac Histopathological Changes in Doxorubicin-Induced Rats Putri, Liza Aulia; Syahrizal, Dedy; Husna, Fauzul; Ridwan, Muhammad; Fitriyani, Sri
Indonesian Journal of Pharmaceutical Science and Technology Vol 13, No 1 (2026)
Publisher : Indonesian Journal of Pharmaceutical Science and Technology

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24198/ijpst.v13i1.69258

Abstract

Doxorubicin is an anthracycline chemotherapeutic agent widely used in clinical practice, but its application is limited by cardiotoxicity that damages myocardial structure and function. Mesenchymal stem cell secretome contains diverse bioactive molecules, including cytokines, growth factors, and extracellular vesicles, which contribute to tissue protection and cellular repair. This study aimed to evaluate the preventive and curative effects of secretome administration on histopathological changes in the hearts of doxorubicin-induced rats. Twenty-four rats were divided into four groups: without treatment (KS), cardiotoxicity group (KK), preventive secretome (P1), and curative secretome (P2). Histopathological assessment included degeneration, inflammatory infiltration, congestion, and necrosis using semi-quantitative scoring. Results showed no significant differences in degeneration, inflammatory infiltration, or congestion among groups. In contrast, necrosis scores differed significantly (p = 0.002), with the highest values observed in the KK group. Secretome administration in the P2 group demonstrated the most pronounced improvement, reflected by a greater reduction in necrosis scores compared to other groups. In conclusion, curative-phase secretome treatment provided the most effective histological improvement by reducing myocardial necrosis, indicating a stronger tissue repair response than preventive administration.
Co-Authors AA Sudharmawan, AA Angilia, Ciecielia Armi, Armi Basri A. Gani, Basri A. Dedy Syahrizal Erni H Purwaningsih, Erni H Fajri, Fauzan Farsa, Bianda S. FIRDAUSA, SARAH Fitri, Maisyithoh Rahma Fitria Fitria Hasan, Denny Irmawati Hijra Novia Suardi Maisun, Maisun Masyudi Masyudi Maysarah, Hilda Miswari, Irna Muhammad Ridwan Nauval, Iflan Noni Zakiah Nova, Vera Noviyanti, Anita Putri, Liza Aulia Qarani, Waisul Rosaria Indah SAFUNI, NANI Sahriana, Ananda Putri Sary, Nirwana L. Sary, Nirwana Lazuardi Sastri Sastri Silvia Wagustina, Silvia Siswahyudianto Sri Fitriyani Suhaila, Suhaila Surya, Erdi Suryana Suryana Suryawati Suryawati Suryawati, S Suyatna, Franciscus D Syahputra, Andika Ari Taufik Suryadi, Taufik Walil, Kamalliansyah Wardhani, Bantari WK. Washilah, Hasya Wawaimuli Arozal Widya Sari Winda Yulia Zeir, Haya A. Zulkarnain Zulkarnain