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All Journal Indonesian Journal of Chemical Analysis (IJCA)
Safitriono, Wahyu Nur
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Chemical Engineering, Chemistry & Bioengineering Chemistry Environmental Science

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Advances in Mesoporous Silica Nanoparticles: Synthesis, Characterization, and Biomedical Uses Saputra, Ozi Adi; Safitriono, Wahyu Nur; Istiqomah, Annisa; Kumalasari, Meiyanti Ratna; Irmawan, Muhammad; Wibowo, Fajar Rakhman
Indonesian Journal of Chemical Analysis (IJCA) Vol. 7 No. 2 (2024): Indonesian Journal of Chemical Analysis
Publisher : Universitas Islam Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20885/ijca.vol7.iss2.art9

Abstract

Mesoporous silica nanoparticles (MSNs) have drawn significant attention due to their exceptional properties and diverse range of applications, particularly in nanomedicine. The distinctive properties of MSNs, such as their high surface area, tunable pore size, and versatile surface chemistry, make them ideal candidates for various biomedical applications. This review aims to present a detailed understanding of MSNs, from synthesis and characterization to their versatile applications in biomedicine, highlighting their significant potential in advancing healthcare technologies. The synthesis methods for MSNs were comprehensively discussed, emphasizing the influence of parameters like solvent, base, alkoxysilane concentrations, and template surfactants on the size and shape of the nanostructures. Different types of MSNs, including MCM-41, SBA-15, KIT-6, and hollow MSNs, are discussed, along with their synthesis protocols and unique characteristics. The review also covers various spectroscopic techniques, such as XRD, XPS, FTIR, NMR, and fluorescence spectroscopy, which are crucial for characterizing MSNs. Furthermore, the biomedical applications of MSNs are highlighted, demonstrating their potential in drug delivery systems, imaging, and diagnostics. The review concludes with a discussion of the future perspectives and challenges in the field, providing insights into potential developments and the prospects for clinical translation.
From Mesoporous Silica to MOF–Silica Composites: Advancements in Nanostructured Drug Delivery Systems Safitriono, Wahyu Nur; Saputra, Ozi Adi; Lestari, Witri Wahyu; Wibowo, Fajar Rakhman
Indonesian Journal of Chemical Analysis (IJCA) Vol. 9 No. 1 (2026): Indonesian Journal of Chemical Analysis
Publisher : Universitas Islam Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20885/ijca.vol9.iss1.art4

Abstract

Recent advances in nanotechnology have enabled the development of versatile drug delivery systems (DDS) using nanoscale carriers, offering significant improvements over conventional therapies. Mesoporous silica nanoparticles (MSNs) and metal–organic frameworks (MOFs) are highly porous nanomaterials with tunable structures and large surface areas, making them promising platforms for drug delivery. MSNs provide controllable particle size, pore size, and surface functionality, allowing efficient loading and controlled release of both hydrophilic and hydrophobic drugs. MOFs, with their high surface area, adjustable pore structures, and chemical versatility, enable high drug loading capacity and stimuli-responsive release. Integrating MOFs with silica to form MOF–silica composites further enhance structural stability, biocompatibility, and drug delivery efficiency. Stimuli-responsive composites can minimize premature drug release and enable targeted delivery in response to environmental triggers, such as pH or near-infrared irradiation. This review highlights the structural and functional differences among MSNs, MOFs, and MOF–silica composites, and discusses their applications in delivering model therapeutic agents, including curcumin, quercetin, and doxorubicin. The advantages, limitations, and future perspectives of these nanocarriers for precision medicine are also addressed, emphasizing their potential to improve therapeutic efficacy while reducing off-target effects.
Co-Authors Annisa Istiqomah, Annisa Fajar Rakhman Wibowo Irmawan, Muhammad Lestari, Witri Wahyu Ozi Adi Saputra, Ozi Adi Sari, Meiyanti Ratna Kumala