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All Journal The Journal of Pure and Applied Chemistry Research Chemistry Indonesian Journal of Chemical Research Indonesian Journal of Chemical Analysis (IJCA) JURNAL BIOSHELL BiosciED: Journal of Biological Science and Education Gudang Jurnal Pengabdian Masyarakat Journal of Biotropical Research and Nature Technology
Irmawan, Muhammad
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Religion Agriculture, Biological Sciences & Forestry Humanities Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Economics, Econometrics & Finance Education Engineering Environmental Science Immunology & microbiology Languange, Linguistic, Communication & Media Materials Science & Nanotechnology Medicine & Pharmacology Social Sciences Other

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Isolasi, Identifikasi, Karakterisasi Dan Uji Toksisitas Senyawa Metabolit Sekunder Fraksi Nonpolar Akar Babandotan (Ageratum conyzoides L) Irmawan, Muhammad; Mandey, Frederyk; Dali, Seniwati
Indonesian Journal of Chemical Research Vol 6 No 1 (2018): Edisi Bulan Juli (Edition For July)
Publisher : Jurusan Kimia, Fakultas Sains dan Teknologi, Universitas Pattimura

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30598/ijcr.2018.6-muh

Abstract

Ageratum Conyzoides L. has a toxic and bioactive component as anti-cancer and especially for the root, it has anti-tumor. In order to figure out the active component, it is necessary to do four steps; isolation, identification, characterization, and toxicity essay Brine Shrimp Lethality Test (BSLT) of non-polar fraction Ageratum conyzoides L plant. Isolation method consist of four parts; extraction, partitioning of Kupchan method, fractionation, and purification. Fractionation method uses press column chromatography (KTT). Furthermore, purification process uses thin layer chromatography (TLC) and characterization with spectroscopy FTIR, 1H-NMR and 13C-NMR. Then characterization utilizes spectroscopy FTIR, 1H-NMR and 13C-NMR. The toxicity essay toward Artemia Salina Leach n-hexane fraction and dichloromethane fraction showed that the fraction had toxic properties with number of LC50 are 0,0237 and 4,642 µg/mL respectively. Moreover, n-hexane fraction has succeed in isolating Stigmasterol compound shaped white crystalline needles with 19.6 mg weight, 143-144 °C melting point and and had toxic properties with number of LC50 are 30,33 µg/mL.
Catatan Tamang Mangkinang (Elaeocarpus glaber Blume) di Kalimantan Tengah: Records of Tamang Mangkinang (Elaeocarpus glaber Blume) in Central Kalimantan Lestari, Ria Windi; Rizki, Muhammad; Aziz, Fadhila; Fatiqin, Awalul; Irmawan, Muhammad
BiosciED: Journal of Biological Science and Education Vol. 5 No. 2 (2024): BiosciED December 2024
Publisher : FKIP, Universitas Palangka Raya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37304/bed.v5i2.18077

Abstract

Abstrak. Elaeocarpus glaber Blume merupakan tumbuhan buah liar dapat dimakan yang memiliki ciri khas endokarp yang berukiran dan baraluran. Saat ini, spesies Elaeocarpus glaber Blume telah mengalami perubahan status konservasi dari terancam menjadi resiko rendah pada laman jejaring IUCN, namun informasi yang diperoleh dilapangan bahwa masyarakat Desa Bukit Rawi telah menebang banyak tanaman dewasa. Sehingga, penelitian ini tetap bertujuan untuk memperkuat penentuan status dengan mengumpulkan data tentang keberadaan Elaeocarpus glaber di Kalimantan Tengah menggunakan metode jelajah dan wawancara. Hasil menunjukkan tercatat delapan lokasi pernah dilaporkan serta satu lokasi adalah terbaru, dikoleksi di habitat tanah liat di tepi sungai Kahayan Tengah di Desa Bukit Rawi. Abstract. Elaeocarpus glaber Blume is an edible wild fruit plant that characteristised by a sculptured to sulcate endocarp. Currently, the Elaeocarpus glaber Blume species has undergone a change in conservation status from Threatened to Least Concern on the IUCN website, even though the field information was obtained that the Bukit Rawi Village community has cut down many mature plants. Therefore, this study still purpose to strengthen the status determination by collecting data on the presence of Elaeocarpus glaber in Central Kalimantan using eksploration method and interviews. The results showed that eight locations were reported and one location was the most recent, which is collected in a clay habitat on the riverbanks of the Kahayan Tengah in Bukit Rawi Village
Advances in Mesoporous Silica Nanoparticles: Synthesis, Characterization, and Biomedical Uses Saputra, Ozi Adi; Safitriono, Wahyu Nur; Istiqomah, Annisa; Kumalasari, Meiyanti Ratna; Irmawan, Muhammad; Wibowo, Fajar Rakhman
Indonesian Journal of Chemical Analysis (IJCA) Vol. 7 No. 2 (2024): Indonesian Journal of Chemical Analysis
Publisher : Universitas Islam Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20885/ijca.vol7.iss2.art9

Abstract

Mesoporous silica nanoparticles (MSNs) have drawn significant attention due to their exceptional properties and diverse range of applications, particularly in nanomedicine. The distinctive properties of MSNs, such as their high surface area, tunable pore size, and versatile surface chemistry, make them ideal candidates for various biomedical applications. This review aims to present a detailed understanding of MSNs, from synthesis and characterization to their versatile applications in biomedicine, highlighting their significant potential in advancing healthcare technologies. The synthesis methods for MSNs were comprehensively discussed, emphasizing the influence of parameters like solvent, base, alkoxysilane concentrations, and template surfactants on the size and shape of the nanostructures. Different types of MSNs, including MCM-41, SBA-15, KIT-6, and hollow MSNs, are discussed, along with their synthesis protocols and unique characteristics. The review also covers various spectroscopic techniques, such as XRD, XPS, FTIR, NMR, and fluorescence spectroscopy, which are crucial for characterizing MSNs. Furthermore, the biomedical applications of MSNs are highlighted, demonstrating their potential in drug delivery systems, imaging, and diagnostics. The review concludes with a discussion of the future perspectives and challenges in the field, providing insights into potential developments and the prospects for clinical translation.
Antioxidant Potential of Secondary Metabolite from Kelakai (Stenochlaena palustris) as a Natural Growth Promoter Through Inhibition of Inducible Nitrite Oxide Synthase (iNOS) Irmawan, Muhammad; Kumalasari, Meiyanti Ratna; Sandriya, Ardi; Fariz Noorrahman, Nabil; Ysrafil, Ysrafil; Tesalonika, Lidya
The Journal of Pure and Applied Chemistry Research Vol. 14 No. 1 (2025): Edition January-April 2025
Publisher : Chemistry Department, The University of Brawijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21776/ub.jpacr.2025.014.01.6534

Abstract

Kelakai (Stenochlaena palustris), a plant native to Central Kalimantan, is recognized for its potent antioxidant properties. This study aimed to investigate the preparation, extraction, phytochemical composition, antioxidant potential, and molecular interactions of secondary metabolites derived from Kelakai, emphasizing its health-promoting benefits and possible use as a natural growth enhancer. The findings revealed that the Kelakai extract contained various secondary metabolites, including alkaloids (8.868%), flavonoids (5.3%), saponins (10.76%), phenolics (1.246%), tannins (0.067%), and triterpenes (30.7%). The extract demonstrated a powerful antioxidant effect, with an IC50 value of 44.81 μg/mL. Molecular docking analysis identified chlorogenic acid and eucalyptol as essential compounds contributing to the extract's antioxidant activity. These compounds effectively inhibit the iNOS protein, with binding free energy (ΔGbinding) values of -10.3044 kcal/mol and -6.0872 kcal/mol, respectively. These findings suggest that kelakai extract possesses significant antioxidant potential and may offer valuable applications as a natural growth promoter for broiler chickens.
Phytochemical Screening n-hexane Extract of Sponge Xestospongia testudinaria from Spermonde Archipelago Kalalinggi, Septaria Yolan; Soekamto, Nunuk Hariani; Firdaus; Appa, Felycitae Ekalaya; Irmawan, Muhammad
Journal of Biotropical Research and Nature Technology Vol. 1 No. 2 (2023): Borneo
Publisher : Prodi Biologi FMIPA Universitas Palangka Raya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52850/borneo.v1i2.8992

Abstract

One of the islands in Indonesia that is inhabited by sponges of various types is the Spermonde Archipelago, which is located in the southern part of the Makassar Strait. Sponge X. testudinaria is one of the sponges that dominates the Spermonde Islands. The difference in environmental conditions where the sponge lives causes the sponge X. testudinaria to have a different adaptation mechanism in producing secondary metabolites as self defense. Research on the of compounds from n-hexane extract sponge X. testudinaria has been carried out using phytochemical tests. Extraction begins with maceration using n-hexane solvent then the solvent is moved using an evaporator. Identification of extract functional groups using IR spectra. The results of the phytochemical screening indicated the presence of alkaloids and steroids which were supported by IR spectrum data indicating the presence of aliphatic NH, C=O and CH groups.
Pemanfaatan Ekoenzim dari Limbah Kulit Nanas dan Jeruk sebagai Disinfektan Alami Irmawan, Muhammad; Pramudita, Dimas; Nababan, Jesika; Imelya, Marsya; Sari, Meiyanti Ratna Kumala
JURNAL BIOSHELL Vol 14 No 2 (2025): Oktober
Publisher : Universitas Islam Jember

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.56013/bio.v14i2.4612

Abstract

Ekoenzim merupakan suatu produk hasil fermentasi dari  limbah organik seperti sisa buah dan sayuran. Limbah kulit nanas menjadi salah satu sisa pangan yang berpotensi digunakan sebagai bahan baku produk ekoenzim. Oleh karena itu, dilakukan penelitian untuk membuat dan mengidentifikasi potensi ekoenzim dari limbah kulit nanas melalui uji fenolik, saponin, organoleptik dan hedonik. Hasil menunjukkan 4 variasi ekoenzim memiliki potensi sebagai disinfektan berdasarkan nilai pH dan mengandung senyawa fenolik (V1-4) dengan total fenolik berturut-turut 12.9, 67.8, 115 dan 146 mg/L).  Selain itu hasil uji organoleptik dan hedonik menunjukkan bahwa 37% panelis menyukai V4 ekoenzim, (V3) 27% dan 18% untuk V1,2. Ekoenzim V4 juga mendapatkan kesukaan paling banyak pada survei kesukaan terhadap variasi ekoenzim, yaitu sebesar 31%. Sehingga V4 menjadi paling berpotensi sebagai disenfektan dan paling disukai.
Sosialisasi Pembuatan Minyak Serai Sebagai Campuran Sabun Bath Bomb Untuk Masyarakat Usia Produktif Kota Palangka Raya Toepak, Erwin Prasetya; Sudyana, I Nyoman; Irmawan, Muhammad; Mahrita, Ani; Suherman
Gudang Jurnal Pengabdian Masyarakat Vol. 2 No. 1 (2024): GJPM - JANUARI s/d JUNI
Publisher : PT. Gudang Pustaka Cendekia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.59435/gjpm.v2i1.129

Abstract

Cymbopogon citratus, biasa disebut serai, adalah tanaman aromatik yang sangat serbaguna yang terkenal dengan sifat terapeutik dan kegunaannya yang luas. Aplikasi ini mencakup minyak pijat, aromaterapi, pengusir serangga, penyegar udara, parfum, kosmetik, dan bahkan tujuan pengobatan. Tanaman serai merupakan salah satu spesies tumbuhan yang mampu mensintesis minyak atsiri. Di Indonesia, pemanfaatan tanaman serai (Cymbopogon citratus) sebagian besar terfokus pada penerapannya sebagai bahan penyedap makanan. Namun, terdapat potensi besar yang belum dimanfaatkan untuk pengembangan minyak atsiri berkualitas tinggi yang berasal dari tanaman ini. Minyak atsiri biasa disebut demikian karena komposisinya yang mencakup esensi dasar dari masing-masing tanaman. Pemanfaatan minyak atsiri lazim dalam produksi sabun bath bomb. Sabun bath bomb telah mengalami lonjakan popularitas yang signifikan karena digabungkan sebagai pelengkap ritual mandi yang menyenangkan, menawarkan pengalaman sensorik multi-segi yang ditandai dengan produksi busa, warna cerah, dan aroma harum yang menyenangkan. Penyuluhan produksi minyak serai dilakukan pada demografi masyarakat di Palangka Raya yang berada pada rentang usia produktif, khususnya pelajar. Sesi pelatihan meliputi pemberian panduan produksi minyak serai melalui metodologi yang lugas. Kegiatan pengabdian kepada masyarakat ini berhasil dilaksanakan dan mendapat sambutan baik dari kalangan mahasiswa.
Co-Authors Annisa Istiqomah, Annisa Ardi Sandriya Arum, Diah Panjar Atviaputra, Alvin Siena Erwin Prasetya Toepak Fadhila Aziz Fajar Rakhman Wibowo Fariz Noorrahman, Nabil Fatiqin, Awalul Felycitae Ekalaya Appa Firdaus Imelya, Marsya Kalalinggi, Septaria Yolan Kristinae, Vivy Mahrita, Ani Mandey, Frederyk Muhammad Rizki Nababan, Jesika Nunuk Hariani Soekamto Ozi Adi Saputra, Ozi Adi Pramudita, Dimas Ria Windi Lestari Safitriono, Wahyu Nur Sari, Meiyanti Ratna Kumala Seniwati Dali Septya, Lia Sudyana, I Nyoman Suherman Tesalonika, Lidya Wulandari, Leony Ysrafil, Ysrafil