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All Journal Jurnal Penelitian Pendidikan IPA (JPPIPA) SOCIAL EDU: Jurnal Ilmu Sosial dan Pendidikan
Ahmad Lubab
Universitas Islam Negeri Sunan Ampel Surabaya
Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Economics, Econometrics & Finance Education Law, Crime, Criminology & Criminal Justice Materials Science & Nanotechnology Mathematics Physics Social Sciences

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EKSPLORASI ETNOMATEMATIKA PADA UDENG PACUL GOWANG SIDOARJO Salsabila; Khurotul Mufidah; Agus Prasetyo Kurniawan; Ahmad Lubab
SOCIAL EDU: Jurnal Ilmu Sosial dan Pendidikan Vol. 1 No. 2 (2025): February
Publisher : PT Innovative Academic Journals

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Abstract

This research explores ethnomathematics in Udeng Pacul Gowang Sidoarjo. The research method used is a qualitative method with an ethnographic approach. The data collection technique used in this research is observation and the data analysis technique used is descriptive analysis. The results of this research prove that there are several mathematical concepts in Udeng Pacul Gowang Sidoarjo which include straight lines, curved lines, flat shapes, and the concept of congruence.
Oxyhydrogen Nanobubbles Suppress FoxP3 and Ki-67 Expression in a Wistar Rat Model of Hepatocellular Carcinoma Natasya Adiba Zahrah; Sri Widyarti; Dyah Kinasih Wuragil; Wibi Riawan; Olly Indrajani; Ahmad Lubab; Aditya Tri Hernowo; Sutiman Bambang Sumitro; Aulanni'am
Jurnal Penelitian Pendidikan IPA Vol 12 No 1 (2026)
Publisher : Postgraduate, University of Mataram

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29303/jppipa.v12i1.13858

Abstract

HCC is difficult to treat due to its complex tumor microenvironment and the ineffectiveness of available therapies. Gas-based anticancer approaches are promising, but are hampered by instability and difficulties in targeted delivery. HHOnbs (containing hydrogen (H2), oxygen (O2), and low-dose hydrogen peroxide (H2O2) at the nanoscale) have been proposed to improve the stability and precision of gas-based therapies. This study aimed to investigate the effects of HHOnbs on the immunoregulatory marker FoxP3 and the proliferation marker Ki-67 in a Wistar rat model of HCC induced by diethylnitrosamine (DEN)/carbon tetrachloride (CCl4). The design used was a true experimental design. HHOnbs were administered intravenously. Liver tissue was assessed using immunohistochemistry to measure FoxP3 and Ki-67 expression. HHOnbs treatment significantly reduced FoxP3 and Ki-67 expression (p<0.05). FoxP3 is a marker of regulatory T cells (Tregs), which often inhibit antitumor immune responses. Its decrease indicates an increased immune response potential. Ki-67 is a marker of cell proliferation. Its decrease indicates the suppression of cancer cell growth. Further investigations are warranted to compare its efficacy with standard therapies, assess different treatment durations, and elucidate the underlying molecular signaling pathways.
Co-Authors Aditya Tri Hernowo Agus Prasetyo Kurniawan Aulanni'am Dyah Kinasih Wuragil Khurotul Mufidah Natasya Adiba Zahrah Olly Indrajani Salsabila Sri Widyarti Sutiman Bambang Sumitro Wibi Riawan