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UJI IN-SILICO SENYAWA TURUNAN KURKUMINOID SEBAGAI INHIBITOR BRUTON TYROSINE KINASE PADA LEUKIMIA LIMFOSITIK KRONIS Mulki Irpani, Abdul; Ilham Bintang, Muhamad; Putriyanti, Al-fira; Adinda, Deistha; Japar Sodik, Jajang
Jurnal Kesehatan Bakti Tunas Husada: Jurnal Ilmu-ilmu Keperawatan, Analis Kesehatan dan Farmasi Vol. 25 No. 1 (2025): Jurnal Kesehatan Bakti Tunas Husada Volume 25 Nomor 1 Tahun 2025
Publisher : LPPM Universitas Bakti Tunas Husada

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36465/jkbth.v25i1.1496

Leukemia is a blood cancer that occurs due to abnormal blood cell growth, especially white blood cells in the bone marrow. Research shows that curcumin is proven to be effective in inhibiting the activity of the NF-κB transcription factor which is often involved in the proliferation of cancer cells. This study aims to determine the potential of natural curcuminoid compounds against specific blood cancers, namely chronic lymphocytic leukemia. Through in-silico testing of curcuminoid derivative compounds against the Bruton Tyrosine Kinase protein target which plays a role in the pathophysiological process of chronic lymphocytic leukemia. The results of docking the test ligand molecule on the Tyrosine-protein kinase BTK enzyme, the native ligand has the lowest binding energy value (ΔG) of -12.04 kcal/mol with an inhibition constant (KI) of 1.49 nM. As a comparison drug, imatinib showed ΔG -11.05 kcal/mol with a KI of 7.88 nM. Test ligands s02, s05, and s08. Ligand s02 showed a ΔG of -9.43 kcal/mol with a KI of 123.19 nM, while s05 had a ΔG of -9.09 kcal/mol with a KI of 218.10 nM. Meanwhile, s08 recorded a ΔG of -9.33 kcal/mol and a KI of 143.83 nM. Although the affinity values of the three test ligands were lower than those of the natural ligands, they had the potential to bind to the target enzyme. Based on the interaction analysis, it was seen that s05 had the potential for competitive inhibition, while s02 and s08 showed lower interaction stability compared to imatinib. This indicates that s05 has the greatest potential as a potential inhibitor of the BTK enzyme compared to other test ligands.

Hubungan Tingkat Kepatuhan Pengobatan Antidiabetes Terhadap Kualitas Hidup Pasien Diabetes Melitus Tipe 2 Rawat Jalan di Salah Satu Rumah Sakit di Kabupaten Bandung Priyadi, Akhmad; Japar Sodik, Jajang; Maulana Sobandi, Mamay; Siti Nurfitria, Rizki; Sabarudin, Cecep; Riyadi, Imam
Public Health and Safety International Journal Vol. 5 No. 01 (2025): Public Health and Safety International Journal (PHASIJ)
Publisher : YCMM

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55642/phasij.v5i01.988

Diabetes Melitus tipe 2 merupakan penyakit metabolisme kronik, yang tidak dapat disembuhkan namun hanya dapat dikontrol dengan terapi farmakologi dan non farmakologi, Jika manajemen kesehatan tidak dilakukan dengan baik maka dapat menyebabkan komplikasi dan mempengaruhi kualitas hidup penderita. Tujuan penelitian ini untuk mengetahui hubungan kepatuhan minum obat dengan kualitas hidup pasien diabetes melitus tipe 2 di salah satu Rumah Sakit di Kabupaten Bandung. Penelitian ini menggunakan metode observasional analitik dengan desain cross sectional yang diambil secara Non-probability sampling. Pengambilan data dilakukan pada bulan Maret – April 2024 terhadap 95 responden diabetes melitus tipe 2. menggunakan kuesioner MMAS-8 (Eight-item Morisky Medication Adherence Scale) dan EQ-5D-5L (Euro-Quality of Life-5 Dimension-5 level). Hasil menunjukkan pasien diabetes melitus tipe 2 memiliki tingkat kepatuhan minum obat sedang (44,2%) dan kualitas hidup tinggi (62,1%). Terdapat hubungan signifikan yang kuat dan searah antara kepatuhan minum obat antidiabetes dan kualitas hidup pasien Diabetes melitus tipe 2 rawat jalan disalah satu Rumah Sakit di Kabupaten Bandung dengan nilai p 0,000 (p < 0,05) dengan tingkatan koefisien korelasi cukup kuat.

Analisis Faktor yang Mempengaruhi Kualitas Hidup pada Pasien Penderita Kanker Payudara di Rumah Sakit Priyadi, Akhmad; Japar Sodik, Jajang; Maulana Sobandi, Mamay; Saidah Mutmainah, Siti; Sabarudin, Cecep; Aqila Fadia, Andira
Public Health and Safety International Journal Vol. 5 No. 01 (2025): Public Health and Safety International Journal (PHASIJ)
Publisher : YCMM

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55642/phasij.v5i01.997

Breast cancer ranks top of all types of cancer experienced by women with an average prevalence of 56.5 per 100,000 female populations in the world. In Indonesia, less than 68,858 cases (16.6%) of a total of 396,914 cases were recorded and more than 22,000 cases ended in death. (Sung et al., 2021). The life of a patient diagnosed with breast cancer will experience many changes in their physical and psychological condition, which will then affect the quality of life of the patient and will be a long-term problem if not treated. Individuals with good quality of life will have physical and mental health, which will enable them to live socially in society according to their role. T The research was conducted quantitatively using cross sectional designs. The sample was used by 75 respondents who met the inclusion criteria of the population at the Hospital. The dependent variable is the quality of life of breast cancer patients, while the independent variables are age, marital status, lifestyle, body mass index, and stage of cancer. Data is collected using EORTC QLQ-C30 questionnaire, which are then analyzed by validating SPSS with an ordinal regression test. The results of the study showed that there was no influence between age (p=0.891), lifestyle (p =0.247), body mass index (p_0.294), and stage of cancer (p−0.268). Whereas for marital status(p=0,000) there was influence on the quality of life of patients with breast cancer.

UJI IN-SILICO SENYAWA TURUNAN KURKUMINOID SEBAGAI INHIBITOR BRUTON TYROSINE KINASE PADA LEUKIMIA LIMFOSITIK KRONIS Mulki Irpani, Abdul; Ilham Bintang, Muhamad; Putriyanti, Al-fira; Adinda, Deistha; Japar Sodik, Jajang
Jurnal Kesehatan Bakti Tunas Husada: Jurnal Ilmu-ilmu Keperawatan, Analis Kesehatan dan Farmasi Vol 25 No 1 (2025): Jurnal Kesehatan Bakti Tunas Husada Volume 25 Nomor 1 Tahun 2025
Publisher : LPPM Universitas Bakti Tunas Husada

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36465/jkbth.v25i1.1496

Leukemia is a blood cancer that occurs due to abnormal blood cell growth, especially white blood cells in the bone marrow. Research shows that curcumin is proven to be effective in inhibiting the activity of the NF-κB transcription factor which is often involved in the proliferation of cancer cells. This study aims to determine the potential of natural curcuminoid compounds against specific blood cancers, namely chronic lymphocytic leukemia. Through in-silico testing of curcuminoid derivative compounds against the Bruton Tyrosine Kinase protein target which plays a role in the pathophysiological process of chronic lymphocytic leukemia. The results of docking the test ligand molecule on the Tyrosine-protein kinase BTK enzyme, the native ligand has the lowest binding energy value (ΔG) of -12.04 kcal/mol with an inhibition constant (KI) of 1.49 nM. As a comparison drug, imatinib showed ΔG -11.05 kcal/mol with a KI of 7.88 nM. Test ligands s02, s05, and s08. Ligand s02 showed a ΔG of -9.43 kcal/mol with a KI of 123.19 nM, while s05 had a ΔG of -9.09 kcal/mol with a KI of 218.10 nM. Meanwhile, s08 recorded a ΔG of -9.33 kcal/mol and a KI of 143.83 nM. Although the affinity values of the three test ligands were lower than those of the natural ligands, they had the potential to bind to the target enzyme. Based on the interaction analysis, it was seen that s05 had the potential for competitive inhibition, while s02 and s08 showed lower interaction stability compared to imatinib. This indicates that s05 has the greatest potential as a potential inhibitor of the BTK enzyme compared to other test ligands.

Uji Aktivitas Antioksidan Ekstrak Buah Mahkota Dewa (Phaleria macrocarpa (Scheff.) Boerl.) Yang Diformulasikan Kedalam Sediaan Masker Gel Zaelani, Diki; Pratama, Reza; Japar Sodik, Jajang; Hilda Restu, Afria
JURNAL FARMASI GALENIKA Vol 11 No 1 (2024): Jurnal Farmasi Galenika Vol 11 No 1
Publisher : Universitas Bhakti Kencana

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.70410/jfg.v11i1.330

This study utilizes the Phaleria macrocarpa fruit (Phaleria macrocarpa (Scheff.) as an active ingredient in gel mask formulation due to its widespread use as a medicinal plant and its antioxidant properties that can inhibit free radicals. The research began with the collection of the fruit from the experimental garden in Lembang-Bandung, identified as Phaleria macrocarpa (Scheff.) Boerl. Extraction was conducted using the maceration method with 96% ethanol for 3x24 hours. Phytochemical screening results indicated the presence of alkaloids, flavonoids, tannins, triterpenoids, and steroids. Antioxidant activity of the gel masks was tested using the DPPH immersion method, resulting in IC50 values of 60.18 ppm, 57.18 ppm, and 54.82 ppm for three different formulations. The pure extract had an IC50 of 45.11 ppm. The gel masks remained stable despite changes in pH and viscosity, with formulation 2 being the most preferred according to the hedonic test. In conclusion, the Phaleria macrocarpa gel mask exhibits effective antioxidant activity and good stability.

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