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All Journal International Journal of Medicine and Health International Journal Of Public Health
Akpe C. I
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Health Professions Nursing Public Health

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Predictive Role Of Oxidative Stress Biomarkers (Malondialdehyde, Glutathione, Catalase and Superoxide Dismutase) in Preeclamptic Pregnant Women In The Third Trimester Of Pregnancy Edebiri O.E; Akpe C. I; Adewole A.S; Onwuka K; Obiesi C. N Nze P.O; Ohiwerei W.O
International Journal of Public Health Vol. 1 No. 4 (2024): December : International Journal of Public Health
Publisher : Asosiasi Riset Ilmu Kesehatan Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.62951/ijph.v2i1.365

Abstract

The predictive role of oxidative stress in the pathophysiology of human pregnancy is of particular interest, as oxidative stress is increased in normotensive pregnant women through systemic inflammatory response, reactive oxygen species (ROS), and reactive nitrogen species (RNS). This study involved 40 consenting pregnant women recruited from St. Philomina Catholic Hospital, Edo State, Nigeria. Data obtained were analyzed using GraphPad Prism 9. Results were expressed as mean ± SEM, with a P-value of ≤ 0.05 considered statistically significant. Malondialdehyde (MDA) increased from 3.75 ± 0.42 U/L in normotensive women to 4.53 ± 0.59 U/L in preeclamptic women. However, this increase was not statistically significant (p<0.05; 0.2903). Catalase activity decreased from 114 ± 8.07 U/L in normotensive women to 84.02 ± 21.58 U/L in preeclamptic women, but this decrease was also not statistically significant (p<0.05; 0.1909). Superoxide dismutase (SOD) increased from 40.82 ± 1.23 U/L in normotensive women to 71.90 ± 5.61 U/L in preeclamptic women. This increase was statistically significant (p<0.05; <0.0001). Glutathione peroxidase (GSH) decreased from 66.74 ± 10.35 U/L in normotensive women to 50.63 ± 8.96 U/L in preeclamptic women, but this decrease was not statistically significant (p<0.05; 0.2466). These findings suggest the potential predictive roles of these biomarkers in identifying and monitoring preeclampsia.
Evaluation Of Liver Enzymes (ALP, ALT, AST and GGT) in Preeclamptic Pregnant Women in the Third Trimester Of Pregnancy Edebiri O.E; Adewole A.S; Akpe C. I; Ehigiamusoe E. A; Ikuenobe V. E; Ohiwerei W.O; Orunta E.D
International Journal of Medicine and Health Vol. 4 No. 1 (2025): International Journal of Medicine and Health
Publisher : Lembaga Pengembangan Kinerja Dosen

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55606/ijmh.v4i1.5618

Abstract

Alkaline Phosphatase (ALP), Alanine Transaminase (ALT), Aspartate Transaminase (AST), and Gamma-Glutamyl Transferase (GGT) are liver enzymes commonly associated with liver dysfunction, and increased or decreased levels of these enzymes may be implicated in the pathophysiology of preeclampsia. This study aims to evaluate the levels of liver enzymes (ALP, ALT, AST, and GGT) in preeclamptic pregnant women in the third trimester of pregnancy. By analyzing these enzymes, the research seeks to identify potential early indicators of preeclampsia. Forty (40) consenting pregnant women were recruited from St. Philomina Catholic Hospital, Edo State, Nigeria. Blood samples were spun in a bucket centrifuge at 2500 RPM (rounds per minute) for 10 minutes, after which plasma was collected and stored frozen in plain sample bottles to be analyzed for liver enzymes (ALP, ALT, AST, and GGT) levels using the spectrophotometric method. Data obtained from the study were analyzed using Graph Pad Prism 9. Results were expressed as mean ± SEM, and a P-value of ≤ 0.05 was considered statistically significant. The present study showed a statistically significant increase in ALP, and a statistically significant decrease in liver enzymes such as ALT and AST were observed in preeclamptic women compared to normotensive pregnant women, indicating various underlying pathophysiological processes such as liver dysfunction.
Co-Authors Adewole A.S Edebiri O.E Ehigiamusoe E. A Ikuenobe V. E Obiesi C. N Nze P.O Ohiwerei W.O Onwuka K Orunta E.D