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All Journal Indonesian Journal of Chemical Science and Technology Jurnal Farmasi Indonesia
Fadhilah, Nabila Nur
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Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Energy Materials Science & Nanotechnology Medicine & Pharmacology

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The LC-MS of Grammatophyllum scriptum (Lindl.)Bl. and Cytoxic Activity Test: LC-MS of Grammatophyllum scriptum (Lindl.)Bl. and Cytoxic Activity Test de Fretes, Christina; Simaremare, Eva; Gunawan, Elsye; Agustini, Verena; Maulana, Yusuf Eka; Fadhilah, Nabila Nur
JFIOnline | Print ISSN 1412-1107 | e-ISSN 2355-696X Vol. 13 No. 2 (2021): Jurnal Farmasi Indonesia
Publisher : Pengurus Pusat Ikatan Apoteker Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (681.143 KB) | DOI: 10.35617/jfionline.v13i2.33

Abstract

Anggrek Macan (Grammatophyllum scriptum (Lindl.) Bl.) merupakan salah satu tanaman yang digemari di kalangan masyarakat sebagai tanaman hias karena bunganya yang indah. Aggrek macan memiliki senyawa metabolit sekunder alkaloid, flavonoid dan tannin yang dapat digunakan sebagai pengobatan tradisional. Namun, penelitian mengenai Anggrek Macan di bidang farmakologi masih sangat terbatas. Tujuan penelitian ini adalah mengetahui kandungan senyawa kimia yang terdapat dalam ekstrak herba Anggrek Macan secara LC-MS/MS serta nilai LC₅₀ dan konsentrasi dari ekstrak herba Anggrek Macan yang paling efektif membunuh larva udang (Artemia salina Leach.). Metode yang digunakan dalam penelitian ini adalah pengambilan sampel dari kebun Anggrek yang ada di Lingkungan FMIPA Universitas Cenderawasih Papua-Indonesia, selanjutnya sampel dibuat dalam bentuk simplisia, diekstraksi dengan etil asetat. Ekstrak selanjutnya dianalisis dengan LC-MS/MS dan dari ekstrak tersebut juga dilakukan uji sitotoksik dengan metode BSLT (Brine Shrimp Lethality Test). Hasil penelitian menunjukkan bahwa Anggrek Macan (Grammatophyllum scriptum (Lindl.) Bl.) mengandung 2′,6′-Dihydroxy-4′-methoxy-dihydrochalcone, Apigenin-7-O-α-L-rhamnose(1→4)-6"-O-acetyl-β-D-glucoside, Kushenol H, Rubrofusarin, 3-Hydroxy baicalein dan Luteolin yang diperoleh dari hasil analisis menggunakan Liquid Chromatography tandem Mass Spectrometry (LC-MS/MS). Ekstrak herba Anggrek Macan memiliki aktivitas sitotoksik dengan nilai LC₅₀ 150,96 ppm dengan tergolong kurang toksik.
Kinetics Study Addition Reaction for Methyleugenol with Formic Acid to Produce The Methyleugenol Formic Ester as Intermediate Compound of Hypertension Drug Fadhilah, Nabila Nur; Nugraha, Asep Wahyu; Purba, Jamalum; Dibyanti, Ratu Evina
Indonesian Journal of Chemical Science and Technology (IJCST) Vol. 8 No. 2 (2025): JULY 2025
Publisher : Universitas Negeri Medan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24114/ijcst.v8i2.68778

Abstract

The methyl eugenol formic ester is the intermediate formation of the 1-(3,4-dimethoxy phenyl)-2-amino-2-cyano propane compound, a hypertension drug. This study aimed to find the value of the reaction order and study the mechanism of an addition reaction of methyl eugenol with formic acid to produce the methyl eugenol formic ester. Gas chromatography analysis of the residual methyl eugenol determines the reaction order. There are two dominant products in the synthesis of methyl eugenol formic ester, resulting in the formation reaction of methyl eugenol formic predictable in a two-way reaction mechanism. The determination of the energy of the reactants, products, and transition compounds in the formation reaction of methyl eugenol formic ester compound prescribed through computational studies using NWChem 6.0 and visualization using Jmol. The results of the analysis of the data obtained several conclusions: The value of the reaction ordered for methyl eugenol with formic acid is the first order. Based on the computational result shows that the enthalpy change for the reaction product is ΔH(1) = -47,810 KJ/mol and ΔH(2) = -60,545 KJ/mol. The activation energy for both transition compounds is Ea(1) = 163,1937 KJ/mol and Ea(2) = 370,3477 KJ/mol. This fact indicates that the formation of methyl eugenol formic ester compound using the method (1) was more likely than (2). The prediction is based on the determination of Ea with the computational chemistry following the experimental result, which shows the product of (1) more than the product of (2).
Co-Authors Asep Wahyu Nugraha de Fretes, Christina Elsye Gunawan Jamalum Purba Maulana, Yusuf Eka Ratu Evina Dibyantini Simaremare, Eva Verena Agustini