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All Journal Scientia Psychiatrica Media Dermato-Venereologica Indonesiana
Aldona, Wenty Septa
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Health Professions Medicine & Pharmacology Neuroscience Public Health

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KEBERHASILAN TERAPI PEMFIGUS VULGARIS DENGAN STEROID-SPARING AGENT MIKOFENOLAT SODIUM DAN AUTOHEMOTERAPI Aldona, Wenty Septa; Nopriyati; Nugroho, Suroso Adi; Budiamal, Susanti
Media Dermato-Venereologica Indonesiana Vol 52 No 1 (2025): Media Dermato Venereologica Indonesiana
Publisher : Perhimpunan Dokter Spesialis Kulit dan Kelamin Indonesia (PERDOSKI)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33820/mdvi.v52i1.518

Abstract

Pendahuluan: Pemfigus vulgaris (PV) merupakan penyakit autoimun ditandai vesikel dan bula pada kulit dan mukosa akibat reaksi autoantibodi terhadap desmoglein (Dsg) 1 dan 3. Terapi lini pertama kortikosteroid (KS) sistemik. Terapi KS memiliki banyak efek samping sehingga diperlukan sparing agent. Pada kasus ini menggunakan sparing agent mikofenolat sodium (MPS) dan autohemoterapi (AHT). Laporan ini bertujuan mengetahui efektivitas MPS dan AHT sebagai sparing agent pada PV. Kasus: Perempuan, 37 tahun dengan lepuh kendur mudah pecah menjadi lecet disertai keropeng coklat-kehitaman pada wajah, leher, badan, kedua lengan dan tungkai. Pemeriksaan histopatologik ditemukan row of tombstones suprabasal, dan direct immunofluorescence (DIF) ditemukan chicken wire pattern interselular. Pasien didiagnosis PV dan diterapi KS sistemik dengan sparing agent MPS dan AHT. Kami melaporkan kasus jarang PV pada usia 37 tahun. Diskusi: Penggunaan sparing agent untuk mengurangi efek samping, mempercepat tapering off, perbaikan klinis dan remisi. Mikofenolat sodium digunakan karena efek samping minimal dan memberikan hasil baik. Autohemoterapi sebagai imunoterapi dengan menyuntikkan darah pasien kembali pada pasien, dapat digunakan pada penyakit vesikobulosa autoimun karena dapat menurunkan kadar autoantibodi. Kesimpulan: Kombinasi KS sistemik, MPS dan AHT memberikan hasil yang memuaskan. Pasien mengalami remisi awal pada pekan ke-2 dan remisi komplet dalam 5 bulan. 
The Clinical Characteristics, Neurobiology, and Treatment Options for Trichotillomania Aldona, Wenty Septa
Scientia Psychiatrica Vol. 4 No. 4 (2023): Scientia Psychiatrica
Publisher : HM Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37275/scipsy.v4i4.137

Abstract

Trichotillomania is characterized by the compulsive act of pulling one's own hair, leading to hair loss and potentially causing functional impairment. Trichotillomania, a psychiatric disorder characterized by the compulsive need to pull out one's own hair, has been documented in the medical literature since the 19th century. Based on prevalence surveys, trichotillomania exhibits a notable presence throughout the population, with point prevalence estimates ranging from 0.5 to 2.0 percent. Trichotillomania, as delineated in the Diagnostic and Statistical Manual of Mental Disorders-5, is categorized as an obsessive-compulsive disorder (OCD); nonetheless, it exhibits notable distinctions from OCD across various dimensions. For instance, the use of habit reversal therapy and the administration of drugs like n-acetylcysteine or olanzapine are common ways to treat trichotillomania. It is important to note that these treatment approaches are not typically employed for the treatment of obsessive-compulsive disorder (OCD). In contrast, it appears that specific first-line medications for obsessive-compulsive disorder (such as selective serotonin reuptake inhibitors) do not demonstrate efficacy in treating trichotillomania. This article provides an overview of the existing body of knowledge pertaining to trichotillomania, a psychiatric disorder characterized by compulsive hair pulling. It also examines the available empirical evidence that supports various treatment approaches for this condition.
Co-Authors Nopriyati Nugroho, Suroso Adi Susanti Budiamal