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All Journal Berkala Ilmu Kesehatan Kulit dan Kelamin Bioscientia Medicina : Journal of Biomedicine and Translational Research Media Dermato-Venereologica Indonesiana Journal of General Procedural Dermatology and Venereology Indonesia Bali Dermatology Venereology and Aesthetic Journal
Nugroho, Suroso Adi
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Biochemistry, Genetics & Molecular Biology Health Professions Immunology & microbiology Medicine & Pharmacology Neuroscience Public Health

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Update Treatment of Male Androgenetic Alopecia Damai Trilisnawati; Sarah Diba; Yuli Kurniawati; Suroso Adi Nugroho; Rusmawardiana Rusmawardiana; Raden Pamudji
Berkala Ilmu Kesehatan Kulit dan Kelamin Vol. 33 No. 1 (2021): APRIL
Publisher : Faculty of Medicine, Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/bikk.V33.1.2021.63-71

Abstract

Background: Male androgenetic alopecia (MAGA), also known as androgenetic alopecia, is the most common hair loss in males who have a genetic predisposition. The pattern of baldness in MAGA starts from the frontal area in a triangular pattern, followed by progressive thinning of the vertex until baldness occurs. Generally, the diagnosis of MAGA is established by clinical examination. FDA has approved a combination of topical minoxidil and oral finasteride for MAGA treatment. Currently, there is another treatment option like dutasteride, a prostaglandin analog, ketoconazole, and co-adjuvant therapy like laser therapy, hair transplantation, and so on. Purpose: To provide an updated treatment for MAGA. Review: Etiopathogenesis of MAGA is influenced by genetic susceptibility and hormonal factors. The European Consensus Group set the evaluation diagnosis of MAGA to include a historyof hair fall, physical examination, hair examination, supporting examination, and clinical documentation. There are therapeutic options for MAGA, including antiandrogen therapies, androgen-independent therapies, and co-adjuvant therapies. The FDA has approved a combination of topical minoxidil and oral finasteride for MAGA treatment. MAGA may affect patients’ quality of life and self-esteem. In general, patients expect higher. Conclusion: MAGA is the most common progressive hair loss in males. The MAGA therapy is expected to achieve cosmetically significant regrowth and to slow additional hair loss.
Efficacy of Calcipotriol 0.005% Ointment for Uremic Xerosis with Pruritus in Chronic Kidney Diseases Undergoing Hemodialysis Patients: Randomized Double Blind Clinical Trial Widyastuti; Yulia Farida Yahya; Suroso Adi Nugroho; Soenarto Kartowigno; M. Izazi Hari Purwoko; Irsan Saleh
Bioscientia Medicina : Journal of Biomedicine and Translational Research Vol. 5 No. 6 (2021): Bioscientia Medicina: Journal of Biomedicine & Translational Research
Publisher : HM Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32539/bsm.v5i6.319

Abstract

Introduction: Uremic xerosis with pruritus (UXP) is a chronic cutaneous complication among patients undergoing maintenance renal dialysis. Uremic xerosis level is directly related with pruritus severity or vice versa. Uremic xerosis with pruritus may lead to discomfort and negative psychological effect. The ethiopathogenesis still unknown, Most of treatments are empirical, and there is no effective and safe therapy. Emollient has not been effective enough to improve quality of life. There is some report about efficacy of topical vitamin D in xerosis and chronic pruritus. Objective: We evaluate the efficacy of calcipotriol 0.005% ointment for uremic xerosis and uremic pruritus in chronic kidney disease patients undergoing hemodialysis. Material & methode: Sixty two patients with UXP were enrolled, randomized double blind study. Patients were divided to two group, calcipotriol 0.005% ointment group or placebo. In baseline, patients were instructed to apply twice daily for four weeks. We assesesment the efficacy and safety of calcipotriol 0.005% ointment and placebo after 2nd and 4th weeks treatment using overall dry skin score (ODSS), visual analog scale (VAS), corneometer and sebumeter. We also assessed adverse effect and tolerance this drugs using visual assessment scale. Results: Overall dry skin score (ODSS) and visual analog scale (VAS) significantly decreased in calcipotriol 0.005% ointment group than in placebo group (p <0.05). Skin hydration level based on Corneometer score and skin surface lipid based on Sebumeter score was significantly increased in calcipotriol 0.005% ointment group than in placebo group (p <0.05). Cure rate and clinical improvement for calcipotriol 0.005% ointment group was significantly higher than placebo group. There was no adverse effect between two groups after treatment. Conclusion: calcipotriol 0.005% ointment is effective than placebo and can be used as alternative or adjuctive treatment and safe and tolerance for UXP.
Role of Androgen on Physiological Function of Pilosebaceous Unit Inda Astri Aryani; Cayadi Sidarta Antonius; Suroso Adi Nugroho; Nopriyati
Bioscientia Medicina : Journal of Biomedicine and Translational Research Vol. 5 No. 6 (2021): Bioscientia Medicina: Journal of Biomedicine & Translational Research
Publisher : HM Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32539/bsm.v5i6.321

Abstract

The pilosebaceous unit is a sebaceous gland with hair follicles. One of the hormones that affects the pilosebaceous unit is androgen, a steroid hormone that plays an important role in the expression of the phenotype of men and women. Androgen consist of testosterone and dihydrotestosterone which are activated by androgen receptors. Androgen in the pilosebaceous unit affect sebum production and hair growth. Androgen receptors in the sebaceous glands are found on sebocytes and in hair follicles in the dermal papillae of hair follicles
Etiology, Diagnosis, and Treatment of Leukorrhea Damai Trilisnawati; Izazi Hari Purwoko; Mutia Devi; Suroso Adi Nugroho; Fitriani; Theresia L. Toruan
Bioscientia Medicina : Journal of Biomedicine and Translational Research Vol. 5 No. 6 (2021): Bioscientia Medicina: Journal of Biomedicine & Translational Research
Publisher : HM Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32539/bsm.v5i6.323

Abstract

The most frequently reported complaints in the urogenital organ system is leukorrhea, also known as fluor albus. Leukorrhea is a discharge secreted from the genital organs, mostly occur in female. Leukorrhea has a significant incidence rate and varies according to many factors such as hormone and infection. Leukorrhea can be physiological in female, but when excess discharge is accompanied by other characteristics, the leukorrhea is considered pathological. This genital discharge also occurs in male for pathological reasons, mainly caused by infection. Several pathogenic infections, whether transmitted through secual contact or not, are the etiology of complaints of leukorrhea. Some specific pathogens will cause different symptoms in the two sex groups. To make a diagnosis, it is important for the examiner to carry out a detailed and coherent history, especially regarding sexual contact and a history of risky sexual behavior. Although some infections are asymptomatic, complications may occur if infections are not treated properly as early as possible. The management of leukorrhea is based on an examination and treatment algorithm with syndromic approach.
Granuloma Inguinale Adi Agung Anantawijaya D; Muhammad Izazi Hari Purwoko; Mutia Devi; Suroso Adi Nugroho
Bioscientia Medicina : Journal of Biomedicine and Translational Research Vol. 5 No. 7 (2021): Bioscientia Medicina: Journal of Biomedicine & Translational Research
Publisher : HM Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32539/bsm.v5i7.330

Abstract

Granuloma ingunale (GI) or donovanosis is a genital ulcer disease caused by theCalymmatobacterium granulomatis. It is a Gram-negative, facultative, obligateintracellular and pleomorphic bacterium. This bacterium has phylogeneticallyclosed to and placed within the Klebsiella genus. Clinically, the disease is com-monly characterized as painless, slowly progressive ulcerative lesions on thegenitals or perineum without regional lymphadenopathy. The lesions are highlyvascular and bleed easily on contact Extragenital lesions may occur but are rareand more common in newborns from mothers with GI genital lesions. Thisdisease is often neglected, therefore it is often misdiagnosed and inaccuratetherapy. Treatment time is 3 weeks or until clinical cure has been achieved forall proposed regimens. It often occurs both in men and women of reproductiveage (20-40 years). This article consists of several theoretical references that havebeen viewed to have a better understanding of GI.
Laboratory Examination of Syphilis M. Izazi Hari Purwoko; Mutia Devi; Suroso Adi Nugroho; Fitriani Fitriani; Raden Pamudji; Nofilia Citra Candra
Bioscientia Medicina : Journal of Biomedicine and Translational Research Vol. 5 No. 8 (2021): Bioscientia Medicina: Journal of Biomedicine & Translational Research
Publisher : HM Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32539/bsm.v5i8.339

Abstract

Syphilis, is sexually transmitted disease caused by spirochete Treponema pallidum subsp.pallidum. It have many diverse clinical manifestations that occur in distinct stages. Early diagnosis and management are the main things to prevent transmission and complication. Direct test or morphological observation is the definitive diagnosis of syphilis. This can be done through animal inoculation test, dark field microscopy, direct fluorescence antibody (DFA), and nucleid acid amplification test (NAAT). While the indirect test is a nontreponemal serologic test consist of Wasserman test, venereal disease research laboratory (VDRL), toluidine red unheated serum test (TRUST), unheated serum reagin (USR), rapid plasma reagin (RPR) and treponemal serologic test, such as T. pallidum passive particle agglutination (TPPA), T. pallidum haemagglutination assay (TPHA), fluorescent treponemal antibody absorption (FTA-Abs), enzyme immunoassay (EIA) and rapid test. The algorithm of serologic test can be divided into traditional or reverse.
Diagnosis, Treatment, and Prognosis of Syphilis in HIV Patient Mutia Devi; Izazi Hari Purwoko; Suroso Adi Nugroho; Inda Astri Aryani; Susanti Budiamal; Putri Laksmi Karim
Bioscientia Medicina : Journal of Biomedicine and Translational Research Vol. 5 No. 11 (2021): Bioscientia Medicina: Journal of Biomedicine & Translational Research
Publisher : HM Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32539/bsm.v5i11.416

Abstract

Syphilis is a sexually transmitted infection caused by the bacterium Treponema pallidum (T. Palladium). Human Immunodeficiency Virus (HIV) is a virus that attacks the body's immune system, decreased the number of CD4 cells that makes the immune system decrease, and facilitates syphilis infection. Syphilis increased the risk of spreading HIV infection with skin barrier destruction. The diagnosis of syphilis is made based on a complete history, including sexual history, clinical manifestations, and examination. The treatment of syphilis with HIV and without HIV similar, penicillin is still the gold standard for syphilis treatment with HIV. Prevention of syphilis with HIV are educated, screening for syphilis and other sexually transmitted infections, as well as early detection and therapy of partners. The prognosis for syphilis in HIV is worse than for syphilis without HIV.
Latent Syphilis Unresponsive to Doxycycline and Azithromycin Cayadi Sidarta Antonius; Mutia Devi; M. Izazi Hari Purwoko; Suroso Adi Nugroho; Fitriani; Susanti Budiamal
Bioscientia Medicina : Journal of Biomedicine and Translational Research Vol. 6 No. 5 (2022): Bioscientia Medicina: Journal of Biomedicine & Translational Research
Publisher : HM Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37275/bsm.v6i5.503

Abstract

Background. Syphilis management is based on the syphilis stage classification. The main treatment for syphilis is currently benzathine penicillin. However, patients allergic to penicillin antibiotics or who are not willing to be injected can be given doxycycline or erythromycin antibiotics. Case presentation. We present a case of a female with latent syphilis. Patient was previously treated with oral antibiotics, such as doxycycline for 30 days and followed by azithromycin for 30 consecutive days. Clinical laboratory examinations show increase of TPHA and VDRL, and the case was considered as unresponsive case. Later, the patients received benzathine penicillin G for three weeks and showed clinical improvement. Conclusion. For patient who refuse to be treated with penicillin injection, the alternative treatments are oral antibiotics. However, there is a reduced number of successful treatments for patients treated with oral antibiotics.
Risk Factors for HIV-positive Status In Condyloma Acuminata Purwoko, Izazi Hari; Karim, Putri Laksmi; Nugroho, Suroso Adi; Toruan, Theresia; ., Fitriani
Journal of General - Procedural Dermatology and Venereology Indonesia Vol. 6, No. 2
Publisher : UI Scholars Hub

Show Abstract | Download Original | Original Source | Check in Google Scholar

Abstract

Background: Condyloma acuminata (CA) is a sexually transmitted infection (STI) caused by human papillomavirus (HPV), especially types 6 and 11. The number of HPV infections increases in immunosuppressed conditions, such as human immunodeficiency virus (HIV) infection. Risk factors in CA patients such as gender, sexual partner, sexual orientation, and sexual intercourse can increase HIV status. Methods: This is a descriptive-analytic study with a cohort retrospective design. The subjects are all CA patients who visited the polyclinic STI Dr. Mohammad Hoesin, General Hospital, Palembang, Indonesia, between 2016-2020. The number of CA patients included in the study were 115 patients aged 14 to 71 years old. Chi-square and multivariate logistic regression were used to analyze the independent variables. Results: The total number of HIV-positive CA patients was 31 (26.8%) out of 115. There were more males than females, and the mean age was 29±9.90, with a range of 14-71 years old. The most common location was the genital (58.3%). Gender, marital status, number of partners, sexual orientation, sexual intercourse, location, and type of lesions had p Conclusion: Risk factors for HIV in CA patients are age, marital status, sexual partner, sexual orientation, and location of lesions. CA patients who were MSM had a 22-fold higher risk for HIV-positive status.
KEBERHASILAN TERAPI PEMFIGUS VULGARIS DENGAN STEROID-SPARING AGENT MIKOFENOLAT SODIUM DAN AUTOHEMOTERAPI Aldona, Wenty Septa; Nopriyati; Nugroho, Suroso Adi; Budiamal, Susanti
Media Dermato-Venereologica Indonesiana Vol 52 No 1 (2025): Media Dermato Venereologica Indonesiana
Publisher : Perhimpunan Dokter Spesialis Kulit dan Kelamin Indonesia (PERDOSKI)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33820/mdvi.v52i1.518

Abstract

Pendahuluan: Pemfigus vulgaris (PV) merupakan penyakit autoimun ditandai vesikel dan bula pada kulit dan mukosa akibat reaksi autoantibodi terhadap desmoglein (Dsg) 1 dan 3. Terapi lini pertama kortikosteroid (KS) sistemik. Terapi KS memiliki banyak efek samping sehingga diperlukan sparing agent. Pada kasus ini menggunakan sparing agent mikofenolat sodium (MPS) dan autohemoterapi (AHT). Laporan ini bertujuan mengetahui efektivitas MPS dan AHT sebagai sparing agent pada PV. Kasus: Perempuan, 37 tahun dengan lepuh kendur mudah pecah menjadi lecet disertai keropeng coklat-kehitaman pada wajah, leher, badan, kedua lengan dan tungkai. Pemeriksaan histopatologik ditemukan row of tombstones suprabasal, dan direct immunofluorescence (DIF) ditemukan chicken wire pattern interselular. Pasien didiagnosis PV dan diterapi KS sistemik dengan sparing agent MPS dan AHT. Kami melaporkan kasus jarang PV pada usia 37 tahun. Diskusi: Penggunaan sparing agent untuk mengurangi efek samping, mempercepat tapering off, perbaikan klinis dan remisi. Mikofenolat sodium digunakan karena efek samping minimal dan memberikan hasil baik. Autohemoterapi sebagai imunoterapi dengan menyuntikkan darah pasien kembali pada pasien, dapat digunakan pada penyakit vesikobulosa autoimun karena dapat menurunkan kadar autoantibodi. Kesimpulan: Kombinasi KS sistemik, MPS dan AHT memberikan hasil yang memuaskan. Pasien mengalami remisi awal pada pekan ke-2 dan remisi komplet dalam 5 bulan. 
Co-Authors Adi Agung Anantawijaya D Aldona, Wenty Septa Antonius, Cayadi Sidarta Damai Trilisnawati Damai Trilisnawati Fitriani Fitriani Fitriani . Fitriani Fitriani Inda Astri Aryani Inda Astri Aryani Indah Astri Aryani Izazi Hari Purwoko Karim, Putri Laksmi Kiki Septiafni M. Izazi Hari Purwoko Muhammad Irsan Saleh Mutia Devi Mutia Devi Mutia Devi Mutia Devi Mutia Devi Mutia Devi Nofilia Citra Candra Nopriyati Nopriyati Purwoko, Izazi Hari Putri Laksmi Karim Raden Pamudji Rusmawardiana Rusmawardiana, Rusmawardiana Sarah Diba Soenarto Kartowigno Susanti Budiamal Toruan, Theresia Widyastuti Yuli Kurniawati Yulia Farida Yahya