Garuda - Garba Rujukan Digital

Pemphigus Vulgaris Combination Adjuvant Therapy of Systemic Corticosteroid with Sparing Agent Sodium Mycophenolate Nopriyati; Cayadi Sidarta Antonius; Susanti Budiamal; Inda Astri Aryani
Archives of The Medicine and Case Reports Vol. 1 No. 1 (2020): Archives of The Medicine and Case Reports
Publisher : HM Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37275/amcr.v1i1.1

Pemphigus Vulgaris(PV) is an autoimmune disease characterized by vesicles and bullae on the skin and mucosa resulting from an autoantibody reaction to desmosomal adhesion molecules desmoglein (Dsg) 1 and 3, which function as strong adhesions between keratinocytes. Pemphigus Vulgarisis more common in the fifth and sixth decades of age. The lesions are fragile blisters on the mucosa and skin. Diagnosing PV requires anamnesis, physical examination,and investigations such as histopathologic examination and direct immunofluorescence. Therapy generally uses steroids. Adjuvant treatmentis given to reduce the side effects of corticosteroids. We reported a male, 59 years old, was treated with blisters that break easily into blisters on the head, face, chest, back, groin and buttocks accompanied by burning and itching. In the scalp, facial, anterior et posteriortrunk, inguinal,and gluteal regions, multiple erythematous maculeswere found with lenticular-plaqueshape; it waspartially confluentwith thick brown crustswhich werechallengingto remove. The histopathologicexamination found the presence of suprabasal bullae with lymphocyte inflammation cells. The patient was diagnosed with PV and treated with corticosteroids with the sparing agent mycophenolate sodium andshowed clinical improvement. The first-linetreatment for pemphigus Vulgarisis systemic corticosteroids. Adjuvant sparing agent therapy is given to reduce the side effects of corticosteroids. Sodium mycophenolate sparing agent was selected because ofitsminimum side effects. In systemic management, the dose of corticosteroid and sparing agent mycophenolate sodium was gradually decreased. The patient experienced initial remission after treatment

Diagnosis, Treatment, and Prognosis of Syphilis in HIV Patient Mutia Devi; Izazi Hari Purwoko; Suroso Adi Nugroho; Inda Astri Aryani; Susanti Budiamal; Putri Laksmi Karim
Bioscientia Medicina : Journal of Biomedicine and Translational Research Vol. 5 No. 11 (2021): Bioscientia Medicina: Journal of Biomedicine & Translational Research
Publisher : HM Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32539/bsm.v5i11.416

Syphilis is a sexually transmitted infection caused by the bacterium Treponema pallidum (T. Palladium). Human Immunodeficiency Virus (HIV) is a virus that attacks the body's immune system, decreased the number of CD4 cells that makes the immune system decrease, and facilitates syphilis infection. Syphilis increased the risk of spreading HIV infection with skin barrier destruction. The diagnosis of syphilis is made based on a complete history, including sexual history, clinical manifestations, and examination. The treatment of syphilis with HIV and without HIV similar, penicillin is still the gold standard for syphilis treatment with HIV. Prevention of syphilis with HIV are educated, screening for syphilis and other sexually transmitted infections, as well as early detection and therapy of partners. The prognosis for syphilis in HIV is worse than for syphilis without HIV.

Latent Syphilis Unresponsive to Doxycycline and Azithromycin Cayadi Sidarta Antonius; Mutia Devi; M. Izazi Hari Purwoko; Suroso Adi Nugroho; Fitriani; Susanti Budiamal
Bioscientia Medicina : Journal of Biomedicine and Translational Research Vol. 6 No. 5 (2022): Bioscientia Medicina: Journal of Biomedicine & Translational Research
Publisher : HM Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37275/bsm.v6i5.503

Background. Syphilis management is based on the syphilis stage classification. The main treatment for syphilis is currently benzathine penicillin. However, patients allergic to penicillin antibiotics or who are not willing to be injected can be given doxycycline or erythromycin antibiotics. Case presentation. We present a case of a female with latent syphilis. Patient was previously treated with oral antibiotics, such as doxycycline for 30 days and followed by azithromycin for 30 consecutive days. Clinical laboratory examinations show increase of TPHA and VDRL, and the case was considered as unresponsive case. Later, the patients received benzathine penicillin G for three weeks and showed clinical improvement. Conclusion. For patient who refuse to be treated with penicillin injection, the alternative treatments are oral antibiotics. However, there is a reduced number of successful treatments for patients treated with oral antibiotics.

Profile of Non-Melanoma Skin Cancer and Malignant Melanoma at Dr. Mohammad Hoesin General Hospital Palembang from 2017 - 2019: A Retrospective Study Yulia Farida Yahya; Odelia Jovita Jusuf Fantoni; Susanti Budiamal; Theresia L. Toruan
Bioscientia Medicina : Journal of Biomedicine and Translational Research Vol. 6 No. 6 (2022): Bioscientia Medicina: Journal of Biomedicine & Translational Research
Publisher : HM Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37275/bsm.v6i6.531

Background: Currently, there is an increasing trend in skin cancer incidence, especially non-melanoma skin cancer (NMSC), including basal cell carcinoma (BCC) and squamous cell carcinoma (SCC), also malignant melanoma (MM), causing an increase in morbidity and mortality rates. The high treatment cost causes an economic burden of disease in the country and negatively impacts public health issues. This study aimed to determine the profile of NMSC and MM regarding the sex, age, occupation, location of the lesion, clinicohistopathological diagnosis of skin cancer in Dr. Mohammad Hoesin General Hospital Palembang January 2017-December 2019. Methods: A retrospective analytical observational study obtained from medical records of NMSC and MM patients in Dr. Mohammad Hoesin General Hospital Palembang from January 2017-December 2019 as confirmed using histopathological results from the Pathology Department. Results: There were 324 new cases of NMSC and MM, including BCC 162 cases (50%) and SCC 130 cases (40.1%), whereas MM 32 cases (9.9%). Women had a higher probability of developing skin cancer with a ratio of 1.13:1. The average age of skin cancer was between 55-64 years old (33.6%), with a mean age of 57 years old. There was a statistically significant relationship between gender, age, occupation, and areas of skin cancer against skin cancer. Furthermore, overexposure to ultraviolet (UV) radiation is related to high-risk occupations, including farmers (50%), while the most frequent location of skin cancer was the face (67.3%). Conclusion: Our study implicated a 1.5-fold increase in new cases of skin cancer between 2017 to 2019. BCC cases were more prevalent than SCC and MM cases. There was also a significant association between skin cancer and occupation also the location of skin cancer as the risk factor for UV exposure. Nevertheless, further research involving larger samples or a multicenter approach is needed.

Diagnosis, Treatment, and Prognosis of Syphilis in HIV Patient Mutia Devi; Izazi Hari Purwoko; Suroso Adi Nugroho; Inda Astri Aryani; Susanti Budiamal; Putri Laksmi Karim
Bioscientia Medicina : Journal of Biomedicine and Translational Research Vol. 5 No. 11 (2021): Bioscientia Medicina: Journal of Biomedicine & Translational Research
Publisher : HM Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32539/bsm.v5i11.416

Syphilis is a sexually transmitted infection caused by the bacterium Treponema pallidum (T. Palladium). Human Immunodeficiency Virus (HIV) is a virus that attacks the body's immune system, decreased the number of CD4 cells that makes the immune system decrease, and facilitates syphilis infection. Syphilis increased the risk of spreading HIV infection with skin barrier destruction. The diagnosis of syphilis is made based on a complete history, including sexual history, clinical manifestations, and examination. The treatment of syphilis with HIV and without HIV similar, penicillin is still the gold standard for syphilis treatment with HIV. Prevention of syphilis with HIV are educated, screening for syphilis and other sexually transmitted infections, as well as early detection and therapy of partners. The prognosis for syphilis in HIV is worse than for syphilis without HIV.

Latent Syphilis Unresponsive to Doxycycline and Azithromycin Cayadi Sidarta Antonius; Mutia Devi; M. Izazi Hari Purwoko; Suroso Adi Nugroho; Fitriani; Susanti Budiamal
Bioscientia Medicina : Journal of Biomedicine and Translational Research Vol. 6 No. 5 (2022): Bioscientia Medicina: Journal of Biomedicine & Translational Research
Publisher : HM Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37275/bsm.v6i5.503

Background. Syphilis management is based on the syphilis stage classification. The main treatment for syphilis is currently benzathine penicillin. However, patients allergic to penicillin antibiotics or who are not willing to be injected can be given doxycycline or erythromycin antibiotics. Case presentation. We present a case of a female with latent syphilis. Patient was previously treated with oral antibiotics, such as doxycycline for 30 days and followed by azithromycin for 30 consecutive days. Clinical laboratory examinations show increase of TPHA and VDRL, and the case was considered as unresponsive case. Later, the patients received benzathine penicillin G for three weeks and showed clinical improvement. Conclusion. For patient who refuse to be treated with penicillin injection, the alternative treatments are oral antibiotics. However, there is a reduced number of successful treatments for patients treated with oral antibiotics.

Profile of Non-Melanoma Skin Cancer and Malignant Melanoma at Dr. Mohammad Hoesin General Hospital Palembang from 2017 - 2019: A Retrospective Study Yulia Farida Yahya; Odelia Jovita Jusuf Fantoni; Susanti Budiamal; Theresia L. Toruan
Bioscientia Medicina : Journal of Biomedicine and Translational Research Vol. 6 No. 6 (2022): Bioscientia Medicina: Journal of Biomedicine & Translational Research
Publisher : HM Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37275/bsm.v6i6.531

Background: Currently, there is an increasing trend in skin cancer incidence, especially non-melanoma skin cancer (NMSC), including basal cell carcinoma (BCC) and squamous cell carcinoma (SCC), also malignant melanoma (MM), causing an increase in morbidity and mortality rates. The high treatment cost causes an economic burden of disease in the country and negatively impacts public health issues. This study aimed to determine the profile of NMSC and MM regarding the sex, age, occupation, location of the lesion, clinicohistopathological diagnosis of skin cancer in Dr. Mohammad Hoesin General Hospital Palembang January 2017-December 2019. Methods: A retrospective analytical observational study obtained from medical records of NMSC and MM patients in Dr. Mohammad Hoesin General Hospital Palembang from January 2017-December 2019 as confirmed using histopathological results from the Pathology Department. Results: There were 324 new cases of NMSC and MM, including BCC 162 cases (50%) and SCC 130 cases (40.1%), whereas MM 32 cases (9.9%). Women had a higher probability of developing skin cancer with a ratio of 1.13:1. The average age of skin cancer was between 55-64 years old (33.6%), with a mean age of 57 years old. There was a statistically significant relationship between gender, age, occupation, and areas of skin cancer against skin cancer. Furthermore, overexposure to ultraviolet (UV) radiation is related to high-risk occupations, including farmers (50%), while the most frequent location of skin cancer was the face (67.3%). Conclusion: Our study implicated a 1.5-fold increase in new cases of skin cancer between 2017 to 2019. BCC cases were more prevalent than SCC and MM cases. There was also a significant association between skin cancer and occupation also the location of skin cancer as the risk factor for UV exposure. Nevertheless, further research involving larger samples or a multicenter approach is needed.

EFFECT OF SUN, VITAMIN D AND SKIN CANCER Yulia Farida Yahya; Theresia L. Toruan; Yuli Kurniawati; Fifa Argentina; Susanti Budiamal; Aryati Fadhila; Nyimas Nursyarifah; Dedi Deddy; Ahmad Ligar Suherman
Conferences of Medical Sciences Dies Natalis Vol. 3 No. 1 (2021): Conference of Medical Sciences Dies Natalis Faculty of Medicine Universitas Sri
Publisher : Fakultas Kedokteran Universitas Sriwijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (225.543 KB)

Indonesia, especially in South Sumatra, is a tropical country where people are exposed to sunlight all the time. The sunlight exposure is both chronic and intermittent, which can cause both beneficial and detrimental effects. One of the examples of the detrimental effects are the increased incidence of skin cancer. Meanwhile, the beneficial effect is the formation of vitamin D in the body that stimulates bone formation, increases body resistance, and prevents skin cancer. At this time, there is an increase in the incidence of skin cancer, and many Indonesian people are deficient in Vitamin D. Currently, the people need to get an explanation through health workers at the TkI Health Facilities and Rivai Abdulah Hospital. It is necessary to increase knowledge about sunlight, the benefits of Vitamin D for health, and its effects on the incidence of skin cancer in health workers.

DIAGNOSIS DAN TATA LAKSANA NEVUS HORI Sarah Diba; Cayadi Sidarta Antonius; Yuli Kurniawati; Soenarto Kartowigno; Susanti Budiamal
Media Dermato-Venereologica Indonesiana Vol 49 No 4 (2022)
Publisher : Perhimpunan Dokter Spesialis Kulit dan Kelamin Indonesia (PERDOSKI)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33820/mdvi.v49i4.284

Nevus Hori (NH) merupakan hipermelanosis dermal didapat yang ditandai bercak coklat keabuan. NH bermanifestasi terutama di daerah fasial seperti zigomatikum, dahi, pelipis, kelopak mata dan pangkal hidung, tetapi dapat juga di ekstra fasial. NH memengaruhi kualitas hidup penderitanya karena dapat menganggu penampilan. Awitan NH bervariasi, dapat terjadi antara usia 12-72 tahun. Genetik memegang peran penting dalam patofisiologi NH. Beberapa faktor pencetus yang telah diidentifikasi terkait NH antara lain, inflamasi, radiasi ultraviolet, kehamilan, kontrasepsi, dan kosmetik. Manifestasi klinis NH sering menyerupai kelainan hiperpigmentasi dermal lain seperti melasma, nevus Ota, dan melanosis Riehl, sehingga masih sering terjadi kesalalahan diagnosis. Penegakan diagnosis dilakukan dengan mempertimbangkan manifestasi klinis pasien. Pemeriksaan penunjang tidak rutin dilakukan pada kasus NH. Bila diperlukan, pemeriksaan baku emas berupa pemeriksaan histopatologi dapat dilakukan. Tata laksana NH memiliki tantangan tersendiri. Tata laksana NH yang utama adalah menghindari tersediri. Tata laksana defenitif untuk kasus MH dilakukan dengan terapi kombinasi, baik terapi farmakologis dan non-farmakologis. Pilihan terapi yang dapat digunakan adalah terapi topikal, dan tindakan invasif seperti dermabrasi, krioterapi dan laser.

THE CORRELATION BETWEEN ADHERENCE TO ANTIRETROVIRAL (ARV) MEDICATION AND CD4 COUNT IN THE OCCURRENCE OF VIROLOGICAL FAILURE AMONG INDIVIDUALS WITH HIV/AIDS Purwoko, Muhammad Izazi Hari; Santoso, Ritchie; Fitriani, Fitriani; Bahar, Erial; Chandra, Riza; Diba, Sarah; Budiamal, Susanti
PREPOTIF : JURNAL KESEHATAN MASYARAKAT Vol. 8 No. 3 (2024): DESEMBER 2024
Publisher : Universitas Pahlawan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31004/prepotif.v8i3.36873

Kegagalan virologi merupakan tantangan yang dihadapi oleh pasien human immunodeficiency virus (HIV) setelah memulai pengobatan, dan dipengaruhi oleh berbagai faktor. Modalitas terapi pada pasien HIV dilakukan dengan antiretroviral (ARV), dengan jumlah sel CD4 memainkan peran penting dalam menentukan waktu untuk memulai ARV. Oleh karena itu, tujuan dari penelitian ini adalah untuk menyelidiki hubungan antara kepatuhan terhadap ARV dan jumlah sel CD4 yang terkait dengan kegagalan virologi pada pasien HIV/AIDS yang telah diobati selama minimal 12 bulan dengan rejimen ARV. Penelitian analitik observasional dengan desain potong lintang dilakukan menggunakan teknik consecutive sampling pada 74 pasien berusia 17 tahun dan menjalani pengobatan ARV selama minimal 12 bulan di Departemen Rawat Jalan Konseling dan Pengujian Sukarela (VCT) dan Penyakit Menular Seksual (STD) Dermatologi, Venereologi, dan Estetika RSMH/FK UNSRI Palembang, serta Pusat Kesehatan Masyarakat Sukarami dan Dempo dari Juni hingga Agustus 2023. Dari total sampel penelitian sebanyak 74 pasien, 26 di antaranya (35,1%) mengalami kegagalan virologi. Kepatuhan terhadap antiretroviral (ARV) (p<0,001) dan jumlah sel CD4 (p<0,001) secara signifikan terkait dengan kegagalan virologi. Analisis multivariat menunjukkan bahwa kepatuhan terhadap ARV (p<0,001) dan jumlah sel CD4 (p<0,001) sangat terkait dengan kegagalan virologi. Penelitian ini menunjukkan bahwa kepatuhan terhadap ARV yang buruk dan jumlah sel CD4 yang rendah terkait dengan kegagalan virologi. Penguatan konseling kepatuhan ARV diperlukan untuk memperbaiki kondisi imunologis dan meningkatkan penekanan virus pada pasien HIV/AIDS.

Title

Found 11 Documents
Search

Abstract

Abstract

Abstract

Abstract

Abstract

Abstract

Abstract

Abstract

Abstract

Abstract

Title Search

Found 11 Documents Search

Abstract

Abstract

Abstract

Abstract

Abstract

Abstract

Abstract

Abstract

Abstract

Abstract

Title

Found 11 Documents
Search