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All Journal Science and Community Pharmacy Journal
Sa'adah, Anifatus
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Health Professions Medicine & Pharmacology

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Isolation Of Moringa Leaf Flavonoids (Moringa Oleifera L.) Using Column Chromatography Sa'adah, Anifatus; Ovikariani
Science and Community Pharmacy Journal Vol. 2 No. 1 (2023): Science and Community Pharmacy
Publisher : STIKES Telogorejo Semarang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.63520/scpj.v2i1.357

Abstract

Preface : Moringa oleifera L. is one plant that contains secondary metabolite compounds such as alkaloids, steroids, tannins, saponins, anthraquinones, terpenoids, and flavonoids. Flavonoids donate their hydroxyl groups to inhibit free radicals. Purpose :This study aimed to isolate flavonoid compounds from Moringa leaf ethanol extract. Method : Extraction was carried out by maceration method and continued isolation using Column Chromatography method with n-butanol: acetic acid: water (4: 1: 5) eluent. Isolate results were identified by TLC, spectro, and FTIR. Result : FTIR analysis on fraction 5 contains flavonoid derivative compounds. Conclusion : It is flavonols with a purity of quercetin of 77.99%.
Validation Of Analysis Method For Determining Content Of Chlorpheniramine Malate (Ctm) In Tablet Preparation By Uv Spectrophotometry Sa'adah, Anifatus
Science and Community Pharmacy Journal Vol. 2 No. 2 (2023): Science and Community Pharmacy
Publisher : STIKES Telogorejo Semarang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.63520/scpj.v2i2.483

Abstract

Abstract: In the pharmaceutical industry, quality control of a medicine is one part of Good Medicine Manufacturing Practices (CPOB) which is used to ensure that the product has quality that is appropriate for its intended use, so that the production results marketed meet the CPOB requirements. Therefore, this study aims to determine the levels of the active substance chlorpheniramine maleate (CTM) in drug samples and compare them with standards using UV spectrophotometry. The research results showed that the maximum CTM wavelength measurement obtained was 263 nm. The linear equation y = 0.01904x + 0.03139 with a correlation coefficient (R) value of 0.995. The SD obtained by sample A was 0.4483 and the % relative standard deviation (%RSD) value was 14.6%, sample B was 0.2020 and the % relative standard deviation (%RSD) value was 6.4%, sample C was 0.0542 and the % relative standard deviation (%RSD) value is 1.3%. The LOQ values obtained on samples A, B and C are not accepted as quantitation limits because they do not meet precision (CV < 20%) and accuracy (bias < ±20%). The average % recovery results obtained for samples A, B, and C were 100%. The range of CTM levels obtained was 159.307%, 145.025%, and 126.195%. Keywords: UV Spectrophotometry, Chlorpheniramine maleat, Validation of analytical methods
An Irritation Test of Optimum Preparation of Celery Extract Face Clay Cleanser With Sodium Lauryl Sulfate (SLS) and Cocamidopropyl Betaine (CAPB) as Surfactants: Irritation Test of Optimum Preparation of Celery Extract Face Clay Cleanser With Sodium Lauryl Sulfate (SLS) and Cocamidopropyl Betaine (CAPB) as Surfactants Bunga Eloystina, Laurencia Julia; Aldila, Silvy; Girsang, Valentina; Sa'adah, Anifatus
Science and Community Pharmacy Journal Vol. 3 No. 2 (2024): Science and Community Pharmacy
Publisher : STIKES Telogorejo Semarang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.63520/scpj.v3i2.580

Abstract

Surfactant is one of the important things in making face clay cleanser preparations. Sodium Lauryl Sulfate (SLS) is an anionic type surfactant that is often used in cosmetic products. The use of Sodium Lauryl Sulfate (SLS) can cause irritation and dry skin. Combination with cocamidopropyl betaine (CAPB) which is amophoteric can reduce skin irritation. Based on this, a safety test is needed which aims to meet the preparation requirements before being marketed to the wider community. One of the safety tests that can be done is the skin irritation test. The test method used is the human patch test. The irritation test of the optimum preparation of face clay cleanser celery herb extract (Apium graviolens L.) with a concentration of 0.5% SLS and 9.5% CAPB was carried out on 6 volunteers consisting of men and women aged 20-35 years, the score of the degree of irritation was 0, which means that the preparation is not irritating. Based on the evaluation with SPSS, it can be concluded that there is no significant difference (p>0.05) for the irritation test results and the optimum preparation of celery herb extract face clay cleanser (Apium graviolens L.) meets the safety requirements.
Co-Authors Aldila, Silvy Bunga Eloystina, Laurencia Julia Girsang, Valentina Ovikariani