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All Journal Jurnal Farmasi dan Sains Indonesia (JFSI) Journal of Pharmaceutical and Sciences. Scientica: Jurnal Ilmiah Sains dan Teknologi Science and Community Pharmacy Journal
Girsang, Valentina
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Religion Agriculture, Biological Sciences & Forestry Humanities Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Civil Engineering, Building, Construction & Architecture Computer Science & IT Decision Sciences, Operations Research & Management Economics, Econometrics & Finance Health Professions Immunology & microbiology Materials Science & Nanotechnology Medicine & Pharmacology Neuroscience Nursing Public Health Social Sciences Other

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ANALISIS EFEK KONSENTRASI EKSTRAK DAUN SIRIH CINA (Peperomia Pellucida L.) SEBAGAI ANTIBAKTERI Staphylococcus Aureus dan Propionibacterium acnes Girsang, Valentina; Widiasari , Anggun; Rustaman , Heri; Saptawati , Tunik; Puspitaningrum , Anisa Nova; Vidiani , Anak Agung Pradnya Paramitha
Scientica: Jurnal Ilmiah Sains dan Teknologi Vol. 2 No. 11 (2024): Scientica: Jurnal Ilmiah Sains dan Teknologi
Publisher : Komunitas Menulis dan Meneliti (Kolibi)

Show Abstract | Download Original | Original Source | Check in Google Scholar

Abstract

Acne vulgaris merupakan infeksi kulit yang umum terjadi, dengan tingkat kejadian berkisar sekitar 80-100%. Kondisi kulit ini dapat dikaitkan dengan proliferasi bakteri Staphylococcus aureus dan Propionibacterium acnes. Daun sirih cina (Peperomia pellucida L.) telah menunjukkan efek penghambatan pada pertumbuhan bakteri, khususnya terhadap Staphylococcus aureus dan Propionibacterium acnes. Tujuan dari penelitian ini adalah untuk menilai aktivitas antibakteri ekstrak daun sirih cina terhadap bakteri ini. Aktivitas antibakteri dievaluasi menggunakan metode difusi agar dengan cakram kertas. Analisis fitokimia mengungkapkan adanya flavonoid, tanin, dan saponin dalam daun sirih cina. Uji antibakteri ekstrak menunjukkan penghambatan bakteri yang signifikan. Zona penghambatan rata-rata ekstrak daun sirih cina terhadap Propionibacterium acnes adalah 8,74 mm pada konsentrasi 5%, 10,936 mm pada konsentrasi 10%, dan 15,67 mm pada konsentrasi 15%. Demikian pula, zona penghambatan terhadap Staphylococcus aureus adalah 8,341 mm pada konsentrasi 5%, 11,065 mm pada konsentrasi 10%, dan 14,293 mm pada konsentrasi 15%.
Pengaruh Variasi Konsentrasi Bahan Pengikat Terhadap Formulasi dan Stabilitas Fisik Tablet Detergen Effervescent Ekstrak Daun Serai Dapur (Cymbopogon citratus) Girsang, Valentina; Kusuma Dewi, Liestyani; Rustaman, Heri; Sa’adah, Anifatus; Wibowo, Anisa Devi Kharisma
Jurnal Farmasi & Sains Indonesia Vol 7 No 2 (2024)
Publisher : LPPM Sekolah Tinggi Ilmu Farmasi Nusaputera

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52216/jfsi.vol7no2p10-19

Abstract

Lemongrass leaves (Cymbopogon citratus) contain saponins that can form foam in water so that they are used as natural compounds that produce foam used in industry. The purpose of this study was to provide the effect of variations in PVP concentrations of 2%, 3% and 4% on the physical characteristics, physical stability and detergenation ability of effervescent detergent tablets of lemongrass leaf extract (Cymbopogon citratus). This study used the maceration extraction method with 96% ethanol and the manufacture of effervescent tablets by the wet granulation method. The results of the characterization and stability study of effervescent tablets of lemongrass leaf extract with variations in PVP concentration showed that the tablets met the requirements for characterization testing of effervescent tablets before and after stability. Based on the results of the foam height test on effervescent tablets before and after stability did not affect the high foam with the results of F1, F2, F3 after stability of 86.56 ± 0.34; 86.56 ± 0.34; 88.20 ± 2.28. This study shows that PVP affects the characteristics and stability of tablets but does not affect the detergent ability of effervescent detergent tablets.
Formulasi Krim Fraksi Ekstrak Daun Kemangi (Ocimum sanctum L) Sebagai Antibakteri Terhadap Staphylococcus aureus dan Escherichia coli Saptawati, Tunik; Nurwidianingsih, Silvia; Girsang, Valentina; Aldila, Silvy
Jurnal Farmasi & Sains Indonesia Vol 7 No 2 (2024)
Publisher : LPPM Sekolah Tinggi Ilmu Farmasi Nusaputera

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52216/jfsi.vol7no2p112-120

Abstract

Dermatosis vesiculobullosa is a public health issue that frequently affects Indonesian society and even the world. Current treatment often involves topical application of a cream to the infected area, utilizing chemical substances and traditional medicine. One of the plants that has antibacterial properties is basil. This study determined the excellence of hexane fraction cream made from basil leaves to kill Staphylococcus aureus and Escherichia coli bacteria. This experimental study used the maceration method with 96% ethanol is used for extraction, while the liquid-liquid extraction method for fractionation. The well diffusion method examined the antibacterial activity. The concentration of the n-hexane fractions is 15%, 30%, and 45%. The physical characteristic tests of the cream include organoleptic, homogeneity, pH, spreadability, adhesion, and viscosity. The researcher conducted a one-way Anova statistical analysis using the post hoc Duncan test. Basil leaf cream with n-hexane fractions at 15%, 30%, and 45% concentrations has an antibacterial activity of 20.09 mm (very strong), 21.47 mm (very strong), and 22.43 mm (very strong) against Staphylococcus aureus. It has an antibacterial activity of 20.10 mm (very strong), 22.83 mm (very strong), and 23.76 mm. The cream formulations with 30% and 45% n-hexane fraction effective at stopping the growth of Staphylococcus aureus and Escherichia coli, with a significance value of 0.000 (p<0.05).
Stability Testing Occurred On Piroxicam Cream Preparation By Using Stearic Acid And Triethanolamine As Emulsifying Agents Aldila, Silvy; Girsang, Valentina; Rahmawati, Ina Sonia; Maharai, Daniel; Sa’adah, Anifatus
Science and Community Pharmacy Journal Vol. 2 No. 2 (2023): Science and Community Pharmacy
Publisher : STIKES Telogorejo Semarang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.63520/scpj.v2i2.482

Abstract

Preface: Piroxicam is classified as a Class 2 product in the Biopharmaceutic Classification System due to its limited solubility in water. The cream preparations underwent optimisation of the stearic acid and triethanolamine concentrations. The optimisation results indicate that the most favourable amounts of stearic acid and triethanolamine (TEA) are 16% and 4% respectively. The physical attributes test yielded positive findings for the formula, indicating a successful cream formulation that satisfied the specified criteria. Purpose: The cream formulation is thereafter submitted to a stability assessment. The purpose of the stability test is to ascertain the long-lasting quality of the preparation when subjected to various storage circumstances. Procedure: Stability tests were conducted over 6 cycles at temperatures of 4° C and 40° C. During the testing phase, various characteristics of the cream preparation were assessed, including organoleptic properties, homogeneity, viscosity, adhesive power, spreadability, and pH. Result: The formulated solution successfully fulfils the criteria of the physical characteristics test, with the following parameter values: pH of 6.8, viscosity of 11010 Cps, spreading power of 6.8 cm, adhesive power of 2.6 seconds, and protective power of 6.5 seconds. Conclusion: The t-test findings conducted before and after assessing the stability of the preparation indicated a p-value greater than 0.05, indicating the absence of a significant difference.
LITERATURE REVIEW : Cost Effective Analysis of Sitagliptin for the Treatment of Diabetes Mellitus Type 2 Vidiani, Anak Agung Pradnya Paramitha; Puspitaningrum, Anisa Nova; Girsang, Valentina; Adrianto, Madyo
Science and Community Pharmacy Journal Vol. 3 No. 1 (2024): Science and Community Pharmacy
Publisher : STIKES Telogorejo Semarang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.63520/scpj.v3i1.546

Abstract

Diabetes mellitus (DM) is a chronic disease characterized by increased glucose levels in the blood. The prevalence of type 2 DM is currently increasing. In pharmacological treatment, metformin is the first-line oral therapy for most patients with type 2 diabetes. Therapy with targeted incretin has been shown to stimulate glucose-dependent insulin secretion, reduce glucagon secretion, improve beta cell function, slow gastric emptying, increase satiety, reduce appetite, and provide general benefits beyond the pancreas. Search for scientific articles by utilizing internet searches through Google Scholar and PubMed. Using keywords related to "Cost Effective Analysis", "Diabetes Mellitus type 2", "Sitagliptine" with Boolean operator "AND". Sitagliptin is less cost-effective when compared to liraglutide. Sitagliptin is the first agent of the DPP-4 inhibitor with other substances following soon after. The evaluation shows that the prevention of complications in patients with type 2 diabetes and cardiovascular disease (CVD) in the SGLT2 inhibitor group is more recommended, namely empaglifozin as the second line compared to sitagliptin.
An Irritation Test of Optimum Preparation of Celery Extract Face Clay Cleanser With Sodium Lauryl Sulfate (SLS) and Cocamidopropyl Betaine (CAPB) as Surfactants: Irritation Test of Optimum Preparation of Celery Extract Face Clay Cleanser With Sodium Lauryl Sulfate (SLS) and Cocamidopropyl Betaine (CAPB) as Surfactants Bunga Eloystina, Laurencia Julia; Aldila, Silvy; Girsang, Valentina; Sa'adah, Anifatus
Science and Community Pharmacy Journal Vol. 3 No. 2 (2024): Science and Community Pharmacy
Publisher : STIKES Telogorejo Semarang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.63520/scpj.v3i2.580

Abstract

Surfactant is one of the important things in making face clay cleanser preparations. Sodium Lauryl Sulfate (SLS) is an anionic type surfactant that is often used in cosmetic products. The use of Sodium Lauryl Sulfate (SLS) can cause irritation and dry skin. Combination with cocamidopropyl betaine (CAPB) which is amophoteric can reduce skin irritation. Based on this, a safety test is needed which aims to meet the preparation requirements before being marketed to the wider community. One of the safety tests that can be done is the skin irritation test. The test method used is the human patch test. The irritation test of the optimum preparation of face clay cleanser celery herb extract (Apium graviolens L.) with a concentration of 0.5% SLS and 9.5% CAPB was carried out on 6 volunteers consisting of men and women aged 20-35 years, the score of the degree of irritation was 0, which means that the preparation is not irritating. Based on the evaluation with SPSS, it can be concluded that there is no significant difference (p>0.05) for the irritation test results and the optimum preparation of celery herb extract face clay cleanser (Apium graviolens L.) meets the safety requirements.
A Literature Review: Effectiveness of NSAIDs in Osteoarthritis Patients Adrianto, Madyo; Anak Agung Pradnya Paramitha Vidiani; Puspitaningrum, Anisa Nova; Girsang, Valentina
Science and Community Pharmacy Journal Vol. 3 No. 2 (2024): Science and Community Pharmacy
Publisher : STIKES Telogorejo Semarang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.63520/scpj.v3i2.582

Abstract

Pain, stiffness, swelling, and decreased joint function are some of the clinical signs of osteoarthritis, a disease that affects numerous anatomical and physiological aspects of joint tissue, cartilage degradation, bone remodeling, and osteophyte development. This literature review's objective is to ascertain the efficacy of NSAIDs in osteoarthritis by searching for journals from PubMed.. The method used was to search for articles through pubmed using the keywords "NSAID", "osteoarthritis", "Therapy" with a filter added for the last 5 years (2019-2024) obtained 103 articles. Then with the keywords "NSAID", "osteoarthritis", "therapy", "efficacy" obtained 71 articles. After analysis, there are 13 journals that can be include into inclusion requirement. NSAIDs preparations are particularly helpful for osteoarthritis therapy, both in knee and hip osteoarthritis. NSAIDs medications in a variety of dose forms, including oral, topical, spray, injection and plaster, are useful in relieving pain in osteoarthritis patients
Efektivitas Antibakteri Ekstrak Daun Glodokan Tiang (Polyalthia longifolia) Terhadap Cutibacterium acnes dan Staphylococcus epidermidis Girsang, Valentina; Nufus , Nunky; Saptawati , Tunik; Sa’adah , Anifatus; Wibowo, Anisa Devi Kharisma; Vidiani , Anak Agung Pradnya Paramitha
Journal of Pharmaceutical and Sciences JPS Volume 8 Nomor 2 (2025)
Publisher : Fakultas Farmasi Universitas Tjut Nyak Dhien

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36490/journal-jps.com.v8i2.815

Abstract

Introduction: Polyalthia longifolia, commonly known as Glodokan tiang, is a plant typically found along roadsides, serving as shade and an ornamental feature in gardens. In addition to its aesthetic function, the leaves of this plant have been found to contain compounds with effective antibacterial activity. Natural ingredients with antibacterial properties, such as Polyalthia longifolia leaf extract, can be an alternative acne treatment due to their lower side effects than chemical drugs. Research Objective: This study aims to test the antibacterial activity of Polyalthia longifolia leaf extract in inhibiting the growth of Staphylococcus epidermidis and Cutibacterium acnes, which are significant causes of acne. Research Method: Polyalthia longifolia leaves were extracted using a maceration method with 70% ethanol as the solvent. The resulting extract was then tested for antibacterial activity using the disc diffusion method at 30%, 35%, 40%, 45%, and 50%. The bacteria used in the tests were Staphylococcus epidermidis and Cutibacterium acnes. Clindamycin was used as a positive control, and sterile water was used as a negative control. The data obtained from the tests were analyzed using the Kruskal-Wallis and post-hoc Games-Howell tests. Results: The study showed that Polyalthia longifolia leaf extract at various concentrations (30%, 35%, 40%, 45%, 50%) exhibited significant antibacterial activity against both bacteria tested. At a concentration of 50%, the extract demonstrated the most potent inhibitory effect on Cutibacterium acnes and Staphylococcus epidermidis, with inhibition zones reaching 15.82 mm and 15.74 mm, respectively. Conclusion: Polyalthia longifolia leaf extract shows significant antibacterial potential against Staphylococcus epidermidis and Cutibacterium acnes. The 50% extract concentration exhibited the most potent inhibitory effect, making it a promising candidate for natural acne treatment with minimal side effects.
Co-Authors Adrianto, Madyo Aldila, Silvy Anak Agung Pradnya Paramitha Vidiani Anisa Devi Kharisma Wibowo Bunga Eloystina, Laurencia Julia Kusuma Dewi, Liestyani Maharai, Daniel Nufus , Nunky Nurwidianingsih, Silvia Puspitaningrum , Anisa Nova Puspitaningrum, Anisa Nova Rahmawati, Ina Sonia Rustaman , Heri Rustaman, Heri Sa'adah, Anifatus Sa’adah , Anifatus Sa’adah, Anifatus Tunik Saptawati Widiasari , Anggun