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All Journal JCPS (Journal of Current Pharmaceutical Sciences) Fundamental and Applied Research in Medicine and Allied Sciences Indonesia
Indri Dwi Rahasasti
Universitas An Nasher Cirebon
Medicine & Pharmacology

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Pengaruh Kombinasi Polimer HPMC dan PVP terhadap Sifat Fisik Sediaan Patch Ekstrak Pelepah Pisang Ambon (Musa paradisiaca var.sapientum L.) Yetti Hariningsih; Indri Dwi Rahasasti; Syamsul Ma’arif; Haqoiroh; Kiki Puspitasary
JCPS (Journal of Current Pharmaceutical Sciences) Vol. 9 No. 1: March 2025
Publisher : LRI - Universitas Muhammadiyah Banjarmasin

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35747/jcps.v9i1.1258

Abstract

The banana plant is one of the traditional plants often used for wound healing. In this study, the sheath of Ambon banana (Musa paradisiaca var. sapientum L.) was used as the active ingredient. The extract of Ambon banana sheath contains secondary metabolite compounds such as flavonoids, saponins, and tannins, which play a role in the wound healing process. The formulation was made in the form of a patch to enhance the effectiveness of active ingredient delivery. This study aims to determine the best patch formulation and analyze the effect of varying concentrations of HPMC and PVP on its physical properties. The patch was prepared using the solvent casting method with three polymer combinations, F1: 2% HPMC and 1% PVP, F2: 1.5% HPMC and 1.5% PVP, F3: 1% HPMC and 2% PVP. The evaluation data were analyzed experimentally and statistically using a one-way ANOVA test. The results showed that the most optimal formula was F1, as it met all the patch testing requirements with the following evaluation data (average ± standard deviation), Weight uniformity 1.1±0.083 (CV<5%), patch thickness: 0.04±0.012 mm (<1 mm),  Folding endurance: 324±6.51 (>300 folds), pH: 5.6±0.025 (range 4.6–8), Moisture absorption: 5.1%±0.182 (<10%). Based on the physical stability test, the results showed that the pH test and weight uniformity had a significance value of ρ > 0.05, indicating no significant differences in each test cycle. Meanwhile, the folding endurance stability test (>300 folds) had a significance value of ρ < 0.05, indicating a significant difference in each test cycle
Formulation and Characterization of a Dissolvable Microneedle Patch Containing Standardized Temu Mangga (Curcuma mangga) Extract for Hyperpigmentation Therapy: An In Vitro and Ex Vivo Study Zola Efa Harnis; Indri Dwi Rahasasti; Revan Busriano Putra; Nurfitria Junita
Fundamental and Applied Research in Medicine and Allied Sciences Indonesia Vol. 1 No. 1 (2025): May, 2025
Publisher : CV. Get Press Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.69855/farmasi.v1i1.388

Abstract

Hyperpigmentation is a common skin disorder associated with Hyperpigmentation is a common skin disorder associated with excessive melanin production, while conventional topical therapies often exhibit limited efficacy due to poor skin permeability. This study aimed to develop and characterize dissolvable microneedle patches containing a standardized Curcuma mangga extract as an alternative transdermal delivery system for hyperpigmentation therapy. Three formulations (F1, F2, and F3) were prepared using varying ratios of hyaluronic acid and polyvinyl alcohol. The microneedles exhibited uniform morphology, sufficient mechanical strength, and effective skin penetration, with complete dissolution occurring within 7–15 minutes. In vitro release studies demonstrated sustained release behavior. Biological evaluation using B16-F10 melanoma cells revealed significant melanin inhibition, with formulation F2 showing the highest activity. Notably, this study is the first to integrate standardized Curcuma mangga extract into a dissolvable microneedle system and to demonstrate its combined transdermal delivery performance and antimelanogenic activity through in vitro and ex vivo evaluations. These findings indicate that Curcuma mangga-loaded microneedles represent a promising and innovative approach for hyperpigmentation therapy, warranting further in vivo investigation.
Development and Validation of an Instrument to Measure Competency Gaps of Hospital Pharmacists in Facing Telemedicine Integration in Urban Areas of Indonesia Diki Aprianto A; Ratna Mildawati; Lilik Septiana; Rialita Lifiani; Indri Dwi Rahasasti
Fundamental and Applied Research in Medicine and Allied Sciences Indonesia Vol. 1 No. 2 (2025): November, 2025
Publisher : CV. Get Press Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.69855/farmasi.v1i2.435

Abstract

The rapid adoption of telemedicine has expanded hospital pharmacists’ roles, particularly in urban areas of developing countries such as Indonesia. However, evidence on pharmacists’ telemedicine-related competency gaps remains limited. This study aimed to develop and validate a hospital-specific instrument to assess such gaps. A methodological design was employed, including instrument development, expert content validation, pilot testing, and psychometric evaluation. The instrument covers six domains: digital health literacy, clinical pharmacy competence in telemedicine, communication skills, legal and ethical awareness, interprofessional collaboration, and telepharmacy service management. Validation involved 210 hospital pharmacists from urban Indonesian hospitals. Exploratory factor analysis confirmed a six-factor structure explaining 72.4% of the variance, with strong internal consistency (Cronbach’s alpha = 0.89). Unlike existing telepharmacy readiness tools, this instrument specifically captures multidimensional competency gaps relevant to hospital-based telemedicine practice. The largest gaps were observed in legal–ethical competencies and digital health literacy. This instrument can support workforce assessment and targeted competency-based training for hospital pharmacists in Indonesia.
Co-Authors Diki Aprianto A Haqoiroh Hariningsih, Yetti Kiki Puspitasary Lilik Septiana Nurfitria Junita Ratna Mildawati Wati Revan Busriano Putra Rialita Lifiani Syamsul Ma’arif Zola Efa Harnis