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All Journal JIMKI: Jurnal Ilmiah Mahasiswa Kedokteran Indonesia Journal of Clinical and Translational Medicine
Siti Zulaikha Risqiyani
Universitas Jember
Health Professions Medicine & Pharmacology Public Health

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Potensi Chimeric Antigen Receptor T Cell (CAR-T Cell) dengan Target Prostate-Specific Membrane Antigen (PSMA) Termodifikasi CRISPR/Cas9 sebagai Terapi Kanker Prostat Ali Habibi; Siti Zulaikha Risqiyani; Dwi Ari Santi Putri
JIMKI: Jurnal Ilmiah Mahasiswa Kedokteran Indonesia Vol 9 No 1 (2021): JIMKI: Jurnal Ilmiah Mahasiswa Kedokteran Indonesia Volume 9.1 Edisi Maret - Juli
Publisher : BAPIN-ISMKI (Badan Analisis Pengembangan Ilmiah Nasional - Ikatan Senat Mahasiswa Kedokteran Indonesia)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.53366/jimki.v9i1.321

Abstract

ABSTRACT Introduction : Prostate cancer is a malignancy of prostate cells which is one of the most common malignancies in men with a prevalence of 137.9 new cases per 100,000 men each year. One of the jobs that have a high risk of prostate cancer is farmers because it is caused by exposure to pesticides and other hazardous substances. Currently, Androgen Deprivation Therapy (ADT) is still a widely used therapy. However, ADT can decrease libido, impotence, hot flashes, and an increased risk of fractures. Due to several disadvantages of ADT therapy, therapeutic innovations for prostate cancer are needed. Method : PRISMA which is based on facts and random data collection by entering predetermined keywords. Of the 94 journals that have been reviewed, 64 of them are considered according to the topic of discussion and are used as references. Results and Discussion : CAR-T Cell modified CRISPR / Cas9 injected into mice proved to be efficient and effective in increasing the function of CAR-T Cell. The immunosuppressive mechanism caused by PD-1 binding with PD-L1 can be resolved using the CRISPR / Cas9-mediated anti PD-1 method so that it can maintain CAR-T Cell activation. Evidenced by the increase in CAR-T cell degranulation and tumor clearance in the in vivo test. Conclusion : Chimeric Antigen Receptor T Cell (CAR-T Cell) with a CRISPR/Cas9 modified Prostate-Specific Membrane Antigen (PSMA) target has the potential to be an effective therapeutic innovation for prostate cancer.
Effect of Pesticide Exposure on Respiratory Symptoms in Agroindustrial Farmers: A Systematic Review Siti Zulaikha Risqiyani; Dini Agustina; Jauhar Firdaus; Bagus Hermansyah
Journal of Clinical and Translational Medicine Vol. 1 No. 1 (2026): August
Publisher : PT Litera Integra Nusantara

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.67580/medixis.v1i1.85

Abstract

Pesticides are a mixture of substances used to control pests, plants, or animals. The inappropriate uses can cause serious problems for farmers. About 3 million cases of global pesticide acute poisoning, 25 million mild acute poisonings, and 300.000 deaths. The inhalation route is the main entry route for chemicals and pesticides. Exposure through inhalation associated with respiratory pathology, can cause respiratory symptoms due to the accumulation of pesticide substances in the respiratory tract. Inhaled pesticides will be stored in the human respiratory tract indicating damage and irritation of respiratory organs, which can cause serious respiratory symptoms. This review aimed to summarize the association between pesticides exposure and respiratory symptoms in agroindustrial farmers. This systematic review was reported based on criteria from Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA). A literature search was conducted with electronic databases, such as PubMed, ScienceDirect, Cochrane Library, and Portal Garuda. P-value with the confidence interval (CI) of 95% was used to determine the association between pesticides exposure and respiratory symptoms. Ten studies were included in the qualitative synthesis. The current study showed pesticides exposure increases respiratory symptoms in farmers. Farmers who use pesticides have a greater frequency of respiratory symptoms than other farmers. Organochlorine and organophosphate have a significant risk of causing respiratory problems, such as cough, phlegm, wheezing, and shortness of breath. Conclusion: This systematic review provides valuable evidence suggesting the correlation between pesticides exposure and respiratory symptoms in agroindustrial farmers.
Co-Authors Ali Habibi Bagus Hermansyah Dini Agustina Dwi Ari Santi Putri Jauhar Firdaus