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All Journal Buletin Veteriner Udayana Journal of Nutrition College e-Journal Pustaka Kesehatan Journal of Agromedicine and Medical Sciences Majalah Obat Tradisional UNEJ e-Proceeding Syifa' MEDIKA: Jurnal Kedokteran dan Kesehatan JURNAL PENDIDIKAN TAMBUSAI Medical and Health Science Journal Buletin Poltanesa Journal of Community Development Journal of Arabic Literature (Jali) Narra J AKSONA CoMPHI Journal : Community Medicine and Public Health of Indonesia Journal Jember Medical Journal (JMJ) International Journal of Health and Information System (IJHIS)
Jauhar Firdaus
Departemen Fisiologi, Fakultas Kedokteran, Universitas Jember
Agriculture, Biological Sciences & Forestry Humanities Biochemistry, Genetics & Molecular Biology Chemistry Computer Science & IT Education Environmental Science Health Professions Immunology & microbiology Library & Information Science Medicine & Pharmacology Neuroscience Nursing Public Health Social Sciences Veterinary

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The Effect of Mirabilis jalapa Leaf Ethanolic Extract against Streptococcus pyogenes Pambudi, Bagus Satrio; Suswati, Enny; Firdaus, Jauhar
Journal of Agromedicine and Medical Sciences Vol 2, No 1 (2016)
Publisher : Medical Faculty of Jember University (Fakultas Kedokteran Universitas Jember)

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Abstract

Streptococcus pyogenes is a Gram positive bacteria that commonly cause disease in human. If not treated immediately, this bacteria can cause serious complication such as reumatic fever that causing heart valve tissue damage. Penicilin, drug of choice to eradicate S. pyogenes, oftenly cause various side effects such as anaphylaxis. This study aimed to investigate the effect of Mirabilis jalapa leaf ethanolic extract against S. pyogenes growth using in vitro techniques. The study design was a quasi experimental design. S. pyogenes culture as the study subject were divided into positive control group (penicilin V 100 IU), negative control group (NaCMC 0,5%), and eight treatment groups that were given with M. jalapa leaf ethanolic extract as much as 0,1 mg/ml, 1 mg/ml, 5 mg/ml, 10 mg/ml, 20 mg/ml, 30 mg/ml, 40mg/ml, and 50 mg/ml. After 24 hours incubation periods, the inhibition zone were found in all treatment group except in concentration 0,1 mg/ml. This study showed that M. jalapa leaf ethanolic extract could inhibit the growth of S. pyogenes. There was significant correlation between the concentration of M. jalapa leaf ethanolic extract and the diameter of inhibition zone (p=0,00), the higher concentration of M. jalapa leaf extract, the larger diameter of inhibition zone of S. pyogenes. Keywords: Mirabilis jalapa, leaf extract, antimicrobial activity
MODULASI AKTIVITAS CIPROFLOXACIN TERHADAP Pseudomonas aeruginosa OLEH N-ASETILSISTEIN DAN VITAMIN C Agustina, Dini; Indreswari, Laksmi; Tristianti, Farmitalia Nisa; El Milla, Kardiana Izza; Hermansyah, Bagus; Wahyudi, Septa Surya; Firdaus, Jauhar
Syifa'Medika Vol 11, No 1 (2020): Syifa' MEDIKA: Jurnal Kedokteran dan Kesehatan
Publisher : Faculty of Medicine

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32502/sm.v11i1.2389

Abstract

Pseudomonas aeruginosa merupakan salah satu bakteri penyebab infeksi yang sulit diobati dengan terapi obat tunggal karena tingkat keberhasilan yang rendah serta kecenderungan menjadi resisten selama pemberian obat tunggal. Salah satu antibiotik yang digunakan adalah ciprofloxacin. Untuk meningkatkan sensitivitas P. aeruginosa terhadap ciprofloxacin, kombinasi N-asetilsistein atau vitamin C mungkin diperlukan. Penelitian ini bertujuan untuk mengetahui pengaruh kombinasi antara N- asetilsistein dan ciprofloxacin serta antara vitamin C dan ciprofloxacin terhadap pertumbuhan P. aeruginosa. Penelitian ini menggunakan uji difusi cakram yang berisi kombinasi konsentrasi ciprofloxacin konstan 1mg/ml dengan N-asetilsistein dalam berbagai konsentrasi 1,25mg/ml, 2,5mg/ml, 5mg/ml, 10mg/ml, dan 20mg/ml dan vitamin C dengan 2,5 mg/ml; 5 mg/ml; 10 mg/ml; 20 mg/ml; dan konsentrasi 40 mg/ml. Dalam kombinasi antara N-asetilsistein dan ciprofloxacin, peningkatan sensitivitas P. aeruginosa terjadi pada konsentrasi 10ml/mg pada kombinasi obat, dan dalam kombinasi antara vitamin C dan ciprofloxacin, peningkatan sensitivitas P. aeruginosa terjadi pada konsentrasi 2, 5 ml/mg pada kombinasi obat di atas kontrol positif. Regresi logaritmik mengungkapkan konsentrasi minimal N- asetilsistein dan vitamin C masing-masing adalah 9,593 mg/ml dan 1,9 mg/ml dapat meningkatkan sensitivitas P. aeruginosa pada ciprofloxacin. Dapat disimpulkan bahwa N-asetilsistein dan vitamin C meningkatkan aktivitas ciprofloxacin untuk menghambat pertumbuhan P. aeruginosa in vitro.
Pengaruh Pemberian Niasin dan Kafein dalam Model Minuman Berenergi terhadap Fisiologi Hati Tikus Wistar Jantan (The Effect of Caffeine and Niacin Administration within Energy Drink Model towards Liver Physiology of Male Wistar Rat) Ngurah Agung Reza Satria Nugraha Putra; Erma Sulistyaningsih; Jauhar Firdaus
Pustaka Kesehatan Vol 5 No 3 (2017)
Publisher : UPT Percetakan dan Penerbitan Universitas Jember

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Abstract

Recently,there are many hepatotoxicity case reports induced by energy drinks and its niacin content is assumed to be the cause of liver injury. Caffeine in energy drinks actually has a hepatoprotective effect. However, this hepatoprotective effect of caffeine is less potent in counteracting the hepatotoxic effect of niacin. This study aimed at determining niacin and caffeine influences in inducing the disruption of liver physiology and the dose of niacin and caffeine in energy drink model which can induce the disruption of liver physiology by measuring AST, ALT, and GGT. As many as 28 male albino wistar rats were divided into seven groups;1 control group and 6 experimental groups, for 49 days. At day 50th, the rats were terminated to measure the AST, ALT, and GGT. The AST and ALT enzyme levels were not significantly correlated (p> 0,05). Otherwise, the GGT enzyme level was significantly correlated (p<0,05). It was showed that niacin and caffeine elevate GGT enzyme at doses 0,491 mg/ 200gr body weight/ day niacin and 1,2275 mg/ 200gr body weight/ day caffeine. These doses are equal to the consumption of three packs of energy drinks per day in human. Keywords: niacin, caffeine, energy drinks, AST, ALT, GGT
Efek Pati Resisten Singkong (Manihot esculenta Crantz) terhadap Indeks HOMA-IR dan HOMA-B Tikus Model Diabetes Maria Ulfa; Elly Nurus Sakinah; Yohanes Sudarmanto; Jauhar Firdaus
Pustaka Kesehatan Vol 7 No 1 (2019): Volume 7 No. 1, 2019
Publisher : UPT Percetakan dan Penerbitan Universitas Jember

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.19184/pk.v7i1.17586

Abstract

Insulin resistance is a condition in which target organs fail to respond normally to insulin. Cassava contains 9,69 percent starch that resist to digestive enzyme in intestine and has been shown to increase insulin sensitivity and enhance β cell function. The aim of this study was to analyze the difference effect of native cassava starch and cassava resistant starch consumption on insulin resistance and β cell function indexes. This study was quasy experimental research with post-test only control group design using 16 male wistar strain rats divided into four groups: K1 (normal rats with standard diet), K2 (diabetic rats with standard diet), P1 (diabetic rats with native cassava starch diet) and P2 (diabetic rats with cassava resistant starch diet). The rats were fed with high fat diet and injected with low-dose streptozotocin to mimic the patogenesis of type 2 diabetes. The rats were then fed with assigned diet for 28 days. The data collection was obtained from laboratory examination of fasting plasma glucose and fasting plasma insulin to determine HOMA-IR and HOMA-B indexes. Post Hoc analysis showed no difference in both indexes between native cassava starch and cassava resistant starch fed groups (p>0,05).
Pengaruh Pemberian Ekstrak Etanol Daun Mirabilis jalapa terhadap Pertumbuhan Vibrio cholerae (The Effect of Mirabilis jalapa's Leaves Ethanolic Extract against the Growth of Vibrio cholerae) Habibbur Rochman Salim; Dini Agustina; Jauhar Firdaus
Pustaka Kesehatan Vol 4 No 3 (2016)
Publisher : UPT Percetakan dan Penerbitan Universitas Jember

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Abstract

Vibrio cholerae is one of the most common bacteria causing acute diarrhea. First-line treatment of diarrhea is tetracycline. However, the drug has some side effects. Therefore it is necessary to have an alternative therapy for V. cholerae especially from herbs. The purpose of this study was to determine the ability and the minimal inhibitory concentration (MIC) of Mirabilis jalapa leaves extract in inhibiting the growth of V. cholerae in in vitro method. This research used a Quasi Experimental Design with Post Test Only Control Group Design. The method of this study used diffusion method on Mueller Hinton Agar. The sample used was V. cholerae culture from the Laboratory of Microbiology Medical Faculty Brawijaya University. The inhibition growth of V. cholerae was observed start at a concentration of 1 mg/ml and increased by increasing concentrations of the extract. Spearman correlation test showed value p=0.000 and r=0.993, indicating significant correlation between the leaves extract of M. jalapa and V. cholerae diameter inhibition zone. These results indicated that M. jalapa leaves extract could inhibit the growth of V. cholerae and had qualitatively MIC 1 mg/ml, while quantitatively 0.2 mg/ml. Keywords: microbiology, Mirabilis jalapa, Vibrio cholerae, in vitro
Efek Ekstrak Kulit Mangga (Mangifera indica L.) Arumanis terhadap Lama Perdarahan Mencit Putih Jantan (The Effect of Arumanis Mango (Mangifera indica L.) Peel Extract on the Bleeding Time of White Male Mice) Komang Dewi Fridayanti; Cicih Komariah; Jauhar Firdaus
Pustaka Kesehatan Vol 5 No 1 (2017)
Publisher : UPT Percetakan dan Penerbitan Universitas Jember

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Abstract

The inhibition of cyclooxygenase 1 (COX-1) enzyme leads to the decrease of tromboxane A2 (TXA2) and decrease the activity of platelet aggregation that marked by the lengthening of bleeding time. This mechanism is important to prevent the occurence of patology that can lead to thrombosis. Flavonoid, polyphenol present in the mango peel, is known to have activity for blocking the COX-1 enzyme. The aim of this research was to know the effect of Arumanis mango peel extract for lengthening the bleeding time on white male mice. The research was true experimental. The sampel was treated for seven days and the bleeding time was measured on the seventh day. The result of analyses Kruskal Wallis shows that there are significant difference intern-treatment group with significance (p) 0.033. The Mann Whitney analyses test shows significant difference between treatment group 2 (P2), treatment group 4 (P4), treatment group 5 (P5) and negative control group (K-). So, it can be concluded that arumanis mango peel extract can lengthening the bleeding time of white male mice.The dosis of 16,8 mg.grBBof mango peel extract givesthe longest mean bleeding timeand it exceeds the mean of positive control group. Keywords: bleeding time, mango, flavonoid
Type 3 Resistant Starch Effect of Cassava (Manihot esculenta Crantz) on Fasting Blood Glucose in Diabetes Mellitus Wistar Rat Models T Ariani Widiastini; Elly Nurus Sakinah; Yudha Nurdian; Jauhar Firdaus
Journal of Agromedicine and Medical Sciences Vol 4 No 3 (2018)
Publisher : Faculty of Medicine, University of Jember

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.19184/ams.v4i3.6469

Abstract

Type 2 Diabetes Mellitus (T2DM) is a condition in which both insulin secretion and insulin sentivity disturbed. One of therapeutic approach of T2DM is through diet modification using resistant starch (RS) that has proven controlling both postprandial and fasting blood glucose. Cassava starch has 28,57% amylose and 51,24% amylopectin that can be increased through autoclaving-cooling process. Therefore, it can resist the digestion proess by amylose enzyme. The aim was to describe the effect of type 3 resistant starch cassava (Manihot esculenta Crantz) on fasting blood glucose (FBG) in Wistar diabetic rat models. This study was quasy experimental post-test only control group design using 16 Wistar rats divided into 4 groups, KN (normal), K- (DM), P1 (DM + cassava starch diet), and P2 (DM + type 3 RS cassava diet). High fat diet (HFD) and low dose streptozotocin (STZ) used as diabetic agents. Rats fed cassava starch or type 3 RS cassava diet for 28 days. GOD-PAP method used to measure the FBG level. The data analyzed using One Way ANOVA test with p>0,05 as significant value. The result shows no significant differences within experimental groups. Keywords: cassava, autoclaving-cooling, resistant starch, FBG
Difference in The Incidence Severe Preeclampsia and Eclampsia between Maternal Age 20-34 Years and >34 Years in dr. Soebandi Hospital Jember Muhammad Fakhri Ali; Yonas Hadisubroto; Jauhar Firdaus
Journal of Agromedicine and Medical Sciences Vol 3 No 2 (2017)
Publisher : Faculty of Medicine, University of Jember

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.19184/ams.v3i2.5065

Abstract

Maternal Mortality Rate (MMR) in Indonesia is still high. The maternal mortality rate continues to rise due to hypertension, one of which is caused by pre-eclampsia and eclampsia. Many factors cause preeclampsia, including advanced maternal age. The purpose of this study was to determine the effect of advanced maternal age during pregnancy with severe preeclampsia and eclampsia in RSD dr. Soebandi Jember. This study used cross sectional approach using 264 samples were divided into two groups, there are pregnant women aged 20-34 years and >34 years. The results of data analysis using Chi Square for severe preeclampsia and obtained p = 0.015 and OR = 2.494, which means there is a significant difference in comparison severe preeclampsia between gestational age of 20-34 years and >34 years. At the age of 20-34 years from 216 samples found 28 people suffering from severe preeclampsia (12.9%). Whereas at the age of mother> 34 years of 48 people found 13 people (27.1%) suffered severe preeclampsia Results of data analysis obtained eclampsia using Fisher and p = 0.554, which means there are no significant differences in comparison eclampsia between gestational age of 20-34 years and >34 years. At the age of 20-34 years from 216 samples found 3 people suffering from eclampsia (1.38%). While at mother age> 34 years from 48 people found 1 person (2.08%) suffered eclampsia.
The Effect of Mirabilis jalapa Leaf Ethanolic Extract against Streptococcus pyogenes Bagus Satrio Pambudi; Enny Suswati; Jauhar Firdaus
Journal of Agromedicine and Medical Sciences Vol 2 No 1 (2016)
Publisher : Faculty of Medicine, University of Jember

Show Abstract | Download Original | Original Source | Check in Google Scholar

Abstract

Streptococcus pyogenes is a Gram positive bacteria that commonly cause disease in human. If not treated immediately, this bacteria can cause serious complication such as reumatic fever that causing heart valve tissue damage. Penicilin, drug of choice to eradicate S. pyogenes, oftenly cause various side effects such as anaphylaxis. This study aimed to investigate the effect of Mirabilis jalapa leaf ethanolic extract against S. pyogenes growth using in vitro techniques. The study design was a quasi experimental design. S. pyogenes culture as the study subject were divided into positive control group (penicilin V 100 IU), negative control group (NaCMC 0,5%), and eight treatment groups that were given with M. jalapa leaf ethanolic extract as much as 0,1 mg/ml, 1 mg/ml, 5 mg/ml, 10 mg/ml, 20 mg/ml, 30 mg/ml, 40mg/ml, and 50 mg/ml. After 24 hours incubation periods, the inhibition zone were found in all treatment group except in concentration 0,1 mg/ml. This study showed that M. jalapa leaf ethanolic extract could inhibit the growth of S. pyogenes. There was significant correlation between the concentration of M. jalapa leaf ethanolic extract and the diameter of inhibition zone (p=0,00), the higher concentration of M. jalapa leaf extract, the larger diameter of inhibition zone of S. pyogenes. Keywords: Mirabilis jalapa, leaf extract, antimicrobial activity
The Potension of Aditory Nerve Damage on Milling Industry Workers in Jember Regency Jauhar Firdaus
Journal of Agromedicine and Medical Sciences Vol 6 No 1 (2020)
Publisher : Faculty of Medicine, University of Jember

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.19184/ams.v6i1.16717

Abstract

Jember Regency is one of the agro-industrial areas in Indonesia with a variety of activities that can produce noise including milling industry. Exposure to noise that is too strong or too long will damage the auditory nerve. The type of material being grounded determines the amount of noise produced so that the potential for hearing nerve damage also varies. This study aims to determine the level of noise produced by the milling industry and analyze the potential for hearing nerve damage in milling workers in Jember Regency. This type of research is observational analytic with cross-sectional approach. This research was conducted by measuring noise in several grinding locations in Jember that were randomly determined. Types of careful milling is grinding meat, coffee, rice, sticky rice and coconut. In addition to measuring the noise level, a short interview was also conducted with the mill workers regarding how long they worked at the mill every day. The measurement results are then analyzed descriptively and compared with standards set by the government and the Occupational Safety and Health Administration (OSHA). In this study it was found that the grinding of meat raw materials produced an average noise level of 88.5 db, coffee of 88.5 db, rice of 88.9 db, sticky rice of 87.3 db and coconut of 80.7 db. The duration of exposure to noise in milling meat, coffee, rice and sticky rice ranges from 9-12 hours a day. While the duration of noise exposure to coconut milling workers ranged from 6-9 hours. Therefore it can be concluded that milling meat, coffee, rice and sticky rice has the potential to cause hearing loss for workers. Keywords: agroindustry, hearing loss, noisy, milling
Co-Authors Abu Khoiri Achmad Subagio Adelia Handoko Aisya, Meutia Citra Alif Kufari Alyssandra Afqorina Agung Amini, Stefia A. Andi Muhammad, Andi Angela, Patricia Angga Mardro Raharjo Aris Prasetyo Aris Prasetyo Azham Purwandhono Bagus Hermansyah Bagus Satrio Pambudi Bagus Satrio Pambudi, Bagus Satrio Bagus Setia Caesarina, Ancah Cahyana, Nugraha Wahyu Cicih Komariah Dini Agustina Dita Diana Parti El Milla, Kardiana Izza Elly Nurus Sakinah, Elly Nurus ENNY SUSWATI Erma Sulistyaningsih Fambudi, Stela S. Habibbur Rochman Salim Hairrudin Hairrudin Haniefah, Yumna Rifda Heni Fatmawati Ida Srisurani Wiji Astuti Inke Kusumastuti Inreswari, Laksmi Irawan Fajar Kusuma Karim, Muhdie Karisma Adya Pertiwi Komang Dewi Fridayanti Kristianingrum Dian Sofiana Kristianingrum Dian Sofiana Kristianingrum Dian Sofiana Kristianningrum Dian Sofiana Laksmi Indreswari Laksmi Indreswari Lubis, Arinie Awindya Marchianti, Ancah CN. Maria Ulfa Moh. Nur Indra Caesar Muhammad Fakhri Ali Muhammad Rijal Fahrudin Hidayat Ngurah Agung Reza Satria Nugraha Putra Nofica, Cheila Nurud Diniyah Pattipeilohy, Florence Pattipeilohy, Florence Marianty Pipiet Wulandari Pralampita, Pulong Wijang Prasetyo, Aris Putri, Dhiani E. Raharjo, Angga Rumastika, Nindya Shinta Sakinah, Elly N. septa surya wahyudi, septa surya Sheilla Rachmania, Sheilla Sudarmanto, Yohanes Sudjarwo, Raisa Supangat Supangat Supangat Supangat Suryono Suryono T Ariani Widiastini Tartila, Jasmine Tristianti, Farmitalia Nisa Winanda, Leony Agnes Savira Yonas Hadisubroto Yudha Nurdian Yuli Hermansyah Zahrah Febianti