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All Journal Jurnal Matematika & Sains The Indonesian Biomedical Journal Jurnal Biologi Tropis Jurnal Ilmu Kedokteran dan Kesehatan Jurnal Health Sains Oshada Jurnal of Syiah Kuala Dentistry Society
Albert Manggading Hutapea
Universitas Advent Indonesia
Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Dentistry Education Health Professions Immunology & microbiology Mathematics Medicine & Pharmacology Nursing Public Health Veterinary

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Sifat Optik Lapisan Tipis In2O3 yang Ditumbuhkan dengan Metode MOCVD Horasdia Saragih; Hasniah Aliah; Euis Sustini; Albert Manggading Hutapea
Jurnal Matematika & Sains Vol 15, No 2 (2010)
Publisher : Institut Teknologi Bandung

Show Abstract | Download Original | Original Source | Check in Google Scholar

Abstract

The In2O3 thin films have been deposited on glass substrate by MOCVD method using In(TMHD)3 metal organic precursor. The growth parameters, such as bubbler temperature 200oC, bubbler pressure 260 Torr, substrate temperature 300oC, flow rate of Ar gas 50 sccm, flow rate of O2 gas 50 sccm, chamber pressure 2x10-3 Torr, and duration of growth from 120 to 180 minutes were used. Three In2O3 thin films with different thicknesses, i.e. 531, 434, and 404 nm were resulted. Optical transmissions of the thin films in the visible wavelength were above of 80%, and not significantly influenced by thickness difference up to about of 127 nm. The optical band gap and Urbach energy band of thin films were 3,76-3,80 eV and 0,20-0,22, respectively. The thin films deposited have indirect forbidden transition.
Effects of Hydrogen-Rich Water on Interleukin-1β, Number of Osteoclasts and Osteoblasts in Streptozotocin-induced Diabetic Rats with Orthodontic Tooth Movement Lina Hadi; Albert Manggading Hutapea; Florenly Florenly
The Indonesian Biomedical Journal Vol 15, No 6 (2023)
Publisher : The Prodia Education and Research Institute (PERI)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18585/inabj.v15i6.2677

Abstract

BACKGROUND: Orthodontic tooth movement (OTM) may increase the risk of treatment-related complications for some diabetes mellitus (DM) patients. Hydrogen-rich water (HRW) has been demonstrated in many studies to reduce oxidative stress and cell damage. This study aimed to examine the levels of interleukin (IL)-1β, blood glucose level, body weight, tooth displacement, and population of osteoclasts and osteoblasts in diabetic rats with OTM.METHODS: Thirty rats (Rattus novergicus) were divided into 6 groups: OTM, HRW, DM, DM+OTM, DM+HRW, and DM+OTM+HRW. DM, DM+OTM, DM+HRW, and DM+OTM+HRW groups were induced with streptozotocin (STZ) after 8 weeks of high-fat diet (HFD) and continued being fed HFD for 4 weeks. OTM, DM+OTM, and DM+OTM+HRW groups were placed on an orthodontic device for the orthodontic treatment. HRW, DM+HRW, and DM+OTM+HRW groups were administered HRW via oral gavage 3 times a day for 4 weeks. At the end of the study, all rats were euthanized and blood samples were collected for IL-1β measurement using enzyme-linked immunosorbent assay (ELISA) kits. Meanwhile, the rats’ maxilla was taken to measure tooth movement, and the number of osteoclast and osteoblast were counted.RESULTS: The highest increase of IL-1β was in the DM+OTM group (140.07±5.14 pg/mL) and the lowest was in the HRW group (92.80±2.89 pg/mL). The average number of osteoblasts were higher in tension sites, while osteoclasts were higher in pressure sites.CONCLUSION: Consumption of HRW in STZ-induced diabetic rats with OTM can reduce IL-1β levels, reduce tooth mobility, and promote bone remodeling.KEYWORDS: diabetes mellitus, hydrogen rich water, interleukin-1β, orthodontic tooth movement, osteoblast, osteoclast
Pengaruh Pemberian Vitamin C dan E terhadap Stres Oksidatif pada Olahraga Renang Zecha, Rosa Nurul; Gunadi, Julia Windi; Hutapea, Albert Manggading
Jurnal Ilmu Kedokteran dan Kesehatan Vol 11, No 6 (2024): Volume 11 Nomor 6
Publisher : Prodi Kedokteran Fakultas Kedokteran Universitas Malahayati

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33024/jikk.v11i6.14513

Abstract

Pada olahraga renang dapat terjadi stres oksidatif apabila terjadi kerusakan otot skelet, terkait dengan intensitas, durasi, frekuensi latihan, dan kondisi kesehatan perenang. Ketidakseimbangan jumlah radikal bebas menyebabkan stres oksidatif. Aktivitas fisik yang berat, radikal bebas dan stres oksidatif menyebabkan kerusakan jaringan dan sel, yang merugikan otot. Vitamin E dan C penting dalam melindungi sel dari stres oksidatif yang dihasilkan oleh olahraga renang yang intens. Studi ini bertujuan untuk memaparkan mekanisme vitamin C dan vitamin E dalam memengaruhi biomarker stres oksidatif pada olahraga renang. Metode yang dilakukan adalah telaah pustaka, dengan mencari sumber literatur dari pubmed, google scholar dengan kata kunci “stres oksidatif”, “vitamin C”, “vitamin E”, dan “renang”. Hasil penelitian didapatkan sebanyak 7 artikel yang membahas pengaruh renang, vitamin C, dan atau vitamin E terhadap biomarker stres oksidatif. Hasil kajian diperoleh bahwa olahraga renang dapat menimbulkan terjadinya kerusakan otot yang dibuktikan dengan peningkatan marker stres oksidatif. Penurunan stres oksidatif dapat dicapai dengan pemberian vitamin C dan atau E, namun tingkat signifikansi dari pengaruhnya dapat bervariasi tergantung dosis dan tingkatan stres oksidasi yang terjadi. Simpulan yang dapat diambil dari telaah pustaka ini adalah vitamin C dan vitamin E dapat memperbaiki stress oksidatif yang terjadi pada olahraga renang melalui mekanisme antioksidan. Kombinasi vitamin C dan E dapat memberikan efek sinergis yang memperkuat efek penurunan stres oksidatif dan peningkatan level antioksidan pada olahraga renang.
Effect of hydrogen-rich water on periodontal disease, interleukin and blood glucose levels in diabetic Albert Manggading HUTAPEA; Lina HADI
Journal of Syiah Kuala Dentistry Society Vol 6, No 1 (2021): June 2021
Publisher : Dentistry Faculty

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24815/jds.v6i1.21892

Abstract

ABSTRACT Diabetes Mellitus (DM) is a metabolic disorder characterized by high blood glucose levelsassociated with periodontal disease and increased levels of inflammatory biomarkers such asinterleukin. Therapeutic effects of molecular hydrogen for a wide range of disease models and humandiseases have been investigated. This review aims to systematically analyze and review animal andhuman studies investigating the effect of HRW on periodontal tissues, interleukin, or blood glucoselevels. An electronic search was conducted via PubMed/Medline, Google Scholar, Wiley Online Library,LILACS, Science.gov, and Cochrane Central Register of Controlled Trials (CONTROL) using thekeywords "Hydrogen Water", "Diabetes Mellitus", "Interleukin" and "Periodontal disease" for studiespublished between January 2011 to May 2021. After the elimination of duplicate items, the primarysearch resulted in 101 articles. After excluding irrelevant articles based on abstract and title, full texts of45 articles were read to exclude additional unrelated studies. Eight studies were included in this reviewfor qualitative analysis. The results showed that Drinking HRW exerts certain antioxidants for oxidativegingival stress and anti-inflammatory effects by decreasing interleukin and decreasing blood glucoselevels for DM patients. KEYWORDS: HRW, DM, Periodontal disease, interleukin
Sugar Crash: Analysis of Diabetes Risk in Office Workers Due to Irregular Work Patterns and Eating Patterns Hutapea, Albert Manggading; Hutapea, Kimberley Maharani Maulibulung
Oshada Vol. 2 No. 2 (2025): Oshada Journal - April
Publisher : PT. Anagata Sembagi Education

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.62872/tnkm3k33

Abstract

This study aims to analyze the risk of type 2 diabetes in office workers affected by sedentary work patterns and irregular eating patterns. Office work tends to require low physical activity, high work pressure, and inconsistent meal times, which can increase the risk of metabolic disorders, including diabetes. This study used a quantitative approach with a survey method of 150 office workers in urban areas, combined with in-depth interviews with 10 key informants. The results showed that 68% of respondents had irregular eating habits and 74% experienced moderate to high work stress. As many as 45% of respondents also showed blood sugar levels that were on the prediabetes threshold. Factors such as consumption of foods high in sugar and carbohydrates, lack of physical activity, and the habit of skipping breakfast contributed significantly to the increased risk of diabetes. These findings emphasize the need for interventions in the form of occupational health education, provision of healthy food in the office environment, and work time arrangements that support a healthy lifestyle. In conclusion, the lifestyle of modern office workers can be a serious risk factor for metabolic health, and requires more comprehensive preventive treatment.
Analysis and Evaluation of Thoroughness and Accuracy of Prescriptions for BPJS Hypertension Outpatients at Hospital X in Bandung City Caroline, Stefania; Madalena, Louis; Hutapea, Albert Manggading
Jurnal Biologi Tropis Vol. 24 No. 1b (2024): Special Issue
Publisher : Biology Education Study Program, Faculty of Teacher Training and Education, University of Mataram, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29303/jbt.v24i1b.8150

Abstract

The evaluation of prescription thoroughness and accuracy is essential to ensure the quality of pharmaceutical services in health facilities, particularly in pharmaceutical installations. This study aims to assess the patterns of antihypertensive drug use among outpatients with hypertension, evaluate the thoroughness and accuracy of prescriptions, and identify gaps in prescription information. Hypertension, a significant and life-threatening condition that has a high mortality rate, with age being a major risk factor. The study used a descriptive method with a retrospective approach, guided by the JNC VIII 2014 guidelines for hypertension management. Results showed that 35% of patient prescriptions lacked thorough information. he results showed that the most prescribed antihypertensive drugs were Calcium Channel Blockers (CCB) (30%), followed by Beta Blockers (27%), Angiotensin Receptor Blockers (ARB) (26%), Angiotensin-Converting Enzyme (ACE) Inhibitors (10%), and Cardioselective Beta Blockers (5%).
THE EFFECT OF RESISTANCE TRAINING AND ANTIOXIDANT SUPPLEMENTATION WITH ASTAXANTHIN ON PLASMA MALONDIALDEHYDE (MDA) LEVELS IN ADULTS Limyati, Yenni; Rahmia, Puteri; Hutapea, Albert Manggading
Jurnal Health Sains Vol. 6 No. 3 (2025): Journal Health Sains
Publisher : Syntax Corporation Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.46799/jhs.v6i3.2142

Abstract

Resistance training has grown in importance for managing oxidative stress, particularly in adults, as it enhances muscle development and overall health. However, it also leads to the formation of reactive oxygen species (ROS), which can result in cellular oxidative damage and potentially hasten the aging process. This review assesses the role of astaxanthin, a powerful antioxidant, in counteracting oxidative stress during resistance training, with a focus on its effects on aging. This study employs a narrative review methodology, evaluating peer-reviewed publications from 2019 to 2024. Keywords used include "Aging," "Antioxidant," "Astaxanthin," "Oxidative Stress," and "Adults." Twenty-five articles were selected for in-depth analysis. The findings suggest that astaxanthin supplementation notably decreases oxidative stress markers, particularly plasma malondialdehyde (MDA) levels, in individuals undergoing resistance training. On a molecular level, astaxanthin activates the Nrf2 pathway, which is responsible for regulating antioxidant enzyme production and supports mitochondrial biogenesis through the PGC-1α pathway. This dual mechanism not only reduces oxidative damage but also enhances energy metabolism, helping maintain cellular function and delaying age-related decline. In conclusion, incorporating astaxanthin supplements into resistance training routines offers promising potential for reducing oxidative stress and promoting healthy aging in adults.
Co-Authors Caroline, Stefania Euis Sustini Florenly Florenly Gunadi, Julia Windi Hasniah Aliah Horasdia Saragih Hutapea, Kimberley Maharani Maulibulung Lina Hadi Lina Hadi Madalena, Louis Rahmia, Puteri Yenni Limyati Zecha, Rosa Nurul