Article Per Year (5 Year)
p-Index From 2021 - 2026
0.408
P-Index
This Author published in this journals
All Journal Jurnal Penelitian Pendidikan IPA (JPPIPA)
Gusbakti Rusip
Prima Indonesia University
Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Education Materials Science & Nanotechnology Physics

Published : 2 Documents Claim Missing Document
Claim Missing Document
Check
Articles

Found 2 Documents
Search

 1 
Antidiabetic Activity of Cep-Cepan Leaf Extract Nanoparticles (Castanopsis costata) in Streptozotocin-Induced White Rat Models Astriani Natalia Br Ginting; Chrismis Novalinda Ginting; Gusbakti Rusip; Linda Chiuman
Jurnal Penelitian Pendidikan IPA Vol 11 No 2 (2025): February
Publisher : Postgraduate, University of Mataram

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29303/jppipa.v11i2.9408

Abstract

The cep-cepan plant (Castanopsis costata) from the Fagaceae family is traditionally used by the Karo community in Medan, North Sumatra, to treat diabetes mellitus, although its efficacy has not yet been scientifically proven. This study aimed to evaluate the effectiveness of the antidiabetic activity of cep-cepan leaf extract nanoparticles (Castanopsis costata) in a streptozotocin-induced white rat model. A total of 25 male white rats were divided into five treatment groups: a positive control group, a negative control group, and three experimental groups treated with extract concentrations of 25, 75, and 150 mg/kg body weight, respectively. Plasma glucose levels were measured every 72 hours for 15 days using blood samples taken from the tail. Pancreatic tissue was then examined, and the data were analyzed using one way anova. The findings showed significant antidiabetic activity in all treatment groups, with p < 0.001. The nanoparticle extract of cep-cepan leaves exhibited the highest antidiabetic potential at a dosage of 150 mg/kg, reducing blood glucose levels by 59.39%. These results suggest that the nanoparticle extract of cep-cepan leaves demonstrates antidiabetic activity in the streptozotocin-induced white rat model, and it has the potential to be developed as an alternative treatment for diabetes mellitus.
Potensi Daya Inhibisi Ekstrak Etanol Daun Sirih Merah (Piper crocatum Ruiz & Pav) Terhadap Mikroorganisme Pada Biofilm Di Pelat Gigi Tiruan Berbahan Hot Curing Acrylic Susanna Halim; Gusbakti Rusip; Siti Farah Syarbaini
Jurnal Penelitian Pendidikan IPA Vol 11 No 3 (2025): March
Publisher : Postgraduate, University of Mataram

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29303/jppipa.v11i3.10825

Abstract

Tooth loss reduces quality of life by affecting chewing and speech function and can interfere with social activities. Hot curing acrylic dentures have the disadvantage of high porosity and surface roughness, so they are susceptible to food residues and microorganisms that can lead to the formation of biofilm and denture stomatitis. Red series leaves (Piper crocatum Ruiz & Pav) have chemical content such as flavonoids, alkaloids, and essential oils that have the potential to be antimicrobials. This study aims to determine the potential of red betel leaf ethanol extract in inhibiting microorganisms in biofilms in denture plates made of hot curing acrylic. This study used the liquid dilution method to test the effectiveness of red betel leaf ethanol extract with concentrations of 10%, 25%, 50% and 75% on the growth of Streptococcus mutans, Lactobacillus acidophilus, and Candida albicans contaminated on round denture plates made of hot curing acrylic. The results showed that the ethanol extract of red betel leaf significantly reduced the number of bacterial and fungal colonies, with a concentration of 75% showing the highest effectiveness, especially against the bacterium Lactobacillus acidophilus with an average colony count of 45.67 ± 4.04. Red betel leaf ethanol extract contains chemical compounds that are effective as antimicrobials in biofilms in denture plates made of hot curing acrylic. This extract has the potential to be an alternative natural ingredient for denture cleaning.
Co-Authors Astriani Natalia Br Ginting Chrismis Novalinda Ginting Linda Chiuman Siti Farah Syarbaini Susanna Halim