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Formulasi dan Uji Mutu Fisik Sediaan Losion Kombinasi Infusa Daun Kelor (Moringa oleifera Lam.) dan Bunga Telang (Clitoria ternatea L.) Novita Silalahi; Annie Rahmatillah; Rahmat Hidayat
Journal of Innovative and Creativity Vol. 6 No. 1 (2026)
Publisher : Fakultas Ilmu Pendidikan Universitas Pahlawan Tuanku Tambusai

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31004/joecy.v6i1.8212

ABSTRACT Moringa leaves (Moringa oleifera Lam.) and butterfly pea flowers (Clitoria ternatea L.) contain flavonoid compounds that act as natural antioxidants capable of scavenging free radicals. This study aimed to formulate a lotion preparation containing a combination of moringa leaf and butterfly pea flower infusions and to evaluate the physical quality of the resulting formulation. Four lotion formulas were prepared, consisting of F0 as a positive control and F1–F3 with variations in the ratio of moringa leaf and butterfly pea flower infusions, namely F1 (2:2), F2 (3:1), and F3 (1:3). Physical quality evaluation included organoleptic test, pH measurement, spreadability, adhesiveness, viscosity, globule size, and centrifugation test. The results showed that all lotion formulas exhibited physical characteristics that met the quality requirements for topical preparations. Organoleptic evaluation indicated that F0 was white, F1 was bluish-green, F2 was green, and F3 was blue in color, with lotion form and strawberry odor. The pH values were 6.26 for F0, 6.37 for F1, 6.63 for F2, and 6.52 for F3. Spreadability ranged from 5–7 cm, adhesiveness was more than 4 seconds, and the average viscosity values were 4,024 cPs for F0, 2,124 cPs for F1, 2,921 cPs for F2, and 2,669 cPs for F3. The globule size was small and uniform, and the centrifugation test showed no phase separation. Keywords: Butterfly Pea Flowers, Moringa Leaves, Skin, Lotion, Physical Quality

Aktivitas Tonikum Infusa Bunga Telang (Clitoria ternatea L.) terhadap Mencit dengan Metode Natatory Exhaustion dan Induksi Tidur Eli Yuliana. H; Siwi Hastuti; Rahmat Hidayat
Journal of Innovative and Creativity Vol. 6 No. 1 (2026)
Publisher : Fakultas Ilmu Pendidikan Universitas Pahlawan Tuanku Tambusai

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31004/joecy.v6i1.8214

ABSTRACT Tonics are agents that can stimulate body activity, thereby delaying feelings of fatigue, lethargy, and exhaustion. This study aimed to determine the ability of butterfly pea flower infusion to increase swimming time and its potential effect on the sleep duration of mice, as well as to evaluate the relationship between dose variation and tonic effects. Butterfly pea flower contains secondary metabolites such as alkaloids and flavonoids, which are known to produce tonic effects. This experimental study used 25 mice as test animals, divided into five groups. The test groups consisted of a negative control (distilled water), a positive control (caffeine 100 mg), and butterfly pea flower infusion at doses of 10%, 20%, and 40%. The results showed that butterfly pea flower infusion exhibited tonic effects in both the natatory exhaustion and sleep induction methods. The 10% dose produced tonic effects of 38.99% ± 10.34% in the natatory exhaustion method and 17.72% ± 6.13% in the sleep induction method. The 20% dose resulted in tonic effects of 52.82% ± 7.39% and 39.38% ± 6.22%, respectively. The 40% dose produced the greatest tonic effect, with values of 79.53% ± 3.82% in the natatory exhaustion method and 59.55% ± 1.72% in the sleep induction method. Keywords: Butterfly Pea Flower, Infusion, Natatory Exhaustion, Sleep Induction, Tonic

Optimasi Nilai Sun Protection Factor (SPF) Ekstrak Daun Bayam Hijau (Amaranthus hybridus L.) Berdasarkan Variasi Pelarut Etanol 70% dan Aseton dengan Metode Spektrofotometri UV-Vis Tasya Aurelia; Rahmat Hidayat; Bagas Ardiyantoro
Journal of Innovative and Creativity Vol. 6 No. 1 (2026)
Publisher : Fakultas Ilmu Pendidikan Universitas Pahlawan Tuanku Tambusai

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31004/joecy.v6i1.8293

ABSTRACT Indonesia has high levels of ultraviolet (UV) exposure, which poses a risk of skin health problems. The use of sunscreen is necessary as a protective measure, but synthetic sunscreens can cause side effects, so natural alternatives are needed. Green amaranth leaves (Amaranthus hybridus L.) contain flavonoids that have the potential to absorb UV rays. This study aims to evaluate the sunscreen activity of green amaranth leaf extract using 70% ethanol and acetone solvents, determine the optimum Sun Protection Factor (SPF) value, and identify the most effective and efficient solvent. Extraction was performed using the maceration method, then the sunscreen activity was tested using UV-Vis spectrophotometry at a wavelength of 290–320 nm with concentration variations of 40, 60, 80, 100, and 120 ppm. The results showed that both extracts had sunscreen activity. The optimum SPF value was obtained at a concentration of 120 ppm, namely 70% ethanol extract 11,45 (maximum protection) and acetone extract 19,11 (ultra protection). Acetone was the most effective and efficient solvent in extracting UV-absorbing compounds. Keywords: 70% Ethanol, Acetone, Green Spinach Leaves (Amaranthus hybridus L.), SPF, Sunscreen

Comparison of the SPF Values of 70% and 96% Ethanol Extracts of Bandotan Leaves (Ageratum conyzoides L.) Using the UV-Vis Spectrophotometric Method Dewianisya Arifatussholiha; Annie Rahmatillah; Rahmat Hidayat
Jurnal FARMASIMED (JFM) Vol 8 No 2 (2026): Jurnal Farmasimed (JFM)
Publisher : Fakultas Farmasi Institut Kesehatan Medistra Lubuk Pakam

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35451/8gtb2161

Indonesia, as a tropical country, has high exposure to ultraviolet radiation that can cause skin damage. Bandotan leaves (Ageratum conyzoides L.) contain flavonoids and tannins capable of absorbing UV radiation, thus having potential to be developed as a safer natural sunscreen agent. This study aimed to determine the Sun Protection Factor (SPF) values of 70% and 96% ethanol extracts of bandotan leaves using the UV-Vis spectrophotometric method and to evaluate the effect of different ethanol solvent concentrations on the SPF values of the extracts. The study used dried bandotan leaf simplicia extracted by maceration method with 70% and 96% ethanol. The obtained extracts were subjected to standardization and phytochemical screening. SPF values were determined in vitro using a UV-Vis spectrophotometer at a wavelength range of 290–320 nm with extract concentrations of 20, 40, 60, 80, and 100 ppm, and calculated using the Mansur method. The results showed that the SPF values of the 70% ethanol extract were 1.1550, 1.8349, 2.4004, 3.3868, and 4.5036, respectively, while the 96% ethanol extract produced SPF values of 1.0821, 2.0559, 2.9325, 3.8779, and 5.1098, categorized from no protection to moderate protection. The difference in ethanol solvent concentration (70% and 96%) had a significant effect on the SPF values of bandotan leaf extract (p < 0.05). Based on these findings, it can be concluded that the 96% ethanol extract of bandotan leaves (Ageratum conyzoides L.) is more effective than the 70% ethanol extract in producing photoprotective activity and therefore has potential to be developed as a natural ingredient in sunscreen formulations.

PENDEKATAN MOLECULAR DOCKING PREDIKSI ADME DAN TOKSISITAS SENYAWA AKTIF BUAH PARE (Momordica charantia L.) SEBAGAI INHIBITOR α-AMYLASE Yosua Christabel Natanael; Tiara Ajeng Listyani; Rahmat Hidayat
Jurnal Analis Farmasi Vol 11, No 1 (2026): JURNAL ANALIS FARMASI
Publisher : Universitas Malahayati

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33024/jaf.v11i1.25053

Latar Belakang: Diabetes mellitus tipe 2 menjadi masalah kesehatan global dengan prevalensi tinggi di Indonesia, mencapai 10,9% pada 2023, didorong oleh resistensi insulin dan gangguan metabolisme karbohidrat. Obat sintetis seperti acarbose sering menimbulkan efek samping gastrointestinal, sehingga diperlukan alternatif alami dari pare yang kaya flavonoid seperti quercetin dan rutin. Tujuan: Penelitian bertujuan menganalisis interaksi 23 senyawa flavonoid pare dengan α-amylase melalui docking molecular, memprediksi profil ADME dan toksisitas, serta mendesain senyawa baru potensial sebagai kandidat antidiabetes.Metode: Penelitian ini dilakukan secara in silico menggunakan PyRx-AutoDock Vina untuk docking, VegaZZ, PyMOL, dan Discovery Studio untuk optimasi dan visualisasi, SwissADME untuk ADME, Toxtree untuk toksisitas. Validasi metode docking dilakukan dengan RMSD 2 Å. Hasil: Hasil docking menunjukkan genistein memiliki binding affinity -7,4 kkal/mol, nilai RMSD 1,538 Å dan genistein memiliki kemiripan dengan ligan natif pada residu ASP300. Genistein memiliki profil ADME yang baik, dan toksisitas yang buruk yaitu High Class III . Desain senyawa baru dari genistein yaitu 4-2-hydroxy-1-hydroxymethoxybutylcyclohexan-1-ol memiliki interaksi asam amino yang sama dengan liganatif dan kontrol positif yaitu ASP300, binding affinity -5,6 kkal/mol, nilai RMSD 1.223 Å, ADME yang baik, dan toksisitas yang rendah. Kesimpulan: Senyawa aktif buah pare berpotensi sebagai inhibitor α-amylase.Kata kunci: α-Amylase, ADME, Molecular docking, Pare, Toksisitas

PENDEKATAN MOLECULAR DOCKING PREDIKSI ADME DAN TOKSISITAS SENYAWA AKTIF BUAH PARE (Momordica charantia L.) SEBAGAI INHIBITOR α-AMYLASE Yosua Christabel Natanael; Tiara Ajeng Listyani; Rahmat Hidayat
Jurnal Analis Farmasi Vol 11, No 1 (2026): JURNAL ANALIS FARMASI
Publisher : Universitas Malahayati

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33024/jaf.v11i1.25053

Latar Belakang: Diabetes mellitus tipe 2 menjadi masalah kesehatan global dengan prevalensi tinggi di Indonesia, mencapai 10,9% pada 2023, didorong oleh resistensi insulin dan gangguan metabolisme karbohidrat. Obat sintetis seperti acarbose sering menimbulkan efek samping gastrointestinal, sehingga diperlukan alternatif alami dari pare yang kaya flavonoid seperti quercetin dan rutin. Tujuan: Penelitian bertujuan menganalisis interaksi 23 senyawa flavonoid pare dengan α-amylase melalui docking molecular, memprediksi profil ADME dan toksisitas, serta mendesain senyawa baru potensial sebagai kandidat antidiabetes.Metode: Penelitian ini dilakukan secara in silico menggunakan PyRx-AutoDock Vina untuk docking, VegaZZ, PyMOL, dan Discovery Studio untuk optimasi dan visualisasi, SwissADME untuk ADME, Toxtree untuk toksisitas. Validasi metode docking dilakukan dengan RMSD 2 Å. Hasil: Hasil docking menunjukkan genistein memiliki binding affinity -7,4 kkal/mol, nilai RMSD 1,538 Å dan genistein memiliki kemiripan dengan ligan natif pada residu ASP300. Genistein memiliki profil ADME yang baik, dan toksisitas yang buruk yaitu High Class III . Desain senyawa baru dari genistein yaitu 4-2-hydroxy-1-hydroxymethoxybutylcyclohexan-1-ol memiliki interaksi asam amino yang sama dengan liganatif dan kontrol positif yaitu ASP300, binding affinity -5,6 kkal/mol, nilai RMSD 1.223 Å, ADME yang baik, dan toksisitas yang rendah. Kesimpulan: Senyawa aktif buah pare berpotensi sebagai inhibitor α-amylase.Kata kunci: α-Amylase, ADME, Molecular docking, Pare, Toksisitas

Preparation Formulation Clay Mask From Butterfly Pea Flower Pollen (Clitoria Ternatea l.) And Yam Powder (Pachyrhizus Erosus l.) As a Natural Antioxidant Dian Nur Aisyah; Rahmat Hidayat; Bangkit Riska Permata
International Journal of Health Engineering and Technology Vol. 4 No. 6 (2026): IJHET MARCH 2026
Publisher : CV. AFDIFAL MAJU BERKAH

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55227/ijhet.v4i6.559

Antioxidants play an important role in preventing cell damage, primarily through free radical scavenging mechanisms. This study aimed to formulate clay masks based on butterfly pea (Clitoria ternatea L.) and jicama (Pachyrhizus erosus L.) flower powder and to evaluate their physical characteristics. Butterfly pea flowers were used for their anthocyanin and flavonoid content, which act as antioxidants, while jicama was chosen for its vitamin C and flavonoid content. Clay mask formulations were made with varying concentrations of butterfly pea and jicama flower powder. These were then tested for organoleptic properties, homogeneity, pH, drying time, and antioxidant activity. The clay mask results showed good physical properties: a semi-solid texture, and a pH value within the skin-friendly range of 4.5-8.0, indicating no irritation. The homogeneity test confirmed that all formulations were uniform, without lumps or unmixed particles. The drying time of the clay masks ranged from 15.19 to 15.26 minutes, meeting the optimal range of 15-20 minutes. Antioxidant activity, formula 0 has an IC50 of 102.75 µg/mL (moderate activity), formula 1 (10% butterfly pea flowers, 10% jicama) shows strong antioxidant activity with an IC50 of 62.15 µg/mL. Formula 2 (12% butterfly pea flowers, 8% jicama) shows strong antioxidant activity with an IC50 of 53.70 µg/mL. Formula 3 (8% butterfly pea flowers, 12% jicama), with an IC50 of 41.20 µg/mL, so it is classified as very strong.

Determination Of Lead And Cadmium Metal Content In Rambai Leaf Simplicia (Baccaurea Motleyana Müll.Arg.) Using Atomic Absorption Spectrophotometry Method Aqila Widya Sari; Rahmat Hidayat; Tiara Ajeng Listyani
International Journal of Health Engineering and Technology Vol. 4 No. 6 (2026): IJHET MARCH 2026
Publisher : CV. AFDIFAL MAJU BERKAH

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55227/ijhet.v4i6.602

Rambai leaf (Baccaurea motleyana Müll. Arg.) is traditionally used to treat smallpox, diarrhea, and bruises, but it has the potential to be contaminated with heavy metals such as lead (Pb) and cadmium (Cd) which are toxic and accumulative. This study aims to determine the levels of Pb and Cd in rambai leaf and compare them with the safe limits of BPOM RI and WHO. The type of research is descriptive quantitative with Atomic Absorption Spectrophotometry (AAS) method using an air-acetylene flame system. The study population was all rambai plants in Nanga Kantuk Village, West Kalimantan, with purposive sampling. The main instrument was SSA contrAA 800, while data analysis was carried out through a linear calibration curve (R> 0.998), regression, and calculation of levels (mg/kg). The results showed Pb levels of 4.29 mg/kg and Cd <LOD (0.0131 mg/L). These results indicate that Pb metal was detected, while Cd was not detected quantitatively. In conclusion, the levels of Pb and Cd in rambai leaf simplicia are still below the safe limits of BPOM RI (Pb ≤ 10 mg/kg; Cd ≤ 0.3 mg/kg), so it is safe to use as a traditional medicine ingredient from the aspect of heavy metal contamination.

The Effect Of Variations In Carbopol Concentration On The Physical Characteristics And SPF Value Of Sunscreen Spray Gel With Ethanol Extract Of Kepok Banana Flowers (Musa Acuminata X M. Balbisiana) By UV-Vis Spectrophotometry Nikita Puspa; Rahmat Hidayat; Alfina Nurrahman
International Journal of Health Engineering and Technology Vol. 4 No. 6 (2026): IJHET MARCH 2026
Publisher : CV. AFDIFAL MAJU BERKAH

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55227/ijhet.v4i6.637

Excessive exposure to UV rays can cause various skin damage so that sunscreen preparations are needed. Kepok banana flowers (Musa acuminata x M. balbisiana) contain flavonoid compounds that have the potential as active ingredients in natural sunscreens, especially in the form of spray gel preparations. This study aims to determine the effect of variations in carbopol concentration on the physical characteristics and SPF value of spray gel preparations using UV-Vis spectrophotometry, and to determine the most optimal formula. Ethanol extract of kepok banana flowers was obtained by maceration method using 96% ethanol. Sunscreen spray gel from ethanol extract of kepok banana flowers was formulated with variations in carbopol concentrations of 0,5% (F1), 0,75% (F2), and 1% (F3). The resulting spray gel was tested including organoleptic, homogeneity, pH, viscosity, adhesion, spray pattern, and SPF value. The results showed that variations in carbopol concentration significantly affected the physical characteristics of the preparation, especially the organoleptic texture, pH, viscosity, and spray pattern, but did not significantly affect the SPF value of the spray gel preparation of ethanol extract of kepok banana flowers (Musa acuminata x M. balbisiana). Formula 2 with a carbopol concentration of 0,75% was determined as the most optimal formula with the most balanced physical characteristics and an SPF value of 15.616 with an ultra protection category.

Formulation And Evaluation Of Sunscreen Spray Gel Preparations From Kepok Banana Flower Extract (Musa Acuminata X M. Balbisiana) With Variations In Extract Concentration Based On SPF Value Natasya Putri Handayani; Rahmat Hidayat; Alfina Nurrahman
International Journal of Health Engineering and Technology Vol. 4 No. 6 (2026): IJHET MARCH 2026
Publisher : CV. AFDIFAL MAJU BERKAH

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55227/ijhet.v4i6.638

UV exposure causes skin damage such as erythema and premature aging, so natural sunscreens are needed such as ethanol extract of kepok banana flowers (Musa acuminata × M. balbisiana) which are rich in flavonoids and polyphenols. The aim of this study was to determine the effect of variations in extract concentration (0.8%, 1%, 1.2%) on the physical characteristics and SPF value of spray gel. This type of descriptive experimental study used the maceration method, formulation with carbopol 940, and in vitro evaluation. The extract population was from Pontianak, samples of three formulas with three replications. Instruments used were UV-Vis spectrophotometer, Brookfield viscometer; ANOVA analysis and linear regression. The results showed pH 5.64-6.25, viscosity 989-1915 cPs, homogeneous, SPF 15.90 (F1) to 18.76 (F3). Conclusion: A concentration of 1.2% is optimal for effective and stable sunscreen spray gel.

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