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All Journal JURNAL FARMASIMED (JFM) Jurnal Sains dan Teknologi International Journal of Health, Engineering and Technology Jurnal An-Najat: Jurnal Ilmu Farmasi dan Kesehatan Journal of Innovative and Creativity Green Health: Journal of Health Sciences, Nursing and Nutrition
Annie Rahmatillah
Universitas Duta Bangsa Surakarta
Aerospace Engineering Agriculture, Biological Sciences & Forestry Automotive Engineering Chemical Engineering, Chemistry & Bioengineering Chemistry Computer Science & IT Control & Systems Engineering Dentistry Education Electrical & Electronics Engineering Energy Engineering Health Professions Immunology & microbiology Industrial & Manufacturing Engineering Languange, Linguistic, Communication & Media Mathematics Mechanical Engineering Medicine & Pharmacology Nursing Public Health Social Sciences Veterinary Other

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Formulasi dan Uji Mutu Fisik Sediaan Losion Kombinasi Infusa Daun Kelor (Moringa oleifera Lam.) dan Bunga Telang (Clitoria ternatea L.) Novita Silalahi; Annie Rahmatillah; Rahmat Hidayat
Journal of Innovative and Creativity Vol. 6 No. 1 (2026)
Publisher : Fakultas Ilmu Pendidikan Universitas Pahlawan Tuanku Tambusai

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31004/joecy.v6i1.8212

Abstract

ABSTRACT Moringa leaves (Moringa oleifera Lam.) and butterfly pea flowers (Clitoria ternatea L.) contain flavonoid compounds that act as natural antioxidants capable of scavenging free radicals. This study aimed to formulate a lotion preparation containing a combination of moringa leaf and butterfly pea flower infusions and to evaluate the physical quality of the resulting formulation. Four lotion formulas were prepared, consisting of F0 as a positive control and F1–F3 with variations in the ratio of moringa leaf and butterfly pea flower infusions, namely F1 (2:2), F2 (3:1), and F3 (1:3). Physical quality evaluation included organoleptic test, pH measurement, spreadability, adhesiveness, viscosity, globule size, and centrifugation test. The results showed that all lotion formulas exhibited physical characteristics that met the quality requirements for topical preparations. Organoleptic evaluation indicated that F0 was white, F1 was bluish-green, F2 was green, and F3 was blue in color, with lotion form and strawberry odor. The pH values were 6.26 for F0, 6.37 for F1, 6.63 for F2, and 6.52 for F3. Spreadability ranged from 5–7 cm, adhesiveness was more than 4 seconds, and the average viscosity values were 4,024 cPs for F0, 2,124 cPs for F1, 2,921 cPs for F2, and 2,669 cPs for F3. The globule size was small and uniform, and the centrifugation test showed no phase separation. Keywords: Butterfly Pea Flowers, Moringa Leaves, Skin, Lotion, Physical Quality
Synergistic Impact of The Combination of Moringa Leaves and Butterfly Pea Flowers Infusion on Cognitive Enhancement Annie Rahmatillah; Anna Fitriawati; Anisa Fadilah Kumala Putri
Jurnal FARMASIMED (JFM) Vol 8 No 1 (2025): Jurnal Farmasimed (JFM)
Publisher : Fakultas Farmasi Institut Kesehatan Medistra Lubuk Pakam

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35451/n9214f64

Abstract

Oxidative stress can induce memory loss, which may be mitigated by antioxidants. Moringa leaves (Moringa oleifera) and butterfly pea flowers (Clitoria ternatea) possess flavonoid chemicals that function as natural antioxidants. This study seeks to evaluate the impact of combined Moringa leaf and butterfly pea flower infusions on enhancing the memory of mice and to identify the optimal dosage. The research utilized male white mice (Mus musculus), categorized into six groups: a normal group, a negative control (aquadest), a positive control (Ginkgo biloba), and three treatment groups receiving various infusion doses. The procedure had three phases: acclimatization (T0), intraperitoneal administration of hyoscine butylbromide (T1), and therapy (T2). The manufacture of INDUK BUNTEL (an infusion of moringa leaves and butterfly pea flowers) was conducted using an infusion extraction method. Testing on test subjects was conducted utilizing the Radial Arm Maze methodology. The findings indicated that the infusion combination at dose III (100 mg/KgBW: 100 mg/KgBW) was the most efficacious in enhancing the memory of mice. The mean mistake rate in mice was 16.44%, representing the lowest score among the treatment groups. The one-way ANOVA test indicated no significant difference across treatment groups with three distinct dose combinations (p > 0.05).
Comparison of the SPF Values of 70% and 96% Ethanol Extracts of Bandotan Leaves (Ageratum conyzoides L.) Using the UV-Vis Spectrophotometric Method Dewianisya Arifatussholiha; Annie Rahmatillah; Rahmat Hidayat
Jurnal FARMASIMED (JFM) Vol 8 No 2 (2026): Jurnal Farmasimed (JFM)
Publisher : Fakultas Farmasi Institut Kesehatan Medistra Lubuk Pakam

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35451/8gtb2161

Abstract

Indonesia, as a tropical country, has high exposure to ultraviolet radiation that can cause skin damage. Bandotan leaves (Ageratum conyzoides L.) contain flavonoids and tannins capable of absorbing UV radiation, thus having potential to be developed as a safer natural sunscreen agent. This study aimed to determine the Sun Protection Factor (SPF) values of 70% and 96% ethanol extracts of bandotan leaves using the UV-Vis spectrophotometric method and to evaluate the effect of different ethanol solvent concentrations on the SPF values of the extracts. The study used dried bandotan leaf simplicia extracted by maceration method with 70% and 96% ethanol. The obtained extracts were subjected to standardization and phytochemical screening. SPF values were determined in vitro using a UV-Vis spectrophotometer at a wavelength range of 290–320 nm with extract concentrations of 20, 40, 60, 80, and 100 ppm, and calculated using the Mansur method. The results showed that the SPF values of the 70% ethanol extract were 1.1550, 1.8349, 2.4004, 3.3868, and 4.5036, respectively, while the 96% ethanol extract produced SPF values of 1.0821, 2.0559, 2.9325, 3.8779, and 5.1098, categorized from no protection to moderate protection. The difference in ethanol solvent concentration (70% and 96%) had a significant effect on the SPF values of bandotan leaf extract (p < 0.05). Based on these findings, it can be concluded that the 96% ethanol extract of bandotan leaves (Ageratum conyzoides L.) is more effective than the 70% ethanol extract in producing photoprotective activity and therefore has potential to be developed as a natural ingredient in sunscreen formulations.
Integrating Biophilic Green Infrastructure and Mental Health: A Novel Framework for Quantifying Restorative Effects of Urban Blue Green Spaces on Psychological Well-Being Puput Mulyono; Annie Rahmatillah; Libin joseph
Green Health International Journal of Health Sciences Nursing and Nutrition Vol. 1 No. 2 (2024): April: Green Health: International Journal of Health Sciences, Nursing and Nutr
Publisher : International Forum of Researchers and Lecturers

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.70062/greenhealth.v1i3.255

Abstract

The growing environmental crisis underscores the need for education systems to foster ecological responsibility among students. This study explores the potential for multifaith schools to cultivate environmental moral education through an interreligious pedagogical model. By integrating diverse religious teachings on ecology, the proposed model aims to promote shared moral values for environmental protection and sustainability. The research addresses the gap in existing environmental education, which often lacks an integrated approach that incorporates various religious perspectives. Through a qualitative research design, the study analyzes curricula, observes classroom practices, conducts interviews with educators, and evaluates existing environmental education frameworks in multifaith schools. The study identifies key strategies, including the incorporation of eco-ethics from different religious traditions, project-based learning, and interfaith dialogues, as effective means of fostering ecological responsibility. However, challenges such as balancing doctrinal differences, overcoming biases, and developing inclusive pedagogy remain. The study emphasizes the importance of designing educational content that respects all faiths and promotes intercultural dialogue, thereby encouraging a collective commitment to sustainability. The findings suggest that multifaith schools can serve as powerful platforms for environmental moral education, highlighting the value of integrating religious perspectives into sustainability education. The study concludes with recommendations for incorporating interreligious eco-ethics into curricula and teacher training programs and suggests future research on the long-term impact of interreligious environmental education and its applicability in diverse cultural contexts.
Uji Aktivitas Antibakteri Propionibacterium Acne ATCC 6919 Ekstrak Etanol Daun Si Kejut (Mimosa Pudica L) Anna Fitriawati; Annie Rahmatillah; Nurul Agustiningrum
INSOLOGI: Jurnal Sains dan Teknologi Vol. 4 No. 6 (2025): Desember 2025
Publisher : Yayasan Literasi Sains Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55123/insologi.v4i6.7080

Abstract

Vulgaris acne is a chronic inflammatory condition commonly experienced by adolescents and young adults, with a prevalence reaching up to 85%. Propionibacterium acnes plays a significant role in the inflammatory process of acne, which is influenced by sebum production, hyperkeratinization, and the inflammatory immune response. Acne treatment often involves antibiotics, but resistance to antibiotics such as erythromycin and clindamycin has increased, creating serious challenges in dermatology. Therefore, the development of non-antibiotic therapies for acne is crucial. One promising alternative is the extract of Mimosa pudica L., also known as the sensitive plant, which is recognized for its antimicrobial activity. The extract of Mimosa pudica L. leaves has been shown to inhibit the growth of various pathogenic bacteria and has potential anti-inflammatory effects based on in silico studies, opening up significant opportunities for the development of plant-based treatments for acne and other inflammatory diseases. This study aims to evaluate the effectiveness of ethanol extract of Mimosa pudica L. leaves in inhibiting the growth of Propionibacterium acnes ATCC 6919. The results of the study show that the 30% ethanol extract can inhibit bacterial growth with an inhibition zone diameter of 11.537 mm, indicating the potential of this extract as a safer and more effective alternative treatment for acne.
Analysis Of Total Polyphenol Content Of Carrot Extract (Daucus Carota L.) Using The Folin-Ciocalteu Method Wa Ode Nurani Arma; Rahmat Hidayat; Annie Rahmatillah
International Journal of Health Engineering and Technology Vol. 4 No. 6 (2026): IJHET MARCH 2026
Publisher : CV. AFDIFAL MAJU BERKAH

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55227/ijhet.v4i6.645

Abstract

Carrots (Daucus carota L.) are known to contain bioactive compounds, particularly phenolic compounds, which act as antioxidants. Objective: This study aimed to determine the total polyphenol content in carrot ethanol extract and evaluate its potential as a natural antioxidant source. This study was a quantitative experimental laboratory study. Carrot simplicia was obtained through a process of sorting, washing, chopping, drying, and grinding, then extracted using 70% ethanol solvent. The total polyphenol content was determined using UV-Vis spectrophotometry with Folin-Ciocalteu reagent and gallic acid as a standard, and the results were expressed in mg Gallic acid equivalent per gram of extract (mg GAE/g). Results: Gallic acid solution was used to obtain a standard curve. The analysis results showed a linear regression equation of y = 0.0161x + 0.042, R2 = 0.9947, with a correlation coefficient (r) value of 0.997. The total phenol content of each sample was determined with three replications. The results showed that carrot ethanol extract had a total polyphenol content of 42,205 mg GAE/g extract. This value indicates that carrot extract contains polyphenol compounds that have the potential to be a source of natural antioxidants.
Formulation Of Antifungal Solid Soap From 96% Ethanol Extract Of Neem Leaves (Azadirachta Indica A.Juss) Against Malassezia Furfur ATCC 14251 Diyah Nurayuni; Anna Fitriawati; Annie Rahmatillah
International Journal of Health Engineering and Technology Vol. 4 No. 6 (2026): IJHET MARCH 2026
Publisher : CV. AFDIFAL MAJU BERKAH

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55227/ijhet.v4i6.667

Abstract

Fungal skin infections are still a health problem in tropical regions, especially those caused by Malassezia furfur, so alternative natural skin cleansing preparations are needed that are safe and effective. Neem leaves (Azadirachta indica A. Juss) are known to have antifungal activity and have the potential to be developed into solid soap preparations. This study aims to formulate an antifungal solid soap made from 96 percent ethanol extract of neem leaves, evaluate the physical quality of the preparation, and test its antifungal activity against Malassezia furfur. This study is a laboratory experimental study with a pretest-posttest only control group design. The study population was neem leaves obtained from Mount Pati District, Semarang, with simplicia samples selected using a purposive sampling technique. The research instruments included formulation equipment, physical quality tests based on SNI 3532:2016, and antifungal activity tests using the well diffusion method, while data analysis was carried out using nonparametric statistical tests. The results showed that all soap formulas met the physical quality requirements, and the formulation with a 10 percent extract concentration produced the largest inhibition zone diameter against Malassezia furfur, although it was still relatively weak. The conclusion of this study is that neem leaf extract solid soap has potential as a natural skin cleanser with antifungal activity, but further development and optimization of the formulation are needed to increase its effectiveness.
Evaluation Of The Antioxidant Activity Of Lotion Containing Ethanolic Extract Of Matoa Leaves (Pometia Pinnata J.R.Forst, & G.Forst.) Mei Vita Rachma Pertiwi; Anna Fitriawati; Annie Rahmatillah
International Journal of Health Engineering and Technology Vol. 4 No. 6 (2026): IJHET MARCH 2026
Publisher : CV. AFDIFAL MAJU BERKAH

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55227/ijhet.v4i6.672

Abstract

Skin exposure to environmental stress produces free radicals and ROS that accelerate aging and skin damage, while antioxidant Lotions from natural extracts such as Matoa leaves (Pometia pinnata) offer protection. This experimental study aimed to evaluate the antioxidant activity of ethanol extracts, the effect of concentration (0.5-6%) on the physical quality of Lotions, and the DPPH scavenging ability of the final Lotion. The population of all Matoa leaf extract Lotion formulations; a sample of 2 kg of fresh leaves from Matesih, Karanganyar was purposively selected. Instruments included a UV-Vis spectrophotometer (517 nm), a Brookfield viscometer, a pH meter; SPSS 28.0 was analyzed by ANOVA, regression for IC50. The extract was very potent (IC50 43.07 ppm) containing flavonoids, alkaloids, saponins, tannins; All Lotions met the standards (homogeneous, pH 5.22-6.34, viscosity 10,100-12,740 cP, spreadability 5-6.5 cm), FV (6%) was optimal (IC50 66.30 ppm, strong). High concentrations increased inhibition but increased viscosity, decreased spreadability (p<0.05). The findings confirm that Matoa Lotion is effective for herbal skin care; further in vivo and stability testing is recommended.
Hubungan Medication Beliefs dengan Kualitas Hidup Pasien Diabetes Melitus Tipe II di RSUD Dr. Moewardi Surakarta Fransiska Luciana Putri; Niken Luthfiyanti; Annie Rahmatillah
An-Najat Vol. 4 No. 3 (2026): Agustus: An-Najat: Jurnal Ilmu Farmasi dan Kesehatan
Publisher : STIKes Ibnu Sina Ajibarang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.59841/an-najat.v4i3.3905

Abstract

Diabetes Melitus Tipe II merupakan penyakit kronis yang memerlukan terapi jangka panjang, sehingga keyakinan pasien terhadap pengobatan (medication beliefs) dapat berperan dalam keberhasilan pengelolaan penyakit dan kualitas hidup. Penelitian ini bertujuan untuk mengetahui hubungan antara medication beliefs dengan kualitas hidup pasien Diabetes Melitus Tipe II di RSUD Dr. Moewardi Surakarta. Penelitian menggunakan desain observasional kuantitatif dengan pendekatan cross-sectional. Sebanyak 96 pasien Diabetes Melitus Tipe II rawat jalan dipilih menggunakan teknik purposive sampling. Data medication beliefs diperoleh menggunakan Beliefs about Medicines Questionnaire (BMQ), sedangkan kualitas hidup diukur menggunakan Diabetes Quality of Life (DQOL). Data dianalisis secara univariat dan bivariat menggunakan uji Pearson Chi-Square. Hasil penelitian menunjukkan bahwa sebagian besar responden memiliki medication beliefs positif, yaitu sebanyak 89 responden (92,7%). Sebanyak 50 responden berada pada kategori kualitas hidup baik dan 46 responden berada pada kategori kualitas hidup sedang. Pada responden dengan medication beliefs positif, 49 responden memiliki kualitas hidup baik dan 40 responden memiliki kualitas hidup sedang, sedangkan seluruh responden dengan medication beliefs negatif berada pada kategori kualitas hidup sedang. Hasil uji Pearson Chi-Square menunjukkan terdapat hubungan yang signifikan antara medication beliefs dengan kualitas hidup pasien Diabetes Melitus Tipe II (p=0,021). Dapat disimpulkan bahwa pasien dengan keyakinan yang lebih positif terhadap pengobatan cenderung memiliki kualitas hidup yang lebih baik. Oleh karena itu, edukasi dan komunikasi mengenai kebutuhan, manfaat, serta kekhawatiran terhadap penggunaan obat perlu diperkuat sebagai bagian dari pelayanan pasien Diabetes Melitus Tipe II.
Formulasi dan Uji Aktivitas Antibakteri Sediaan Gel Anti Jerawat Ekstrak Daun Sirih Gading Lemon (Epipremnum aureum) Terhadap Bakteri Propionibacterium acnes ATCC 6919 Elsa Vernanda Candra Dewi; Septian Maulid Wicahyo; Annie Rahmatillah
An-Najat Vol. 4 No. 3 (2026): Agustus: An-Najat: Jurnal Ilmu Farmasi dan Kesehatan
Publisher : STIKes Ibnu Sina Ajibarang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.59841/an-najat.v4i3.3984

Abstract

Acne (acne vulgaris) is a skin condition caused by various factors, one of which is infection by the bacterium Propionibacterium acnes. The leaves of the lemon pothos (Epipremnum aureum) are known to contain secondary metabolites such as flavonoids, alkaloids, saponins, tannins, and triterpenoids that have potential antibacterial properties. This study aims to determine the physical quality of an ethanol leaf extract gel formulation of golden pothos, its antibacterial activity against Propionibacterium acnes ATCC 6919, and to identify the optimal gel concentration for inhibiting the growth of this bacterium. The study showed that all gel formulations met physical quality requirements, including organoleptic properties, homogeneity, pH, viscosity, and spreadability. Phytochemical analysis revealed that the ethanol extract of lemon-leaved betel leaves contains flavonoids, alkaloids, saponins, tannins, and triterpenoids. The average inhibition zone diameters against Propionibacterium acnes were 6.1 mm at 4%, 7.4 mm at 8%, and 9.3 mm at 16%, respectively, while the positive control measured 12.1 mm, and the negative control showed no inhibitory effect. The results of the One-Way ANOVA test showed a significant difference among the treatment groups (p = 0.006).
Co-Authors Anisa Fadilah Kumala Putri Anna Fitriawati Dewianisya Arifatussholiha Diyah Nurayuni Elsa Vernanda Candra Dewi Fransiska Luciana Putri Libin joseph Mei Vita Rachma Pertiwi Nabila Dhea Fitriani Niken Luthfiyanti Novita Silalahi Nurul Agustiningrum Puput Mulyono Rahmat Hidayat Rohmana, Vivin Marwiyati Septian Maulid Wicahyo Wa Ode Nurani Arma