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All Journal Jurnal Farmanesia Jurnal Riset Ilmu Kesehatan Umum dan Farmasi
Sri Budiasih
Institut Kesehatan Mitra Bunda
Health Professions Medicine & Pharmacology Public Health

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Optimasi Dan Formulasi Sediaan Gel Ekstrak Etanol Hydrocotyle Verticillata Thub Dengan Variasi Konsentrasi HPMC Dengan Penambahan Asam Usnat Habibie Deswilyaz Ghiffari; Alqushay Alqushay; Sri Budiasih; Tommy Julianto
Jurnal Riset Ilmu Kesehatan Umum dan Farmasi (JRIKUF) Vol. 2 No. 1 (2024): Januari : Jurnal Riset Ilmu Kesehatan Umum dan Farmasi (JRIKUF)
Publisher : LPPM STIKES KESETIAKAWANAN SOSIAL INDONESIA

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.57213/jrikuf.v2i1.155

Abstract

Hydrocotyle verticillata Thub is a plant that can be used to treat burns. Usnic acid can inhibit pathogenic microorganisms and can act as an anti-inflammatory, both of which can contribute to the wound healing process. The aim of this research is to determine the extract of gotu kola leaves which is formulated into a gel preparation. Gel is a semi-solid system produced by small particles or large organic molecules that penetrate through a liquid. The gel is easy to use, easily absorbed into the skin, and contains soothing and moisturizing properties that have a healing effect. Gel formulations were made with varying concentrations of HPMC F1 (8%), F2 (8%), F3 (8%), F4 (9%), F5 (10%). The gel produced organoleptically has a distinctive gel aroma, green to brownish in color. In the homogeneity test, all preparations were homogeneous and there were no granules, the pH test showed a pH value ranging from 5.17-6.36, the spreadability test was 5.1-6.4 cm. In the viscosity test, the results were 9,250-40,000 cps, the adhesion test obtained results in 13-64 seconds and the cycling test was stable during storage. Based on the research that has been carried out, it can be concluded that the ethanol extract of gotu kola leaves (Hydrocotyle verticillata Thub)can be formulated into a gel preparation and the results of the physical evaluation of the ethanol extract gel preparation of gotu kola leaves(Hydrocotyle verticillata Thub) with varying concentrations of HPMC and the addition of usnic acid are satisfactory. condition.
FORMULASI OBAT KUMUR JERNIH BERBASIS MINYAK ATSIRI DENGAN TEKNIK SOLUBILISASI SERTA PENAMBAHAN EKSTRAK RESIN JERNANG (DAEMONOROPS DRACO) Deroza Chariesy; Tommy Julianto; Sri Budiasih
Jurnal Farmanesia Vol 12 No 2 (2025): Jurnal Farmanesia
Publisher : UNIVERSITAS SARI MUTIARA INDONESIA

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.51544/jf.v12i2.5941

Abstract

Latar belakang: Karies gigi akibat Streptococcus mutans dapat dicegah dengan obat kumur, namun formulasi sintetik berpotensi menimbulkan efek samping sehingga diperlukan alternatif alami. Minyak atsiri (serai wangi, kayu manis, cengkih, jeruk nipis) serta ekstrak resin jernang (Daemonorops draco) diketahui mengandung senyawa antibakteri. Tujuan: Penelitian ini merancang formulasi obat kumur jernih berbasis minyak atsiri dan kombinasi dengan ekstrak resin jernang serta melihat aktivitas antibakteri sediaan. Metode: Delapan formula disusun, kemudian dievaluasi meliputi organoleptik, pH, viskositas, homogenitas, serta diuji aktivitas antibakteri terhadap S. mutans dengan metode difusi cakram. Hasil: Hasil penelitian menunjukkan pada pemeriksaan organoleptis pada formula tidak memberikan perbedaan warna, rasa, bau, kecuali pada kombinasi jeruk nipis dan jernang mengalami perubahan warna menjadi merah keruh. Pada uji pH seluruh formula berada pada rentang 6,2–7,5. Uji viskositas konsisten dalam rentang 4–7 cP. Pemeriksaan homogenitas seluruh formula menunjukkan hasil homogen dan uji cycling test menunjukkan seluruh formula tetap stabil kecuali F8 yang memperlihatkan kekeruhan. Namun semua formula obat kumur dengan konsentrasi minyak atsiri di dalam batas yang aman dan memenuhi estetika warna tidak dapat menunjukkan terbentuknya zona hambat. Kesimpulan: Sediaan kumur yang mengandung minyak atsiri dan resin jernang telah berhasil dibuat serta stabil dalam penyimpanan namun belum memiliki aktivitas antibakteri yang mencukupi.
Co-Authors Alqushay Alqushay Deroza Chariesy Ghiffari, Habibie Deswilyaz Tommy Julianto