Article Per Year (5 Year)
p-Index From 2021 - 2026
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All Journal Indonesian Journal of Global Health research Indonesian Journal of Global Health Research
Yunnie Trisnawati
Universitas Sumatera Utara & Adam Malik Hospital
Education Health Professions Languange, Linguistic, Communication & Media Nursing Public Health

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Antibiotic Resistance in the Pediatric Intensive Care Unit: Literature Review Nina Melina Ginting; Hendri Wijaya; Arlinda Sari Wahyuni; Yunnie Trisnawati; Rita Evalina; Ayodhia Pitaloka Pasaribu
Indonesian Journal of Global Health Research Vol 7 No 3 (2025): Indonesian Journal of Global Health Research
Publisher : GLOBAL HEALTH SCIENCE GROUP

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37287/ijghr.v7i3.6087

Abstract

Antibiotics have been overused, the unwise use of antibiotics has become a special concern and has led to resistance. Almost 50% of antibiotic therapy is initiated inappropriately and without correct identification of the etiological agent. The high number of inappropriate antibiotic prescriptions contributes to the occurrence of antibiotic resistance and increased risk of death. MDR pathogens result in a 40% increase in mortality in hospital-acquired infections. The purpose of this study was to discuss the pattern of the resistance of antibiotic therapy in pediatric patients admitted to the PICU. Method: The search strategy was conducted through three databases (Google Scholar, Pubmed, Science Direct) which published during 2015-2025, using MeSH words “Antibiotic Resistance” AND “Pediatric intensive care unit”. There were thousand studies found, then by using the PRISMA flowchart, which total ten studies were included. PICU has a higher ratio of pathogen composition and bacterial resistance. Many factors can lead to antibiotic resistance, it might be caused by unnecessary or suboptimal prescribed antibiotic therapy from community before, previous health care and the hospital itself. The high number of inappropriate antibiotic prescriptions contributes to the occurrence of antibiotic resistance. Antibiotic resistance can lead to longer hospital stays and increased risk of mortality.
Prognostic Significance of Increasing pSOFA Scores in Paediatric Sepsis Nadia Setianingsih; Yunnie Trisnawati; Arlinda Sari Wahyuni; Bugis Mardina Lubis; Hendri Wijaya; Rosmayanti Syafriani Siregar
Indonesian Journal of Global Health Research Vol. 8 No. 1 (2026): Indonesian Journal of Global Health Research
Publisher : GLOBAL HEALTH SCIENCE GROUP

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37287/ijghr.v8i1.238

Abstract

Sepsis is a major cause of morbidity and mortality among children worldwide, particularly in low- and middle-income countries. Early identification and continuous monitoring of organ dysfunction are critical components in paediatric sepsis management. The Paediatric Sequential Organ Failure Assessment (pSOFA) score is used to evaluate organ dysfunction and predict the risk of mortality. The aim of the study was to investigate the association between an increase in pSOFA score (∆pSOFA) and mortality among paediatric sepsis patients. This retrospective cohort study included paediatric patients aged 1 month to 18 years diagnosed with sepsis and treated in the PICU from January to December 2023. Receiver Operating Characteristic (ROC) curve analysis was performed to evaluate the predictive value of the pSOFA score for mortality. A total of 87 patients were included in the analysis, with 36 deaths recorded within the first 7 days. Patients with ∆pSOFA ≥1 had a six-fold higher risk of mortality (p<0.001; 95% CI: 3.26–11.02). The day-1 pSOFA score showed poor predictive ability (AUC=0.50), whereas the day-3 score demonstrated good predictive performance (AUC=0.85). An increase in the pSOFA score is significantly associated with a higher risk of mortality in paediatric sepsis patients.
Co-Authors Arlinda Sari Wahyuni Ayodhia Pitaloka Pasaribu Bugis Mardina Lubis Hendri Wijaya Nadia Setianingsih Nina Melina Ginting Rita Evalina Rosmayanti Syafriani Siregar