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Studi Literatur: Sauropus Androgynus (Pemanfaatan dan Toksisitasnya) Marina Silalahi; Hertina Silaban
Jurnal Kesehatan Manarang Vol 5 No 2 (2019): Desember 2019
Publisher : Politeknik Kesehatan Kemenkes Mamuju

Sauropus androgynus (SA) have been used as a vegetable and medicine especially by local communities in Southeast Asia. In 1994 â€“ 1995 reported the occurrence of lung disorders due to consuming juice made from leaves and young shoots which mostly resulted in death. The local comunities in Indonesian, SA uses a vegetables to increase the production of breast milk, therefore a confrehensive study of the use and toxicity of SA is needed. This study is based on literature studies of scientific articles or books published online or offline. The data obtained from the article is then synthesized so that information is obtained that is comprehensive about SA. Ethnobotany study of SA used as a source of vitamins, increases milk production, anti-obesity, and its processing is adjusted to the intended use. The using of SA through of fresh (without cooking) results in bronchiolitis obliterans (BO) which results in damage to the brochioles caused by papaverine compounds. Papaverine is a compound that is damaged by heating, because the use in the form of boiled vegetables is relatively safe. SA has bioactivity as an antimicrobial, antidiabetic mellitus, anti-cholesterol, anti-oxidant, anti-anemia, and increases hormones. The use of SA by means of preheating is relatively safe, but to prevent toxicity it needs to be limited to the amount of consumption and consumption over a long period of time.

Studi Literatur: Sauropus Androgynus (Pemanfaatan dan Toksisitasnya) Marina Silalahi; Hertina Silaban
Jurnal Kesehatan Manarang Vol 5 No 2 (2019): Desember 2019
Publisher : Politeknik Kesehatan Kemenkes Mamuju

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33490/jkm.v5i2.177

Sauropus androgynus (SA) have been used as a vegetable and medicine especially by local communities in Southeast Asia. In 1994 – 1995 reported the occurrence of lung disorders due to consuming juice made from leaves and young shoots which mostly resulted in death. The local comunities in Indonesian, SA uses a vegetables to increase the production of breast milk, therefore a confrehensive study of the use and toxicity of SA is needed. This study is based on literature studies of scientific articles or books published online or offline. The data obtained from the article is then synthesized so that information is obtained that is comprehensive about SA. Ethnobotany study of SA used as a source of vitamins, increases milk production, anti-obesity, and its processing is adjusted to the intended use. The using of SA through of fresh (without cooking) results in bronchiolitis obliterans (BO) which results in damage to the brochioles caused by papaverine compounds. Papaverine is a compound that is damaged by heating, because the use in the form of boiled vegetables is relatively safe. SA has bioactivity as an antimicrobial, antidiabetic mellitus, anti-cholesterol, anti-oxidant, anti-anemia, and increases hormones. The use of SA by means of preheating is relatively safe, but to prevent toxicity it needs to be limited to the amount of consumption and consumption over a long period of time.

Patterns and Appropriateness of Antihypertensive Use in Preeclampsia: A Retrospective Study at a Jakarta Tertiary Hospital (2022-2024) Abitmer Gultom; Hertina Silaban; Yohanes Baptistuta Paser
Contagion: Scientific Periodical Journal of Public Health and Coastal Health Vol 7, No 3 (2025): CONTAGION
Publisher : Universitas Islam Negeri Sumatera Utara, Medan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30829/contagion.v7i3.25682

Preeclampsia (PE) complicates approximately 2-8% of pregnancies worldwide and remains a leading cause of maternal and perinatal morbidity and mortality, contributing to more than 50,000 maternal deaths and nearly 500,000 neonatal deaths annually. Appropriate antihypertensive therapy is essential to prevent disease progression and adverse outcomes. This non-experimental, cross-sectional, retrospective study was conducted at the Indonesian Christian University Hospital from August to December 2024. All medical records of patients with preeclampsia during the study period were included using total sampling (N = 52). Variables included patient characteristics, type of antihypertensive therapy, and appropriateness of drug use. Appropriateness was evaluated using the 4Ts criteria (appropriate indication, appropriate drug, appropriate dose, and appropriate patient) based on the POGI 2016 guideline. Data were analyzed as proportions with 95% confidence intervals (CI), and associations between preeclampsia severity and antihypertensive patterns were explored descriptively. Most patients were aged >35 years (50%), in the third trimester of pregnancy (94.2%), and diagnosed with mild preeclampsia (80.8%). In mild preeclampsia, nifedipine monotherapy was the most frequently prescribed antihypertensive (92.9%; 95% CI: approximately 80-99%). In severe preeclampsia, nifedipine monotherapy was used in 50% of cases (95% CI: approximately 19-81%), whereas nifedipine-methyldopa combination therapy accounted for 40% (95% CI: approximately 13-74%). Evaluation of antihypertensive use showed 100% appropriateness for indication, drug selection, dose, and patient suitability, indicating entirely rational use in accordance with guidelines. Antihypertensive prescribing patterns for preeclampsia in this hospital largely adhered to clinical guidelines, with nifedipine as the mainstay therapy for both mild and severe cases. These findings support the effectiveness of guideline-based pharmacotherapy for the management of preeclampsia and highlight the need for further multicenter studies to evaluate clinical outcomes and long-term maternal-fetal safety.. Keywords: Preeclampsia, Antihypertensive Agents, Nifedipine, Drug Utilization, Pregnancy, Guideline Adherence.

The Effectiveness of Rosella Tea on Lipid Profile and Blood Pressure in Hypertensive Patients with Comorbidities Hertina Silaban; Angelina Cindy Wahyudi; Achnes Pangaribuan
Asian Journal of Healthcare Analytics Vol. 5 No. 1 (2026): May 2026
Publisher : PT FORMOSA CENDEKIA GLOBAL

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55927/ajha.v5i1.16523

This study contributes to public health knowledge by evaluating rosella tea as a complementary therapy for hypertensive patients with comorbidities. The process involved a systematic review and meta-analysis of 10 clinical trials published from 2015 to 2025, identified through PubMed, ScienceDirect, Google Scholar, and ResearchGate. The implementation method followed PRISMA guidelines and used RevMan 5.4 to assess Mean Differences. The study schedule focused on analyzing the latest literature up to the year 2025. Results indicate that rosella tea consumption does not significantly lower blood pressure or lipid profiles. Consequently, patients should prioritize standard pharmacological treatments until further standardized research is available.

Rationality of Prescription of Antibiotics in Patients with Acute Upper Respiratory Tract Infection Hertina Silaban; Welita Selyn Dami; Erica Gilda Misnawati Simanjuntak; Daniel Reinaldo Parsaoran Situmorang; Jimmi M. P. Aritonang
Indonesian Journal of Global Health Research Vol 7 No 3 (2025): Indonesian Journal of Global Health Research
Publisher : GLOBAL HEALTH SCIENCE GROUP

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37287/ijghr.v7i3.6520

Acute upper respiratory tract infection is an infectious disease caused by microorganisms, one of which is bacteria, so antibiotics are given. Rational use of antibiotics can provide benefits for recovery and does not cause harm that can cause problems or threats to the health of sufferers. Inappropriate administration of antibiotics can hurt patients, one of which is antibiotic resistance. Objective to obtain an overview of the rationality of antibiotic prescription in patients with acute upper respiratory tract infections at the Baun Health Center, Kupang Regency in 2020. This study was conducted using non-experimental research that is descriptive by taking medical record data retrospectively. Sampling was carried out using the non-probability sampling technique and the purposive sampling type, namely determining the sample based on certain considerations where the sample must meet the inclusion criteria, the number of cases of acute upper respiratory tract infections in 2020 was 226 cases. Data collection using secondary data, namely data obtained from medical records of patients with acute upper respiratory tract infections in 2020 at the Baun Health Center, Kupang Regency. The data obtained will be analyzed descriptively quantitatively, including: the percentage of rational and irrational antibiotic prescriptions, the frequency of types of antibiotics used. Acute upper respiratory tract infections (URTIs) in Baun Health Center mostly occurred in the 20–44 years age group (32.7%) and were more often experienced by women (59.3%), with the most common diagnosis being rhinosinusitis (48.2%); The most commonly used antibiotic was amoxicillin monotherapy, given to 89.4% of patients; The use of antibiotics showed 100% accuracy of indication and patient, 90.3% accuracy of drug, 65% accuracy of dose, and 55.3% rationality of use. Most in the 20–44 years age group (28.3%) and women (39.3%). Acute upper respiratory tract infections (URTIs) at the Baun Health Center, Kupang Regency, occurred most in the 20–44 years age group and were more often experienced by women, with rhinosinusitis as the most common diagnosis. Antibiotic use was dominated by amoxicillin monotherapy. Evaluation of the appropriateness of antibiotic use showed quite good results in terms of indications, patient selection, and type of drug, but there were still shortcomings in the appropriateness of dosage and overall rationality of use. The rationality of treatment was most often found in the 20–44 years age group and in female patients.

The Calm Before the Storm: Wellens Syndrome Revisited Nolly O. H Rantung; Nurul Azria; Jeremy P. D. Suling; Hertina Silaban
Indonesian Journal of Global Health Research Vol 7 No 5 (2025): Indonesian Journal of Global Health Research
Publisher : GLOBAL HEALTH SCIENCE GROUP

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37287/ijghr.v7i5.6908

Wellens syndrome is a characteristic electrocardiographic pattern indicating a critical stenosis of the left anterior descending (LAD) coronary artery and is a warning sign for an impending anterior myocardial infarction. Early recognition is crucial, as this pattern typically appears when the patient is pain-free and cardiac biomarkers are standard, which can potentially mislead clinicians. This case report aims to highlight the importance of recognizing the pattern of Wellens Syndrome through the clinical description of patient Mr. A, a 61-year-old male with hypertension and chronic kidney disease who presented with chest pain that has subsided. We present a 61-year-old Melanesian man with a history of hypertension and stage 3 chronic kidney disease, who had recent anginal chest pain that resolved upon evaluation. On examination, blood pressure was 154/80 mmHg, heart rate 78/min, respiratory rate 20/min, temperature 36.7°C, oxygen saturation 99% on room air, and minimal pitting oedema in both legs. The ECG obtained showed biphasic T waves in leads V2–V4 with the patient feels no chest pain at all, consistent with a type A Wellens pattern. Troponin T was negative (< 40 ng/L), and no ST elevation or pathologic Q waves were observed. Chest X-ray showed cardiomegaly. Coronary angiography revealed a critical stenosis in the proximal LAD. The patient underwent percutaneous coronary intervention with stent placement to the proximal LAD. Wellens syndrome represents a “pre-infarction” state that should be identified to prompt urgent revascularization before extensive myocardial infarction occurs. This case underscores the importance of recognizing Wellens syndrome as “the calm before the storm” and avoiding conservative management that could lead to adverse outcomes.

Bioactivity of Breadfruit Leaf Extract (Artocarpus Altilis) Fri Rahmawati; Hertina Silaban; Claudia Zenith Azriza
Indonesian Journal of Global Health Research Vol. 7 No. 6 (2025): Indonesian Journal of Global Health Research
Publisher : GLOBAL HEALTH SCIENCE GROUP

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37287/ijghr.v7i6.513

Breadfruit leaves (Artocarpus altilis) contain various secondary metabolites such as flavonoids, tannins, terpenoids, and alkaloids which are potential bioactive compounds for therapeutic purposes. This study is an experimental laboratory research aimed at identifying bioactive compound groups and evaluating the antibacterial and antioxidant activities of breadfruit leaf extract. Extraction was carried out using the maceration method with 96% ethanol p.a as solvent. Identification of bioactive compounds was analyzed by Gas Chromatography Mass Spectrometry (GC-MS) method, antibacterial testing by the disc diffusion method, and antioxidant evaluation using a modified Ferric Reducing Antioxidant Power (FRAP) assay. The test bacteria used were Klebsiella pneumoniae and Staphylococcus aureus, gentamicin and chloramphenicol as positive controls. Ascorbic acid was used as the positive control for the antioxidant assay. The GC-MS analysis revealed the presence of active compounds such as Tricyclo [4.3.0.0(7,9)] nonane, trans-11-tetradecenyl acetate, ethyl tridecanoate, α-farnesol isomer, vitamin E, and β-sitosterol. The extract showed antibacterial activity against both tested bacteria, with the smallest effective concentrations of 50 mg/mL for K. pneumoniae and 25 mg/mL for S. aureus, resulting in inhibition zones of 0.3125 mm and 1.5375 mm, respectively, although these values did not meet the sensitivity criteria. The antioxidant activity test showed a potential antioxidant value of 9.84 mg AAE/g extract, using ascorbic acid as the standard curve.

Evaluasi Cakupan Imunisasi Dasia Berdasarkan Data Program Rutin Sebelum dan Pascapandemi COVID-19 Fransiska Sitompul; Mairani Sakinah; Hertina Silaban; Linggom Kurniaty
Nursing Care and Health Technology Journal (NCHAT) Vol. 7 No. 1 (2027): Nursing and Health Care Technology-January to June Period
Publisher : Progres Ilmiah Kesehatan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.56742/nchat.v7i1.349

Imunisasi adalah upaya untuk meningkatkan kekebalan seseorang secara aktif terhadap suatu penyakit, sehingga suatu saat terpajan dengan penyakit tersebut tidak akan sakit atau hanya mengalami sakit ringan. Adanya Covid-19 secara global sejak ditetapkan sebagai Public Health Emergency of International Concern (PHEIC) pada 30 Januari 2020 dan sebagai pandemi pada 11 Maret 2020 oleh WHO, memberikan dampak pada pelaksanaan program kesehatan khususnya pelayanan imunisasi dan surveilans PD3I. Berdasarkan data dari GAVI, WHO dan UNICEF menyebutkan bahwa setidaknya 80 juta anak usia kurang dari 1 tahun memiliki risiko untuk menderita penyakit difteri, campak dan polio akibat terganggunya pelayanan imunisasi rutin di tengah pandemi Covid -19. Penelitian ini bertujuan mengevaluasi capaian program imunisasi dasar usia 0 – 24 bulan di Puskesmas Kecamatan Cakung (Periode Covid-19 tahun 2020 dan 2023). Desain penelitian yaitu desain repeated cross-sectional descriptive study dengan pendekatan survei observasional. Penelitian dilakukan di Puskesmas Kecamatan Cakung, Jakarta Timur dan lama penelitian dari Juli 2023 – Juni 2024. Teknik pengambilan sampel dilakukan dengan total sampling. Data diambil dari rekam medik dan sistem SiCantik. Data di analisis univariat, sebagai analisis deskriptif (Microsoft Excel) dengan menggunakan rumus cakupan imunisasi. Hasil penelitian menunjukkan capaian imunisasi dasar tahun 2020 tercapai sebanyak 9.1% dan tahun 2023 tidak tercapai sebanyak 7.4%; capaian imunisasi dasar lanjutan tahun 2020 tidak tercapai sebanyak 6% dan tahun 2023 tercapai sebanyak 8%.

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