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All Journal Current Biochemistry Pro-Life Majalah Kedokteran Jurnal ComunitA Servizio AJARCDE (Asian Journal of Applied Research for Community Development and Empowerment) International Journal of Health and Pharmaceutical (IJHP) Indonesian Journal of Advanced Research (IJAR) Indonesian Journal of Global Health Research
Fri Rahmawati
Universitas Kristen Indonesia
Agriculture, Biological Sciences & Forestry Humanities Biochemistry, Genetics & Molecular Biology Civil Engineering, Building, Construction & Architecture Computer Science & IT Decision Sciences, Operations Research & Management Earth & Planetary Sciences Education Energy Environmental Science Immunology & microbiology Languange, Linguistic, Communication & Media Library & Information Science Medicine & Pharmacology Nursing Public Health Social Sciences

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Antibacterial Activity and Phytochemical Analysis of Geranium homeanum Turez Leaves Fri Rahmawati; Maria Bintang; I Made Artika
Current Biochemistry Vol. 4 No. 3 (2017)
Publisher : IPB University

Show Abstract | Download Original | Original Source | Check in Google Scholar

Abstract

Geranium homeanum Turez is a herbaceous plant used as an empirical medicine. This research was carried out to test the antibacterial activity and determine minimum inhibition concentration (MIC) to Staphylococcus aureus and Pseudomonas aeruginosa with agar diffution method and phytochemical analysis of geranium leaves  by Harbone method. The young and old geranium leaves were blended then filtrated. The obtained filtrate was divided into two parts, one part heated by autoclave and the other was unheated. Each filtrate was tested against to Staphylococcus aureus and Pseudomonas aeruginosa. Geranium leaves filtrate having the highest antibacterial activity was heated at 500C until it  become dry powder.  The powder was used to measure MIC and phytochemical analysis.The results showed that the antibacterial activity of young leaves filtrate was higher than the old leaves filtrat, and the unheated leaves filtrate was higher than heated filtrate one. MIC of S. aureus and P. aeruginosa, were as follows 15 mg/ml and 20 mg/mL respectively. The antibacterial activity of powder geranium’s leaves  filtrate was weaker than 100 µg/mL ampicilline. Phytochemical analysis of geranium leaves showed positive contents of alkaloid and triterpenoid.
Uji Toksisitas dan Fitokimia Jamu Pelancar Menstruasi Berbahan Dasar Jahe (Zingiberis rhizome) Fri Rahmawati; Ignatia Hulukiti
Majalah Kedokteran UKI Vol. 32 No. 3 (2016): JULI-SEPTEMBER
Publisher : Fakultas Kedokteran Universitas Kristen Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33541/mkvol34iss2pp60

Abstract

Abstrak Jamu merupakan salah satu obat tradisional asli Indonesia yang telah digunakan secara turun-temurun. Salah satu contoh jamu yang banyak digunakan dan beredar di masyarakat adalah jamu pelancar mentruasi. Tujuan penelitian ini adalah untuk mengetahui nilai toksisitas jamu pelancar mentruasi yang berbahan dasar rimpang jahe dengan menggunan metode brine shrimp lethality test (BSLT) dan melakukan analisis fitokimia dengan metode Harbone. Uji toksisitas terhadap larva udang Artemia salina Leach dilakukan dengan tiga konsentrasi, yaitu 2.000 ppm, 4.000 ppm dan 6.000 ppm. Hasil penelitian menunjukkan semua konsentrasi jamu pelancar mentruasi memiliki daya bunuh terhadap larva udang. Nilai Lethal Concentration 50% (LC50) jamu pelancar mentruasi berbahan dasar rimpang jahe terhadap larva udang Artemia salina Leach. sebesar 3.131 ppm. Jamu pelancar mentruasi tersebut mengandung senyawa metabolit sekunder seperti alkaloid, flavonoid, fenol, saponin, steroid dan triterpenoid Kata Kunci: jamu, analisis fitokimia, LC50 Abstract “Jamu” is Indonesia’s traditional medicine which has been used for generations. One of the widely used and sold jamu in Indonesia is indicated for normalizing menstruation. The aim of this study was to know the lethal concentration 50% value (LC50) and to screen phytochemical compounds of jamu for normalizing menstruation which rich of of ginger (Zingiberis rhizome). The toxicity test was done using the brine shrimp lethality test (BSLT) and phytochemical compounds were screened using the Harbone methods. The toxicity test for larvae Artemia salina Leach was done at three concentration levels: 2,000 ppm; 4,000 ppm; and 6,000 ppm. The results of the BSLT showed that all concentration levels exhibited the activity of Artemia salina Leach, with a LC50 value of 3,131 ppm. Phytochemical screening revealed the presence of alkaloids, flavonoids phenol, saponins, steroids and triterpenoid in jamu for normalizing menstruation. Keywords: jamu, phytochemical analysis, LC50,
Analisis Fitokimia dan Uji Antibakteri Ekstrak Bonggol Pisang Kepok (Musa acuminata × balbisiana) Fri Rahmawati; Ivena S. Yanitara; Rima Yanie; Lucia S. Sunarti
Majalah Kedokteran UKI Vol. 34 No. 4 (2018): OKTOBER-DESEMBER
Publisher : Fakultas Kedokteran Universitas Kristen Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33541/mkvol34iss2pp60

Abstract

Abstrak Bonggol pisang kepok (Musa acuminata × balbisiana) merupakan salah satu bagian tanaman pisang yang jarang dimanfaatkan, sehingga sering menjadi limbah lingkungan. Penelitian yang dilakukan bertujuan untuk mengetahui kandungan fitokimia bonggol pisang kepok dengan metode Harbone dan menguji aktivitas antibakteri bonggol pisang kepok terhadap Staphylococcus aureus dan Escherichia coli dengan metode difusi agar. Bonggol pisang kepok diekstraksi dengan metode maserasi menggunakan pelarut akuades, etanol 70% dan etanol 90%. Hasil penelitian menunjukkan bahwa semua ekstrak bonggol pisang (akuades, etanol 70%, dan etanol 90%) mengandung flavonoid, saponin, tanin dan steroid. Uji antibakteri menunjukkan bahwa ekstrak etanol 90% bonggol pisang kepok memiliki aktivitas antibakteri terbesar pada Staphylococcus aureus dan Escherichia coli dengan diameter zona hambat masing-masing sebesar 9.33 mm dan 6.67 mm. Kata kunci: Antibakteri, bonggol pisang, fitokimia Abstract The corm of Pisang kepok (Musa acuminata × balbisiana ) is part of banana plants which have not being used very often, rather they have been constantly made into waste. This research was carried out using phytochemical analysis by Harbone method and antibacterial test of pisang kepok corms on Staphylococcus aureus and Escherichia coli with agar diffution method. Samples of pisang kepok corms were macerated either with aquadest, 70% ethanol and 90% ethanol. The results showed that phytochemical analysis of pisang kepok corms positively contained flavonoid, tannin, triterpenoid and steroid. The extracts of 90% ethanol had the highest antibacterial activity against Staphylococcus aureus and Escherichia coli with diameter inhibition zone of 9.33 mm and 6.67 mm. Keywords: Antibacterial, banana corm, phytochemical
Aktivitas Antioksidan dan Toksisitas Ekstrak Kembang Kol (Brassica oleracea var. Botrytis) Fri Rahmawati; Antonio A. I. Tjiarwana; Maria Bintang
Majalah Kedokteran UKI Vol. 35 No. 2 (2019): APRIL - JUNI
Publisher : Fakultas Kedokteran Universitas Kristen Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33541/mkvol34iss2pp60

Abstract

Abstrak Antioksidan merupakan senyawa yang mampu menghambat reaksi radikal bebas di dalam tubuh. Penelitian yang dilakukan bertujuan untuk menentukan aktivitas antioksidan dengan metode DPPH (2,2-diphenyl-1-pikril hidrazil) dan uji toksisitas dengan metode BSLT (Brine Shrimp Lethality Test) terhadap ekstrak kembang kol (Brassica oleracea var. Botrytis). Ekstrak kembang kol dibuat dengan metode maserasi menggunakan etanol 70% sebagai pelarut. Hasil penelitian menunjukkan bahwa nilai IC50 ekstrak etanol kembang kol sebesar 292.26 ppm dan nilai LC50 sebesar 677.95 ppm. Kata Kunci: kembang kol, Antioksidan, toksisitas Abstract Antioxidants are compounds that can inhibit the reaction of free radicals in the human body. This study aims to determine the antioxidant activity with DPPH (2,2-diphenyl-1-pikril hidrazil) method and toxicity test by the BSLT (Brine Shrimp Lethality Test) method of cauliflower extract (Brassica oleracea var. Botrytis). Cauliflower extract was made using maceration extraction method with 70% ethanol as solvent. The results showed that the IC50 and value of cauliflower ethanol extract was 292.26 ppm and LC50 677.95 ppm. Keywords: cauliflower, Antioxidant, toxicity
Potensi Antijamur Ekstrak Andaliman (Zanthoxylum acanthopodium) terhadap Candida albicans Fri Rahmawati; John Jackson Yang; Irene Rumiris Bavelina
Jurnal Pro-Life Vol. 9 No. 3 (2022): November
Publisher : Program Studi Pendidikan Biologi Fakultas Keguruan dan Ilmu Pendidikan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33541/jpvol6Iss2pp102

Abstract

Andaliman (Zanthoxylum acanthopodium DC) is a plant that grows and is widely used in Sumatra, especially by the Batak tribe (North Sumatra). Andaliman is empirically used for the treatment of diarrhea, toothache, and is a natural food preservative. Resistance increase of antifungal drugs to Candida albicans, so research is needed to find new ingredients that are effective as antifungals. The use of traditional medicines derived from plants can be an alternative for the community as an antifungal. The aim of the research was to determine the class of active compounds and the potential of andaliman fruit extract to inhibit the growth of C. albicans. The extraction process uses the maceration method with 70% ethanol and aquadest as a solvent. The antifungal activity test method used was the disc diffusion method and the phytochemical test using the Harborne method. The concentration of andaliman extract used was 50%, 40%, 30%, 20% and 10%, positive control was fluconazole and negative control was distilled water. The results showed that the andaliman extract was able to inhibit the growth of C. albicans with the lowest concentration of 10%. Andaliman extract (ethanol and aquadest) contains active compounds in the form of flavonoids, tannins, saponins, and steroids.
Penyuluhan Pencegahan Stunting dan Pengukuran Antropometri di Posyandu Cempaka RW “A” Kelurahan Kemirimuka, Kecamatan Beji, Depok-Jawa Barat Fri Rahmawati; Maria Bintang; Albert Jackson Yang; Elferida Sormin
JURNAL Comunità Servizio : Jurnal Terkait Kegiatan Pengabdian kepada Masyarakat, terkhusus bidang Teknologi, Kewirausahaan dan Sosial Kemasyarakatan Vol. 5 No. 2 (2023): OKTOBER
Publisher : Lembaga Penelitian dan Pengabdian kepada Masyarakat (LPPM), Univesitas Kristen Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33541/cs.v5i2.4936

Abstract

Malnutrition is still a major problem in infants and children globally. Data from the World Health Organization (WHO) for 2020 shows that the prevalence of stunting globally is in the high category because it is between 20% - 30%. Indonesia is the sixth country in the South-East Asia region with 36,4% of stunting cases. Incidence of stunting occurs due to chronic malnutrition in children after birth. Malnutrition can occur as a result of a child after birth getting insufficient food or breast milk for growth. Therefore it is necessary to do various ways to prevent the incidence of stunting in the community, one of the efforts is through counseling to prevent stunting by using herbal ingredients to increase breast milk and monitoring the nutritional status of toddlers through anthropometric measurements. Community service activities carried out included counseling on stunting prevention and anthropometric measurements at Posyandu Cempaka RW “A”, Kemirimuka Village, Beji District, Depok City, JABAR. Based on the results of anthropometric measurements, based on weight and height, it is known that most of the respondents who came to Community servicetivities were normally and excess nutritious, but there were respondents who were stunted.
Education on the Importance of Breast Milk and Complementary Foods for Breast Milk (MPASI) as an Effort to Prevent Stunting Louisa Ariantje Langi; Fri Rahmawati; Ida Bagus Eka Utama Wija; Ganda Pariama; Nia Reviani
AJARCDE (Asian Journal of Applied Research for Community Development and Empowerment) Vol. 8 No. 1 (2024)
Publisher : Asia Pacific Network for Sustainable Agriculture, Food and Energy (SAFE-Network)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29165/ajarcde.v8i1.378

Abstract

Stunting is a form of growth failure (growth faltering) due to the accumulation of nutritional deficiencies that last for a long time starting from pregnancy until the age of 24 months. Optimal nutritional intake for newborns by providing exclusive breast milk as the main food until the age of 6 months and then continuing until the age of 2 years accompanied by appropriate and high-quality complementary foods will prevent stunting in toddlers. One important effort to prevent stunting is by empowering the community, especially parents, to pay attention to the intake of breast milk and complementary foods for their babies. By providing knowledge to the public about the importance of correct breastfeeding and MPASI, it is hoped that the public can change their behavior to prioritize exclusive breastfeeding and correct MPASI. This community service method uses an educational approach through outreach with a total of 139 participants who live in five villages in Jatigede District, Sumedang Regency, West Java. Socialization involving experts gave results that there was an increase in participants' knowledge as measured using pre-test and post-test instruments. The percentage of participants who experienced an increase in knowledge from 139 participants, the results obtained were 118 participants (85%) experienced an increase in knowledge about breast milk and complementary foods, and 19 people (14%) had the same knowledge before and after socialization while 2 people (1%) gained The score decreased during the post-test due to several factors, including some participants who did not have time to complete the post-test questionnaire due to having to do other work
The Relationship Between Random Blood Glucose Levels and The Incidence of Diabetic Foot Ulcers Nur Nunu Prihantini; Fri Rahmawati; Zefeilyne Angelita Permata Sitorus; John Jackson Yang; Frisca Angreni
International Journal of Health and Pharmaceutical (IJHP) Vol. 6 No. 2 (2026): May 2026
Publisher : CV. Inara

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.51601/ijhp.v6i2.615

Abstract

Diabetes mellitus is a global health challenge characterized by an ever-increasing number of cases annually. The most feared chronic complication of diabetes mellitus is diabetic foot ulcer (DFU), which significantly increases the risk of amputation and mortality rates. This study aims to analyze the relationship between random blood sugar (RBS) levels and the incidence of DFU in type 2 diabetes mellitus patients at Paragon Hospital, Citeureup 2026. The research method used is an analytical observational design with a cross-sectional approach. A total of 54 subjects meet the inclusion criteria out of 109 type 2 diabetes mellitus patients. Medical record data were statistically analyzed using the Chi-Square test. The results indicated that DFU patients were predominantly male (53.7%) and belonged to the 46-55 age group (38.9%). Clinical findings showed that the majority of research subjects (88.9%) had high random blood sugar levels (≥ 200 mg/dL). Statistical test results yielded a p-value of 0.000 (p < 0.05), indicating a significant relationship between high RBS levels and the incidence of DFU. Based on the result the concluded that uncontrolled RBS levels are a primary trigger for DFU. Chronic hyperglycemia triggers vascular and nerve damage, which inhibits the tissue healing process in the feet. Optimal control of RBS levels is essential as a preventive measure to avoid amputation complications in type 2 diabetes patients.
Potensi Antioksidan, Skrining, dan Identifikasi Metabolit Sekunder Ekstrak Beras Hitam (Oryza sativa L. Indica) Fri Rahmawati; Maria Bintang; Albert Jackson Yang; Ni Made Devi Damayanti
Pro-Life Vol. 11 No. 2 (2024): Juli
Publisher : Program Studi Pendidikan Biologi Fakultas Keguruan dan Ilmu Pendidikan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33541/pro-life.v11i2.5655

Abstract

Black rice (Oryza sativa L. indica) is a variety of pigmented rice that, apart from acting as a popular food ingredient, can also be used for health because it has active compounds that have the potential to act as antioxidants. The research carried out aimed to determine antioxidant potency, conduct secondary metabolite screening, and characterize the active compound content of black rice extract. It was macerated using a 96% pro-analysis (p.a.) ethanol solvent. Antioxidant potency was tested using the 2,2-diphenyl-1-picrylhydrazyl (DPPH) and ferric reducing antioxidant power (FRAP) methods, secondary metabolite screening using the Harbone method, and identification of active compounds using Gas Chromatography-Mass Spectrometry (GC-MS). It was found that black rice extract has potential as an antioxidant, using the DPPH method, the 50% Inhibition Concentration (IC50) value of black rice extract and vitamin C was 97.34 ppm and 2.64 ppm, respectively, but using the FRAP method, the IC50 values of black rice extract and vitamin C were 181.83 ppm and 7.84 ppm, respectively. Secondary metabolite screening detected that in black rice extract there were active compounds in the flavonoid and steroid groups, GC-MS identification results showed that the extract contained the most compound, hexadecanoic acid.
Potensi Antioksidan Rumput Kebar (Biophytum Umbraculum) dengan Metode 2.2-Diphenyl-1-Picrylhydrazyl (DPPH) dan Ferric Reducing Antioxidant Power (FRAP) Fri Rahmawati; Maria Bintang; Albert Jackson Yang; Hazella Ishera Talakua
Pro-Life Vol. 12 No. 1 (2025): Maret
Publisher : Program Studi Pendidikan Biologi Fakultas Keguruan dan Ilmu Pendidikan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33541/pro-life.v12i1.6319

Abstract

Oxidative stress is one of the causes of heart disease, atherosclerosis, and cancer. Efforts to overcome oxidative stress include the use of natural antioxidants. Flavonoids and phenolics are secondary metabolite compounds in plants that have antioxidant activity. Plants that are believed to be able to overcome oxidative stress include Kebar grass. Kebar grass (Biophytum umbraculum) is one of the plants that empirically has many benefits including as a female fertility drug by the Kebar-Papua community. The study aimed to determine the antioxidant potential and total phenolic and flavonoid content of Kebar grass extract. Kebar grass extract was obtained through maceration extraction with 96% pro-analysis (p.a) ethanol solvent. Antioxidant testing used the 2.2-diphenyll-1-picrylhydrazyl (DPPH) and ferric reducing antioxidant power (FRAP) methods using antioxidant standards, namely ascorbic acid (vitamin C) and gallic acid, while measuring total phenolic and flavonoid levels used the Folin-Ciocalteu and aluminium chloride methods, respectively. The results showed that the total phenolic and flavonoid levels of Kebar grass extract were 52.26 ± 3.94 mg GAE/g dw (dry weight) and 22.15 ± 2.79 mg QE/g dw Kebar grass extract, respectively, while the antioxidants of Kebar grass extract with the DPPH method had an inhibition concentration 50 (IC50) value of 183.44 ppm and a vitamin C standard of 4.46 ppm, and antioxidant testing using the FRAP method obtained a reducing power 50 (RP50) value of Kebar grass extract of 5043.76 ppm with a gallic acid standard value of 101.8 ppm.
Co-Authors Albert Jackson Yang Antonio A. I. Tjiarwana Claudia Zenith Azriza Elferida Sormin Frisca Angreni Ganda Pariama Hazella Ishera Talakua Hertina Silaban I MADE ARTIKA Ignatia Hulukiti Irene Rumiris Bavelina Ivena S. Yanitara John Jackson Yang Louisa Ariantje Langi Lucia S. Sunarti MARIA BINTANG Maria Bintang Maria Bintang Maria Bintang Ni Made Devi Damayanti Nia Reviani Nur Nunu Prihantini Putu Athalia Vidya Nariswari Rima Yanie Romauli Lumbantobing Wija, Ida Bagus Eka Utama Zefeilyne Angelita Permata Sitorus