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All Journal Jurnal Anestesi Perioperatif Molucca Medica
Tuahuns, Achmad
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Biochemistry, Genetics & Molecular Biology Education Health Professions Immunology & microbiology Medicine & Pharmacology Neuroscience Nursing Public Health

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HUBUNGAN EKSPRESI RESEPTOR ESTROGEN DENGAN DERAJAT HISTOPATOLOGI PADA PASIEN KANKER PAYUDARA DI KOTA AMBON Tipaheuw, Desmiranty Annysa; Rahawarin, Halidah; Tuahuns, Achmad
Molucca Medica Vol 18 No 1 (2025): VOLUME 18, NOMOR 1, APRIL 2025
Publisher : Pattimura University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30598/molmed.2025.v18.i1.83

Abstract

Kanker payudara merupakan keganasan yang umumnya berasal dari sel epitel duktus dan berkembang menjadi karsinoma duktal invasif. Data World Health Organization (WHO) 2022 menyebutkan angka kematian sebanyak 670.000 kasus dari total 2,3 juta perempuan dengan kanker payudara. Modalitas diagnostik untuk menegakkan diagnosis kanker payudara menggunakan metode pemeriksaan histopatologi. Selain itu, terdapat pemeriksaan imunohistokimia untuk menentukan subtipe molecular, prognosis dan terapinya. Ekspresi reseptor estrogen pada kanker payudara merupakan salah satu penanda untuk menentukan subtipe molekular yang berhubungan dengan terapi dan prognosis kanker payudara. Penelitian ini bertujuan untuk untuk mengetahui hubungan ekspresi reseptor estrogen dengan derajat histopatologi pada pasien kanker payudara di Kota Ambon. Penelitian analitik kuantitatif ini menggunakan data sekunder dengan pendekatan cross-sectional. Hasil penelitian menunjukkan hasil tertinggi reseptor estrogen positif 23 orang (62,2%) dan derajat II yaitu 23 orang (62,2%). Hasil uji chi-square didapatkan nilai p = 0,372 menunjukkan tidak terdapat hubungan yang signifikan antara ekspresi reseptor estrogen dengan derajat histopatologi pada pasien kanker payudara di Kota Ambon.
Efek Analgesia Pemberian Lidokain 2,64% Teralkalinisasi dalam Alkohol 70% Secara Topikal Sebelum Flebotomi Huka, Joel Apriyanto Fejacreyo; Angkejaya, Ony Wibriyono; Tuahuns, Achmad; Devi, Cokorda Istri Arintha; Hataul, Is Ikhsan; Lilihata, Jilientasia
Jurnal Anestesi Perioperatif Vol 13, No 3 (2025)
Publisher : Faculty of Medicine, Universitas Padjadjaran

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.15851/jap.v13n3.4054

Abstract

Background: Phlebotomy is an essential procedure in healthcare, but it often causes pain due to its invasive nature. Although lidocaine is effective as a local anesthetic, the injectable formulation and low pH may induce pain before the anesthetic effect begins. Therefore, alkalinized lidocaine administered topically is considered a potential alternative to reduce pain and accelerate anesthetic onset. This study is essential to evaluate the effectiveness of this approach. This research aimed to assess the effect of 2.64% alkalinized lidocaine in 70% alcohol, applied topically, on phlebotomy pain levels, measured using the Numeric Rating Scale (NRS).Methods: This study employed a single-masked randomized controlled trial (RCT) with a posttest-only control group design. Samples were obtained via simple random sampling, yielding 20 paired samples from 135 eligible participants. On the first day, participants underwent phlebotomy after the application of alkalinized lidocaine, and on the tenth day, phlebotomy was repeated using 70% alcohol as the control. Pain was measured using the NRS and analyzed using the Wilcoxon test.Results: NRS scores in the control group were significantly higher than those in the experimental group, with a p-value of 0.001.Discussion: Alkalinized lidocaine effectively reduced phlebotomy pain, likely due to an increased non-ionic fraction that enhances tissue penetration and accelerates anesthetic onset. These findings align with existing literature, although generalization remains limited by the small sample size and single-masked design.Conclusion: Topically applied 2.64% alkalinized lidocaine in 70% alcohol is effective in reducing pain associated with phlebotomy.
Co-Authors Angkejaya, Ony Wibriyono Devi, Cokorda Istri Arintha Hataul, Is Ikhsan Huka, Joel Apriyanto Fejacreyo Lilihata, Jilientasia Rahawarin, Halidah Tipaheuw, Desmiranty Annysa