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All Journal Parapemikir Jurnal Ilmiah Farmasi Jurnal Kesehatan Bakti Tunas Husada
Kartono, Teguh Hary
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Chemistry Health Professions Immunology & microbiology Medicine & Pharmacology Nursing Physics Public Health

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FORMULASI TABLET EKSTRAK ETANOL DAUN SALAM (SYZYGIUM POLYANTHUM) DENGAN VARIASI AVICEL PH 101 DAN AMPROTAB SEBAGAI BAHAN PENGERING Serahli, Ubun Fadli; Kartono, Teguh Hary; Prayogi, Syaiful; L, Nur Afni
Parapemikir : Jurnal Ilmiah Farmasi Vol 13, No 1 (2024): Parapemikir : Jurnal Ilmiah Farmasi
Publisher : Pusat Penelitian dan Pengabdian Masyarakat Politeknik Harapan Bersama

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30591/pjif.v13i1.6199

Abstract

Penggunaan tanaman sebagai obat trasdisional pembuatan dan bentuk sediaanya masih sederhana, sehingga kurang diminati karena kurang praktis. Pengolahan suatu tanaman obat menjadi bentuk sediaan yang mudah digunakan sangat perlu untuk dilakukan, Daun salam (Syzygium polyanthum) merupakan rempah-rempahan dan sudah digunakan secara turun temurun untuk pengobatan, seperti untuk pengobatan kolesterol tinggi, kencing manis (diabetes mellitus), tekanan darah tinggi (hipertensi), sakit maag (gastritis), diare, dan asam urat. Ekstrak daun salam dapat diformulasikan menjadi bentuk sediaan tablet. Tujuan riset ini untuk memeperoleh formula optimal tablet ekstrak etanol daun salam dengan avicel PH 101 dan amprotab sebagai pengering. Metode SLD di terapkan dalam penentuan formula dengan bantuan aplikasi Design Expert. Tablet berhasil diformulasikan dengan kombinasi optimum avicel pH 101 - amprotab pada komposisi 114,77 dan 5,23 mg.
POTENSI SENYAWA ANTI INFLAMASI DARI DAUN SIRSAK (Annona muricata L.) PADA ENZIM COX-2 SECARA IN SILICO Prayogi, Syaiful; Kartono, Teguh Hary; Maulana, Luthfi Hidayat; Saldi, Miftahul; Amelia, Yulita
Jurnal Kesehatan Bakti Tunas Husada: Jurnal Ilmu-ilmu Keperawatan, Analis Kesehatan dan Farmasi Vol 26 No 1 (2026)
Publisher : LPPM Universitas Bakti Tunas Husada

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36465/jkbth.v26i1.1548

Abstract

Inflammation is still a major cause of death in the world, especially in tropical regions (including Indonesia). The use of non-steroidal anti-inflammatory drugs (NSAIDs) has many side effects and is even toxic. Efforts to find drugs with low toxic effects require long stages and high costs. This effort can be accelerated with a computational approach in the early stages of drug development through the CADD technique by minimizing the risk of failure in later stages. The protein that plays a role in delaying inflammation is the cyclooxygenase (COX) enzyme. Inhibition of COX-2 has much lower side effects than inhibition of COX-1. COX-2 is induced by inflammatory stimuli expressed in synovial cells, leukocytes, fibroblasts, and macrophages, therefore becoming one of the target proteins in inflammation. Natural compounds of the phenolic, flavonoid, and alkaloid groups have been reported to have potential as anti-inflammatories. Soursop leaves are known to be rich in flavonoids. The empirical efficacy of soursop leaves (Annona muricata L.) has been known by the Indonesian people in the treatment of rheumatism or rheumatoid arthritis, anti-inflammatory, antipyretic, and analgesic. This study was conducted in silico with a molecular docking approach using iGemDock v2.1 software. The binding between ligand-target (COX enzyme) was evaluated using Discovery Studio Visualizer. The results showed that all test compounds inhibited COX-2, the isohamnetin 3 robinobioside compound has the potential to be a selective inhibitor of COX-2 when compared to other test compounds and with a reference drug (ibuprofen).
Co-Authors Amelia, Yulita L, Nur Afni Maulana, Luthfi Hidayat Prayogi, Syaiful Saldi, Miftahul Serahli, Ubun Fadli