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All Journal Journal of Islamic Pharmacy Medfarm: Jurnal Farmasi dan Kesehatan Journal of Electronic and Electrical Power Application Parapemikir Jurnal Ilmiah Farmasi
Prayogi, Syaiful
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Biochemistry, Genetics & Molecular Biology Chemistry Control & Systems Engineering Electrical & Electronics Engineering Energy Engineering Health Professions Immunology & microbiology Materials Science & Nanotechnology Medicine & Pharmacology Physics Public Health

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FORMULASI TABLET EKSTRAK ETANOL DAUN SALAM (SYZYGIUM POLYANTHUM) DENGAN VARIASI AVICEL PH 101 DAN AMPROTAB SEBAGAI BAHAN PENGERING Serahli, Ubun Fadli; Kartono, Teguh Hary; Prayogi, Syaiful; L, Nur Afni
Parapemikir : Jurnal Ilmiah Farmasi Vol 13, No 1 (2024): Parapemikir : Jurnal Ilmiah Farmasi
Publisher : Pusat Penelitian dan Pengabdian Masyarakat Politeknik Harapan Bersama

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30591/pjif.v13i1.6199

Abstract

Penggunaan tanaman sebagai obat trasdisional pembuatan dan bentuk sediaanya masih sederhana, sehingga kurang diminati karena kurang praktis. Pengolahan suatu tanaman obat menjadi bentuk sediaan yang mudah digunakan sangat perlu untuk dilakukan, Daun salam (Syzygium polyanthum) merupakan rempah-rempahan dan sudah digunakan secara turun temurun untuk pengobatan, seperti untuk pengobatan kolesterol tinggi, kencing manis (diabetes mellitus), tekanan darah tinggi (hipertensi), sakit maag (gastritis), diare, dan asam urat. Ekstrak daun salam dapat diformulasikan menjadi bentuk sediaan tablet. Tujuan riset ini untuk memeperoleh formula optimal tablet ekstrak etanol daun salam dengan avicel PH 101 dan amprotab sebagai pengering. Metode SLD di terapkan dalam penentuan formula dengan bantuan aplikasi Design Expert. Tablet berhasil diformulasikan dengan kombinasi optimum avicel pH 101 - amprotab pada komposisi 114,77 dan 5,23 mg.
KAJIAN SENYAWA FENOLIK PADA TANAMAN PISANG (MUSA SP.) DAN INTERAKSINYA TERHADAP COX-2: IN SILICO Rahman, Aulia; Mulyanto, Baedi; Salsabila, Assyifa Hanum; Prayogi, Syaiful; Maulana, Luthfi Hidayat
Parapemikir : Jurnal Ilmiah Farmasi Vol 13, No 1 (2024): Parapemikir : Jurnal Ilmiah Farmasi
Publisher : Pusat Penelitian dan Pengabdian Masyarakat Politeknik Harapan Bersama

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30591/pjif.v13i1.6195

Abstract

Siklooksigenase-2 (COX-2) merupakan enzim yang berperan dalam mekanisme terjadinya inflamasi. Obat inflamasi dengan target COX-2 kebanyakan kurang selektif sehingga sering menimbulkan efek samping. Perlu dilakukan upaya penemuan senyawa baru yang selektif terhadap COX-2 terutama dengan eksplorasi tanaman. Tanaman pisang (Musa sp.) dilaporkan banyak mengandung senyawa fenolik yang memiliki aktivitas biologis. Penelitian ini bertujuan untuk mengkaji konstituen fenolik dari tanaman pisang yang memiliki aktivitas penghambat selektif COX-2 secara in silico. Kristal protein enzim COX-2 (PDBID: 4PH9) digunakan sebagai target docking dan COX-1 (PDBID: 1EQG) digunakan sebagai pembanding selektivitas. Tahapan dalam penelitian meliputi pemodelan senyawa, preparasi protein target, validasi metode, dan visualisasi hasil. Senyawa kaempferol 3-O-rhamnoside-7-O-glucoside (1) menunjukan selektivitasnya terhadap enzim COX-2 dibuktikan dengan energi pengikatan terkecil terhadap COX-2 (-149,87 kkal/moL) dan memiliki energi pengikatan terbesar terhadap COX-1 (-115,89 kkal/moL).
Molecular Docking of Hygrophila auriculata (Schum.) Heine Compounds Targeting PBP2 Protein in Neisseria gonorrhoeae Salmasfattah, Novyananda; Prayogi, Syaiful; Prasetyawan, Fendy
Journal of Islamic Pharmacy Vol 10, No 1 (2025): J. Islamic Pharm.
Publisher : Universitas Islam Negeri Maulana Malik Ibrahim Malang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18860/jip.v10i1.31740

Abstract

Antibiotic resistance in gonorrhoea cases and patients is detrimental. Amidst the rising cases of gonorrhoea caused by Neisseria gonorrhoeae, Hygrophila auriculata (Schum.) Heine has activity as an antibiotic for the disease. The penicillin-binding protein 2 (PBP2) is a transpeptidase that catalyses the formation of cross-bridges on bacterial cell wall peptidoglycan, which will be the target of this plant. The purpose of molecular docking study is to see the binding affinity, compounds in Hygrophila auriculata (Schum.) Heine and ceftriaxone which is used as a comparison drug, will be targeted at PBP protein. Discovery studio visualizer v21.1.0.20298 was used for PBP2 protein preparation and visualisation. DoG Site Scorer was used to predict ligand binding sites on PBP2 proteins. PyRx 0.8 was used for virtual screening, validating of the docking method, and ligand preparation. Compounds in Hygrophila auriculata (Schum.) Heine as ligands were derived from MPDB 2.0 and the following PubChem codes; apigenin CID 5280443, luteolin CID 5280445, allagic acid CID 5281855, gallic acid CID 370, quercetin CID 5280343, lupeol CID 259846, lupenone CID 92158, betulin CID 72326, stigmasterol CID 5280794, and comparator drug ceftriaxone CID 447043. The binding affinity of ellagic acid -9,8 from Hygrophila auriculata (Schum.) Heine was lower than ceftriaxone -9,4 on the target PBP2 protein. Some of the amino acid residues that appear in protein-ligand docking include: ALA A:310, THR A:500 and 347, LYS A:313, and SER A:362. These amino acid residues owned by the PBP2 protein serve as the bonding bridge. Ellagic acid, the compound has potential as an antibiotic in gonorrhoea. Further testing and studies are needed to strengthen the evidence of the findings in this study
UJI AKTIVITAS ANTIOKSIDAN Syzygium polyanthum DAN Terminalia catappa L. SECARA IN VITRO DAN IN SILICO Maulana, Luthfi Hidayat; Prastyono, Rizki Noor; Prayogi, Syaiful; Murniningsih, Erni; Alfarikhi, M. Zidan
Parapemikir : Jurnal Ilmiah Farmasi Vol 12, No 3 (2023): Parapemikir : Jurnal Ilmiah Farmasi
Publisher : Pusat Penelitian dan Pengabdian Masyarakat Politeknik Harapan Bersama

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30591/pjif.v12i3.5163

Abstract

Reactive Oxygen Species (ROS) is a radical which is a by-product of metabolic processes. An imbalance between the number of free radicals and the amount of endogenous antioxidants can cause oxidative stress and cause problems for body cells that can cause various metabolic diseases or other degenerative diseases. Exogenous antioxidants can be chemical compounds resulting from synthesis or materials derived from nature that can inhibit the oxidation process. Phenol group compounds can be used as antioxidants. Salam plants (Syzygium polyanthum) and ketapang (Terminalia catappa L.) are rich in phenols. In vitro antioxidant testing using other methods such as DPPH (2,2-Diphenyl-1-Pikrylhidrazyl), in silico, molecular docking was carried out by targeting the heme oxygenase-1 (HO-1) protein to test antioxidant activity with analysis showing binding and strengthening evidence of impending chemical interactions. Based on in vitro testing, ketapang leaf extract has better antioxidant activity compared to bay leaf extract, with an IC50 value of 6.631 and the in silico results of the constituent compounds of ketapang leaves have the best docking value, namely compound 14 with a value of -88.18. Both of these test results reinforce each other
Computational Analysis of Biflavonoid Derivatives through Molecular Docking on ALK Kinase Receptor as Potential Inhibitors of A549 Cell Proliferation Rahayu, Feri Kanti; Cahyani, Arinda Nur; Prayogi, Syaiful; Anggraeni, Dossy Susan; Zahra, Putri Aulia; Ernanda, Azzahra Rhisma; Falupi, Indah Fajar; Rahma, Dila
MEDFARM: Jurnal Farmasi dan Kesehatan Vol 14 No 2 (2025): Medfarm: Jurnal Farmasi dan Kesehatan
Publisher : LPPM Akafarma Sunan Giri Ponorogo

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.48191/medfarm.v14i2.678

Abstract

Lung cancer remains one of the leading causes of cancer-related mortality worldwide. In Indonesia, it ranks third after cervical and breast cancers, with non-small-cell lung carcinoma (NSCLC) being the most prevalent type, accounting for 85–88% of cases. Anaplastic lymphoma kinase (ALK) is a key molecular target in NSCLC, contributing significantly to carcinogenesis. However, resistance to current ALK-targeted therapies poses a major challenge. To address this, new drug discovery efforts are urgently needed. While drug development is typically time-consuming and costly, Computer-Aided Drug Design (CADD) offers an efficient strategy at the early stages. Biflavonoid derivatives have shown anticancer potential but are limited by poor solubility and low activity, warranting further optimization. This study explores structural modifications of biflavonoid derivatives to identify potential ALK inhibitors. The results indicate that the modified compounds (Compounds A and B) demonstrated binding affinities comparable to the reference drug, Entrectinib, suggesting their promise as novel anticancer candidates.
Computational Investigation of α-Glucosidase Inhibition by Phytochemical Compounds from Muntingia calabura L. Leaves: Insights into Potential Antidiabetic Agents Prayogi, Syaiful; Rahman, Aulia; Mahbubah, Tsaiatul; Maisaan, Nabilla Defira Putri
MEDFARM: Jurnal Farmasi dan Kesehatan Vol 14 No 2 (2025): Medfarm: Jurnal Farmasi dan Kesehatan
Publisher : LPPM Akafarma Sunan Giri Ponorogo

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.48191/medfarm.v14i2.682

Abstract

Diabetes Mellitus (DM) is a degenerative disease that poses a major global health problem. It is characterized by increased blood glucose levels (hyperglycemia). Common therapeutic agents for DM include sulfonylureas, biguanides, and α-glucosidase inhibitors. However, the use of α-glucosidase inhibitors is often associated with several issues such as the presence of non-intestinal α-glucosidase in various body cells, gastrointestinal side effects (diarrhea, bloating, abdominal discomfort), and high IC₅₀ values indicating low potency and efficacy against the α-glucosidase enzyme. This study aims to explore the potential of flavonoid compounds from Muntingia calabura L. (kersen) leaves as α-glucosidase inhibitors through in silico analysis. The study was conducted using molecular docking to evaluate the binding affinity and interaction of flavonoid compounds with the α-glucosidase enzyme. The docking results showed that 8 ligands test exhibited strong binding affinities, inhibitors constants, and stable interactions with the active site of α-glucosidase, comparable to standard inhibitors (acarbose). The two most promising ligands as α-glucosidase inhibitors were identified as 20,40-Dihydroxy-30-methoxydihydrochalcone (50) and (-)-30-Methoxy-20,40,β-trihydroxydihydrochalcone (51), exhibiting binding affinities and inhibition constants of –7.33 kcal/mol; 4.27 μM and –7.30 kcal/mol; 4.45 μM, respectively, have promising potential as natural α-glucosidase inhibitors and may serve as lead compounds for the development of new antidiabetic agents. Their inhibitory potential was further supported by favorable ADMET parameters and compliance with Lipinski’s rule of five. Further in vitro and in vivo studies are needed to confirm these findings.
TECHNOLOGY READINESS LEVEL TEST OF INTEGRATED STEAM DISTILLATION AND DRYING SYSTEM (DRYSTILLA) BASED ON ELECTRONIC CONTROL Dien Hawa, Sarah; Noor Prasetyono, Rizki; Syauqi, Achmad; Prayogi, Syaiful
Journal of Electronic and Electrical Power Applications Vol. 5 No. 1 (2025): JEEPA Volume 5 Nomor 1
Publisher : Program Studi Teknik Elektro Universitas Peradaban

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.58436/jeepa.v5i1.2549

Abstract

Cardamom is a high-value spice commodity with significant potential as a raw material for essential oil production; however, its utilization at the village-farmer level remains dominated by the sale of raw materials due to limited postharvest technology. This study aims to experimentally evaluate the performance and Technology Readiness Level (TRL) of DryStilla, an integrated steam distillation and drying system specifically designed for small-scale, village-based cardamom processing. The research employs an engineering-based experimental method through field testing in a real operational environment at the Cardamom Berkarya Farmer Group in Karangkemiri Village. The evaluation focuses on technical performance, operational efficiency, essential oil yield, system stability, and initial economic impacts. The experimental results indicate that DryStilla reduces drying time from 2–3 days to 6–8 hours, increases essential oil yield by more than 50% (approximately 3.0–3.5%), and significantly reduces the loss of volatile compounds compared to conventional methods. The integrated drying and steam distillation system also improves energy efficiency, operational simplicity, and suitability for village-scale production. TRL assessment shows that DryStilla has achieved TRL levels 7–8, indicating that the system has been successfully demonstrated and operates stably in a real operational environment. These findings demonstrate that DryStilla has strong potential as an appropriate postharvest technology to support cardamom downstream processing, enhance product value, and strengthen the economic independence of rural farmers
Co-Authors Achmad Syauqi Alfarikhi, M. Zidan Anggraeni, Dossy Susan Arinda Nur Cahyani Aulia Rahman Dien Hawa, Sarah Ernanda, Azzahra Rhisma Falupi, Indah Fajar Fendy Prasetyawan Kartono, Teguh Hary L, Nur Afni Mahbubah, Tsaiatul Maisaan, Nabilla Defira Putri Maulana, Luthfi Hidayat Mulyanto, Baedi Murniningsih, Erni Noor Prasetyono, Rizki Prastyono, Rizki Noor Rahayu, Feri Kanti Rahma, Dila Salmasfattah, Novyananda Salsabila, Assyifa Hanum Serahli, Ubun Fadli Zahra, Putri Aulia