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All Journal Jurnal Ilmu Kefarmasian Indonesia Jurnal Mekar
Valencia, Regina
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Arts Humanities Biochemistry, Genetics & Molecular Biology Education Health Professions Medicine & Pharmacology Public Health

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Evaluation of the combination patch of betel leaf extract (Piper sp.) - ultrasonic assisted extraction as a transdermal delivery system on fibroblast cell formation and collagen density Valencia, Regina; Trinovita, Elsa; Shinta, Herlina Eka; Toemon, Angeline Novia; Ysrafil, Ysrafil
JURNAL ILMU KEFARMASIAN INDONESIA Vol 23 No 1 (2025): JIFI
Publisher : Faculty of Pharmacy, Universitas Pancasila

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35814/jifi.v23i2.1687

Abstract

The combination of red betel (Piper crocatum) and green betel (Piper betle L.) leaves is believed to act synergistically in enhancing wound healing. Transdermal patches offer advantages over conventional topical forms due to their sustained drug release, ease of application, and prolonged therapeutic effect. This study evaluated the histopathological effects of a combination patch containing betel leaf extracts for incision wound treatment in Wistar rats. The studies used an true experimental post-test-only control group design, five groups were tested: a blank patch (K−), a povidone-iodine patch (K+), and combination extract patches at concentrations of 7.5% (K1), 15% (K2), and 30% (K3), applied over 14 days with six animals per group. Patch characteristics were assessed through organoleptic tests, thickness, weight uniformity, folding endurance, and pH, while wound healing was evaluated through histological analysis of fibroblast cell counts and collagen density. Statistical analysis was conducted using the Kruskal-Wallis test followed by Mann-Whitney post-hoc tests. The 30% combination patch (K3) showed the most significant healing effect, with fibroblast counts exceeding 50 cells and dense collagen formation scoring +3. These results indicate that a transdermal patch combining Piper crocatum and Piper betle L. extracts effectively promotes wound healing by enhancing fibroblast proliferation and collagen synthesis.
PENGEMASAN PAKET WISATA CITY TOUR BERBASIS BUDAYA DI KOTA DENPASAR BALI Mulyana, Hadi; Nurhayati, Ainun; Meisya Auliyaa, Dwi; Ramdhani, Fauzi; Valencia, Regina
JURNAL MEKAR Vol. 4 No. 1 (2025): APRIL 2025
Publisher : Puslitabmas Batam Tourism Polytecnic

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.59193/jmr.v4i1.384

Abstract

Denpasar City has a lot of cultural tourism potential such as historical buildings, arts, traditional markets and community culture. Therefore, this potential can be developed into a city tour package in Denpasar. This study aims to determine the potential of cultural tourism in Denpasar and how to package culture-based city tour packages. This research uses data collection techniques such as observation, interviews and literature review. The results show that the main tourism potential in Denpasar is the charm of temples and shrines, traditional markets and museums. This potential is then packaged into four tour packages, namely Melali ke Puri, Heritage Denpasar City Tour, Beautiful Cultural of Denpasar City Tour, and Historic Denpasar City Tour. In the packaging of these tour packages, information is provided in the form of narratives, tables and graphs. In this way, culture-based city tour packages in Denpasar can attract tourists.
Co-Authors Angeline Novia Toemon, Angeline Novia Elsa Trinovita Meisya Auliyaa, Dwi Mulyana, Hadi Nurhayati, Ainun Ramdhani, Fauzi Ysrafil, Ysrafil