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All Journal Abdimas Galuh: Jurnal Pengabdian Kepada Masyarakat Proceeding ISETH (International Summit on Science, Technology, and Humanity)
Kurniawati, Yuwandira
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Agriculture, Biological Sciences & Forestry Computer Science & IT Economics, Econometrics & Finance Engineering Law, Crime, Criminology & Criminal Justice Medicine & Pharmacology Nursing Social Sciences Other

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Effectiveness of Ethanol Extract of Aegle Marmelos Fruit Flesh on Hela Cell Apoptosis Wulandari, Ervita Sri; Yunitama, Alifa Agil Dhillu; Futana, Ninda Pradani; Izzati, Shaula Nur; Wahyuni, Sri; Kurniawati, Yuwandira
Proceeding ISETH (International Summit on Science, Technology, and Humanity) 2024: Proceeding ISETH (International Summit on Science, Technology, and Humanity)
Publisher : Universitas Muhammadiyah Surakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.23917/iseth.5509

Abstract

Background: Maja plant (Aegle marmelos) or plant commonly known as mojo, is one of the plants that contains many secondary metabolites, one of which is flavonoids. Flavonoids can be used to induce apoptosis mechanisms in cancer cells, so that specific apoptosis mechanisms in cancer cells become more effective and toxicity to normal cells is minimized. Aim: This study aims to evaluate the effectiveness of ethanol extract of maja fruit flesh (Aegle marmelos) in inducing apoptosis of HeLa cells in cervical cancer. Methodology: The method used includes ethanol extraction from maja fruit flesh and treatment of HeLa cells with various concentrations of the extract. Identification of compound content in Aegle marmelos was carried out by phytochemical tests. Apoptosis measurements were carried out using the MTT Assay method and flow cytometry analysis. Results: The results showed that 96% ethanol extract of Aegle marmelos contained secondary metabolites in the form of alkaloids, saponins, tannins, and flavonoids. The IC50 value of the MTT Assay results of maja fruit flesh extract was 7,573 µg/mL, with an apoptosis percentage of 17.6% and had an effect on inhibiting the growth of HeLa cells in the S phase as measured using the flow cytometry method. Value: The flavonoid content in 96% ethanol extract of maja fruit flesh (Aegle marmelos) has an apoptotic effect on HeLa cells. This is evidenced by the IC50 value index of 7,573 µg/mL, an apoptosis percentage of 17.6%, and the presence of inhibition in the S phase in the cell cycle.
Peningkatan Kapasitas Produksi Jamu Instan KWT Sri Rejeki Melalui Penggunaan Mesin Peras Empon-Empon Nurwaini, Setyo; Wijayanti, Rita; Nugraheni, Ambar Yunita; Abid, Muhammad Maslakul; Wibowo, Farrel Maulana; Kurniawati, Yuwandira; Fachriani, Galuh; Maulana, Fahmi Alief; Mubarok, Afrizal; Baiti, Nurul; Aurum, Mursalina Nanda
Abdimas Galuh Vol 6, No 1 (2024): Maret 2024
Publisher : Universitas Galuh

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25157/ag.v6i1.13193

Abstract

Ibu-ibu Kelompok Wanita Tani (KWT) Sri Rejeki, Bendosari, Cabeyan, Sukoharjo telah membuat produk jamu (jahe, temulawak, dan kunyit asam) instan dan telah melakukan kegiatan penjualan produk. Penjualan produk dilakukan pada kegiatan-kegiatan insidental yang ada di kabupaten Sukoharjo. Tujuan kegiatan pengabdian ini untuk meningkatkan kapasitas produksi jamu instan yang diproduksi oleh ibu-ibu KWT. Metode yang digunakan adalah pelatihan pembuatan jamu instan dengan menggunakan alat peras empon-empon dalam salah satu prosesnya. Penggunaan mesin peras mengurangi waktu yang diperlukan untuk memeras empon-empon yang, sehingga dalam satu siklus pembuatan, jumlah produksi jamu instan meningkat. Pemasaran melalui akun media sosial juga dilakukan untuk produk jamu instan yang dibuat.
Co-Authors Abid, Muhammad Maslakul Ambar Yunita Nugraheni Aurum, Mursalina Nanda Baiti, Nurul Fachriani, Galuh Futana, Ninda Pradani Izzati, Shaula Nur Maulana, Fahmi Alief Mubarok, Afrizal Rita Wijayanti Setyo Nurwaini Sri Wahyuni Wibowo, Farrel Maulana Wulandari, Ervita Sri Yunitama, Alifa Agil Dhillu