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All Journal Jurnal Ilmu Kedokteran (Journal of Medical Science) Zona Kedokteran: Program Studi Pendidikan Dokter Universitas Batam
Sofyan Andri
Unknown Affiliation
Biochemistry, Genetics & Molecular Biology Dentistry Health Professions Medicine & Pharmacology Nursing Public Health Veterinary

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DEVELOPMENT OF VIDEO VIRTUAL REALITY-BASED LEARNING MEDIA FOR PREECLAMPSIA AND ECLAMPSIA CASES IN CLINICAL CLERKSHIP Sofyan Andri; Renardy Reza Razali; Yossi Mariati; Olivia Makmur
Zona Kedokteran: Program Studi Pendidikan Dokter Universitas Batam Vol 15 No 2 (2025): Zona Kedokteran: Program Studi Pendidikan Dokter Universitas Batam
Publisher : Universitas Batam

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37776/zked.v15i2.1787

Abstract

ABSTRACT Background: preeclampsia and eclampsia are high-risk pregnancy complications that can endanger both the mother and the fetus. The lack of clinical experience among young doctors in managing these conditions can impact their decision-making skills and patient management. Aims: the aims of this study to give innovative solution to enhance their competence in learning about preeclampsia and eclampsia with Virtual Reality (VR)-based learning media Methods: The method used in developing this media is the ADDIE model (Analysis, Design, Development, Implementation, Evaluation), which uses a mixed quantitative and qualitative approach. VR media is developed by presenting interactive simulations that allow users to experience various clinical situations realistically and deeply. Results: Statistical analysis shows that the learning method using VR provides significant advantages in improving theoretical understanding, practical skills, and confidence of clinical clerkship compared to conventional learning methods. These results support the research hypothesis that the use of VR is more effective in the context of learning preeclampsia and eclampsia. Conclusion: the development of VR-based media has the potential to become an innovative tool supporting medical education, particularly in enhancing the preparedness of young doctors in managing critical obstetric cases Keywords: Virtual Reality, Learning Media, Pre-eclampsia, Eclampsia, Clinical clerkship
Pengaruh Pemberian Esomeprazole Terhadap Ekspresi Imunohistokimia Soluble Fms-Like Tyrosine Kinase (Sflt-1) Dan Soluble Endoglin (Seng) Pada Tikus Dengan Model Preeklamsia Andri, Sofyan; Aldiansyah, Dudy; Dina, Sarah; Marpaung, Johny; Adenin, Ichwanul; Faradina, Dwi
Jurnal Ilmu Kedokteran Vol 19, No 1 (2025): Jurnal Ilmu Kedokteran
Publisher : Fakultas Kedokteran Universitas Riau

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.26891/JIK.v19i1.2025.66-76

Abstract

Preeclampsia is a systemic disorder affecting approximately 3–8% of pregnant women, occurring during or after pregnancy. The exact cause and underlying mechanisms of this condition remain unclear. It is believed that the anti-angiogenic molecules soluble fms-like tyrosine kinase-1 (sFlt-1) and soluble endoglin (sEng), which are excessively produced by the placenta in preeclampsia, play a significant role in endothelial dysfunction. Recent studies suggest that esomeprazole, a proton pump inhibitor, is generally well tolerated in preeclamptic patients. This study aimed to evaluate the effect of esomeprazole administration on the reduction of sFlt-1 and sEng expression in a preeclampsia-induced rat model using an analytical approach with a quasi-experimental design. The research was conducted at two laboratories within the Faculty of Medicine and the Faculty of Mathematics and Natural Sciences at Universitas Sumatera Utara: the Anatomical Pathology Laboratory and the Biology Laboratory. The study subjects consisted of 30 healthy and active female laboratory rats (Rattus norvegicus), aged 10 weeks, modeled to resemble preeclamptic conditions. The study was carried out in May 2021. After the intervention, significant differences were observed between the intervention and control groups in systolic blood pressure, diastolic blood pressure, and mean arterial pressure (MAP) (p = 0.001; p = 0.014; p = 0.001). Additionally, the proportion of proteinuria was lower in the intervention group than in the control group. The mean expression levels of sFlt-1 and sEng also showed statistically significant differences between the intervention and control groups (p = 0.002; p = 0.001). The findings indicate statistically significant changes in MAP, systolic and diastolic blood pressure, and proteinuria across all groups following the intervention. A comparison of sFlt-1 and sEng expression levels among the negative control, positive control, and intervention groups revealed statistically significant differences. Esomeprazole administration at a dosage of 4.68 mg/kgBW/day significantly reduced sFlt-1 expression, demonstrating the therapeutic potential of esomeprazole in suppressing anti-angiogenic factors in preeclampsia.
Co-Authors Adenin, Ichwanul Aldiansyah, Dudy Dina, Sarah Dwi Faradina Marpaung, Johny Olivia Makmur Renardy Reza Razali Yossi Mariati