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All Journal Jurnal Ilmu Kedokteran (Journal of Medical Science) Jurnal Pengabdian UntukMu NegeRI Jurnal SOLMA JMM (Jurnal Masyarakat Mandiri) Indonesian Journal of Obstetrics & Gynecology Science Medfarm: Jurnal Farmasi dan Kesehatan Zona Kedokteran: Program Studi Pendidikan Dokter Universitas Batam
Sofyan Andri
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Religion Biochemistry, Genetics & Molecular Biology Chemistry Computer Science & IT Dentistry Economics, Econometrics & Finance Education Health Professions Law, Crime, Criminology & Criminal Justice Medicine & Pharmacology Nursing Public Health Social Sciences Veterinary Other

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DEVELOPMENT OF VIDEO VIRTUAL REALITY-BASED LEARNING MEDIA FOR PREECLAMPSIA AND ECLAMPSIA CASES IN CLINICAL CLERKSHIP Sofyan Andri; Renardy Reza Razali; Yossi Mariati; Olivia Makmur
Zona Kedokteran: Program Studi Pendidikan Dokter Universitas Batam Vol 15 No 2 (2025): Zona Kedokteran: Program Studi Pendidikan Dokter Universitas Batam
Publisher : Universitas Batam

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37776/zked.v15i2.1787

Abstract

ABSTRACT Background: preeclampsia and eclampsia are high-risk pregnancy complications that can endanger both the mother and the fetus. The lack of clinical experience among young doctors in managing these conditions can impact their decision-making skills and patient management. Aims: the aims of this study to give innovative solution to enhance their competence in learning about preeclampsia and eclampsia with Virtual Reality (VR)-based learning media Methods: The method used in developing this media is the ADDIE model (Analysis, Design, Development, Implementation, Evaluation), which uses a mixed quantitative and qualitative approach. VR media is developed by presenting interactive simulations that allow users to experience various clinical situations realistically and deeply. Results: Statistical analysis shows that the learning method using VR provides significant advantages in improving theoretical understanding, practical skills, and confidence of clinical clerkship compared to conventional learning methods. These results support the research hypothesis that the use of VR is more effective in the context of learning preeclampsia and eclampsia. Conclusion: the development of VR-based media has the potential to become an innovative tool supporting medical education, particularly in enhancing the preparedness of young doctors in managing critical obstetric cases Keywords: Virtual Reality, Learning Media, Pre-eclampsia, Eclampsia, Clinical clerkship
Pengaruh Pemberian Esomeprazole Terhadap Ekspresi Imunohistokimia Soluble Fms-Like Tyrosine Kinase (Sflt-1) Dan Soluble Endoglin (Seng) Pada Tikus Dengan Model Preeklamsia Andri, Sofyan; Aldiansyah, Dudy; Dina, Sarah; Marpaung, Johny; Adenin, Ichwanul; Faradina, Dwi
Jurnal Ilmu Kedokteran Vol 19, No 1 (2025): Jurnal Ilmu Kedokteran
Publisher : Fakultas Kedokteran Universitas Riau

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.26891/JIK.v19i1.2025.66-76

Abstract

Preeclampsia is a systemic disorder affecting approximately 3–8% of pregnant women, occurring during or after pregnancy. The exact cause and underlying mechanisms of this condition remain unclear. It is believed that the anti-angiogenic molecules soluble fms-like tyrosine kinase-1 (sFlt-1) and soluble endoglin (sEng), which are excessively produced by the placenta in preeclampsia, play a significant role in endothelial dysfunction. Recent studies suggest that esomeprazole, a proton pump inhibitor, is generally well tolerated in preeclamptic patients. This study aimed to evaluate the effect of esomeprazole administration on the reduction of sFlt-1 and sEng expression in a preeclampsia-induced rat model using an analytical approach with a quasi-experimental design. The research was conducted at two laboratories within the Faculty of Medicine and the Faculty of Mathematics and Natural Sciences at Universitas Sumatera Utara: the Anatomical Pathology Laboratory and the Biology Laboratory. The study subjects consisted of 30 healthy and active female laboratory rats (Rattus norvegicus), aged 10 weeks, modeled to resemble preeclamptic conditions. The study was carried out in May 2021. After the intervention, significant differences were observed between the intervention and control groups in systolic blood pressure, diastolic blood pressure, and mean arterial pressure (MAP) (p = 0.001; p = 0.014; p = 0.001). Additionally, the proportion of proteinuria was lower in the intervention group than in the control group. The mean expression levels of sFlt-1 and sEng also showed statistically significant differences between the intervention and control groups (p = 0.002; p = 0.001). The findings indicate statistically significant changes in MAP, systolic and diastolic blood pressure, and proteinuria across all groups following the intervention. A comparison of sFlt-1 and sEng expression levels among the negative control, positive control, and intervention groups revealed statistically significant differences. Esomeprazole administration at a dosage of 4.68 mg/kgBW/day significantly reduced sFlt-1 expression, demonstrating the therapeutic potential of esomeprazole in suppressing anti-angiogenic factors in preeclampsia.
The Relationship Between Pregnant Women’s Knowledge, Attitudes, and Behaviors Toward Tetanus Toxoid Immunization Andri, Sofyan; noviardi, Noviardi; Oktama, Nizan Dani
MEDFARM: Jurnal Farmasi dan Kesehatan Vol 14 No 2 (2025): Medfarm: Jurnal Farmasi dan Kesehatan
Publisher : LPPM Akafarma Sunan Giri Ponorogo

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.48191/medfarm.v14i2.613

Abstract

Tetanus Toxoid (TT) immunization remains a critical strategy in preventing maternal and neonatal deaths caused by tetanus. Despite its proven effectiveness, TT immunization coverage in Indonesia including in Pekanbaru City remains below target. Among the contributing factors are pregnant women's levels of knowledge, attitudes, and behaviors, which are believed to significantly influence immunization uptake. Objective: This study aimed to assess the relationship between pregnant women’s knowledge, attitudes, and behaviors and their participation in TT immunization programs across three health center areas in Pekanbaru: Simpang Tiga, Rejosari, and Okura. Methods: A descriptive analytic quantitative study with a cross-sectional design was conducted, involving 111 pregnant women who attended antenatal care (ANC) visits in May 2025. Data were analyzed using the Chi-Square test, Spearman Rank correlation, Cramer’s V, and logistic regression, with a significance level set at p < 0.05. Results: The study found statistically significant differences in knowledge, attitudes, and behaviors among the three health center areas (p < 0.05). Notably, good knowledge did not always correspond to positive attitudes—many well-informed respondents still exhibited negative attitudes. However, a strong correlation was observed between attitude and behavior (Cramer’s V = 0.552). Logistic regression revealed that knowledge (OR = 0.201; p = 0.005), attitude (OR = 2.068; p = 0.036), and behavior (OR = 5.660; p < 0.001) significantly influenced TT immunization uptake, with behavior emerging as the most dominant factor. Conclusion: Efforts to improve TT immunization coverage must go beyond knowledge-based education and focus on fostering positive attitudes and reinforcing supportive behaviors. Behavior-centered interventions and effective communication by health workers are essential to strengthen immunization outcomes.
Gene and Germline Editing in Maternal and Reproductive Health: A Narrative Review of Ethical Dilemmas and Scientific Advances Suhaimi, Donel; Andri, Sofyan; Hutapea, Anastasya; Arihta, Sandi
Indonesian Journal of Obstetrics & Gynecology Science Volume 9 Number 1 March 2026
Publisher : Dep/SMF Obstetri & Ginekologi Fakultas Kedokteran Universitas Padjadjaran

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24198/obgynia.v9i1.939

Abstract

Introduction: In Utero Genetic Editing (IUGE) is an emerging technology intended to modify the fetal genome to prevent or treat genetic disorders before birth. While it presents significant medical potential, it raises complex ethical, legal, and regulatory challenges. Current interventions remain largely animal-based, with human applications at theoretical or preclinical stages.Methods: This review examines ethical guidelines, legal frameworks, and regulatory perspectives globally and in Indonesia. Sources included WHO, the Indonesian Obstetrics and Gynecology Association (POGI), Indonesian health laws, and journals such as the American Journal of Obstetrics and Gynecology (AJOG). Literature was drawn from PubMed, WHO databases, Indonesian archives, and AJOG publications (2015–2025).Results: WHO emphasized precaution and transparency, while POGI stressed maternal–fetal safety under strict oversight. Indonesia lacks specific regulation, requiring interventions to respect safety and human dignity. The United States and European Union maintain restrictive regulations, including embryo research bans.Conclusion: IUGE is promising for reproductive health but remains ethically and legally unresolved, requiring clearer frameworks before clinical translation. AbstrakPendahuluan: In Utero Genetic Editing (IUGE) merupakan teknologi baru untuk memodifikasi genom janin guna mencegah atau mengobati kelainan genetik sejak sebelum lahir. Teknologi ini menjanjikan manfaat medis, namun menimbulkan tantangan etik, hukum, dan regulasi. Hingga kini, sebagian besar intervensi masih berbasis penelitian hewan, sementara aplikasi pada manusia berada pada tahap teoritis atau pra-klinis.Metode: Kajian ini menelaah pedoman etik, kerangka hukum, dan regulasi dari perspektif global dan Indonesia. Sumber mencakup WHO, Perkumpulan Obstetri dan Ginekologi Indonesia (POGI), peraturan kesehatan nasional, serta jurnal internasional seperti American Journal of Obstetrics and Gynecology (AJOG). Literatur diperoleh dari PubMed, basis data WHO, arsip hukum Indonesia, dan publikasi AJOG (2015–2025).Hasil: WHO menekankan prinsip kehati-hatian dan transparansi, sementara POGI menegaskan keselamatan ibu–janin dengan pengawasan ketat. Indonesia belum memiliki regulasi khusus, tetapi mensyaratkan intervensi genetik menjaga keselamatan dan martabat manusia. Negara seperti Amerika Serikat dan Uni Eropa menetapkan aturan restriktif, termasuk larangan riset embrio.Kesimpulan: IUGE berpotensi meningkatkan kesehatan reproduksi, namun memerlukan regulasi yang lebih jelas sebelum penerapan klinis.Kata kunci: In Utero Genetic Editing, etika, regulasi, terapi janin, bioetika
Tatalaksana Cuci Tangan Dan Penanganan Luka Sederhana Pada Petani Sawit Di Desa Sari Galuh, Kampar: Pendekatan Kesehatan Masyarakat Ulfah, Ulfah; Asni, Enikarmila; Hamidy, Yulis; Juananda, Desby; Maryanti, Yossi; Sonia Sahara, Nabilla; Dhani, Rahma; Andri, Sofyan; Aiyulie Novri, Dhini; Agung Soripada, Timotius
Jurnal Pengabdian UntukMu NegeRI Vol. 10 No. 1 (2026): Pengabdian Untuk Mu negeRI
Publisher : LPPM UMRI

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37859/jpumri.v10i1.10690

Abstract

This community service programme aimed to improve hygiene awareness and basic wound-care skills among palm-oil farmers in Sari Galuh Village, Kampar District, Riau Province. Farmers frequently experience minor injuries from sharp tools, palm thorns, and exposure to dirt, which increases infection risk. However, proper hand-washing practice and simple wound-care knowledge are still lacking. The intervention included hand-washing training based on WHO standards, education on simple wound care, provision of hand-washing facilities, and distribution of first-aid kits. A total of 41 participants attended the programme. Evaluation using pre-test and post-test instruments showed significant improvement in participants’ knowledge and skills. The program effectively strengthened preventive health behaviours and is recommended as a sustainable community health empowerment model for agricultural groups.
ANALISIS RISIKO STRES DAN DEPRESI PADA IBU HAMIL DENGAN PLACENTA ACCRETA SPECTRUM DISORDER DI RSUD ARIFIN ACHMAD Sofyan Andri; Dhini Ayulie Novri; Fahreza Lazuardi Nasution; Akbar Husaini Angkat
Zona Kedokteran: Program Studi Pendidikan Dokter Universitas Batam Vol 16 No 1 (2026): Zona Kedokteran: Program Studi Pendidikan Dokter Universitas Batam
Publisher : Universitas Batam

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37776/zked.v16i1.2113

Abstract

Abstrak Placenta Accreta Spectrum Disorder (PASD) merupakan komplikasi obstetri berat dengan risiko morbiditas dan mortalitas maternal yang tinggi. Selain dampak fisik, diagnosis PASD berpotensi menimbulkan reaksi stres akut dan meningkatkan risiko depresi pada ibu hamil. Penelitian ini bertujuan untuk membandingkan risiko stres dan depresi antara ibu hamil dengan dan tanpa PASD, serta menganalisis hubungan antara risiko stres dan depresi pada pasien PASD. Penelitian ini menggunakan desain deskriptif analitik dengan pendekatan potong lintang. Subjek penelitian terdiri dari 68 ibu hamil (34 PASD dan 34 non-PASD) yang menjalani antenatal care di RSUD Arifin Achmad Kota Pekanbaru periode Agustus–Oktober 2025, dengan teknik consecutive sampling. Risiko stres dinilai menggunakan Impact of Event Scale–Revised (IES-R), sedangkan risiko depresi dinilai menggunakan Edinburgh Postnatal Depression Scale (EPDS). Hasil penelitian menunjukkan bahwa risiko stres akut secara signifikan lebih tinggi pada kelompok PASD dibandingkan non-PASD (23,53% vs 0%; p = 0,001). Risiko depresi juga secara signifikan lebih tinggi pada kelompok PASD dibandingkan kontrol (p = 0,006). Terdapat hubungan yang sangat bermakna antara stres akut dan risiko depresi pada pasien PASD (p < 0,001; Cramér’s V = 1,00). Analisis multivariat menunjukkan bahwa pekerjaan dan penghasilan merupakan prediktor independen risiko stres (p = 0,009 dan p = 0,007), sedangkan suku, agama, dan pekerjaan berhubungan dengan risiko depresi pada pasien PASD. Kesimpulannya, diagnosis PASD berhubungan erat dengan peningkatan risiko stres akut dan depresi pada ibu hamil, sehingga skrining kesehatan mental perlu diintegrasikan dalam penatalaksanaan PASD. Kata kunci: Placenta Accreta Spectrum Disorder (PASD), Stress, Depresi, Kehamilan, IES-R, EPDS
Pemberdayaan Masyarakat: Optimalisasi Edukasi Gizi dan Kesehatan Ibu Hamil Sebagai Upaya Preventif Stunting di Desa Buluh Cina, Kabupaten Kampar, Provinsi Riau Simanjuntak, Asnika Putri; Andri, Sofyan; Novri, Dhini Aiyulie; Arnif, Iqbal; Habib, Alltop Amri Ya
Jurnal SOLMA Vol. 15 No. 1 (2026)
Publisher : Universitas Muhammadiyah Prof. DR. Hamka (UHAMKA Press)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22236/solma.v15i1.21186

Abstract

Pendahuluan: Ibu hamil di Desa Buluh Cina, Kabupaten Kampar, masih menghadapi rendahnya pemahaman gizi seimbang, keterbatasan dukungan keluarga, serta minimnya pendampingan berbasis komunitas yang berpotensi meningkatkan risiko stunting sejak masa kehamilan. Studi ini bertujuan untuk meningkatkan pengetahuan, sikap, dan praktik gizi ibu hamil melalui gerakan edukasi berbasis komunitas. Metode: Pendekatan deskriptif dengan evaluasi kuantitatif sederhana melalui pretest dan postest. Kegiatan meliputi identifikasi masalah, penyuluhan partisipatif, diskusi interaktif, praktik penyusunan menu gizi seimbang berbasis pangan lokal, serta pendampingan oleh kader posyandu dan keluarga. Hasil: Adanya peningkatan skor pengetahuan ibu hamil dari 55% menjadi 82%, perubahan sikap positif dari 40% menjadi 85%, serta peningkatan keterlibatan keluarga dan kader posyandu dari 35% menjadi 75%. Kesimpulan: Gerakan edukasi gizi berbasis komunitas efektif meningkatkan kapasitas ibu hamil dan berpotensi direplikasi sebagai model pencegahan stunting sejak masa kehamilan.
EDUKASI HIV BERBASIS SEKOLAH UNTUK PENCEGAHAN PERILAKU BERISIKO PADA REMAJA Andri, Sofyan; Simanjuntak, Asnika Putri; Novri, Dhini Aiyulie; Anakita, Cantika; S., Donel; Razali, Renardy Reza
JMM (Jurnal Masyarakat Mandiri) Vol 10, No 2 (2026): April
Publisher : Universitas Muhammadiyah Mataram

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31764/jmm.v10i2.37760

Abstract

Abstrak: Remaja merupakan kelompok yang rentan terhadap risiko penularan HIV akibat keterbatasan pengetahuan dan masih adanya sikap serta perilaku berisiko. Kegiatan pengabdian ini bertujuan meningkatkan pengetahuan, sikap, dan perilaku pencegahan HIV pada remaja melalui edukasi berbasis sekolah. Metode yang digunakan berupa penyuluhan dan diskusi interaktif tentang HIV yang dilaksanakan kepada 240 siswa sebagai mitra kegiatan. Evaluasi dilakukan menggunakan kuesioner pengetahuan, sikap, dan perilaku pencegahan HIV setelah kegiatan, yang terdiri dari 61 pertanyaan. Hasil menunjukkan bahwa 52,5% peserta memiliki tingkat pengetahuan baik, 58,8% menunjukkan sikap positif terhadap pencegahan HIV, dan 84,6% telah menerapkan perilaku pencegahan yang baik. Capaian ini menunjukkan bahwa edukasi HIV berbasis sekolah berkontribusi positif dalam memperkuat literasi kesehatan dan mendorong pencegahan perilaku berisiko pada remaja. Program ini berpotensi menjadi model intervensi promotif dan preventif di lingkungan sekolah.Abstract: Adolescents are a vulnerable group for HIV transmission due to limited knowledge and the persistence of risky attitudes and behaviors. This community service program aimed to enhance knowledge, attitudes, and HIV preventive behaviors among adolescents through school-based education. The program was conducted through health education sessions and interactive discussions involving 240 students as program partners. Evaluation was carried out using a questionnaire assessing knowledge, attitudes, and HIV-related preventive behaviors after the activity, consisting of 61 questions. The results indicated that 52.5% of participants had good knowledge, 58.8% demonstrated positive attitudes toward HIV prevention, and 84.6% reported good preventive behaviors. These findings suggest that school-based HIV education contributes to improved health literacy and supports the reduction of risky behaviors among adolescents. This program has the potential to serve as a promotive and preventive model for HIV education in school settings.
Co-Authors Adenin, Ichwanul Agung Soripada, Timotius Aiyulie Novri, Dhini Akbar Husaini Angkat Aldiansyah, Dudy Alltop Amri Ya Habib Anakita, Cantika Arihta, Sandi Arnif, Iqbal Desby Juananda, Desby Dhani, Rahma Dhini Aiyulie Novri Dhini Ayulie Novri Dina, Sarah Donel S Dwi Faradina Enikarmila Asni Fahreza Lazuardi Nasution Hutapea, Anastasya Marpaung, Johny Maryanti, Yossi Noviardi Noviardi, Noviardi Oktama, Nizan Dani Olivia Makmur Razali, Renardy Reza Renardy Reza Razali S., Donel Simanjuntak, Asnika Putri Sonia Sahara, Nabilla Ulfah Ulfah Yossi Mariati Yulis Hamidy