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All Journal Jurnal Biologi Tropis Mandala of Health : A Scientific Journal
Satriawan, Wira
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Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Dentistry Health Professions Immunology & microbiology Public Health

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PATOPHYSIOLOGY AND LATEST TREATMENT OPTIONS OF VASCULITIS: A LITERATURE REVIEW Suryantarini, Ni Wayan Puspa Wijaya; Satriawan, Wira
Mandala Of Health Vol 18 No 1 (2025): Mandala of Health: A scientific Journal
Publisher : Fakultas Kedokteran Universitas Jenderal Soedirman

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20884/1.mandala.2025.18.1.14892

Abstract

Inflammation is a body defense process against various potentially damaging causes. Excessive inflammation in the vascular can cause an autoimmune process in vasculitis disease. Vasculitis can cause damage to the tissues and organs that are vascularized. So far, the heterogeneous pathophysiology and clinical manifestations of the disease have been well understood. Although therapy with glucocorticoids is effective for disease remission, complications that often occur earlier in patients can fail the therapy. Therefore, a more effective method for accurate diagnosis is needed as a patient management approach. A more detailed and interrelated understanding of the disease will further encourage the improvement of the quality of the medical procedures so that it is expected to improve the patient’s prognosis. This literature review aimed to explain detail started from the prevalence of vasculitis cases, followed by the underlying risk factors and the development of effective diagnostic and management flows to date. The method of this literature review was searching for articles from various databases in PubMed, Google Scholar, and the Google search engine. Based on various literature obtained, each classification of vasculitis has unique characteristics including the type of inflammation that occurs and the onset of the disease that differs for each age group. The diagnostic flow still starts from anamnesis to the use of imaging and laboratory examinations and the application of criteria for a definitive diagnosis. Further management is differentiated based on the type of vasculitis, treatment phase, and response to therapy. Further studies are needed, especially in determining the reference values ​​of laboratory examinations used for diagnosis, determining the dose of therapy, and efforts to treat complications that occur. Vasculitis remains a heterogeneous autoimmune disease that requires further attention in efforts to establish a diagnosis and apply the most appropriate management to the patient’s condition.
The Role of Musical Hobbies in Enhancing Children's Learning Concentration Wulandari, Inayah; Prasetya, Rangga Cahya; Satriawan, Wira; Semadi, I Kadek; Harahap, Herpan Syafii
Jurnal Biologi Tropis Vol. 25 No. 3 (2025): Juli-September
Publisher : Biology Education Study Program, Faculty of Teacher Training and Education, University of Mataram, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29303/jbt.v25i3.9185

Abstract

Childhood is a golden period for brain development. Musical activities such as listening, singing, and playing instruments involve various sensory and motor systems and can enhance brain function. These activities stimulate different areas of the brain and are believed to support cognitive functions, including concentration during learning. This study used a literature review method. Sources were collected from academic databases such as PubMed, Google Scholar, and ProQuest. The review found that musical activities enhanced the structure and function of several brain regions. Early musical training increased grey matter connectivity in hippocampus, primary motor cortex, supplementary motor area, and broca’s area. White matter development also occurred in motor cortex, occipital lobe, arcuate fasciculus, and corpus callosum. In addition, musical engagement activated brain's reward system, particularly involving dopamine, which supported persistence and focus in learning. Musical hobbies contributed positively to improvement of children's learning concentration. This occurred through mechanisms of brain neuroplasticity that were influenced by regular engagement with musical activities. It was recommended that musical activities be introduced from an early age, especially during golden period, with selection of appropriate types of music, such as classical music that promotes calmness and supports attention.
Pathophysiology of Cognitive Dysfunction Due to Decompression Sickness in Diver Pratiwi, Baiq Bunga Citra; Suryantarini, Ni Wayan Puspa Wijaya; Satriawan, Wira; Jacob, Lusye Diana; Harahap, Herpan Syafii
Jurnal Biologi Tropis Vol. 25 No. 4 (2025): Oktober-Desember
Publisher : Biology Education Study Program, Faculty of Teacher Training and Education, University of Mataram, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29303/jbt.v25i4.10138

Abstract

Cognitive impairment can occur due to factors that affect the structural and functional integrity of brain areas that specifically play a role in each cognitive domain. Severe cognitive impairment causes morbidity and mortality. One condition that can lead to complications such as a cognitive impairment is Decompression Sickness (DCS). DCS is an important risk for divers and manifestations of cognitive impairment need to be recognized earlier to prevent progression to a more severe stage. The literature used was collected from the Google Scholar, ScienceDirect, and PubMed databases with restrictions: publication year 2015-2025, Indonesian or English languages, and research with human subjects. The results of the literature review indicate that the pathophysiology of cognitive impairment after onset of DCS is still not clearly understood. The principles that are understood so far include the impact of nitrogen gas bubble circulation in cerebral arteries, extensive brain ischemia, white matter damage, and hyperbaric pressure administration can simultaneously improve cognitive function in patients. It can be concluded that neurological symptoms in DCS can develop into severe cognitive impairment if not recognized and treated immediately. The underlying relationship is mainly related to the impact of nitrogen gas embolism, cerebral ischemia, and extensive damage to cognitive areas of the brain.
Co-Authors Herpan Syafii Harahap Jacob, Lusye Diana Prasetya, Rangga Cahya Pratiwi, Baiq Bunga Citra Semadi, I Kadek Suryantarini, Ni Wayan Puspa Wijaya Wulandari, Inayah