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All Journal Jurnal Biologi Tropis Mandala of Health : A Scientific Journal
Suryantarini, Ni Wayan Puspa Wijaya
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Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Dentistry Health Professions Immunology & microbiology Public Health

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PATOPHYSIOLOGY AND LATEST TREATMENT OPTIONS OF VASCULITIS: A LITERATURE REVIEW Suryantarini, Ni Wayan Puspa Wijaya; Satriawan, Wira
Mandala Of Health Vol 18 No 1 (2025): Mandala of Health: A scientific Journal
Publisher : Fakultas Kedokteran Universitas Jenderal Soedirman

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20884/1.mandala.2025.18.1.14892

Abstract

Inflammation is a body defense process against various potentially damaging causes. Excessive inflammation in the vascular can cause an autoimmune process in vasculitis disease. Vasculitis can cause damage to the tissues and organs that are vascularized. So far, the heterogeneous pathophysiology and clinical manifestations of the disease have been well understood. Although therapy with glucocorticoids is effective for disease remission, complications that often occur earlier in patients can fail the therapy. Therefore, a more effective method for accurate diagnosis is needed as a patient management approach. A more detailed and interrelated understanding of the disease will further encourage the improvement of the quality of the medical procedures so that it is expected to improve the patient’s prognosis. This literature review aimed to explain detail started from the prevalence of vasculitis cases, followed by the underlying risk factors and the development of effective diagnostic and management flows to date. The method of this literature review was searching for articles from various databases in PubMed, Google Scholar, and the Google search engine. Based on various literature obtained, each classification of vasculitis has unique characteristics including the type of inflammation that occurs and the onset of the disease that differs for each age group. The diagnostic flow still starts from anamnesis to the use of imaging and laboratory examinations and the application of criteria for a definitive diagnosis. Further management is differentiated based on the type of vasculitis, treatment phase, and response to therapy. Further studies are needed, especially in determining the reference values ​​of laboratory examinations used for diagnosis, determining the dose of therapy, and efforts to treat complications that occur. Vasculitis remains a heterogeneous autoimmune disease that requires further attention in efforts to establish a diagnosis and apply the most appropriate management to the patient’s condition.
ETIOLOGI DIAGNOSIS DAN MANAJEMEN SUMBATAN JALAN NAPAS Suryantarini, Ni Wayan Puspa Wijaya; Ansary, M Fathir Rahadian; Sultan Firdaus, Nadine Aisyah; Artha Jaya Kusuma, I Gusti Ketut
Mandala Of Health Vol 17 No 2 (2024): Mandala of Health: a Scientific Journal
Publisher : Fakultas Kedokteran Universitas Jenderal Soedirman

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20884/1.mandala.2024.17.2.12443

Abstract

Airway obstruction is an emergency condition characterized by occlusion of the lumen of the airway caused by various etiologies, ranging from benign to malignant. Cases of airway obstruction require immediate management starting from an immediate evaluation of the patient’s condition, establishing a diagnosis of etiology and severity, and planning the most appropriate management. Awake intubation, tracheostomy incision, also balloon and stent placement are still quite effective and recommended in various guidelines. Trained medical personnel are essential for the success of the management process of patients with airway obstruction. The high mortality rate makes this condition require attention and treatment as early as possible. The literature review aims to discuss the etiology of airway obstruction that is often encountered in health facilities, as well as the diagnostic modalities and selection of appropriate managements.
DETEKSI DINI ATRIAL FIBRILASI UNTUK MENURUNKAN RISIKO STROKE Suryantarini, Ni Wayan Puspa Wijaya
Mandala Of Health Vol 17 No 2 (2024): Mandala of Health: a Scientific Journal
Publisher : Fakultas Kedokteran Universitas Jenderal Soedirman

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20884/1.mandala.2024.17.2.12529

Abstract

Stroke is one of the major causes of death and contributes to loss of productivity in daily activities throughout the world. Every year it is estimated that there are 13,7 million new cases of stroke with a possibility of 1 in 4 people over 25 years will developing stroke. Stroke has various pathogenesis depending on the age at which the onset of stroke and the type of stroke. The increase in prevalence and mortality due to stroke has prompted many studies to examine stroke risk factors as well as early detection and management, including prevention. One common form of cardiac arrhythmia, is atrial fibrillation or AF, is one of the triggering factors for stroke with a five-fold risk. AF often does not manifest the symptoms in patients. Early detection of AF in all individuals, especially those at high risk of AF and stroke, is crucial to initiating early intervention and reducing the possibility of complications. Various devices have been developed to detect the occurrence of AF in asymptomatic and at-risk patients. This literature aims to explain how to detect early atrial fibrillation, including screening for AF symptoms, physical examination, ECG examination, use of technological devices, stratifying the risk of stroke in AF patients, and finally the prevention strategies for both AF and stroke.
SCORING SYSTEM APPLICATION IN MANAGEMENT CHOICES AND PROGNOSIS OF THE PROCEDURE IN PATIENT WITH RISK OF AIRWAY OBSTRUCTION: ARTICLE REVIEW Asriantin, Isna; Suryantarini, Ni Wayan Puspa Wijaya
Mandala Of Health Vol 18 No 2 (2025): Mandala of Health: A Scientific Journal
Publisher : Fakultas Kedokteran Universitas Jenderal Soedirman

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20884/1.mandala.2025.18.2.17680

Abstract

Airway obstruction is a life-threatening condition that requires prompt recognition and management to prevent morbidity and mortality. Intubation remains the gold standard for securing the airway; however, failed attempts are common and may delay other life-saving interventions. To improve decision-making in selecting appropriate procedures and predicting outcomes, various scoring systems have been developed. This article aims to review the application of scoring systems in management choices and prognosis of patients with risk of airway obstruction. This study employed a systematic literature review by searching PubMed, ScienceDirect, and ProQuest databases using the keywords “scoring system,” “airway obstruction,” “difficulty,” and “management prediction.” Eligible studies included original research and case reports published in English or Indonesian between 2020 and 2025, with complete full-text availability. Eight relevant articles were identified and analyzed. The findings suggest that proper application of validated scoring systems may reduce the incidence of failed intubation, guide elective tracheostomy decisions, and improve prognosis in patients at risk of airway obstruction. Nevertheless, inappropriate or excessive use may lead to unnecessary procedures and complications. Further research is needed to validate these tools across diverse populations and to develop simplified scoring models with higher sensitivity and specificity.
Pathophysiology of Cognitive Dysfunction Due to Decompression Sickness in Diver Pratiwi, Baiq Bunga Citra; Suryantarini, Ni Wayan Puspa Wijaya; Satriawan, Wira; Jacob, Lusye Diana; Harahap, Herpan Syafii
Jurnal Biologi Tropis Vol. 25 No. 4 (2025): in Progress
Publisher : Biology Education Study Program, Faculty of Teacher Training and Education, University of Mataram, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29303/jbt.v25i4.10138

Abstract

Cognitive impairment can occur due to factors that affect the structural and functional integrity of brain areas that specifically play a role in each cognitive domain. Severe cognitive impairment causes morbidity and mortality. One condition that can lead to complications such as a cognitive impairment is Decompression Sickness (DCS). DCS is an important risk for divers and manifestations of cognitive impairment need to be recognized earlier to prevent progression to a more severe stage. The literature used was collected from the Google Scholar, ScienceDirect, and PubMed databases with restrictions: publication year 2015-2025, Indonesian or English languages, and research with human subjects. The results of the literature review indicate that the pathophysiology of cognitive impairment after onset of DCS is still not clearly understood. The principles that are understood so far include the impact of nitrogen gas bubble circulation in cerebral arteries, extensive brain ischemia, white matter damage, and hyperbaric pressure administration can simultaneously improve cognitive function in patients. It can be concluded that neurological symptoms in DCS can develop into severe cognitive impairment if not recognized and treated immediately. The underlying relationship is mainly related to the impact of nitrogen gas embolism, cerebral ischemia, and extensive damage to cognitive areas of the brain.
Antibibiotics Susceptibility Testing Against Staphylococcus Aureus from Nasal Isolates in Food Handlers in Canteen of Mataram University Suryantarini, Ni Wayan Puspa Wijaya; Hasbi, Nurmi; Ayunda, Rahmah Dara
Jurnal Biologi Tropis Vol. 24 No. 1b (2024): Special Issue
Publisher : Biology Education Study Program, Faculty of Teacher Training and Education, University of Mataram, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29303/jbt.v24i1b.7891

Abstract

Staphylococcal food poisoning is caused by bacteria Staphylococcus aureus that contaminate food such as through transmission from the nose of the food handlers. Severe bacterial food poisoning requires appropriate antibiotic therapy. This study aims to test the susceptibility and compare the diameter of the inhibition zones of several antibiotics against S. aureus. The study is an experimental analytical consisting of sterilization of materials and antibiotics sensitivity testing using disc diffusion technique with replication. Statistical tests were carried out using the SPSS One Way ANOVA and Post Hoc Test. The result showed that S. aureus was still sensitive to four antibiotics with the average diameter for gentamicin, ciprofloxacin, clindamycin, and chloramphenicol were 17.7 mm, 28.95 mm, 23.58 mm, and 23.08 mm, respectively. Statistical tests showed a significant difference in the diameter of inhibition zone from four antibiotics (p < .05). Ciprofloxacin produced the largest inhibition zone and gentamicin produced the smallest zone, while clindamycin and chloramphenicol did not show a significant difference (p > .05). It can be concluded that the four antibiotics are still suitable to treat diseases such as food poisoning caused by S. aureus. Personal hygiene of food handlers is important to prevent transmission of disease through food. Prevention of antibiotic resistance is carried out by paying attention to the appropriate use of antibiotics in the community. Further research with the larger size of sample and other antibiotics using different techniques is needed.
Co-Authors Ansary, M Fathir Rahadian Artha Jaya Kusuma, I Gusti Ketut Asriantin, Isna Ayunda, Rahmah Dara Hasbi, Nurmi - Herpan Syafii Harahap Jacob, Lusye Diana Pratiwi, Baiq Bunga Citra Satriawan, Wira Sultan Firdaus, Nadine Aisyah