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All Journal Indonesian Journal of Biomedicine and Clinical Sciences Jurnal Pharma Bhakta
Rosa Juwita Hesturini
Unknown Affiliation
Biochemistry, Genetics & Molecular Biology Health Professions Immunology & microbiology Medicine & Pharmacology Neuroscience

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Antihyperlipidemic activity of kaffir lime leaf extract (Citrus hystrix DC) on hypercholesterolemic model mice Anjani, Ade Giriayu; Rosa Juwita Hesturini
Indonesian Journal of Biomedicine and Clinical Sciences Vol 57 No 2 (2025)
Publisher : Published by Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22146/inajbcs.v57i2.16602

Abstract

Kaffir lime (Citrus hystrix DC) is rich in various bioactive substances like flavonoids, tannins, saponins, hesperidin, and several monoterpenes, which are believed to have antihyperlipidemic activity. Hyperlipidemia is a metabolic issue that can lead to high blood pressure and weight gain. This condition is the result of an imbalance in cholesterol levels, including total cholesterol, elevated LDL, and reduced HDL. This study aimed to investigate the antihyperlipidemic activity of kaffir lime leaf extract (C. hystrix DC) on hypercholesterolemic model mice. It was pre- and post-control group design study. Tweenty-five male mice (Mus musculus) weighing 16-21g at 12 wk of age were used in this study. Five mice as normal control mice group (Group 1) were only administered 1% CMC-Na solution and 20 mice were administered an atherogenic diet to induce hyperlipidemic model. The hyperlipidemic mice were then randomly divided into four groups i.e. positive control mice group (Group 2) were administered simvastatin suspendet in 1% CMC-Na at dose of 0.03 mg/g BW, treatment mice group (Group 3-5) were administered C. hystrix DC leaf extract suspendet in 1% CMC-Na at doses of 0.21; 0.28; and 0.35 mg/g BW, respectively. The interventions were administered one daily for 14 d. Blood sampling from the retroorbital plexus of the mice was conducted before and 14 d after the intervention for lipid profile analysis. The serum total cholesterol, LDL, HDL, and triglyceride levels were measured by the CHOD-PAP (cholesterol oxidase-phenyl amino phyrazolone) enzymatic method. A significant decrease in total cholesterol, LDL, triglycerides levels, and a significant increase in the HDL level were observed in the treatment group at doses of 0.28; 0.35 mg/g BW compared to the normal control group (p<0.05). The maximal antihyperlipidemic activity was observed at dose of 0.28 mg/g BW. In conclusion, the C. hystrix DC leaf extract has antihyperlipidemic model mice.
STUDY OF PHYTOCHEMICAL COMPOUND CONTENT AND ANALGESIC ACTIVITY OF ETHANOL EXTRAK OF CELERY LEAF (Apium graveolens L.) WRITHING TEST METHOD: STUDY OF PHYTOCHEMICAL COMPOUND CONTENT AND ANALGESIC ACTIVITY OF ETHANOL EXTRAK OF CELERY LEAF (Apium graveolens L.) WRITHING TEST METHOD Rosa Juwita Hesturini; Fathul Hidayatul Hasanah; Dwi Wahyuni; Briandini Dwi Astuti; Anis Anggrayni
JURNAL PHARMA BHAKTA Vol 6 No 1 (2026): Mei (2026)
Publisher : FACULTY OF PHARMACY, INSTITUT ILMU KESEHATAN BHAKTI WIYATA

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.56710/jpb.v6i1.173

Abstract

Background: The celery plant (Apium graveolens L.) belongs to the Apiaceae family and is one of the vegetable commodities that is widely used for flavoring and decorating dishes with various health benefits. Objective: This study aims to determine the content of phytochemical compounds and analgesic activity of celery leaves. Through a systematic review article. Method: The research method with systematic literature review was carried out by searching for articles or journals related to phytochemical compound content and analgesic activities of celery. which had been published in journals. Literature search was conducted in April-May 2021 through Google Scholar, then journals were selected based on exclusion and inclusion criteria. Conclusions: The inclusion criteria, namely journals published last 5 years, the journal discusses the content of phytochemical compounds and analgesic activity of ethanol extract of celery leaves using the writhing test method. And as for the exclusion criteria, the data in the journal is incomplete and the journal does not discuss the celery plant. Based on the results of a systematic literature review of 5 published journals indicate that celery plant contains phytochemicals flavonoid compounds, tannins, saponins flavor-glucoside (apiin), apigenin and have analgesic activity.
Co-Authors Ade Giriayu Anjani Anis Anggrayni Briandini Dwi Astuti Dwi Wahyuni Fathul Hidayatul Hasanah