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All Journal MPI (Media Pharmaceutica Indonesiana) Jurnal Kesehatan Tambusai Jurnal EduHealth Journal of Health Research Science Indonesian Journal of Biomedicine and Clinical Sciences Jurnal Pharma Bhakta
Ade Giriayu Anjani
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Biochemistry, Genetics & Molecular Biology Chemistry Dentistry Health Professions Immunology & microbiology Materials Science & Nanotechnology Medicine & Pharmacology Neuroscience Nursing Public Health Veterinary

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Acute Decompensated Heart Failure+Atrial Fibrilation : Case Report Ade Giriayu Anjani; Shofyatul Fajriyah
Jurnal EduHealth Vol. 15 No. 04 (2024): Jurnal EduHealt (inpres), Year 2024
Publisher : Sean Institute

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Abstract

Heart Failure is a health issue with high mortality and morbidity rates in both developed and developing countries, such as Indonesia. The prevalence of heart failure in Asia is generally similar to that reported in Europe (1–3%), while in Indonesia, the prevalence is reported to be greater than 5%. Heart failure increases among geriatric patients, affecting 6% of those aged 60-79 years and up to 14% of those over 80 years old. Acute Decompensated Heart Failure (ADHF) is the progressive worsening of symptoms and clinical signs of heart failure in patients who have been previously diagnosed with the condition. The underlying mechanisms of clinical deterioration in patients include increased congestion and disease progression. ADHF and AF often occur together and can lead to hemodynamic instability and death. AF is the most common supraventricular dysrhythmia in patients with ADHF, with a prevalence of 25%-40%. The combination of ADHF and AF results in adverse clinical outcomes, including prolonged hospitalization and increased mortality. A 50-year- old woman complained of shortness of breath accompanied by palpitations that started 10 days before hospital admission and worsened in the last 2 days. The patient has a history of an enlarged heart for the past 3 years. A transthoracic echocardiogram revealed atrial fibrillation with a rapid ventricular rate (RV) of 90-130 beats per minute, left ventricular dilation (LVIDd 5.5 cm), decreased right ventricular systolic function (TAPSE 1.4 cm), left atrial dilation (LAVI 64.45 ml/m2), and right atrial dilation (RA major 5.8 cm). The electrocardiogram showed atrial fibrillation, abnormal ST & T waves, and prolonged ǪT interval.
Formulasi dan Uji Stabilitas Sediaan Masker Gel Peel-Off Ekstrak Seledri (Apium graveolens L.) dengan Variasi Konsentrasi Polivinil Alkohol (PVA) Pramasari, Nadia; Marcelina, Ananda; Shoviantari, Fenita; Hayati, Rachma Nur; Hesturini, Rosa Juwita; Anjani, Ade Giriayu
MPI (Media Pharmaceutica Indonesiana) Vol. 7 No. 1 (2025): JUNE
Publisher : Fakultas Farmasi, Universitas Surabaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24123/mpi.v7i1.7424

Abstract

Seledri (Apium graveolens L.) memiliki kandungan flavonoid, saponin dan tanin yang memiliki aktivitas antibakteri pada Cutibacterium acnes. Penelitian ini bertujuan untuk mengembangkan manfaat seledri dalam bentuk masker gel peel-off dengan konsentrasi polivinil alkohol (PVA) sebagai lapisan film sebesar 4%, 7%, dan 10%, serta mengetahui hasil uji mutu fisik dan uji stabilitas menggunakan metode cycling test dengan suhu ± 4°C dan ± 40°C selama 3 siklus. Analisis data hasil uji stabilitas diolah menggunakan uji One Way ANOVA. Hasil uji mutu fisik menunjukan bahwa masker gel peel-off ekstrak seledri dengan variasi konsentrasi PVA memiliki perbedaan pada hasil uji organoleptis, uji pH, uji daya sebar, uji daya lekat dan uji waktu mengering. Hasil uji stabilitas menunjukkan bahwa ketiga formula masker gel peel-off ekstrak seledri stabil selama pengujian. Konsentrasi PVA yang menunjukkan hasil paling baik yaitu PVA 10% dengan bentuk sangat kental, pH 5,42 ± 0,02, daya sebar 5,16 ± 0,03 cm, daya lekat 5,23 ± 0,06 detik, dan waktu mengering 18,0 ± 1,0 menit. Celery (Apium graveolens L.) contains flavonoids, saponins and tannins which have antibacterial activity against Cutibacterium acnes. This study aims to develop the benefits of celery in the form of a peel-off gel mask with a concentration of polyvinyl alcohol (PVA) as a film layer of 4%, 7%, and 10%, also determining the results of physical quality and stability tests using the cycling test method with temperatures of ± 4°C and ± 40°C for 3 cycles. Analysis of stability test data was processed using the One-Way ANOVA test. The results of the physical quality test showed that the celery extract peel-off gel mask with variations in PVA concentration had differences in the results of organoleptic, pH, spreadability, adhesion and drying time tests. The stability test results showed that the three celerys extract peel-off gel mask formulas were stable during testing. The PVA concentration that showed the best results was 10% PVA with a very thick form, pH 5.42 ± 0.02, spreadability 5.16 ± 0.03 cm, adhesiveness 5.23 ± 0.06 seconds, and drying time 18.0 ± 1.0 minutes. Submitted: 27-03-2025, Revised: 26-05-2025, Accepted: 03-06-2025, Published regularly: June 2025
Antihyperlipidemic activity of kaffir lime leaf extract (Citrus hystrix DC) on hypercholesterolemic model mice Anjani, Ade Giriayu; Rosa Juwita Hesturini
Indonesian Journal of Biomedicine and Clinical Sciences Vol 57 No 2 (2025)
Publisher : Published by Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22146/inajbcs.v57i2.16602

Abstract

Kaffir lime (Citrus hystrix DC) is rich in various bioactive substances like flavonoids, tannins, saponins, hesperidin, and several monoterpenes, which are believed to have antihyperlipidemic activity. Hyperlipidemia is a metabolic issue that can lead to high blood pressure and weight gain. This condition is the result of an imbalance in cholesterol levels, including total cholesterol, elevated LDL, and reduced HDL. This study aimed to investigate the antihyperlipidemic activity of kaffir lime leaf extract (C. hystrix DC) on hypercholesterolemic model mice. It was pre- and post-control group design study. Tweenty-five male mice (Mus musculus) weighing 16-21g at 12 wk of age were used in this study. Five mice as normal control mice group (Group 1) were only administered 1% CMC-Na solution and 20 mice were administered an atherogenic diet to induce hyperlipidemic model. The hyperlipidemic mice were then randomly divided into four groups i.e. positive control mice group (Group 2) were administered simvastatin suspendet in 1% CMC-Na at dose of 0.03 mg/g BW, treatment mice group (Group 3-5) were administered C. hystrix DC leaf extract suspendet in 1% CMC-Na at doses of 0.21; 0.28; and 0.35 mg/g BW, respectively. The interventions were administered one daily for 14 d. Blood sampling from the retroorbital plexus of the mice was conducted before and 14 d after the intervention for lipid profile analysis. The serum total cholesterol, LDL, HDL, and triglyceride levels were measured by the CHOD-PAP (cholesterol oxidase-phenyl amino phyrazolone) enzymatic method. A significant decrease in total cholesterol, LDL, triglycerides levels, and a significant increase in the HDL level were observed in the treatment group at doses of 0.28; 0.35 mg/g BW compared to the normal control group (p<0.05). The maximal antihyperlipidemic activity was observed at dose of 0.28 mg/g BW. In conclusion, the C. hystrix DC leaf extract has antihyperlipidemic model mice.
CASE REPORT : PREECLAMPSIA Anjani, Ade Giriayu; Pramasari, Nadia; Marhenta, Yogi Bhakti
Jurnal Kesehatan Tambusai Vol. 6 No. 2 (2025): JUNI 2025
Publisher : Universitas Pahlawan Tuanku Tambusai

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31004/jkt.v6i2.43038

Abstract

Preeklamsia merupakan suatu kelainan pada kehamilan yang ditandai dengan peningkatan tekanan darah atau hipertensi disertai proteinuria yang terjadi pada usia kehamilan lebih dari 20 minggu pada wanita yang awalnya memiliki tekanan darah normal. Prevalensi preeklamsia sekitar 5% - 15% dari seluruh ibu hamil. Hal ini dapat menimbulkan komplikasi berat bahkan kematian pada ibu dan janin apabila tidak ditangani dengan baik. Presentasi kasus: Seorang wanita berusia 50 tahun dengan tinggi badan pasien 145 cm, berat badan pasien 50 kg dan IMT 23,7, dirawat di rumah sakit dengan diagnosis GIII P2002 37/38 GHHIU + PE + IUGR/IUGR. Tekanan darah pasien 177/102 mmHg dengan RR 19x/menit, suhu tubuh 36,6OC, dan SO2 98% serta kadar Hb 7,2 g/dL, HCT 23,8%, MCV 72,3 fl, MCH 21,9, SCr 0,51mg/dL, BUN 6mg/dL, Kalium 3,4mmol/l, Albumin 3,23g/dL. Pasien tidak memiliki riwayat hipertensi, diabetes melitus, alergi dan asma. Riwayat pemeriksaan pasien pada usia kehamilan 35/36 minggu dimana pasien USG, kemudian didapatkan hasil fetus yang diduga IUGR dan memerlukan NICU sehingga pasien diberikan surat rujukan. Kesimpulan: Berdasarkan pharmaceutical care, pemberian terapi pada pasien sudah sesuai dengan pedoman. Pada pasien dengan preeklamsia, diagnosis yang tepat serta penanganan dan penatalaksanaan yang tepat oleh tim multidisiplin dapat mencegah komplikasi preeklamsia dan meningkatkan hasil pengobatan pasien preeklamsia.  
Kepatuhan minum obat pada pasien lansia dengan diabetes melitus Sari, Dwi Evi Diyan; Seran, Krisogonus Ephriono; Fajriyah, Shofiatul; Anjani, Ade Giriayu; Wahyuni, Kumala Sari Poespita Dewi
Journal of Health Research Science Vol. 5 No. 02 (2025): Journal of Health Research Science
Publisher : Lembaga Penelitian Sekolah Tinggi Ilmu Kesehatan Kuningan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.34305/51mj0d78

Abstract

Latar Belakang: Kepatuhan pengobatan pada pasien diabetes melitus lanjut usia masih rendah akibat penurunan kognitif dan keterbatasan fisik. Penelitian ini bertujuan mengetahui pengaruh faktor sosiodemografi terhadap kepatuhan pengobatan pada lansia dengan diabetes melitus di Kabupaten Sleman.Metode: Penelitian observasional analitik cross sectional pada 76 lansia dengan diabetes tipe 2 peserta Prolanis Puskesmas. Data diperoleh dari rekam medis dan wawancara menggunakan kuesioner Morisky Green Levine Scale (MGLS). Analisis hubungan dilakukan dengan uji Chi-Square.Hasil: Mayoritas peserta perempuan (61,84%), usia 60–70 tahun (76,32%), dan berpendidikan menengah (55,26%). Tingkat kepatuhan didominasi kategori sedang (53%), diikuti rendah (35%) dan tinggi (12%). Tidak ditemukan hubungan antara faktor sosiodemografi (usia, jenis kelamin, pendidikan, pekerjaan, durasi penyakit, jumlah obat) dan tingkat kepatuhan (p > 0,05).Kesimpulan: Mayoritas pasien lanjut usia dengan diabetes melitus di Kabupaten Sleman memiliki kepatuhan sedang terhadap pengobatan dan tidak ada keterkaitan antara faktor sosiodemografi dengan kepatuhan pengobatan.
ANALGESIC POTENTIAL OF ETHANOL EXTRACT OF KETAPANG LEAVES (Terminalia catappa L.) ON MICE USING THE HOTPLATE METHOD Hesturini, Rosa Juwita; Anjani, Ade Giriayu; Briandini Dwi Astuti; Afdyta Doria Bilhis
JURNAL PHARMA BHAKTA Vol 5 No 2 (2025): November 2025
Publisher : FACULTY OF PHARMACY, INSTITUT ILMU KESEHATAN BHAKTI WIYATA

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Abstract

Background: Pain is a sensory experience from tissue damage that can occur over a certain duration. Pain management is generally carried out by administering analgesic drugs. Ketapang leaves have potential as a natural analgesic alternative. Objective: To evaluate the analgesic activity of ketapang leaf extract in male white mice. Methods: A total of 15 mice were divided into five groups: 0.5% Na CMC as a negative group, a positive control Asetil salisilat acid 500 mg/KgBW, and three treatment groups given sampel at doses of 300 mg/KgBW, 400 mg/KgBW, and 500 mg/KgBW. The analgesic test was conducted using the hot plate methog, and the mice's response to heat stimulus was observed for 60 minutes after oral suspension administration. Results: Extract at various doses significantly increased the latency period of the mice compared to the negative control group. The highest latency period was shown by the 500 mg/KgBW dose, which was 9.39 seconds. This suspected activity is due to the content of flavonoid, alkaloid, saponin, and steroid compounds, which may blockade of the cyclooxygenase pathway. Conclusion: The extract of ketapang leaves possesses analgesic percentages of 33%, 36%, and 55%, respectively. The most effective dose was 500 mg/KgBW, with an analgesic percentage of 55%.
The Effects of Varying Saffron Extract Concentration on the Physical Quality, Stability and Antioxidant Activity Tests of Gel Dosage Form Pramasari, Nadia; Shoviantari, Fenita; Rumwarin, Yuliana; Yuliati, Ninis; Anjani, Ade Giriayu; Hesturini, Asih Imulda; Sugiyartono
MPI (Media Pharmaceutica Indonesiana) Vol. 7 No. 2 (2025): DECEMBER
Publisher : Fakultas Farmasi, Universitas Surabaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24123/mpi.v7i2.7905

Abstract

Saffron (Crocus sativus L) is a plant that contains antioxidants, which is known as “red gold” and belongs to the iris family (Iridaceae). Saffron stigmas are reported to have antioxidant activity to prevent free radicals. This study aimed to determine the effects of varying saffron extract concentrations on the physical quality, stability, and antioxidant activity of the gel dosage form. There were 3 gel preparation formulations containing 1% (F1), 2% (F2), and 3% (F3) saffron extract. Physical quality tests for the saffron extract gel were included organoleptic test, homogeneity test, pH test, adhesion test, and spreadability test. A stability test was conducted at 25 ± 2°C for 1 month. Antioxidant activity test was performed using DPPH. The results of the physical quality tests, stability tests, and antioxidant tests were analyzed using SPSS. The results of the saffron extracts in gel F1, F2, and F3 met the requirements, and no differences in F1, F2, and F3. The stability test revealed differences in adhesiveness among F1, F2, and F3. The antioxidant activity test of the saffron extract gel dosage form was included in the moderate antioxidant category, with the IC50 values of formulation 1 (195.25 ppm), formulation 2 (178.31 ppm), and formulation 3 (159.26 ppm). The results of the antioxidant activity test on saffron extract also showed a moderate category. This study showed that all physical quality tests met the requirements, the preparation was unstable during storage, and the antioxidant activity was categorized as moderate.
Co-Authors Afdyta Doria Bilhis Briandini Dwi Astuti Fenita Shoviantari, Fenita Hayati, Rachma Nur Hesturini, Asih Imulda Marcelina, Ananda Marhenta, Yogi Bhakti Nadia Pramasari Ninis Yuliati, Ninis Rosa Juwita Hesturini Rosa Juwita Hesturini Rumwarin, Yuliana Sari, Dwi Evi Diyan Seran, Krisogonus Ephriono Shofiatul Fajriyah Shofyatul Fajriyah Sugiyartono Wahyuni, Kumala Sari Poespita Dewi