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All Journal Chimica et Natura Acta Sriwijaya Bioscientia Molekul: Jurnal Ilmiah Kimia
Melani, Fitria
Unknown Affiliation
Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Chemistry Environmental Science Immunology & microbiology Materials Science & Nanotechnology Medicine & Pharmacology

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Studi Etnobotani Tumbuhan yang Berkhasiat Sebagai Obat Oleh Masyarakat di Tiga Desa Kecamatan Maro Sebo Kabupaten Muaro Jambi Putri, Silvi Ayudiah; Melani, Fitria; Zulnita, Anis; Tarigan, Indra Lasmana
Sriwijaya Bioscientia Vol 5 No 1 (2024)
Publisher : Biology Department, Faculty of Mathematics and Natural Sciences, Sriwijaya University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24233/sribios.5.1.2024.440

Abstract

Tanaman obat telah banyak digunakan oleh masyarat dari zaman dahulu hingga sekarang dalam membantu menyembuhkan penyakit. Studi etnobotani dapat digunakan untuk menjelaskan mengenai hubungan masyarakat tradisional dalam memanfaatkan tanaaman obat tersebut. Salah satu masyarakat yang masih mempertahankan budaya tersebut adalah masyarakat di tiga desa di Kecamatan Maro Sebo. Kabupaten Muaro Jambi. Penelitian dilakukan di tiga desa, yatiu Desa Baru, Bakung dan Danau Kedap di Kecamatan Maro Jambi, Kabupaten Muaro Jambi. Penelitian dilakukan dengan metode deskriptif eksplotarif yaitu metode dengan teknik pengumpulan informasi secara partisipatif atau wawancara. Hasil penelitian diperoleh 60 jenis tanaman obat yang digunakan oleh masyarakat. Dari 60 jenis tanaman obat tersebut terdiri dari 42 jenis famili berbeda. Jenis tanaman yang banyak digunakan adalah berhabitus pohon dengan persentase 31,67%. Bagian tumbuhan yang banyak dimanfaatkan adalah daun dengan persentase 55%. Sedangkan cara pengolahan tanaman obat yang paling banyak digunakan oleh masyarakat adalah dengan cara direbus dengan persentase 60%.
In-silico of Vascular Endothelial Growth Factor Receptor-2 (VEGFR-2) Inhibitors of Seven Bioactive Compounds from Sonneratia alba Latief, Madyawati; Melani, Fitria; Yusnaidar, Yusnaidar; Tarigan, Indra Lasmana
Chimica et Natura Acta Vol 13, No 2 (2025)
Publisher : Departemen Kimia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24198/cna.v13.n2.59525

Abstract

Cancer is a disorder resulting from genetic changes, abnormal growth, and spread to other parts of the body. Cancer treatment is commonly administered through chemotherapy, which often results in adverse side effects. Therefore, research is essential to identify safer alternative cancer therapies. This study aims to identify potential bioactive compound ligand receptor targets from Sonneratia alba as anticancer candidates in silico by identifying VEGFR target proteins based on their pharmacophores and studying their interactions through the reverse docking method. Docking simulations between the native ligand (Tivozanib) and the receptor yielded promising results, with a free energy value of -12.76 kcal/mol and an inhibition constant of 440.70 μM. Among the seven bioactive compounds, Meperidine (C15H21NO2) exhibited favorable outcomes, showing a free energy value of -7.39 kcal/mol and an inhibition constant of 3.83 μM. Additionally, the meperidine and gibberellin A7 compounds formed three and four hydrogen bonds, respectively, including one with Ala866, and interacted with 15 and 18 amino acid residues, such as Glu917, Cys919, Glu885, and Asp1046. The presence of active sites on the ligand or test compounds that bind to the target receptor indicates a potential for comparable affinity in inhibiting VEGFR-2 receptor activity.
Metabolomic Profiling LC-MS Based Bioactive Compound of Sonneratia alba, Antioxidant Activities and Its In-silico molecular docking Studies Tarigan, Indra Lasmana; Latief, Madyawati; Anshori, Jamaludin Al; Melani, Fitria; Putri, Silvi Ayudiah; Husna, Naimul; Warni, Tri; Ramadhan, Ilham Ifandi; Yusnaidar, Yusnaidar; Sutrisno, Sustrisno
Molekul Vol 20 No 2 (2025)
Publisher : Universitas Jenderal Soedirman

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20884/1.jm.2025.20.2.13578

Abstract

ABSTRACT. Mangrove Perepat (Sonneratia alba) plants have various potentials that need to be utilized optimally because they have varying bioactive compound content. A comprehensive exploration of secondary metabolite compound content and plant bioactivity based on metabolomics and in-silico molecular docking is needed to see the effects of single or multiple compounds. This study aimed to obtain a profile of medicinal compounds from Perepat leaves as antioxidants. Extraction was carried out using five gradients of Ethanol: Water concentration. EP1 (water), EP2 (25% Ethanol), EP3 (50% Ethanol), EP4 (75% Ethanol), EP5 (100% Ethanol). The research was carried out through extraction, antioxidant determination, metabolomics, and molecular docking. Exploration data showed that increasing ethanol concentration increased phenolics, flavonoids, and antioxidant activity. EP5 has the highest total phenolics and flavonoids of 24.978 mgGAE/g and 42.97 mgQE/g, respectively, with an IC50 value of 8.263 ppm. Docking analysis of 37 test compounds identified 12 compounds with low binding energy, ranging from -7 to -9 kcal/mol, with the NADPH oxidase protein receptor (PDB ID: 2CDU). These compounds include kaempferol-3-rhamnoside, meperidine, apigenin-7-O-glucoside, 2-keto benzothiazole 54, methyl propanoic acid, salicyloylaminotriazole, salicylihalamide A, and gibberellin A7. Our findings suggest that S. alba extract holds potential for further exploration as a natural antioxidant source. Keywords: Antioxidant; In-silico; Metabolomics; S. alba
Co-Authors Husna, Naimul Indra Lasmana Tarigan Jamaludin Al-Anshori Madyawati Latief Putri, Silvi Ayudiah Ramadhan, Ilham Ifandi Sutrisno, Sustrisno Warni, Tri Yusnaidar, Yusnaidar Zulnita, Anis