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All Journal CHEMPUBLISH JOURNAL Makara Journal of Science Jurnal Pengabdian Pada Masyarakat Molekul: Jurnal Ilmiah Kimia
Warni, Tri
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Pelatihan Masyarakat Desa Setiris, Kecamatan Muaro Sebo dalam Mengolah Tumbuhan Sungkai Menjadi Minuman Herbal Bermanfaat Teh Sungkai Natasya, Dian; Oktavioni, Marsella; Warni, Tri; Bulan, Catherine Putri; Sinurat, Julius Alvin Novensius; Sari, Tika; Latief, Madyawati; Tarigan, Indra Lasmana
Jurnal Pengabdian Pada Masyarakat Vol 9 No 4 (2024): Jurnal Pengabdian Pada Masyarakat
Publisher : Universitas Mathla'ul Anwar Banten

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30653/jppm.v9i4.862

Abstract

Sungkai (Peronema canescens Jack) merupakan tumbuhan obat yang banyak dimanfaatkan secara tradisional oleh masyarakat sebagai obat luka, diare, obat kumur dan malaria. Kegiatan pengabdian ini bertujuan untuk memberikan pemahaman khasiat daun sungkai secara saintifik melalui pelatihan pemanfaatan daun sungkai sebagai minuman herbal. Kegiatan pendampingan dimulai dari sosialisasi dan edukasi untuk peningkatan pemahaman serta pelatihan pengolahan daun sungkai menjadi teh berstandar dengan penambahan herbal lainnya guna meningkatkan keterampilan masyarakat dan diakhiri dengan survei untuk evaluasi kegiatan. Teh daun sungkai dibuat dalam empat variasi: variasi 1 (daun sungkai + gula aren + kayu manis), variasi 2 (daun sungkai + gula aren + lemon), variasi 3 (daun sungkai + kayu manis + madu) dan variasi 4 (daun sungkai + lemon + madu). Hasil observasi dan survei terhadap masyarakat terkait variasi teh sungkai, ditemukan bahwa masyarakat menyukai variasi teh sungkai mencapai 87 – 94% dengan tingkat preferensi 25% pada masing-masing varisi 1, 2, 3, dan 4. Kegiatan ini meningkatkan pengetahuan dan keterampilan masyarakat mencapai 95%. Sungkai (Peronema canescens Jack) is a medicinal plant traditionally used by the community as a medicine for caterpillars, diarrhea, mouthwash, and malaria. This activity aims to provide an understanding of the scientific efficacy of sungkai leaves through training in the use of sungkai leaves as herbal drinks. The mentoring activity begins with socialization and education to increase understanding and training in processing sungkai leaves into standardized tea with the addition of other herbs to improve community skills. It ends with a survey to evaluate the activity. Sungkai leaf tea is made in four variations: variation 1 (sungkai leaves + palm sugar + cinnamon), variation 2 (sungkai leaves + palm sugar + lemon), variation 3 (sungkai leaves + cinnamon + honey), and variation 4 (sungkai leaves + lemon + honey). The results of observations and surveys of the community regarding variations of sungkai tea found that the community liked the variation of sungkai tea, reaching 87 - 94% with a preference level of 25% for each variation 1, 2, 3, and 4. This activity increased community knowledge and skills by 95%.
Synthesis of Carboxymethyl Cellulose from Nypa fruticans for Coating Metformin on Zn-Based Metal-Organic Framework Nanohybrid as a Bionanocomposite Drug Delivery System Delviani, Delviani; Maharani, Viola Giary Rizkillah; Shadrina, Putri Nur; Warni, Tri; Azizah, Regina Wan; Tarigan, Indra Lasmana; Latief, Madyawati
Makara Journal of Science
Publisher : UI Scholars Hub

Show Abstract | Download Original | Original Source | Check in Google Scholar

Abstract

Diabetes is a common and rapidly spreading disease that affects 6.6% of the world’s population. Metformin hydrochloride (HCl) is an effective oral pharmacological treatment for type 2 diabetes mellitus (T2DM) patients because of its capability to reduce glucose levels and the risk of hypoglycaemia. However, gastrointestinal sensitivities to this drug can cause diarrhoea, nausea, vomiting and stomach ache. An alternative is controlled release technology by coating metformin with carboxymethyl cellulose (CMC) and zinc-metal-organic framework (Zn-MOF) through the encapsulation method. Therefore, this study aimed to coat metformin formulations using CMC in a Zn-MOF to control release into the body and minimise the side effects related to doses. The results showed that CMC/metformin@Zn-MOF encapsulation had a controlled blood sugar lowering effect and stable healing effectiveness even at a low concentration of 1:10 of local metformin. In vitro, the released concentrations from local metformin tablets and CMC/Metformin@Zn-MOF were 199.50 ppm of 500 ppm and 42.182 ppm of 50 ppm, with release percentages of 39.90% and 84.364%, respectively. This study found that metformin masking using CMC and Zn-MOF maximally produced a modified release formula along the intestine by reducing the concentration to increase tolerability in lowering blood sugar effectively for T2DM patients with minimal side effects.
Comparative Study of Macerated and Soxhlet-Extracted Moringa Oleifera Leaf Extracts: LC-MS-Based Metabolomic Profiling, Antioxidant Activity, and In Silico Target Prediction Muadifah, Afidatul; Sulastri, Sulastri; Sowe, Momodou Salieu; Lintang, Anggun; Warni, Tri
Chempublish Journal Vol. 9 No. 1 (2025): Chempublish Journal
Publisher : Department of Chemistry, Faculty of Science and Technology Universitas Jambi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22437/chp.v9i1.36870

Abstract

Moringa leaves (Moringa oleifera L.) are rich in secondary metabolites such as flavonoids, alkaloids, tannins, saponins, and terpenoids, which function as natural antioxidants. This study aimed to analyze the metabolite profile of M. oleifera leaf extracts obtained through two extraction techniques using LC-MS, evaluate their antioxidant activity via the DPPH assay, and predict the interaction between NADPH oxidase (as a receptor) and key plant-derived compounds through molecular docking. LC-MS results indicated that the maceration method yielded 101 secondary metabolites, with flavonoid derivatives comprising 70.99% of the extract, dominated by five key compounds including Kaempferol 3-O-robinobioside and Luteolin-7-glucoside. In contrast, the Soxhlet method resulted in 83 identified compounds, with a higher proportion of flavonoids (75.61%), and prominent compounds including quercetin-3-O-glucoside and Kaempferol 3-(6G-malonylneohesperidoside). Antioxidant testing with DPPH at concentrations of 10, 50, and 100 ppm revealed the Soxhlet extract had a stronger activity (IC₅₀ = 14.328 ppm) compared to the macerated extract (IC₅₀ = 32.092 ppm), with statistically significant differences (p < 0.05). Molecular docking demonstrated that Kaempferol 3-(6G-malonylneohesperidoside) exhibited the strongest binding affinity to NADPH oxidase (-10.1 kcal/mol), followed by other flavonoid derivatives. These findings underscore the antioxidant potential of M. oleifera, particularly from Soxhlet extraction, and suggest its promising application in pharmaceutical development as a natural antioxidant source.
Metabolomic Profiling LC-MS Based Bioactive Compound of Sonneratia alba, Antioxidant Activities and Its In-silico molecular docking Studies Tarigan, Indra Lasmana; Latief, Madyawati; Anshori, Jamaludin Al; Melani, Fitria; Putri, Silvi Ayudiah; Husna, Naimul; Warni, Tri; Ramadhan, Ilham Ifandi; Yusnaidar, Yusnaidar; Sutrisno, Sustrisno
Molekul Vol 20 No 2 (2025)
Publisher : Universitas Jenderal Soedirman

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20884/1.jm.2025.20.2.13578

Abstract

ABSTRACT. Mangrove Perepat (Sonneratia alba) plants have various potentials that need to be utilized optimally because they have varying bioactive compound content. A comprehensive exploration of secondary metabolite compound content and plant bioactivity based on metabolomics and in-silico molecular docking is needed to see the effects of single or multiple compounds. This study aimed to obtain a profile of medicinal compounds from Perepat leaves as antioxidants. Extraction was carried out using five gradients of Ethanol: Water concentration. EP1 (water), EP2 (25% Ethanol), EP3 (50% Ethanol), EP4 (75% Ethanol), EP5 (100% Ethanol). The research was carried out through extraction, antioxidant determination, metabolomics, and molecular docking. Exploration data showed that increasing ethanol concentration increased phenolics, flavonoids, and antioxidant activity. EP5 has the highest total phenolics and flavonoids of 24.978 mgGAE/g and 42.97 mgQE/g, respectively, with an IC50 value of 8.263 ppm. Docking analysis of 37 test compounds identified 12 compounds with low binding energy, ranging from -7 to -9 kcal/mol, with the NADPH oxidase protein receptor (PDB ID: 2CDU). These compounds include kaempferol-3-rhamnoside, meperidine, apigenin-7-O-glucoside, 2-keto benzothiazole 54, methyl propanoic acid, salicyloylaminotriazole, salicylihalamide A, and gibberellin A7. Our findings suggest that S. alba extract holds potential for further exploration as a natural antioxidant source. Keywords: Antioxidant; In-silico; Metabolomics; S. alba
Co-Authors Azizah, Regina Wan Bulan, Catherine Putri Delviani, Delviani Husna, Naimul Indra Lasmana Tarigan Jamaludin Al-Anshori Lintang, Anggun Madyawati Latief Maharani, Viola Giary Rizkillah Melani, Fitria Muadifah, Afidatul Natasya, Dian Oktavioni, Marsella Putri, Silvi Ayudiah Ramadhan, Ilham Ifandi Sari, Tika Shadrina, Putri Nur Sinurat, Julius Alvin Novensius Sowe, Momodou Salieu Sulastri Sulastri Sutrisno, Sustrisno Yusnaidar, Yusnaidar