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All Journal Alchemy : Journal of Chemistry Sriwijaya Bioscientia Molekul: Jurnal Ilmiah Kimia
Putri, Silvi Ayudiah
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Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Energy Environmental Science Immunology & microbiology Materials Science & Nanotechnology Medicine & Pharmacology

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Studi Etnobotani Tumbuhan yang Berkhasiat Sebagai Obat Oleh Masyarakat di Tiga Desa Kecamatan Maro Sebo Kabupaten Muaro Jambi Putri, Silvi Ayudiah; Melani, Fitria; Zulnita, Anis; Tarigan, Indra Lasmana
Sriwijaya Bioscientia Vol 5 No 1 (2024)
Publisher : Biology Department, Faculty of Mathematics and Natural Sciences, Sriwijaya University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24233/sribios.5.1.2024.440

Abstract

Tanaman obat telah banyak digunakan oleh masyarat dari zaman dahulu hingga sekarang dalam membantu menyembuhkan penyakit. Studi etnobotani dapat digunakan untuk menjelaskan mengenai hubungan masyarakat tradisional dalam memanfaatkan tanaaman obat tersebut. Salah satu masyarakat yang masih mempertahankan budaya tersebut adalah masyarakat di tiga desa di Kecamatan Maro Sebo. Kabupaten Muaro Jambi. Penelitian dilakukan di tiga desa, yatiu Desa Baru, Bakung dan Danau Kedap di Kecamatan Maro Jambi, Kabupaten Muaro Jambi. Penelitian dilakukan dengan metode deskriptif eksplotarif yaitu metode dengan teknik pengumpulan informasi secara partisipatif atau wawancara. Hasil penelitian diperoleh 60 jenis tanaman obat yang digunakan oleh masyarakat. Dari 60 jenis tanaman obat tersebut terdiri dari 42 jenis famili berbeda. Jenis tanaman yang banyak digunakan adalah berhabitus pohon dengan persentase 31,67%. Bagian tumbuhan yang banyak dimanfaatkan adalah daun dengan persentase 55%. Sedangkan cara pengolahan tanaman obat yang paling banyak digunakan oleh masyarakat adalah dengan cara direbus dengan persentase 60%.
Metabolomic Profiling LC-MS Based Bioactive Compound of Sonneratia alba, Antioxidant Activities and Its In-silico molecular docking Studies Tarigan, Indra Lasmana; Latief, Madyawati; Anshori, Jamaludin Al; Melani, Fitria; Putri, Silvi Ayudiah; Husna, Naimul; Warni, Tri; Ramadhan, Ilham Ifandi; Yusnaidar, Yusnaidar; Sutrisno, Sustrisno
Molekul Vol 20 No 2 (2025)
Publisher : Universitas Jenderal Soedirman

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20884/1.jm.2025.20.2.13578

Abstract

ABSTRACT. Mangrove Perepat (Sonneratia alba) plants have various potentials that need to be utilized optimally because they have varying bioactive compound content. A comprehensive exploration of secondary metabolite compound content and plant bioactivity based on metabolomics and in-silico molecular docking is needed to see the effects of single or multiple compounds. This study aimed to obtain a profile of medicinal compounds from Perepat leaves as antioxidants. Extraction was carried out using five gradients of Ethanol: Water concentration. EP1 (water), EP2 (25% Ethanol), EP3 (50% Ethanol), EP4 (75% Ethanol), EP5 (100% Ethanol). The research was carried out through extraction, antioxidant determination, metabolomics, and molecular docking. Exploration data showed that increasing ethanol concentration increased phenolics, flavonoids, and antioxidant activity. EP5 has the highest total phenolics and flavonoids of 24.978 mgGAE/g and 42.97 mgQE/g, respectively, with an IC50 value of 8.263 ppm. Docking analysis of 37 test compounds identified 12 compounds with low binding energy, ranging from -7 to -9 kcal/mol, with the NADPH oxidase protein receptor (PDB ID: 2CDU). These compounds include kaempferol-3-rhamnoside, meperidine, apigenin-7-O-glucoside, 2-keto benzothiazole 54, methyl propanoic acid, salicyloylaminotriazole, salicylihalamide A, and gibberellin A7. Our findings suggest that S. alba extract holds potential for further exploration as a natural antioxidant source. Keywords: Antioxidant; In-silico; Metabolomics; S. alba
Studi In Silico Senyawa Bioaktif Kopi Arabika (Coffea Arabica) Sebagai Kandidat Antikanker terhadap Reseptor PI3K p110-delta subunit Melani, Fitria; Putri, Silvi Ayudiah; Zulnita, Anis; Latief, Madyawati; Sutrisno, Sustrisno; Tarigan, Indra Lasmana
ALCHEMY:Journal of Chemistry Vol 13, No 1 (2025): ALCHEMY: JOURNAL OF CHEMISTRY
Publisher : Department of Chemistry, Faculty of Science and Technology UIN Maulana Malik Ibrahim Malan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18860/al.v13i1.28636

Abstract

Each year, 9.6 million people lose their lives to cancer, making it the world's second worst killer. Cancer is a disorder that results from genetic changes and has abnormal growth and spreads to other parts of the body. Cancer treatment is currently done with chemotherapy which has unfavorable side effects, so research needs to be done to determine safer alternatives to cancer treatment. This study aims to determine the activity of bioactive compounds in Arabica coffee beans that have potential as anticancer through identification of target receptors and interaction studies using molecular docking methods against PI3K p110-delta subunit receptors. The results showed that of the 21 compounds, five compounds gave good results, namely compounds 4-O-feruloylqunic acid, 4-O-caffeoylqunic acid, gluconic acid, 3-O-feruloylqunic acid and 3-O-caffeoylqunic acid with bond energy (ΔG) and inhibition constant values of -5.47; -5.33; -4.73; -4.69; -4.40 kcal/mol and 98.02; 123.62; 340.97; 363.82; 591.97 μM, respectively. So that these test ligands/compounds can have potential as PI3K receptor inhibitors in cancer treatment
Co-Authors Husna, Naimul Indra Lasmana Tarigan Jamaludin Al-Anshori Madyawati Latief Melani, Fitria Ramadhan, Ilham Ifandi Sutrisno, Sustrisno Warni, Tri Yusnaidar, Yusnaidar Zulnita, Anis