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All Journal Biofaal Journal Berita Kedokteran Masyarakat
Ernestia, Henrita
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Biochemistry, Genetics & Molecular Biology Materials Science & Nanotechnology Medicine & Pharmacology Nursing Public Health

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The Role of Telomerase in Celullar Senescence and Its Implications For Anti-Aging Therapy Defi, Ratna Shintia; Ernestia, Henrita; Pukan, Ferdinandus Krisna
Biofaal Journal Vol 6 No 1 (2025): Biofaal Journal
Publisher : Pattimura University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30598/biofaal.v6i1pp20-28

Abstract

Aging is a complex biological process influenced by genetic, environmental, and lifestyle factors. One of the primary mechanisms contributing to aging is telomere shortening, which plays a crucial role in genome stability and cellular regeneration. As individuals age, progressive telomere shortening can trigger cellular apoptosis and tissue dysfunction, impacting health and skin aesthetics. Consequently, telomere-based anti-aging therapies have become a significant focus of strategies aimed at slowing the aging process and improving quality of life. Several studies have explored various therapeutic approaches, including telomerase activation, bioactive compounds, and genetic engineering technologies to maintain telomere length and enhance cellular function. This literature review aims to analyze recent developments in telomere-based anti-aging therapies, evaluate their effectiveness, and discuss their potential applications in health and aesthetic medicine. A deeper understanding of telomere mechanisms and their therapies is expected to facilitate the development of more effective and sustainable anti-aging strategies.
Association between cholesterol and blood pressure examination in Sampangan, Semarang City: a preliminary study Christyana, To Lidwina Prillya Indra; Riwanto, Ignatius; Sebong, Perigrinus H; Sutanto, Eviana Budiartanti; Ernestia, Henrita; Tjitradinata, Cynthia; Kristanti, Alberta Widya
BKM Public Health and Community Medicine Vol 39 No 12 (2023)
Publisher : Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22146/bkm.v39i12.9841

Abstract

Purpose: This study aims to determine the baseline prevalence and association between blood pressure and cholesterol examination. Method: This preliminary study used a cross-sectional design to analyze the secondary blood pressure and cholesterol levels data in the Sampangan sub-district, Semarang City. The total sampling technique covered those enrolled in the metabolic syndrome screening from January to April 2023. The logistic regression test was used in data analysis. Results: 58 respondents took blood pressure checks, while only 40 had cholesterol checks. The probability of males getting changes in cholesterol levels was higher than that of females (OR = 8.69; p-value = 0.01). However, neither (female nor male) had a significant relationship, and there was no difference in the chances of changes in blood pressure (OR = 1.43; p = 0.72). Respondents above 60 years had a significant association with changes in blood pressure compared to those under 60 years (OR = 0.09; p = 0.007). Conclusion: This study revealed males of a certain age experience higher changes in cholesterol levels compared to females. People over 60 years old tend to have higher blood pressure compared to those under 60 years old. These findings propose an outreach strategy for health screening for patients with limited mobility, transportation access, and finances for routine checkups at public or government healthcare facilities.
Co-Authors Christyana, To Lidwina Prillya Indra Defi, Ratna Shintia Ignatius Riwanto, Ignatius Kristanti, Alberta Widya Pukan, Ferdinandus Krisna Sebong, Perigrinus H Sutanto, Eviana Budiartanti Tjitradinata, Cynthia