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All Journal Jurnal Ilmiah Ibnu Sina (JIIS): Ilmu Farmasi dan Kesehatan Jurnal Medika Farmaka
Efraim Lian, Kevin
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Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Immunology & microbiology Medicine & Pharmacology

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A Review : Pengembangan Obat Rheumatoid Arthritis (RA) dengan Berbagai Pendekatan Amelia, Ferda; Kaniawati, Marita; Gabriela Da Costa Soares, Fidelia s; Languwila, Indrawati; Dwi Fatma, Ira; Jefry, Jefry; Efraim Lian, Kevin; Irene Welmince Bokotei, Martini; Taofiq Putra Pratama, Muhamad; Septri Rahmawati, Nabila; Kasihtheisya, Naida; Subakti, Nanda; Dodit Rinaldi, Muhammad
Jurnal Medika Farmaka Vol 3 No 1 (2025): Jurnal Medika Farmaka
Publisher : LP4M STIKes Karsa Husada Garut

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33482/jmedfarm.v3i1.59

Abstract

Introduction: Rheumatoid Arthritis (RA) is an autoimmune disease characterized by chronic inflammation of the joints, which can lead to cartilage damage and disability. Not all standard medications for RA therapy are efficient for all patients and long-term use can cause serious side effects. Therefore, it is necessary to develop drugs for RA involving various approaches, both pharmacological and non-pharmacological. Method: This article review is based on references to several articles from online databases published nationally and internationally. Result: From the article search, there were 10 articles discussing RA drug development from various approaches. Conclusion: Based on the review of articles carried out, there is drug development using a pharmacological approach including the use of natural ingredients such as purslane tea, red betel leaf extract, secang plants and curcumin, nanotechnology-based innovations such as composite hydrogel and MTX nanocarriers, a drug repurposing approach to the discovery of new drugs alpha-linolenic acid and Belatacept as well as non-pharmacological approaches with complementary therapies such as red ginger and warm betel compresses. Keywords: Drug development, treatment, rheumatoid arthritis
POTENSI KOMBINASI EKSTRAK ETANOL DAUN DADAP SEREP (Erythrina subumbrans) DAN PEGAGAN (Centella asiatica) DALAM MENURUNKAN RISIKO DISFUNGSI ENDOTEL PADA TIKUS DENGAN DIET TINGGI FRUKTOSA Kaniawati, Marita; Sulaeman, Agus; Nurfazri Istiqomah, Aulia; Efraim Lian, Kevin
Jurnal Ilmiah Ibnu Sina (JIIS): Ilmu Farmasi dan Kesehatan Vol 11 No 1 (2026): Jurnal Ilmiah Ibnu Sina
Publisher : Sekolah Tinggi Ilmu Kesehatan ISFI Banjarmasin

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36387/jiis.v11i1.2875

Abstract

Fructose has long been known as a sugar additive or sweetener, commonly found in soft drinks, pastries, and other processed foods. High levels of added sugar in the daily diet increase the risk of various metabolic disorders, including insulin resistance. Insulin resistance can lead to impaired endothelial function (endothelial dysfunction), which can lead to impaired vasodilation responses. Endothelial dysfunction can lead to an increased risk of cardiovascular diseases such as atherosclerosis, coronary heart disease (CHD), hypertension, and other vascular diseases. The aim of this study was to identify the potential of a combination of dadap serep (Erythrina subumbrans) and pegagan (Centella asiatica) to reduce the risk of endothelial dysfunction (as measured by nitric oxide (NO) levels) triggered by high fructose consumption. This research method is an in vivo experimental preventive using 36 rats divided into normal group, induction group, comparison group of curcumin 9 mg/kgBW, test group 1 EEPDS 50:100 mg/kgBW, test group 2 EEPDS 100:100 mg/kgBW and test group 3 EEPDS 100:50 mg/kgBW. Measurement of NO levels using the Griess method, while insulin resistance examination was carried out using the insulin tolerance test method. The results showed that the combination group of EEPDS 100:50 mg/kgBW was the group that showed the most optimal effect in maintaining endothelial function and had the best insulin sensitivity. The conclusion of this study shows that the combination of EEPDS 100:50 mg/kgBW is effective in maintaining insulin sensitivity and maintaining endothelial function in rats.
Co-Authors Agus Sulaeman Amelia, Ferda Dodit Rinaldi, Muhammad Dwi Fatma, Ira Gabriela Da Costa Soares, Fidelia s Irene Welmince Bokotei, Martini Jefry Jefry Kasihtheisya, Naida Languwila, Indrawati Marita Kaniawati Nurfazri Istiqomah, Aulia Septri Rahmawati, Nabila Subakti, Nanda Taofiq Putra Pratama, Muhamad