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All Journal Farmasains : Jurnal Ilmiah Ilmu Kefarmasian Majalah Farmasi dan Farmakologi (Trends in Pharmacy and Pharmaceutical Sciences) Jurnal Ilmiah Ibnu Sina (JIIS): Ilmu Farmasi dan Kesehatan
Nurfazri Istiqomah, Aulia
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Medicine & Pharmacology

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PENETAPAN TOKSISITAS AKUT DAN SUBKRONIK PADA EKSTRAK ETANOL DAUN KATUK (Sauropus androgynus (L). Merr) Putra, Hendra Mahakam; Sulaeman, Agus; Nurfazri Istiqomah, Aulia; Nurfadillah, Ilham
Majalah Farmasi dan Farmakologi Vol. 27 No. 3 (2023): MFF
Publisher : Faculty of Pharmacy, Hasanuddin University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20956/mff.v27i3.26462

Abstract

Daun katuk (Sauropus androgynus) dapat digunakan sebagai obat herbal karena kaya akan kandungan metabolit sekunder dan nutrisi. Untuk menjamin keamanan dalam penggunaannya sebagai obat herbal, dilakukan uji toksisitas akut dan toksisitas subkronik dengan menggunakan ekstrak etanol daun katuk pada tikus wistar betina dengan mengacu pada dosis uji dari OECD dan Badan Pengawas Obat dan Makanan (BPOM) yaitu dosis tunggal 300 mg/kg bb, 2.000 mg/kg bb, 5.000 mg/kg bb untuk uji toksisitas akut dan dosis harian 50 mg/kg bb, 100 mg/kg bb, 200 mg/kg bb untuk uji toksisitas subkronik. Tikus diamati setiap hari untuk gejala toksik masing-masing selama 14 dan 28 hari, dan pada hari ke 0 dan 28, untuk uji toksisitas subkronik dilakukan pengukuran biokimia darah yaitu SGOT, SGPT, dan Kreatinin. Di akhir percobaan, indeks berat organ juga ditentukan untuk semua tikus. Hasil penelitian menunjukkan bahwa pemberian ekstrak etanol daun katuk tidak menimbulkan gejala toksik dan tidak menyebabkan kematian pada hewan uji. Pemberian ekstrak daun katuk juga tidak mempengaruhi bobot badan secara signifikan jika dibandingkan dengan kelompok yang diberi N-CMC 1%. Hasil uji biokimia SGOT, SGPT, dan kreatinin juga dalam batas normal dan tidak ada perbedaan bermakna (p>0,05) antara kelompok normal dan kelompok uji. Oleh karena itu, penelitian ini dapat disimpulkan bahwa ekstrak etanol daun katuk praktis tidak toksik dengan nilai LD50 >5.000 mg/kg bb dan aman digunakan untuk konsumsi sehari-hari.
POTENSI KOMBINASI EKSTRAK ETANOL DAUN DADAP SEREP (Erythrina subumbrans) DAN PEGAGAN (Centella asiatica) DALAM MENURUNKAN RISIKO DISFUNGSI ENDOTEL PADA TIKUS DENGAN DIET TINGGI FRUKTOSA Kaniawati, Marita; Sulaeman, Agus; Nurfazri Istiqomah, Aulia; Efraim Lian, Kevin
Jurnal Ilmiah Ibnu Sina (JIIS): Ilmu Farmasi dan Kesehatan Vol 11 No 1 (2026): Jurnal Ilmiah Ibnu Sina
Publisher : Sekolah Tinggi Ilmu Kesehatan ISFI Banjarmasin

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36387/jiis.v11i1.2875

Abstract

Fructose has long been known as a sugar additive or sweetener, commonly found in soft drinks, pastries, and other processed foods. High levels of added sugar in the daily diet increase the risk of various metabolic disorders, including insulin resistance. Insulin resistance can lead to impaired endothelial function (endothelial dysfunction), which can lead to impaired vasodilation responses. Endothelial dysfunction can lead to an increased risk of cardiovascular diseases such as atherosclerosis, coronary heart disease (CHD), hypertension, and other vascular diseases. The aim of this study was to identify the potential of a combination of dadap serep (Erythrina subumbrans) and pegagan (Centella asiatica) to reduce the risk of endothelial dysfunction (as measured by nitric oxide (NO) levels) triggered by high fructose consumption. This research method is an in vivo experimental preventive using 36 rats divided into normal group, induction group, comparison group of curcumin 9 mg/kgBW, test group 1 EEPDS 50:100 mg/kgBW, test group 2 EEPDS 100:100 mg/kgBW and test group 3 EEPDS 100:50 mg/kgBW. Measurement of NO levels using the Griess method, while insulin resistance examination was carried out using the insulin tolerance test method. The results showed that the combination group of EEPDS 100:50 mg/kgBW was the group that showed the most optimal effect in maintaining endothelial function and had the best insulin sensitivity. The conclusion of this study shows that the combination of EEPDS 100:50 mg/kgBW is effective in maintaining insulin sensitivity and maintaining endothelial function in rats.
Proteksi Ekstrak Daun Pacing Terhadap Resistensi Insulin dan Studi Keamanannya terhadap Fungsi Hati dan Ginjal Nurfazri Istiqomah, Aulia; Lestari, Kharina Septi; Aligita, Widhya; Rahmah, Farizkah; Novianti, Tamia Rizqi; Raveani, Vina Julia
Farmasains : Jurnal Ilmiah Ilmu Kefarmasian Vol. 13 No. 1 (2026)
Publisher : Universitas Muhammadiyah Prof. DR. HAMKA

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22236/farmasains.v13i1.17593

Abstract

Insulin resistance is one of the primary causes of diabetes mellitus, leading to reduced tissue sensitivity to insulin and an increased risk of metabolic complications. The Ethanol Extract of Pacing leaves (EEPL) was evaluated for its potential to prevent insulin resistance in a rat model of diabetes induced by a high-fat, high-fructose diet. The rats were administered EEPL at doses of 150, 300, and 450 mg/kg Body Weight (BW) for 42 days. In addition, a 90-day subchronic toxicity study was conducted to assess potential adverse effects on the liver and kidneys. The results demonstrated that a dose of 300 mg/kg BW significantly improved insulin sensitivity. Biochemical parameters, including creatinine, urea, Serum Glutamic Oxaloacetic Transaminase (SGOT), and Serum Glutamic Pyruvic Transaminase (SGPT), remained within normal ranges, indicating preserved liver and kidney function. However, mild histopathological changes were observed in the kidneys, such as glomerular congestion and tubular necrosis, while the hepatic structure remained normal, with no significant hepatocellular damage. In conclusion, EEPL at a dose of 300 mg/kg BW provides an effective protective effect against insulin resistance, with relatively good safety for long-term use. Nevertheless, further studies are required to confirm its safety in humans.
Co-Authors Agus Sulaeman Aligita, Widhya Efraim Lian, Kevin Lestari, Kharina Septi Marita Kaniawati Novianti, Tamia Rizqi Nurfadillah, Ilham Putra, Hendra Mahakam Rahmah, Farizkah Raveani, Vina Julia