Article Per Year (5 Year)
p-Index From 2021 - 2026
0.61
P-Index
This Author published in this journals
All Journal PCJN Pharmaceutical and Clinical Journal of Nusantara
Wijiyaningsih, Dinda
Unknown Affiliation
Health Professions Medicine & Pharmacology Neuroscience Nursing Public Health

Published : 3 Documents Claim Missing Document
Claim Missing Document
Check
Articles

Found 3 Documents
Search

 1 
Characterization and Screening Phytochemicals Orange Purut Leaves (Citrus hystrix) Extract from Kampar, Riau Wijiyaningsih, Dinda; Ridwanto, Ridwanto; Yuniarti, Rafita; Pulungan, Ainil Fithri
PCJN: Pharmaceutical and Clinical Journal of Nusantara Vol. 3 No. 02 (2025): PCJN: Pharmaceutical and Clinical Journal of Nusantara
Publisher : CV. Nusantara Scientific Medical

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.58549/pcjn.v3i01.83

Abstract

Orange purut leaves (Citrus hystrix) are one of the shrubs that have high economic value because they contain vitamin C and are often used as a food flavoring. The aim of this research is to determine whether orange purut leaf extract contains phytochemicals and to characterize the properties of orange purut leaf extract. Phytochemical screening of orange purut leaf extract (Citrus hystrix) included the examination of flavonoids, tannins, saponins, steroids/triterpenoids, alkaloids, and glycosides. Phytochemical screening was conducted on both simplicia powder and simplicia extract, and characterization of the simplicia was carried out. The water content of orange purut leaves was found to be 8%, the water-soluble juice content was 37.9%, the ethanol-soluble juice content was 19%, the total ash content was 7.6%, and the acid-insoluble ash content was 0.6%. Orange purut leaf extract positively contains alkaloids, flavonoids, saponins, tannins, steroids/triterpenoids, and glycosides.
Analysis of Sulfamethoxazole and Trimethoprim Content in Novatrim Tablets Using Ultraviolet Spectrophotometry Wijiyaningsih, Dinda; Agustina, Sry
PCJN: Pharmaceutical and Clinical Journal of Nusantara Vol. 2 No. 01 (2023): PCJN: Pharmaceutical and Clinical Journal of Nusantara
Publisher : CV. Nusantara Scientific Medical

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.58549/pcjn.v2i03.72

Abstract

The accurate quantification of fixed-dose combination antibiotics is critical for ensuring therapeutic safety and efficacy. This study determined the content of sulfamethoxazole (SMX) and trimethoprim (TMP) in Novatrim tablets using the UV multicomponent spectrophotometric simultaneous equation method with phosphate buffer pH 7 as solvent. Maximum wavelengths were established at 270 nm (SMX) and 275 nm (TMP). Absorptivity constants determined were: a¹SMX = 0.2601, a²SMX = 0.2113, a¹TMP = 0.2170, a²TMP = 0.1721 (mL·µg⁻¹·cm⁻¹). Six replicate analyses of Novatrim tablets yielded SMX contents of 3.12%–40.39% and TMP contents of 1.92%–76.16%, both below the Farmakope Indonesia VI acceptance criterion of 93.0%–107.0%. The structural basis for UV detection was elucidated: SMX absorbs through a benzene–SO₂–isoxazole conjugated chromophore with a para-aminophenyl auxochrome (–NH₂); TMP absorbs through a diaminopyrimidine–trimethoxybenzyl chromophore system with –NH₂ and –OCH₃ auxochromes. Subthreshold recoveries were primarily attributed to reference standard degradation compromising chromophore and auxochrome integrity, compounded by out-of-range absorbance measurements and high spectral overlap between the two analytes. This study highlights the critical importance of reference standard storage conditions in multicomponent UV spectrophotometric analysis.
Antibacterial Activity of n-Hexane Extract of Jengkol (Archidendron pauciflorum) Peel Against Escherichia coli Siregar, Juni Yanti Peronika; Fitri, Nurya Syah; Wijiyaningsih, Dinda
PCJN: Pharmaceutical and Clinical Journal of Nusantara Vol. 4 No. 01 (2025): PCJN: Pharmaceutical and Clinical Journal of Nusantara
Publisher : CV. Nusantara Scientific Medical

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.58549/pcjn.v3i03.140

Abstract

Jengkol peel (Archidendron pauciflorum) is a plant with medicinal potential, as it contains bioactive compounds such as saponins, tannins, and flavonoids known to inhibit bacterial growth. Escherichia coli is a Gram-negative bacterium commonly associated with gastrointestinal tract infections. This study aimed to evaluate the antibacterial potential of n-hexane extract of jengkol peel against Escherichia coli. The antibacterial activity was assessed using the disc diffusion method by measuring the diameter of inhibition zones formed around the paper discs. The results demonstrated that the inhibition zone at a concentration of 500 ppm had a diameter of 15.47 mm (Strong category). These findings confirm that n-hexane extract of jengkol peel (Archidendron pauciflorum) possesses the ability to inhibit the growth of Escherichia coli.
Co-Authors Fithri Pulungan, Ainil Fitri, Nurya Syah Ridwanto Ridwanto Siregar, Juni Yanti Peronika Sry Agustina Yuniarti, Rafita