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All Journal Jurnal Penelitian Farmasi dan Herbal PCJN Pharmaceutical and Clinical Journal of Nusantara
Br Sembiring, Novitaria
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Health Professions Medicine & Pharmacology Neuroscience Nursing Public Health

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Efficacy Test of Tetanus Leaf (Leea aequata L.) Ethanol Extract against Bacteria (Pseudomonas aeruginosa) Lumban Gaol, Irma Yohana; Bangar, Roy Indrianto; Kaban, Vera Estefania; Br Sembiring, Novitaria; Harahap, Daimah Wirdatus Sanaun
PCJN: Pharmaceutical and Clinical Journal of Nusantara Vol. 3 No. 01 (2025): PCJN: Pharmaceutical and Clinical Journal of Nusantara
Publisher : CV. Nusantara Scientific Medical

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.58549/pcjn.v3i01.86

Abstract

Antibiotic-resistant nosocomial infections are caused by the opportunistic bacterium Pseudomonas aeruginosa. The purpose of this study is to use the disc diffusion method to assess the antibacterial efficacy of Tetanus (Leea aequata L.) leaf ethanol extract against Pseudomonas aeruginosa. The antibacterial activity was evaluated at 25%, 50%, and 75% concentrations after the leaves were extracted by maceration with 96% ethanol. The findings indicated that the antibacterial activity was depending on concentration, with respective minimum inhibition level measuring 12.97 mm, 16.7 mm, and 21.06 mm. The negative control (DMSO) displayed no inhibition zone, but the positive control (gentamicin) displayed KHM measuring 25.03 mm. The data distribution did not differ significantly, according to statistical analysis (p > 0.05). Bioactive substances that can harm bacterial cell structures, including flavonoids, alkaloids, tannins, and saponins, were thought to be responsible for this antibacterial action. According to these results, tetanus leaf extract may be used as a natural antibacterial agent and as a substitute for antibiotics in the treatment of Pseudomonas aeruginosa infections
Antioxidant Activity Test of The Ethyl Acetate Fraction of Tetanus Leaf (Leea aequata L.) Using The DPPH Method Waruwu, Loice Desy Krisna Yanti; Bangar, Roy Indrianto; Kaban, Vera Estefania; Br Sembiring, Novitaria
PCJN: Pharmaceutical and Clinical Journal of Nusantara Vol. 3 No. 01 (2025): PCJN: Pharmaceutical and Clinical Journal of Nusantara
Publisher : CV. Nusantara Scientific Medical

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.58549/pcjn.v3i01.88

Abstract

Degenerative diseases, such as diabetes, stroke, and cancer, are increasingly common in modern society, with free radicals as one of the main causes. Both natural and artificial sources of antioxidants are available. However, natural antioxidants are a better choice due to concerns over the negative effects of synthetic antioxidants. This study aims to evaluate the antioxidant activity of ethanol extract from titanus (leea aequata L.) leaves using DPPH (2,2-diphenyl-1-picrylhydrazyl) method. titanus leaves are known to contain secondary metabolites that have potential as antioxidants, including flavonoids and phenols. This type of research is an experimental method. The extraction process was carried out by maceration method using 96% ethanol, followed by fractionation using solvents with different polarities to obtain ethyl acetate fraction. The results showed that the ethyl acetate fraction showed the ability as a free radical antidote with an IC50 value of 11.309 ppm, which indicates significant antioxidant activity. These results indicate that titanus leaf extract has the potential to be used as a source of natural antioxidants in the prevention of degenerative diseases.
Antioxidant Activity Test of Titanus (Leea aequata L) Leaf Extract with DPPH Method Sihotang, Nurhanifah; Bangar, Roy Indrianto; Kaban, Vera Estefania; Br Sembiring, Novitaria; Harahap, Daimah Wirdatus Sanaun
PCJN: Pharmaceutical and Clinical Journal of Nusantara Vol. 3 No. 01 (2025): PCJN: Pharmaceutical and Clinical Journal of Nusantara
Publisher : CV. Nusantara Scientific Medical

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.58549/pcjn.v3i01.90

Abstract

Free radicals play an important role in oxidative stress, which can lead to a number of degenerative diseases, including heart disease, cancer and premature aging. Natural and artificial ingredients can be used to make antioxidants. The use of synthetic antioxidants is starting to be limited because excessive use can cause negative side effects, such as the accumulation of toxins in the body. This study aims to evaluate the antioxidant activity of tetanus (Leea aequata L.) leaf extract using DPPH method. Free radicals generated during metabolism can cause cell damage and contribute to various degenerative diseases. Therefore, it is important to find effective sources of antioxidants. In this study, Tetanus leaves were extracted using 96% ethanol solvent through maceration method. Antioxidant activity was evaluated by measuring the IC50 value against DPPH radical. The results showed that tetanus leaf extract had an IC50 value of 39.484 ppm, which indicated significant antioxidant activity. These results indicate that tetanus leaf extract can function as a free radical scavenging agent, which could potentially serve as a raw material in the development of herbal medicine to prevent oxidative stress-related diseases.
SKRINNING RESEP INTERAKSI OBAT PASIEN DIABETES MELITUS DAN GAGAL GINJAL PERIODE OKTOBER S.D DESEMBER 2023 DI RUMAH SAKIT RASYIDA MEDAN Rambe, Octia Rambe Octia; Br Sembiring, Novitaria
Jurnal Penelitian Farmasi Dan Herbal Vol 7 No 2 (2025): Jurnal Penelitian Farmasi Dan Herbal
Publisher : Fakultas Farmasi Institut Kesehatan DELI HUSADA Deli Tua

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36656/jpfh.v7i2.2357

Abstract

Prescription screening is a critical phase in pharmaceutical services conducted bypharmacists and pharmaceutical technical personnel upon receiving aprescription from a patient. This study specifically aims to eval_uate the outcomesof prescription screening based on administrative and pharmaceutical conformityanalysis at Rasyida Hospital, Medan. The research method employed is adescriptive cross-sectional approach with a retrospective design, collecting datafrom the period of October to December 2023. The study reveals thatadministrative eval_uations in prescription screening include several essentialelements such as the patient's name, age/date of birth, address, body weight,the prescribing doctor's name and registration number (SIP), hospital address,doctor’s initials, practice phone number, and the prescription date. On the otherhand, pharmaceutical review focuses on elements such as the name of themedication. With the rising morbidity rate and increased medication use inhospitals, addressing drug-related problems—particularly those stemming frominappropriate medication use—has become more urgent. Prescriptionassessment plays a key role in preventing such issues. This study aims toidentify the elements with the highest level of incompleteness or prescribingerrors. Incomplete prescriptions are a major trigger for medication errors,making prescription screening by pharmacists across healthcare facilities—suchas hospitals, community health centers, and pharmacies—a critical practice.Screening encompasses both administrative and pharmaceutical aspects,highlighting the essential role of pharmacists in mitigating potential health risksfor patients.
Co-Authors Bangar, Roy Indrianto Harahap, Daimah Wirdatus Sanaun Lumban Gaol, Irma Yohana Rambe, Octia Rambe Octia Sihotang, Nurhanifah Vera Estefania Kaban Waruwu, Loice Desy Krisna Yanti