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All Journal Nusantara Scientific Medical Research Journal PCJN Pharmaceutical and Clinical Journal of Nusantara Journal of Pharmaceutical and Sciences.
Bangar, Roy Indrianto
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Antioxidant Activity Test of The Aqueous Fraction of Tetanus Leaves (Leea aequata L.) Using The DPPH Method Siregar, Nurhakiki; Bangar, Roy Indrianto; Kaban, Vera Estefania; Simanjuntak, Nerly Juli Pranita
PCJN: Pharmaceutical and Clinical Journal of Nusantara Vol. 3 No. 01 (2025): PCJN: Pharmaceutical and Clinical Journal of Nusantara
Publisher : CV. Nusantara Scientific Medical

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.58549/pcjn.v3i01.85

Abstract

Antioxidants play a crucial role in neutralizing free radicals, thereby helping to prevent cell damage and maintain overall health. This study aims to evaluate the antioxidant activity of the aqueous fraction of Tetanus (Leea aequata L.) leaf extract using the 2,2-diphenyl-1-picrylhydrazyl (DPPH) method. The extraction process was carried out through maceration using ethanol as a solvent, followed by aqueous fractionation. Antioxidant activity was measured based on the extract’s ability to scavenge DPPH free radicals, expressed as the IC₅₀ value. The results showed that the aqueous fraction of Tetanus leaf extract exhibited high antioxidant activity, with an IC₅₀ value of 30.23 mg/L. The total phenolic and flavonoid contents in the aqueous fraction were 460.70 mg GAE/100g and 12,621.14 mg QE/100g, respectively. These findings align with pre vious studies indicating that the ethanolic extract of Leea angulata leaves also possesses strong antioxidant activity with a similar IC₅₀ value. Therefore, the aqueous fraction of Tetanus leaf extract has the potential to be an effective natural antioxidant source and can be further developed as a raw material for health supplements or pharmaceutical products.
Efficacy Test of Tetanus Leaf (Leea aequata L.) Ethanol Extract against Bacteria (Pseudomonas aeruginosa) Lumban Gaol, Irma Yohana; Bangar, Roy Indrianto; Kaban, Vera Estefania; Br Sembiring, Novitaria; Harahap, Daimah Wirdatus Sanaun
PCJN: Pharmaceutical and Clinical Journal of Nusantara Vol. 3 No. 01 (2025): PCJN: Pharmaceutical and Clinical Journal of Nusantara
Publisher : CV. Nusantara Scientific Medical

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.58549/pcjn.v3i01.86

Abstract

Antibiotic-resistant nosocomial infections are caused by the opportunistic bacterium Pseudomonas aeruginosa. The purpose of this study is to use the disc diffusion method to assess the antibacterial efficacy of Tetanus (Leea aequata L.) leaf ethanol extract against Pseudomonas aeruginosa. The antibacterial activity was evaluated at 25%, 50%, and 75% concentrations after the leaves were extracted by maceration with 96% ethanol. The findings indicated that the antibacterial activity was depending on concentration, with respective minimum inhibition level measuring 12.97 mm, 16.7 mm, and 21.06 mm. The negative control (DMSO) displayed no inhibition zone, but the positive control (gentamicin) displayed KHM measuring 25.03 mm. The data distribution did not differ significantly, according to statistical analysis (p > 0.05). Bioactive substances that can harm bacterial cell structures, including flavonoids, alkaloids, tannins, and saponins, were thought to be responsible for this antibacterial action. According to these results, tetanus leaf extract may be used as a natural antibacterial agent and as a substitute for antibiotics in the treatment of Pseudomonas aeruginosa infections
Formulation and Evaluation of Tetanus Leaf (Leea aequata L.) Ethanol Extract on Tablet Preparation using Wet Granulation Method Ningsih, Wulan Seppia; Bangar, Roy Indrianto; Kaban, Vera Estefania; Harahap, Daimah Wirdatus Sanaun
PCJN: Pharmaceutical and Clinical Journal of Nusantara Vol. 3 No. 01 (2025): PCJN: Pharmaceutical and Clinical Journal of Nusantara
Publisher : CV. Nusantara Scientific Medical

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.58549/pcjn.v3i01.87

Abstract

Degenerative diseases are currently widely suffered, especially in Indonesian society, as many as 30% of the population is detected with degenerative diseases. One alternative treatment that is widely consumed by Indonesian society is herbal or traditional medicine, one of the plants that is widely consumed by society, especially in Indonesia, namely Tetanus Leea Aequata L leaves. These leaves are often found, especially in the Karo area. The purpose of this study was to use ethanol extract of tetanus Leea Aequata leaves as tablets using the wet granulation method. The content contained in the leaves, such as Flavonoids, can be used as an alternative medicine to treat degenerative diseases by using a comparison of muchilago amyli used as a binder, namely f1 20%, f2 10% and F3 5% based on this study, a formula was obtained that can be used to make tablets, namely formula 1 20% muchilago amyli
Antioxidant Activity Test of The Ethyl Acetate Fraction of Tetanus Leaf (Leea aequata L.) Using The DPPH Method Waruwu, Loice Desy Krisna Yanti; Bangar, Roy Indrianto; Kaban, Vera Estefania; Br Sembiring, Novitaria
PCJN: Pharmaceutical and Clinical Journal of Nusantara Vol. 3 No. 01 (2025): PCJN: Pharmaceutical and Clinical Journal of Nusantara
Publisher : CV. Nusantara Scientific Medical

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.58549/pcjn.v3i01.88

Abstract

Degenerative diseases, such as diabetes, stroke, and cancer, are increasingly common in modern society, with free radicals as one of the main causes. Both natural and artificial sources of antioxidants are available. However, natural antioxidants are a better choice due to concerns over the negative effects of synthetic antioxidants. This study aims to evaluate the antioxidant activity of ethanol extract from titanus (leea aequata L.) leaves using DPPH (2,2-diphenyl-1-picrylhydrazyl) method. titanus leaves are known to contain secondary metabolites that have potential as antioxidants, including flavonoids and phenols. This type of research is an experimental method. The extraction process was carried out by maceration method using 96% ethanol, followed by fractionation using solvents with different polarities to obtain ethyl acetate fraction. The results showed that the ethyl acetate fraction showed the ability as a free radical antidote with an IC50 value of 11.309 ppm, which indicates significant antioxidant activity. These results indicate that titanus leaf extract has the potential to be used as a source of natural antioxidants in the prevention of degenerative diseases.
Antioxidant Activity Test of Titanus (Leea aequata L) Leaf Extract with DPPH Method Sihotang, Nurhanifah; Bangar, Roy Indrianto; Kaban, Vera Estefania; Br Sembiring, Novitaria; Harahap, Daimah Wirdatus Sanaun
PCJN: Pharmaceutical and Clinical Journal of Nusantara Vol. 3 No. 01 (2025): PCJN: Pharmaceutical and Clinical Journal of Nusantara
Publisher : CV. Nusantara Scientific Medical

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.58549/pcjn.v3i01.90

Abstract

Free radicals play an important role in oxidative stress, which can lead to a number of degenerative diseases, including heart disease, cancer and premature aging. Natural and artificial ingredients can be used to make antioxidants. The use of synthetic antioxidants is starting to be limited because excessive use can cause negative side effects, such as the accumulation of toxins in the body. This study aims to evaluate the antioxidant activity of tetanus (Leea aequata L.) leaf extract using DPPH method. Free radicals generated during metabolism can cause cell damage and contribute to various degenerative diseases. Therefore, it is important to find effective sources of antioxidants. In this study, Tetanus leaves were extracted using 96% ethanol solvent through maceration method. Antioxidant activity was evaluated by measuring the IC50 value against DPPH radical. The results showed that tetanus leaf extract had an IC50 value of 39.484 ppm, which indicated significant antioxidant activity. These results indicate that tetanus leaf extract can function as a free radical scavenging agent, which could potentially serve as a raw material in the development of herbal medicine to prevent oxidative stress-related diseases.
Identifikasi Glibenklamid Pada Jamu Kencing Manis Yang Beredar di Medan Johor Andriani, Vina; Sembiring , Novitaria Br; Bangar, Roy Indrianto
Journal of Pharmaceutical and Sciences JPS Volume 8 Nomor 2 (2025)
Publisher : Fakultas Farmasi Universitas Tjut Nyak Dhien

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36490/journal-jps.com.v8i2.889

Abstract

Background: The increasing use of traditional herbal medicine (jamu) for diabetes treatment in the community has been accompanied by a rise in counterfeiting practices, particularly through the addition of synthetic drugs such as glibenclamide (C₂₃H₂₈ClN₃O₅S) to enhance efficacy and sales. This poses potential health risks, thereby necessitating strict monitoring of circulating herbal products. Objective: This study aims to identify the presence of glibenclamide in three samples of antidiabetic jamu available in Medan Johor using Fourier-Transform Infrared Spectroscopy (FTIR). Method: Identification was carried out by comparing the FTIR spectra of the samples (wavenumber range 650–4000 cm⁻¹) with that of the BPFI glibenclamide standard. The characteristic functional groups of glibenclamide used as reference were 3369.5 cm⁻¹ (Amide N–H Stretching), 1714.6 cm⁻¹ (C=O Stretching), and 1155.5 cm⁻¹ (S=O Stretching). Results: The analysis showed that none of the three samples (A2, A3, A4) exhibited absorption peaks corresponding to the critical wavenumbers of glibenclamide. Therefore, the tested samples were declared free from the pharmaceutical chemical substance (PCS) glibenclamide. Conclusion: These findings indicate that the three jamu products are safe for consumption when used as directed. However, routine surveillance by the National Agency of Drug and Food Control (BPOM) remains essential to ensure the safety of herbal products on the market. Further studies using more sensitive methods such as UV-Vis spectrophotometry are recommended to verify these results.
Screening of Drug Interaction Prescreption for Outpatients with Diabetes Mellitus and Hypertension from October to December 2023 at Advent Hospital Medan Khairatunawa, Tisa; Bangar, Roy Indrianto
NSMRJ: Nusantara Scientific Medical Research Journal Vol. 3 No. 01 (2025): NSMRJ: Nusantara Scientific Medical Research Journal
Publisher : CV. Nusantara Scientific Medical

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.58549/nsmrj.v3i01.101

Abstract

Diabetes mellitus and hypertension are two chronic conditions that frequently occur simultaneously and require long-term pharmacological therapy. The combination of treatments in patients with both diseases increases the potential for drug interactions, which can compromise therapeutic effectiveness and elevate the risk of adverse effects. This study aimed to evaluate the severity of drug interactions in outpatients with diabetes mellitus and hypertension at Advent Hospital Medan during the period from October to December 2023. A non-experimental descriptive study with a cross-sectional design was employed, using retrospective data from 191 outpatient prescriptions that met the inclusion criteria. Evaluation was conducted on administrative, pharmaceutical, and clinical aspects of the prescriptions, with a primary focus on identifying drug interactions using the reference database Drugs.com. The results showed that drug interactions were present in 52.4% of the analyzed prescriptions. Most interactions were classified as moderate in severity, predominantly involving pharmacodynamic mechanisms. The most frequent interacting drug combinations included metformin, glimepiride, amlodipine, bisoprolol, and candesartan. The high prevalence of drug interactions among patients with diabetes mellitus and hypertension highlights the importance of systematic prescription screening as a preventive measure. These findings can serve as a basis for developing rational drug use policies and enhancing patient safety in clinical practice.
Co-Authors Br Sembiring, Novitaria Harahap, Daimah Wirdatus Sanaun Khairatunawa, Tisa Lumban Gaol, Irma Yohana Ningsih, Wulan Seppia Sembiring , Novitaria Br Sihotang, Nurhanifah Simanjuntak, Nerly Juli Pranita Siregar, Nurhakiki Vera Estefania Kaban vina andriani Waruwu, Loice Desy Krisna Yanti