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All Journal MPI (Media Pharmaceutica Indonesiana) Indonesian Journal of Agricultural Research Bionature
Hafsan
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Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Chemistry Economics, Econometrics & Finance Environmental Science Health Professions Immunology & microbiology Materials Science & Nanotechnology Medicine & Pharmacology Social Sciences Veterinary

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Mini Review: Controlling of Blood Glucose Levels Utilizing Lactic Acid Bacteria Fatmawati Nur; Hafsan; Faten Khudair
Bionature Vol. 24 No. 2 (2023): Oktober 2023
Publisher : Jurusan Biologi Universitas Negeri Makassar

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Abstract

Lactic acid bacteria (LAB) interest promises a prospective dietary approach for enhancing the management of blood sugar levels in individuals diagnosed with diabetic and those presenting with pre-diabetic conditions. This review article summarizes the available evidence on the role of LAB in blood sugar regulation, focusing on the mechanisms underlying its effects and relevant research results. LAB supplementation has been shown to improve glucose tolerance and insulin sensitivity in animal and human studies, as well as to reduce fasting blood glucose levels in individuals with type 2 diabetes. Potential mechanisms underlying the effects of LAB on blood glucose control include improving insulin sensitivity, reducing inflammation, and improving intestinal barrier function. However, further supporting studies are needed to fully understand the optimal strain and dose of LAB for blood glucose control and to elucidate the mechanisms by which they exert their effects. Despite promising results, the safety and potential side effects of LAB supplements should also be carefully considered. Overall, this review highlights the potential of LAB as a dietary strategy for blood sugar regulation in individuals with diabetic and pre-diabetic.
Modulation of broiler carcass cholesterol levels through Lactobacillus plantarum intervention Mursalim; Hafsan; Fatmawati Nur; Khudaer, Faten
Indonesian Journal of Agricultural Research Vol. 8 No. 3 (2025): InJAR, Vol. 8, No. 3, November 2025
Publisher : Talenta Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32734/injar.v8i3.20284

Abstract

High cholesterol in poultry meat poses a serious public health concern, driving research on healthier animal products. Probiotics such as Lactobacillus plantarum have been investigated for their potential to reduce meat cholesterol through gut microbiota modulation. This study evaluated the effectiveness of L. plantarum derived from Dangke in lowering carcass cholesterol of broiler chickens. The intervention was conducted orally before feeding to ensure precise dosage intake. Four treatment groups were applied: P0 (control), P1 (10⁶ CFU/ml), P2 (10⁸ CFU/ml), and P3 (10¹⁰ CFU/ml). Results showed that P0 had the highest cholesterol level (0.069 mg/dL), while P2 recorded the lowest (0.061 mg/dL), indicating the most significant reduction. This effect is attributed to enhanced colonization of L. plantarum in the cecum, which modulates lipid metabolism and increases bile acid excretion. Beyond cholesterol reduction, broiler performance parameters such as feed conversion ratio (FCR) and body weight gain also improved in probiotic groups, especially at 10⁸ CFU/ml, supporting previous evidence on probiotic efficacy in poultry production. The findings highlight L. plantarum as a promising functional probiotic for reducing cholesterol while enhancing growth efficiency in broilers. From a practical standpoint, incorporation into drinking water may represent a more feasible application strategy, ensuring uniform distribution and easier adoption at the farm level. Future research should address optimal intervention strategies, the sustainability of effects on meat quality, and potential synergistic applications with other probiotics or prebiotics to further enhance poultry health and product safety.
Molecular Docking Analysis of Compounds in Coleus blumei Leaves as Potential Antibiotics Against Methicillin-Resistant Staphylococcus aureus Sukmawaty, Eka; Amanda, Sabilla Suryaning; Hafsan; Nur, Fatmawati; Pratiwi, Afryanti
MPI (Media Pharmaceutica Indonesiana) Vol. 7 No. 2 (2025): DECEMBER
Publisher : Fakultas Farmasi, Universitas Surabaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24123/mpi.v7i2.7419

Abstract

This study investigated the potential of phytochemical compounds from Coleus blumei leaves as anti-Methicillin-Resistant Staphylococcus aureus (MRSA) candidates through a validated molecular docking and absorption-distribution-metabolism-excretion-toxicology (ADMET)-based screening approach. The ligand structures were energy-minimized using MMFF94 followed by PM7 to obtain stable conformers prior to docking. Protein targets consisted of PBP2a and the extracellular antibiotic-sensing domain of MecR1 (benzylpenicilloyl- and oxacilloyl-acylated forms), both of which play central roles in the mecA-mediated resistance pathway of MRSA. Docking simulations were performed using AutoDock Vina v1.2.7 and validated through redocking of co-crystallized ligands, yielding RMSD values <2.0 Å. Among the eight tested compounds, Hexahydro-3H-1[2’-trifluoromethyl]-6’[4’’-trifluoromethylphenyl]- exhibited the strongest binding affinities, surpassing reference β-lactam antibiotics and demonstrating key interactions with residues involved in allosteric activation of PBP2a and ligand sensing in MecR1. ADMET predictions further supported its drug-likeness and safety profile, although experimental confirmation remains necessary. These findings highlight this compound as a promising anti-MRSA lead candidate and underscore the need for subsequent in vitro and in vivo evaluations to substantiate its mechanistic and therapeutic potential.
Co-Authors Amanda, Sabilla Suryaning Faten Khudair Fatmawati Nur Fatmawati Nur Khudaer, Faten Mursalim Pratiwi, Afryanti Sukmawaty, Eka