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All Journal JAPI: Jurnal Akses Pengabdian Indonesia Journal of Citizenship Indonesian Journal of Jamu
Putri, Fadhilah Eka
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Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Chemistry Economics, Econometrics & Finance Health Professions Medicine & Pharmacology Nursing Public Health Social Sciences Other

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Virtual Screening of Flavonoid Compounds as Potential Antibiofilm Agents Targeting Glucosyltransferase Kurniatin, Popi Asri; Putri, Fadhilah Eka; Purwanto, Ukhradiya Magharaniq Safira
Jurnal Jamu Indonesia Vol. 10 No. 2 (2025): Jurnal Jamu Indonesia
Publisher : Tropical Biopharmaca Research Center, IPB University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29244/jji.v10i2.372

Abstract

Dental caries are caused by plaque formation resulting from biofilm accumulation on tooth surfaces. The bacterium Streptococcus mutans plays a crucial role in biofilm formation, partly through the production of glucosyltransferase, which catalyzes biofilm synthesis. Flavonoids are secondary metabolites commonly found in plants, known for diverse biological properties, including antibiofilm effects. This study aimed to screen the potential of flavonoid compounds as antibiofilm agents through inhibition of glucosyltransferase using an in-silico approach. A total of 87 flavonoid compounds obtained from the ZINC database were evaluated via molecular docking methods. Screening results based on binding free energy (ΔG) values, analyzed using the PyRX-Virtual Screening Tool, indicated that 36 compounds had potential to inhibit glucosyltransferase. Further molecular docking using AutoDock Vina identified nine compounds with ΔG values more favorable than the natural ligand of glucosyltransferase (maltose). Molecular interaction analysis using LigPlot+ and PyMOL revealed that taxifolin, gallocatechin, and sakuranetin interacted with three catalytic residues of the enzyme, whereas the remaining six compounds interacted with two catalytic residues. Liquiritigenin exhibited the lowest ΔG (-7.0 kcal/mol) and an inhibition constant (Ki) of 7.39 µM, indicating high affinity for glucosyltransferase. This compound formed two hydrogen bonds and four hydrophobic interactions, engaging two catalytic residues of the enzyme, Asn481 and Trp517. These findings highlight the potential of flavonoids as antibiofilm agents via glucosyltransferase inhibition. Further experimental validation through in vitro studies is necessary to confirm these in-silico findings.
Gerakan Penolakan Masyarakat Adat Terhadap Reklamasi Teluk Benoa Hairiyah, Salma Maisyatul; Putri, Fadhilah Eka
Journal of Citizenship Volume 3 Issue 2, 2024
Publisher : HK-Publishing

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37950/joc.v3i2.516

Abstract

AbstractDecision to the reclamation of Benoa Bay which was based on human greed for nature invited a lot of rejection, especially from the Balinese people, plus there was a change in the status of Benoa Bay which was originally a conservation area in Presidential Decree No. 45 of 2011 became a cultivation area in Presidential Decree no. 51 of 2014. The movement of the Balinese people against the reclamation of Benoa Bay is colored by the thick collective identity of Balinese indigenous people. Initially, the reason for the movement against reclamation was dominated by reasons for the quality of life of the people and the health of the Balinese environment, but with the intervention of indigenous peoples, this movement has slowly shown a narrative of defending the sanctity of the Benoa Bay area. Writing this journal aims to examine the role of indigenous peoples in the movement against the Benoa Bay reclamation. The preparation of this journal uses a qualitative method of literature study approach. The result obtained is that the Balinese people formed a collective group of indigenous peoples who held an action. This action is based on the fact that reclamation is considered to be able to destroy various sacred points in Benoa Bay.Keywords: Benoa Bay reclamation, Indigenous peoples, Social movements. AbstrakKeputusan reklamasi teluk benoa yang berlandaskan keserakahan manusia terhadap alam mengundang banyak penolakan terutama dari masyarakat bali, ditambah lagi ada perubahan status teluk benoa yang semula adalah wilayah konservasi pada Perpres No. 45 Tahun 2011 menjadi kawasan budidaya pada Perpres No. 51 Tahun 2014. Gerakan masyarakat bali menolak reklamasi teluk benoa diwarnai dengan pekatnya identitas kolektif warga adat bali. Pada awalnya alasan gerakan penolakan reklamasi ini didominasi oleh alasan kualitas kehidupan masyarakat dan kesehatan lingkungan bali, namun atas campur tangan masyarakat adat perlahan gerakan ini memperlihatkan narasi pembelaan kesucian wilayah teluk benoa. Ditulisnya jurnal ini bertujuan untuk mengkaji peran masyarakat adat pada gerakan penolakan reklamasi teluk benoa. Penyusunan jurnal ini menggunakan metode kualitatif pendekatan studi literature. Hasil yang didapat ialah masyarakat bali membentuk kelompok kolektif masyarakat adat yang mengadakan aksi. Aksi tersebut didasari karena reklamasi dianggap dapat menghancurkan beragam titik suci yang ada di teluk benoa.Kata kunci: Reklamasi Teluk Benoa, Masyarakat adat, Gerakan sosial.
Pendampingan Pembuatan Nomor Induk Berusaha (NIB) Sebagai Legalitas Usaha Dan Syarat Pendaftaran Sertifikat Halal Produk Bagi UMKM Di Desa Cijaku Widiati, Siti; Subagja, Fikri Ahmad; Setianingrum, Huldah Nilan; Suwarno, Esternia Gladys; Sitompul, Gebi Levia; Tasmi, Tasmi; Putri, Fadhilah Eka; Puspitasari, Windi; Fadilah, Amelia; Rizqullah, Ahmad Rafi; Sumardi, Dedi; Pratama, Thairq Al Aziz
JAPI (Jurnal Akses Pengabdian Indonesia) Vol 8, No 2 (2023)
Publisher : Universitas Tribhuwana Tunggadewi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33366/japi.v8i2.5000

Abstract

Usaha Mikro Kecil Menengah (UMKM) memberikan kontribusi untuk meningkatkan pendapatan daerah namun permasalahan yang banyak dijumpai adalah pengurusan Nomor Identitas Berusaha (NIB). Desa Cijaku, Kabupaten Lebak selaku mitra yaitu usaha emping melinjo Mak Edol juga memiliki permasalahan terkait legalitas usaha. Berdasarkan permasalahan tersebut Tim Pengabdian Kepada Masyarakat Universitas Sultan Ageng Tirtayasa membantu memberikan solusi agar pelaku usaha untuk mendapatkan izin usaha dan izin komersial atau operasional. Tujuan Pengabdian Kepada Masyarakat ini adalah meningkatkan pemaham mitra terkait legalitas usaha dan memberikan pendampingan dalam pembuatan Nomor Induk Berusaha (NIB) melalui sistem online Single Submission dan Sertifikasi Halal melalui sistem SiHalal. Metode yang digunakan adalah deskriptif dengan teknik observasi, wawancara, dokumentasi, dan substansi Iptek. Berdasarkan kegiatan Pengabdian Kepada Masyarakat yang telah dilakukan bahwa usaha emping melinjo Mak Edol telah berhasil memperoleh Nomor Induk Berusaha (NIB) dan sertifikat halal. 
Co-Authors Fadilah, Amelia Hairiyah, Salma Maisyatul Nurwijayanti Pratama, Thairq Al Aziz Purwanto, Ukhradiya Magharaniq Safira Puspitasari, Windi Rizqullah, Ahmad Rafi Setianingrum, Huldah Nilan Sitompul, Gebi Levia Subagja, Fikri Ahmad Sumardi, Dedi Suwarno, Esternia Gladys Widiati, siti